Single Frame Laser Diode Photoacoustic Imaging: Denoising and Reconstruction

Denoising convolutional neural networks for photoacoustic microscopy

Photoacoustic imaging is a new imaging technology in recent years, which combines the advantages of high resolution and rich contrast of optical imaging with the advantages of high penetration depth of acoustic imaging. Photoacoustic imaging has been widely used in biomedical fields, such as brain imaging, tumor detection and so on. The signal-to-noise ratio (SNR) of image signals in photoacoustic imaging is generally low due to the limitation of laser pulse energy, electromagnetic interference in the external environment and system noise. In order to solve the problem of low SNR of photoacous…

Sinogram super-resolution and denoising convolutional neural network (SRCN) for limited data photoacoustic tomography

The quality of the reconstructed photoacoustic image largely depends on the amount of photoacoustic (PA) boundary data available, which in turn is proportional to the number of detectors employed. In case of limited data (owing to less number of detectors due to cost/instrumentation constraints), the reconstructed PA images suffer from artifacts and are often noisy. In this work, for the first time, a deep learning based model was developed to super resolve and denoise the photoacoustic sinogram data. The proposed method was compared with existing nearest neighbor interpolation and wavelet bas…

Spatiotemporal singular value decomposition for denoising in photoacoustic imaging with low-energy excitation light source

Photoacoustic (PA) imaging is an emerging hybrid imaging modality that combines rich optical spectroscopic contrast and high ultrasonic resolution and thus holds tremendous promise for a wide range of pre-clinical and clinical applications. Compact and affordable light sources such as light-emitting diodes (LEDs) and laser diodes (LDs) are promising alternatives to bulky and expensive solid-state laser systems that are commonly used as PA light sources. These could accelerate the clinical translation of PA technology. However, PA signals generated with these light sources are readily degraded …

Simultaneous Denoising and Localization Network for Photoacoustic Target Localization

A significant research problem of recent interest is the localization of targets like vessels, surgical needles, and tumors in photoacoustic (PA) images. To achieve accurate localization, a high photoacoustic signal-to-noise ratio (SNR) is required. However, this is not guaranteed for deep targets, as optical scattering causes an exponential decay in optical fluence with respect to tissue depth. To address this, we develop a novel deep learning method designed to explicitly exhibit robustness to noise present in photoacoustic radio-frequency (RF) data. More precisely, we describe and evaluate …

Improving needle visibility in LED-based photoacoustic imaging using deep learning with semi-synthetic datasets

Photoacoustic imaging has shown great potential for guiding minimally invasive procedures by accurate identification of critical tissue targets and invasive medical devices (such as metallic needles). The use of light emitting diodes (LEDs) as the excitation light sources accelerates its clinical translation owing to its high affordability and portability. However, needle visibility in LED-based photoacoustic imaging is compromised primarily due to its low optical fluence. In this work, we propose a deep learning framework based on U-Net to improve the visibility of clinical metallic needles w…

基于硅光子学激光多普勒测振仪的非接触式光声成像

Non-contact photoacoustic imaging with a silicon photonics-based Laser Doppler Vibrometer

本文提出一种基于硅光子学激光多普勒测振仪的非接触式光声成像方法，使用紧凑型脉冲激光二极管激发并扫描LDV光束，在模拟血管的硅胶样品上实现了二维光声图像重建，检测到生理范围内的光声信号。