In this article, we analyze perinatal data with birth weight (BW) as primarily interesting response variable. Gestational age (GA) is usually an important covariate and included in polynomial form. However, in opposition to this univariate regression, bivariate modeling of BW and GA is recommended to distinguish effects on each, on both, and between them. Rather than a parametric bivariate distribution, we apply conditional copula regression, where marginal distributions of BW and GA (not necessarily of the same form) can be estimated independently, and where the dependence structure is modeled conditional on the covariates separately from these marginals. In the resulting distributional regression models, all parameters of the two marginals and the copula parameter are observation-specific. Besides biometric and obstetric information, data on drinking water contamination and maternal smoking are included as environmental covariates. While the Gaussian distribution is suitable for BW, the skewed GA data are better modeled by the three-parametric Dagum distribution. The Clayton copula performs better than the Gumbel and the symmetric Gaussian copula, indicating lower tail dependence (stronger dependence when both variables are low), although this non-linear dependence between BW and GA is surprisingly weak and only influenced by Cesarean section. A non-linear trend of BW on GA is detected by a classical univariate model that is polynomial with respect to the effect of GA. Linear effects on BW mean are similar in both models, while our distributional copula regression also reveals covariates' effects on all other parameters.
Bivariate meta-analysis provides a useful framework for combining information across related studies and has been utilised to combine evidence from clinical studies to evaluate treatment efficacy on two outcomes. It has also been used to investigate surrogacy patterns between treatment effects on the surrogate endpoint and the final outcome. Surrogate endpoints play an important role in drug development when they can be used to measure treatment effect early compared to the final outcome and to predict clinical benefit or harm. The standard bivariate meta-analytic approach models the observed …
A bivariate distribution with continuous margins can be uniquely decomposed via a copula and its marginal distributions. We consider the problem of estimating the copula function and adopt a Bayesian approach. On the space of copula functions, we construct a finite-dimensional approximation subspace that is parametrized by a doubly stochastic matrix. A major problem here is the selection of a prior distribution on the space of doubly stochastic matrices also known as the Birkhoff polytope. The main contributions of this paper are the derivation of a simple formula for the Jeffreys prior and sh…
Copulas allow to learn marginal distributions separately from the multivariate dependence structure (copula) that links them together into a density function. Vine factorizations ease the learning of high-dimensional copulas by constructing a hierarchy of conditional bivariate copulas. However, to simplify inference, it is common to assume that each of these conditional bivariate copulas is independent from its conditioning variables. In this paper, we relax this assumption by discovering the latent functions that specify the shape of a conditional copula given its conditioning variables We le…
Conditional copulas are flexible statistical tools that couple joint conditional and marginal conditional distributions. In a linear regression setting with more than one covariate and two dependent outcomes, we propose the use of additive models for conditional bivariate copula models and discuss computation and model selection tools for performing Bayesian inference. The method is illustrated using simulations and a real example.
There exist many bivariate parametric copulas to model bivariate data with different dependence features. We propose a new bivariate parametric copula family that cannot only handle various dependence patterns that appear in the existing parametric bivariate copula families, but also provides a more enriched dependence structure. The proposed copula construction exploits finite mixtures of bivariate normal distributions. The mixing operation, the distinct correlation and mean parameters at each mixture component introduce quite a flexible dependence. The new parametric copula is theoretically …
Parametric conditional copula models allow the copula parameters to vary with a set of covariates according to an unknown calibration function. Flexible Bayesian inference for the calibration function of a bivariate conditional copula is proposed via a sparse Gaussian process (GP) prior distribution over the set of smooth calibration functions for the single index model (SIM). The estimation of parameters from the marginal distributions and the calibration function is done jointly via Markov Chain Monte Carlo sampling from the full posterior distribution. A new Conditional Cross Validated Pseu…
We study the behavior of bivariate empirical copula process $\mathbb{G}_n(\cdot,\cdot)$ on pavements $[0,k_n/n]^2$ of $[0,1]^2,$ where $k_n$ is a sequence of positive constants fulfilling some conditions. We provide a upper bound for the strong approximation of $\mathbb{G}_n(\cdot,\cdot)$ by a Gaussian process when $k_n/n \searrow γ$ as $n\rightarrow \infty,$ where $0 \leq γ\leq 1.$
Université du Québec à Montréal（蒙特利尔魁北克大学）；Université de Montréal（蒙特利尔大学）；Université catholique de Louvain（天主教鲁汶大学）
A recommender system based on ranks is proposed, where an expert's ranking of a set of objects and a user's ranking of a subset of those objects are combined to make a prediction of the user's ranking of all objects. The rankings are assumed to be induced by latent continuous variables corresponding to the grades assigned by the expert and the user to the objects. The dependence between the expert and user grades is modelled by a copula in some parametric family. Given a prior distribution on the copula parameter, the user's complete ranking is predicted by the mode of the posterior predictive…
We propose a copula-based measure of asymmetry between the lower and upper tail probabilities of bivariate distributions. The proposed measure has a simple form and possesses some desirable properties as a measure of asymmetry. The limit of the proposed measure as the index goes to the boundary of its domain can be expressed in a simple form under certain conditions on copulas. A sample analogue of the proposed measure for a sample from a copula is presented and its weak convergence to a Gaussian process is shown. Another sample analogue of the presented measure, which is based on a sample fro…
In this work we propose a semiparametric bivariate copula whose density is defined by a piecewise constant function on disjoint squares. We obtain the maximum likelihood estimators of model parameters and prove that they reduce to the sample copula under specific conditions. We further propose to carry out a full Bayesian analysis of the model and introduce a spatial dependent prior distribution for the model parameters. This prior allows the parameters to borrow strength across neighbouring regions to produce smooth posterior estimates. To characterise the posterior distribution, via the full…
Vine copulas allow to build flexible dependence models for an arbitrary number of variables using only bivariate building blocks. The number of parameters in a vine copula model increases quadratically with the dimension, which poses new challenges in high-dimensional applications. To alleviate the computational burden and risk of overfitting, we propose a modified Bayesian information criterion (BIC) tailored to sparse vine copula models. We show that the criterion can consistently distinguish between the true and alternative models under less stringent conditions than the classical BIC. The …
Approximate Bayesian computation (ABC) refers to a family of inference methods used in the Bayesian analysis of complex models where evaluation of the likelihood is difficult. Conventional ABC methods often suffer from the curse of dimensionality, and a marginal adjustment strategy was recently introduced in the literature to improve the performance of ABC algorithms in high-dimensional problems. The marginal adjustment approach is extended using a Gaussian copula approximation. The method first estimates the bivariate posterior for each pair of parameters separately using a 2-dimensional Gaus…
We propose a copula density estimator that can include information on bivariate marginals when the information is available. We use B-splines for copula density approximation and include information on bivariate marginals via a penalty term. Our estimator satisfies the constraints for a copula density. Under mild conditions, the proposed estimator is consistent.
Diagnostic test accuracy studies typically report the number of true positives, false positives, true negatives and false negatives. There usually exists a negative association between the number of true positives and true negatives, because studies that adopt less stringent criterion for declaring a test positive invoke higher sensitivities and lower specificities. A generalized linear mixed model (GLMM) is currently recommended to synthesize diagnostic test accuracy studies. We propose a copula mixed model for bivariate meta-analysis of diagnostic test accuracy studies. Our general model inc…
We first review an approach that had been developed in the past years to introduce concepts of "bivariate ageing" for exchangeable lifetimes and to analyze mutual relations among stochastic dependence, univariate ageing, and bivariate ageing. A specific feature of such an approach dwells on the concept of semi-copula and in the extension, from copulas to semi-copulas, of properties of stochastic dependence. In this perspective, we aim to discuss some intricate aspects of conceptual character and to provide the readers with pertinent remarks from a Bayesian Statistics standpoint. In particular …
In this paper, we propose simple estimation methods dedicated to a semiparametric family of bivariate copulas. These copulas can be simply estimated through the estimation of their univariate generating function. We take profit of this result to estimate the associated measures of association as well as the high probability regions of the copula. These procedures are illustrated on simulations and on real data.
Vine copulas are a highly flexible class of dependence models, which are based on the decomposition of the density into bivariate building blocks. For applications one usually makes the simplifying assumption that copulas of conditional distributions are independent of the variables on which they are conditioned. However this assumption has been criticised for being too restrictive. We examine both simplified and non-simplified vine copulas in three dimensions and investigate conceptual differences. We show and compare contour surfaces of three-dimensional vine copula models, which prove to be…
A bivariate integer-valued autoregressive process of order 1 (BINAR(1)) with copula-joint innovations is studied. Different parameter estimation methods are analyzed and compared via Monte Carlo simulations with emphasis on estimation of the copula dependence parameter. An empirical application on defaulted and non-defaulted loan data is carried out using different combinations of copula functions and marginal distribution functions covering the cases where both marginal distributions are from the same family, as well as the case where they are from different distribution families.
In genome wide association studies (GWAS), researchers are often dealing with non-normally distributed traits or a mixture of discrete-continuous traits. However, most of the current region-based methods rely on multivariate linear mixed models (mvLMMs) and assume a multivariate normal distribution for the phenotypes of interest. Hence, these methods are not applicable to disease or non-normally distributed traits. Therefore, there is a need to develop unified and flexible methods to study association between a set of (possibly rare) genetic variants and non-normal multivariate phenotypes. Cop…
The paper considers the problem of establishing data support for the simplifying assumption (SA) in a bivariate conditional copula model. It is known that SA greatly simplifies the inference for a conditional copula model, but standard tools and methods for testing SA tend to not provide reliable results. After splitting the observed data into training and test sets, the method proposed will use a flexible training data Bayesian fit to define tests based on randomization and standard asymptotic theory. Theoretical justification for the method is provided and its performance is studied using si…
Recently, Serfling and Xiao (2007) extended the L-moment theory (Hosking, 1990) to the multivariate setting. In the present paper, we focus on the two-dimension random vectors to establish a link between the bivariate L-moments (BLM) and the underlying bivariate copula functions. This connection provides a new estimate of dependence parameters of bivariate statistical data. Consistency and asymptotic normality of the proposed estimator are established. Extensive simulation study is carried out to compare estimators based on the BLM, the maximum likelihood, the minimum distance and rank approxi…
The current statistical procedures implemented in statistical software packages for pooling of diagnostic test accuracy data include hSROC regression and the bivariate random-effects meta-analysis model (BRMA). However, these models do not report the overall mean but rather the mean for a central study with random-effect equal to zero and have difficulties estimating the correlation between sensitivity and specificity when the number of studies in the meta-analysis is small and/or when the between-study variance is relatively large. This tutorial on advanced statistical methods for meta-analys…
Normal copula with a correlation coefficient between $-1$ and $1$ is tail independent and so it severely underestimates extreme probabilities. By letting the correlation coefficient in a normal copula depend on the sample size, Hüsler and Reiss (1989) showed that the tail can become asymptotically dependent. In this paper, we extend this result by deriving the limit of the normalized maximum of $n$ independent observations, where the $i$-th observation follows from a normal copula with its correlation coefficient being either a parametric or a nonparametric function of $i/n$. Furthermore, both…
Copulas are mathematical objects that fully capture the dependence structure among random variables and hence, offer a great flexibility in building multivariate stochastic models. In statistics, a copula is used as a general way of formulating a multivariate distribution in such a way that various general types of dependence can be represented. In case of bivariate sample, the notion of estimating copula is closely related to that of testing independence in a bivariate sample, as when the components of the bivariate sample are independent the copula becomes simply product of two uniform distr…
Rigby & Stasinopoulos (2005) introduced generalized additive models for location, scale and shape (GAMLSS) where the response distribution is not restricted to belong to the exponential family and its parameters can be specified as functions of additive predictors that allows for several types of covariate effects (e.g., linear, non-linear, random and spatial effects). In many empirical situations, however, modeling simultaneously two or more responses conditional on some covariates can be of considerable relevance. In this article, we extend the scope of GAMLSS by introducing a bivariate copu…
A bivariate copula mixed model has been recently proposed to synthesize diagnostic test accuracy studies and it has been shown that is superior to the standard generalized linear mixed model (GLMM) in this context. Here we call trivariate vine copulas to extend the bivariate meta-analysis of diagnostic test accuracy studies by accounting for disease prevalence. Our vine copula mixed model includes the trivariate GLMM as a special case and can also operate on the original scale of sensitivity, specificity, and disease prevalence. Our general methodology is illustrated by re-analysing the data o…
In probability and statistics, reliable modeling of bivariate continuous characteristics remains a real insurmountable consideration. During analysis of bivariate data, we have to deal with heterogeneity that is present in data. Therefore, for dealing with such a scenario, we investigate a novel technique based on a Farlie-Gumbel-Morgenstern (FGM) copula and the inverse Topp-Leone (ITL) model in this study. The idea is to use the oscillating functionalities of the FGM copula and the flexibility of the ITL model to propose a serious bivariate solution for the modeling of bivariate lifetime phen…
A new class of copulas based on order statistics was introduced by Baker (2008). Here, further properties of the bivariate and multivariate copulas are described, such as that of likelihood ratio dominance (LRD), and further bivariate copulas are introduced that generalize the earlier work. One of the new copulas is an integral of a product of Bessel functions of imaginary argument, and can attain the Fréchet bound. The use of these copulas for fitting data is described, and illustrated with examples. It was found empirically that the multivariate copulas previously proposed are not flexible e…
Vine copulas are a type of multivariate dependence model, composed of a collection of bivariate copulas that are combined according to a specific underlying graphical structure. Their flexibility and practicality in moderate and high dimensions have contributed to the popularity of vine copulas, but relatively little attention has been paid to their extremal properties. To address this issue, we present results on the tail dependence properties of some of the most widely studied vine copula classes. We focus our study on the coefficient of tail dependence and the asymptotic shape of the sample…
This paper extends the analysis of bivariate seemingly unrelated regression (SUR) Tobit model by modeling its nonlinear dependence structure through the Clayton copula. The ability in capturing/modeling the lower tail dependence of the SUR Tobit model where some data are censored (generally, at zero point) is an additionally useful feature of the Clayton copula. We propose a modified version of the inference function for margins (IFM) method (Joe and Xu, 1996), which we refer to as MIFM method, to obtain the estimates of the marginal parameters and a better (satisfactory) estimate of the copul…
This research is motivated by discovering and underpinning genetic causes for the progression of a bilateral eye disease, Age-related Macular Degeneration (AMD), of which the primary outcomes, progression times to late-AMD, are bivariate and interval-censored due to intermittent assessment times. We propose a novel class of copula-based semiparametric transformation models for bivariate data under general interval censoring, which includes the case 1 interval censoring (current status data) and case 2 interval censoring. Specifically, the joint likelihood is modeled through a two-parameter Arc…
Bivariate Frank Copula: Some More Results on Point Estimation of the Association Parameter from a Bayesian Perspective and Revisiting the Goodness of Fit Tests with an Application to Model Groundwater Data from Dong Thap, Vietnam
Faculty of Applied Science, Ho Chi Minh City University of Technology (HCMUT)（胡志明市理工大学应用科学学院）；Vietnam National University Ho Chi Minh City（越南国家大学胡志明市分校）；Faculty of Mathematics and Statistics, Ton Duc Thang University（Ton Duc Thang大学数学与统计学院）
Simplified vine copulas (SVCs), or pair-copula constructions, have become an important tool in high-dimensional dependence modeling. So far, specification and estimation of SVCs has been conducted under the simplifying assumption, i.e., all bivariate conditional copulas of the vine are assumed to be bivariate unconditional copulas. We introduce the partial vine copula (PVC) which provides a new multivariate dependence measure and which plays a major role in the approximation of multivariate distributions by SVCs. The PVC is a particular SVC where to any edge a j-th order partial copula is assi…
A bivariate cure copula model with zero-inflated gamma frailty for right-censored data
Graduate Institute for Advanced Studies, SOKENDAI（SOKENDAI 高级研究研究生院）；Institute of Statistical Mathematics（统计数学研究所）；School of Informatics and Data Science, Hiroshima University（广岛大学信息科学与数据科学学院）
Extreme-value copulas arise as the limiting dependence structure of component-wise maxima. Defined in terms of a functional parameter, they are one of the most widespread copula families due to their flexibility and ability to capture asymmetry. Despite this, meeting the complex analytical properties of this parameter in an unconstrained setting remains a challenge, restricting most uses to models with very few parameters or nonparametric models. Focusing on the bivariate case, we propose a novel semiparametric approach. Our procedure relies on a series of transformations, including Williamson…
Poverty is a multidimensional concept often comprising a monetary outcome and other welfare dimensions such as education, subjective well-being or health, that are measured on an ordinal scale. In applied research, multidimensional poverty is ubiquitously assessed by studying each poverty dimension independently in univariate regression models or by combining several poverty dimensions into a scalar index. This inhibits a thorough analysis of the potentially varying interdependence between the poverty dimensions. We propose a multivariate copula generalized additive model for location, scale a…
Copula mixed models for trivariate (or bivariate) meta-analysis of diagnostic test accuracy studies accounting (or not) for disease prevalence have been proposed in the biostatistics literature to synthesize information. However, many systematic reviews often include case-control and cohort studies, so one can either focus on the bivariate meta-analysis of the case control studies or the trivariate meta-analysis of the cohort studies, as only the latter contains information on disease prevalence. In order to remedy this situation of wasting data we propose a hybrid copula mixed model via a com…
Vine copulas (or pair-copula constructions) have become an important tool for high-dimensional dependence modeling. Typically, so called simplified vine copula models are estimated where bivariate conditional copulas are approximated by bivariate unconditional copulas. We present the first non-parametric estimator of a non-simplified vine copula that allows for varying conditional copulas using penalized hierarchical B-splines. Throughout the vine copula, we test for the simplifying assumption in each edge, establishing a data-driven non-simplified vine copula estimator. To overcome the curse …
Starting from the characterization of extreme-value copulas based on max-stability, large-sample tests of extreme-value dependence for multivariate copulas are studied. The two key ingredients of the proposed tests are the empirical copula of the data and a multiplier technique for obtaining approximate p-values for the derived statistics. The asymptotic validity of the multiplier approach is established, and the finite-sample performance of a large number of candidate test statistics is studied through extensive Monte Carlo experiments for data sets of dimension two to five. In the bivariate …
We describe here a new method to estimate copula measure. From N observations of two variables X and Y, we draw a huge number m of subsamples (size n<N), and we compute the joint ranks in these subsamples. Then, for each bivariate rank (p,q) (0<p,q<n+1), we count the number of subsamples such that there exist an observation of the subsample with bivariate rank (p,q). This counting gives an estimate of the density of the copula. The simulation study shows that this method seems to gives a better than the usual kernel method. The main advantage of this new method is then we do not need to choose…
