Breast cancer is the most common invasive cancer in women, and the second main cause of death. Breast cancer screening is an efficient method to detect indeterminate breast lesions early. The common approaches of screening for women are tomosynthesis and mammography images. However, the traditional manual diagnosis requires an intense workload by pathologists, who are prone to diagnostic errors. Thus, the aim of this study is to build a deep convolutional neural network method for automatic detection, segmentation, and classification of breast lesions in mammography images. Based on deep learning the Mask-CNN (RoIAlign) method was developed to features selection and extraction; and the classification was carried out by DenseNet architecture. Finally, the precision and accuracy of the model is evaluated by cross validation matrix and AUC curve. To summarize, the findings of this study may provide a helpful to improve the diagnosis and efficiency in the automatic tumor localization through the medical image classification.
Deep Learning Predicts Mammographic Breast Density in Clinical Breast Ultrasound Images
University of Hawai’i at Mānoa（夏威夷大学马诺阿分校）；University of Hawai’i Cancer Center（夏威夷大学癌症中心）；The Queen’s Medical Center（皇后医疗中心）；Hawaiʻi Pacific Health（夏威夷太平洋健康）；Hawaiʻi Diagnostic Radiology Services（夏威夷诊断放射服务中心）
Purpose: To develop and evaluate the accuracy of a multi-view deep learning approach to the analysis of high-resolution synthetic mammograms from digital breast tomosynthesis screening cases, and to assess the effect on accuracy of image resolution and training set size. Materials and Methods: In a retrospective study, 21,264 screening digital breast tomosynthesis (DBT) exams obtained at our institution were collected along with associated radiology reports. The 2D synthetic mammographic images from these exams, with varying resolutions and data set sizes, were used to train a multi-view deep …
University of Oklahoma（俄克拉荷马大学）；ShanghaiTech University（上海科技大学）；University of Oklahoma Health Sciences Center（俄克拉荷马大学健康科学中心）
This study aims to develop a novel computer-aided diagnosis (CAD) scheme for mammographic breast mass classification using semi-supervised learning. Although supervised deep learning has achieved huge success across various medical image analysis tasks, its success relies on large amounts of high-quality annotations, which can be challenging to acquire in practice. To overcome this limitation, we propose employing a semi-supervised method, i.e., virtual adversarial training (VAT), to leverage and learn useful information underlying in unlabeled data for better classification of breast masses. …
National School of Medicine of Sfax（斯法克斯医学院）；CES-Computer, Electronic And Smart engineering systems design Laboratory（计算机、电子与智能工程系统设计实验室）；National School of Engineers of Sfax（斯法克斯工程师学院）
Breast cancer is considered as one of a major health problem that constitutes the strongest cause behind mortality among women in the world. So, in this decade, breast cancer is the second most common type of cancer, in term of appearance frequency, and the fifth most common cause of cancer related death. In order to reduce the workload on radiologists, a variety of CAD systems; Computer-Aided Diagnosis (CADi) and Computer-Aided Detection (CADe) have been proposed. In this paper, we interested on CADe tool to help radiologist to detect cancer. The proposed CADe is based on a three-step work fl…
Locating region of interest for breast cancer masses in the mammographic image is a challenging problem in medical image processing. In this research work, the keen idea is to efficiently extract suspected mass region for further examination. In particular to this fact breast boundary segmentation on sliced rgb image using modified intensity based approach followed by quad tree based division to spot out suspicious area are proposed in the paper. To evaluate the performance DDSM standard dataset are experimented and achieved acceptable accuracy.
MammoFL: Mammographic Breast Density Estimation using Federated Learning
University of Pennsylvania（宾夕法尼亚大学）；Massachusetts Institute of Technology（麻省理工学院）；GSK（葛兰素史克）；Indiana University School of Medicine（印第安纳大学医学院）；Mayo Clinic（梅奥诊所）
DSU-Net: An Attention-Enhanced Dense Skip U-Net for Breast Lesion Segmentation in Mammographic Images
Department of Biomedical Engineering, University of Wisconsin-Milwaukee（威斯康星大学密尔沃基分校生物医学工程系）；Department of Mechanical Engineering, Northern Arizona University（北亚利桑那大学机械工程系）
RADIFUSION: A multi-radiomics deep learning based breast cancer risk prediction model using sequential mammographic images with image attention and bilateral asymmetry refinement
Monash University Malaysia（莫纳什大学马来西亚分校）；The University of Oklahoma（俄克拉荷马大学）；Karolinska Institute（卡罗林斯卡学院）；Karolinska University Hospital（卡罗林斯卡大学医院）；University of Malaya（马来亚大学）；The University of Melbourne（墨尔本大学）
Exploring the interplay of label bias with subgroup size and separability: A case study in mammographic density classification
Department of Biomedical Engineering, University of Calgary, Canada Department of Radiology, University of Calgary, Canada Hotchkiss Brain Institute, University of Calgary, Canada Alberta Children's Hospital Research Institute, University of Calgary, Canada Department of Computing, Imperial College London, UK
Breast cancer is one of the leading causes of female mortality in the world. This can be reduced when diagnoses are performed at the early stages of progression. Further, the efficiency of the process can be significantly improved with computer aided diagnosis. Deep learning based approaches have been successfully applied to achieve this. One of the limiting factors for training deep networks in a supervised manner is the dependency on large amounts of expert annotated data. In reality, large amounts of unlabelled data and only small amounts of expert annotated data are available. In such scen…
Northeastern University（东北大学）；China Medical University（中国医科大学）；University of Luebeck（吕贝克大学）
Background: Breast cancer has the highest prevalence in women globally. The classification and diagnosis of breast cancer and its histopathological images have always been a hot spot of clinical concern. In Computer-Aided Diagnosis (CAD), traditional classification models mostly use a single network to extract features, which has significant limitations. On the other hand, many networks are trained and optimized on patient-level datasets, ignoring the application of lower-level data labels. Method: This paper proposes a deep ensemble model based on image-level labels for the binary classificat…
Abstract PURPOSES this study aims to perform microcalsification detection by performing image enhancement in mammography image by using transformation of negative image and histogram equalization. image mammography with .pgm format changed to. jpg format then processed into negative image result then processed again using histogram equalization. the results of the image enhancement process using negative image techniques and equalization histograms are compared and validated with MSE and PSNR on each mammographic image. CONCLUSION: Image enhancement process on mammography image can be done, ho…
Mammography is using low-energy X-rays to screen the human breast and is utilized by radiologists to detect breast cancer. Typically radiologists require a mammogram with impeccable image quality for an accurate diagnosis. In this study, we propose a deep learning method based on Convolutional Neural Networks (CNNs) for mammogram denoising to improve the image quality. We first enhance the noise level and employ Anscombe Transformation (AT) to transform Poisson noise to white Gaussian noise. With this data augmentation, a deep residual network is trained to learn the noise map of the noisy ima…
Our objective is to show the feasibility of using simulated mammograms to detect mammographically-occult (MO) cancer in women with dense breasts and a normal screening mammogram who could be triaged for additional screening with magnetic resonance imaging (MRI) or ultrasound. We developed a Conditional Generative Adversarial Network (CGAN) to simulate a mammogram with normal appearance using the opposite mammogram as the condition. We used a Convolutional Neural Network (CNN) trained on Radon Cumulative Distribution Transform (RCDT) processed mammograms to detect MO cancer. For training CGAN, …
Efficient Medical Image Retrieval Using DenseNet and FAISS for BIRADS Classification
Universiti Sains Malaysia（马来西亚理科大学）；Baruch College, The City University of New York（纽约市立大学巴鲁克学院）；International Islamic University Malaysia（马来西亚国际伊斯兰大学）
Mammographic Breast Positioning Assessment via Deep Learning
Istanbul Technical University（伊斯坦布尔理工大学）；Acibadem Healthcare Group（阿西巴德姆医疗集团）；Acibadem Mehmet Ali Aydinlar University（阿西巴德姆穆罕默德·阿里·艾丁拉尔大学）；Sisli Hamidiye Etfal Training and Research Hospital（锡什利哈米迪耶埃特法尔培训与研究医院）
Comparative Analysis of Segment Anything Model and U-Net for Breast Tumor Detection in Ultrasound and Mammography Images
Florida Atlantic University（佛罗里达大西洋大学）；University of Massachusetts Lowell（马萨诸塞大学洛厄尔分校）；Shahid Beheshti University of Medical Sciences（沙希德·贝赫什提医科大学）；Missouri University of Science and Technology（密苏里科技大学）；Florida International University（佛罗里达国际大学）
Santa Clara University（圣克拉拉大学）；Harvard Medical School（哈佛医学院）；Massachusetts General Hospital（麻省总医院）；University of Utah（犹他大学）
Objective: Employing transfer learning (TL) with convolutional neural networks (CNNs), well-trained on non-medical ImageNet dataset, has shown promising results for medical image analysis in recent years. We aimed to conduct a scoping review to identify these studies and summarize their characteristics in terms of the problem description, input, methodology, and outcome. Materials and Methods: To identify relevant studies, MEDLINE, IEEE, and ACM digital library were searched. Two investigators independently reviewed articles to determine eligibility and to extract data according to a study pro…
Addressing Uncertainty in Imbalanced Histopathology Image Classification of HER2 Breast Cancer: An interpretable Ensemble Approach with Threshold Filtered Single Instance Evaluation (SIE)
American International University-Bangladesh（孟加拉美国国际大学）；Bangladesh University of Business and Technology（孟加拉商业技术大学）；King Saud University（沙特国王大学）；Southern Illinois University（南伊利诺伊大学）
Advanced Multi-Architecture Deep Learning Framework for BIRADS-Based Mammographic Image Retrieval: Comprehensive Performance Analysis with Super-Ensemble Optimization
Universiti Sains Malaysia（马来西亚理科大学）；Baruch College, The City University of New York（纽约城市大学巴鲁克学院）；International Islamic University Malaysia（马来西亚国际伊斯兰大学）
Beijing Institute of Technology（北京理工大学）；Université 8 Mai 1945 Guelma（盖勒马8 Mai 1945大学）；National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College（中国医学科学院北京协和医学院肿瘤医院国家癌症中心国家肿瘤临床研究中心）
Mammography remains the most prevalent imaging tool for early breast cancer screening. The language used to describe abnormalities in mammographic reports is based on the breast Imaging Reporting and Data System (BI-RADS). Assigning a correct BI-RADS category to each examined mammogram is a strenuous and challenging task for even experts. This paper proposes a new and effective computer-aided diagnosis (CAD) system to classify mammographic masses into four assessment categories in BI-RADS. The mass regions are first enhanced by means of histogram equalization and then semiautomatically segment…
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital（马萨诸塞州总医院阿西诺拉·A·马丁诺斯生物医学成像中心）；Memorial Sloan Kettering Cancer Center（纪念斯隆·凯特琳癌症中心）；University of Colorado School of Medicine（科罗拉多大学医学院）；Harvard Medical School（哈佛医学院）
Breast cancer is the most common cancers and early detection from mammography screening is crucial in improving patient outcomes. Assessing mammographic breast density is clinically important as the denser breasts have higher risk and are more likely to occlude tumors. Manual assessment by experts is both time-consuming and subject to inter-rater variability. As such, there has been increased interest in the development of deep learning methods for mammographic breast density assessment. Despite deep learning having demonstrated impressive performance in several prediction tasks for applicatio…
According to the World Health Organization, breast cancer is the main cause of cancer death among adult women in the world. Although breast cancer occurs indiscriminately in countries with several degrees of social and economic development, among developing and underdevelopment countries mortality rates are still high, due to low availability of early detection technologies. From the clinical point of view, mammography is still the most effective diagnostic technology, given the wide diffusion of the use and interpretation of these images. Herein this work we propose a method to detect and cla…
University of Girona（赫罗纳大学）；Parc Tauli Hospital Universitari（帕克陶利大学医院）；Institut d’Investigacio i Innovacio Parc Tauli (I3PT)（帕克陶利研究与创新研究所（I3PT））
Early detection of breast cancer has a major contribution to curability, and using mammographic images, this can be achieved non-invasively. Supervised deep learning, the dominant CADe tool currently, has played a great role in object detection in computer vision, but it suffers from a limiting property: the need of a large amount of labelled data. This becomes stricter when it comes to medical datasets which require high-cost and time-consuming annotations. Furthermore, medical datasets are usually imbalanced, a condition that often hinders classifiers performance. The aim of this paper is to…
Deep learning has made a breakthrough in medical image segmentation in recent years due to its ability to extract high-level features without the need for prior knowledge. In this context, U-Net is one of the most advanced medical image segmentation models, with promising results in mammography. Despite its excellent overall performance in segmenting multimodal medical images, the traditional U-Net structure appears to be inadequate in various ways. There are certain U-Net design modifications, such as MultiResUNet, Connected-UNets, and AU-Net, that have improved overall performance in areas w…
Image Processing represents the backbone research area within engineering and computer science specialization. It is promptly growing technologies today, and its applications founded in various aspects of biomedical fields especially in cancer disease. Breast cancer is considered the fatal one of all cancer types according to recent statistics all over the world. It is the most commonly cancer in women and the second reason of cancer death between females. About 23% of the total cancer cases in both developing and developed countries. In this work, an interpolation process was used to classify…
Indian Institute of Information Technology Allahabad（阿拉哈巴德印度信息技术学院）；National University of Singapore（新加坡国立大学）；Bioinformatics Institute, A*STAR（新加坡科技研究局生物信息学研究所）；Image and Pervasive Access Lab（图像与普适访问实验室）；Singapore Eye Research Institute（新加坡眼科研究所）
Currently, the computational complexity limits the training of high resolution gigapixel images using Convolutional Neural Networks. Therefore, such images are divided into patches or tiles. Since, these high resolution patches are encoded with discriminative information therefore; CNNs are trained on these patches to perform patch-level predictions. However, the problem with patch-level prediction is that pathologist generally annotates at image-level and not at patch level. Due to this limitation most of the patches may not contain enough class-relevant features. Through this work, we tried …
DBT-DINO: Towards Foundation model based analysis of Digital Breast Tomosynthesis
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School（阿提诺拉·A·马丁诺生物医学影像中心、麻省总医院和哈佛医学院）；Department of Radiology, Charité - Universitätsmedizin Berlin（放射科、柏林夏里特大学医学院）；Mass General Brigham Data Science Office（麻省总医院数据科学办公室）；Department of Computer Science, Institute for Machine Learning, ETH Zürich（计算机科学系、机器学习研究所、苏黎世联邦理工学院）；Massachusetts General Hospital Cancer Center and Harvard Medical School（麻省总医院癌症中心和哈佛医学院）；Department of Radiology, Massachusetts General Hospital（放射科、麻省总医院）；Department of Radiology, University of Wisconsin School of Medicine and Public Health（放射科、威斯康星大学医学与公共卫生学院）
Cancer is the uncontrollable cell division of abnormal cells inside the human body, which can spread to other body organs. It is one of the non-communicable diseases (NCDs) and NCDs accounts for 71% of total deaths worldwide whereas lung cancer is the second most diagnosed cancer after female breast cancer. Cancer survival rate of lung cancer is only 19%. There are various methods for the diagnosis of lung cancer, such as X-ray, CT scan, PET-CT scan, bronchoscopy and biopsy. However, to know the subtype of lung cancer based on the tissue type H and E staining is widely used, where the staining…
Mayo Clinic（梅奥诊所）；Ohio State University（俄亥俄州立大学）；West Virginia University School of Medicine（西弗吉尼亚大学医学院）；NVIDIA Inc.（英伟达公司）
Screening mammograms are a routine imaging exam performed to detect breast cancer in its early stages to reduce morbidity and mortality attributed to this disease. In order to maximize the efficacy of breast cancer screening programs, proper mammographic positioning is paramount. Proper positioning ensures adequate visualization of breast tissue and is necessary for effective breast cancer detection. Therefore, breast-imaging radiologists must assess each mammogram for the adequacy of positioning before providing a final interpretation of the examination; this often necessitates return patient…
According to the World Health Organization, breast cancer is the most common form of cancer in women. It is the second leading cause of death among women round the world, becoming the most fatal form of cancer. Mammographic image segmentation is a fundamental task to support image analysis and diagnosis, taking into account shape analysis of mammary lesions and their borders. However, mammogram segmentation is a very hard process, once it is highly dependent on the types of mammary tissues. In this work we present a new semi-supervised segmentation algorithm based on the modification of the Gr…
Indian Institute of Information Technology Allahabad（阿拉哈巴德印度信息技术学院）；National University of Singapore（新加坡国立大学）；Bioinformatics Institute, A*STAR（新加坡科技研究局生物信息学研究所）；Image and Pervasive Access Lab(IPAL), CNRS UMI 2955（法国国家科学研究中心UMI 2955图像与普适访问实验室）；Singapore Eye Research Institute（新加坡眼科研究所）
Researchers working on computational analysis of Whole Slide Images (WSIs) in histopathology have primarily resorted to patch-based modelling due to large resolution of each WSI. The large resolution makes WSIs infeasible to be fed directly into the machine learning models due to computational constraints. However, due to patch-based analysis, most of the current methods fail to exploit the underlying spatial relationship among the patches. In our work, we have tried to integrate this relationship along with feature-based correlation among the extracted patches from the particular tumorous reg…
Current deep learning based detection models tackle detection and segmentation tasks by casting them to pixel or patch-wise classification. To automate the initial mass lesion detection and segmentation on the whole mammographic images and avoid the computational redundancy of patch-based and sliding window approaches, the conditional generative adversarial network (cGAN) was used in this study. Subsequently, feeding the detected regions to the trained densely connected network (DenseNet), the binary classification of benign versus malignant was predicted. We used a combination of publicly ava…
Breast Cancer Image Classification Method Based on Deep Transfer Learning
The Hong Kong University of Science and Technology（香港科技大学）；University of Southampton（南安普顿大学）；Trine University（特莱恩大学）；Southwest Jiaotong University（西南交通大学）
MAM-E: Mammographic synthetic image generation with diffusion models
Computer Vision and Robotics Institute (ViCOROB), University of Girona（赫罗纳大学计算机视觉与机器人研究所（ViCOROB））；Clínica Girona, Institute of Diagnostic Imaging (IDI) Girona, University of Girona（赫罗纳大学赫罗纳诊所诊断影像研究所（IDI））
Cone-beam breast computed tomography (CT) provides true 3D breast images with isotropic resolution and high-contrast information, detecting calcifications as small as a few hundred microns and revealing subtle tissue differences. However, breast is highly sensitive to x-ray radiation. It is critically important for healthcare to reduce radiation dose. Few-view cone-beam CT only uses a fraction of x-ray projection data acquired by standard cone-beam breast CT, enabling significant reduction of the radiation dose. However, insufficient sampling data would cause severe streak artifacts in CT imag…
East Delta University（东三角洲大学）；University of Chittagong（吉大港大学）
Breast cancer has become a symbol of tremendous concern in the modern world, as it is one of the major causes of cancer mortality worldwide. In this regard, breast ultrasonography images are frequently utilized by doctors to diagnose breast cancer at an early stage. However, the complex artifacts and heavily noised breast ultrasonography images make diagnosis a great challenge. Furthermore, the ever-increasing number of patients being screened for breast cancer necessitates the use of automated end-to-end technology for highly accurate diagnosis at a low cost and in a short time. In this conce…
Early detection of breast cancer through screening mammography yields a 20-35% increase in survival rate; however, there are not enough radiologists to serve the growing population of women seeking screening mammography. Although commercial computer aided detection (CADe) software has been available to radiologists for decades, it has failed to improve the interpretation of full-field digital mammography (FFDM) images due to its low sensitivity over the spectrum of findings. In this work, we leverage a large set of FFDM images with loose bounding boxes of mammographically significant findings …
STA-Risk: A Deep Dive of Spatio-Temporal Asymmetries for Breast Cancer Risk Prediction
Intelligent Systems Program, University of Pittsburgh（匹兹堡大学智能系统项目）；Department of Radiology, University of Pittsburgh（匹兹堡大学放射科）；Department of Biomedical Informatics and Department of Bioengineering University of Pittsburgh（匹兹堡大学生物医学信息学系和生物工程系）
Australian Institute for Machine Learning（澳大利亚机器学习研究所）；The University of Adelaide（阿德莱德大学）；Science and Engineering Faculty, Queensland University of Technology（昆士兰科技大学科学与工程学院）；Institute for Systems and Robotics（系统与机器人研究所）；Instituto Superior Tecnico（高等理工学院）
The training of medical image analysis systems using machine learning approaches follows a common script: collect and annotate a large dataset, train the classifier on the training set, and test it on a hold-out test set. This process bears no direct resemblance with radiologist training, which is based on solving a series of tasks of increasing difficulty, where each task involves the use of significantly smaller datasets than those used in machine learning. In this paper, we propose a novel training approach inspired by how radiologists are trained. In particular, we explore the use of meta-…
