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arXiv 2209.04787stat.ME
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纵向数据与生存时间数据的时变二元Copula联合模型

A time-varying bivariate copula joint model for longitudinal and time-to-event data

Zili Zhang, Christiana Charalambous, Peter Foster

AI总结:

针对常规联合模型条件独立假设难验证的问题,提出含随机效应及时变二元Copula的联合模型,其参数估计对Copula误设稳健,生存概率预测性能更优,并应用于PBC数据。

摘要:

本文提出了一种时变二元Copula联合模型,该模型通过随机效应和时变二元Copula,在每个时间点对重复测量的纵向结局和生存数据进行联合建模。常规联合模型通常假设纵向过程和生存时间过程共享特定于受试者的潜在随机效应或类别,且给定这些潜在变量时,两个过程条件独立。在此假设下,两个过程的联合似然易于推导,它们的关联以及群体间的异质性由不可观测的潜在变量自然引入。然而,由于这些潜在变量的不可观测性,条件独立假设难以验证。因此,除随机效应外,引入时变二元Copula以解释两个过程之间额外的时间依赖性关联。所提出的模型在某些Copula下包含常规联合模型作为特例。模拟研究表明,所提出模型中的参数估计量对Copula误设具有稳健性,且在预测生存概率方面比常规联合模型具有更优性能。本文对原发性胆汁性肝硬化(PBC)数据进行了真实数据应用。

英文摘要:

A time-varying bivariate copula joint model, which models the repeatedly measured longitudinal outcome at each time point and the survival data jointly by both the random effects and time-varying bivariate copulas, is proposed in this paper. A regular joint model normally supposes there exist subject-specific latent random effects or classes shared by the longitudinal and time-to-event processes and the two processes are conditionally independent given these latent variables. Under this assumption, the joint likelihood of the two processes is straightforward to derive and their association, as well as heterogeneity among the population, are naturally introduced by the unobservable latent variables. However, because of the unobservable nature of these latent variables, the conditional independence assumption is difficult to verify. Therefore, besides the random effects, a time-varying bivariate copula is introduced to account for the extra time-dependent association between the two processes. The proposed model includes a regular joint model as a special case under some copulas. Simulation studies indicates the parameter estimators in the proposed model are robust against copula misspecification and it has superior performance in predicting survival probabilities compared to the regular joint model. A real data application on the Primary biliary cirrhosis (PBC) data is performed.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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