arXivDaily arXiv每日学术速递 周一至周五更新
北美退伍军人节(Veterans Day),12 日无更新
arXiv 2101.05352stat.ME
收藏

环境混合物的贝叶斯多指标模型

Bayesian Multiple Index Models for Environmental Mixtures

Glen McGee, Ander Wilson, Thomas F. Webster, Brent A. Coull

AI总结:

提出贝叶斯多指标模型框架,结合响应面与暴露指标方法优点,统一环境混合物分析,在NHANES数据中实现良好拟合与高可解释性。

摘要:

环境健康研究的一个重要目标是评估环境暴露混合物带来的风险。混合物分析中两类流行的模型是响应面方法和暴露指标方法。响应面方法估计高维曲面,因此高度灵活但难以解释。相比之下,暴露指标方法将线性模型的系数分解为总体混合效应和单个指标权重;当模型假设成立时,这些模型产生易于解释的效应估计和有效的推断,但与大多数简约模型一样,当这些假设不成立时会产生偏差。在本文中,我们提出了一个贝叶斯多指标模型框架,结合了两者的优点,允许暴露指标与健康结果之间存在非线性和非加性关系,同时降低暴露向量的维度并通过变量选择估计指标权重。该框架包含响应面和暴露指标模型作为特例,从而统一了这两种分析策略。这种统一增加了分析环境混合物和健康可能的模型范围,允许从灵活性和可解释性不同的模型谱中选择合适的分析。在国家健康与营养检查调查(NHANES)中,对端粒长度与18种有机污染物关联的分析表明,所提出的方法对数据的拟合与更复杂的响应面方法一样好,并产生更易解释的结果。

英文摘要:

An important goal of environmental health research is to assess the risk posed by mixtures of environmental exposures. Two popular classes of models for mixtures analyses are response-surface methods and exposure-index methods. Response-surface methods estimate high-dimensional surfaces and are thus highly flexible but difficult to interpret. In contrast, exposure-index methods decompose coefficients from a linear model into an overall mixture effect and individual index weights; these models yield easily interpretable effect estimates and efficient inferences when model assumptions hold, but, like most parsimonious models, incur bias when these assumptions do not hold. In this paper we propose a Bayesian multiple index model framework that combines the strengths of each, allowing for non-linear and non-additive relationships between exposure indices and a health outcome, while reducing the dimensionality of the exposure vector and estimating index weights with variable selection. This framework contains response-surface and exposure-index models as special cases, thereby unifying the two analysis strategies. This unification increases the range of models possible for analyzing environmental mixtures and health, allowing one to select an appropriate analysis from a spectrum of models varying in flexibility and interpretability. In an analysis of the association between telomere length and 18 organic pollutants in the National Health and Nutrition Examination Survey (NHANES), the proposed approach fits the data as well as more complex response-surface methods and yields more interpretable results.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

↑