The BraTS dataset contains a mixture of high-grade and low-grade gliomas, which have a rather different appearance: previous studies have shown that performance can be improved by separated training on low-grade gliomas (LGGs) and high-grade gliomas (HGGs), but in practice this information is not available at test time to decide which model to use. By contrast with HGGs, LGGs often present no sharp boundary between the tumor core and the surrounding edema, but rather a gradual reduction of tumor-cell density.
Utilizing our 3D-to-2D fully convolutional architecture, DeepSCAN, which ranked highly in the 2019 BraTS challenge and was trained using an uncertainty-aware loss, we separate cases into those with a confidently segmented core, and those with a vaguely segmented or missing core. Since by assumption every tumor has a core, we reduce the threshold for classification of core tissue in those cases where the core, as segmented by the classifier, is vaguely defined or missing.
We then predict survival of high-grade glioma patients using a fusion of linear regression and random forest classification, based on age, number of distinct tumor components, and number of distinct tumor cores.
We present results on the validation dataset of the Multimodal Brain Tumor Segmentation Challenge 2020 (segmentation and uncertainty challenge), and on the testing set, where the method achieved 4th place in Segmentation, 1st place in uncertainty estimation, and 1st place in Survival prediction.
Can Foundation Models Really Segment Tumors? A Benchmarking Odyssey in Lung CT Imaging
College of Computer Science and Software Engineering, Shenzhen University（计算机科学与软件工程学院，深圳大学）；Department of Naval, Electrical, Electronics and Telecommunications Engineering, University of Genoa（海军、电气、电子与电信工程部门，热那亚大学）
University of California, Santa Barbara（加利福尼亚大学圣巴巴拉分校）；University of California, Irvine（加利福尼亚大学欧文分校）
We propose a novel, simple and effective method to integrate lesion prior and a 3D U-Net for improving brain tumor segmentation. First, we utilize the ground-truth brain tumor lesions from a group of patients to generate the heatmaps of different types of lesions. These heatmaps are used to create the volume-of-interest (VOI) map which contains prior information about brain tumor lesions. The VOI map is then integrated with the multimodal MR images and input to a 3D U-Net for segmentation. The proposed method is evaluated on a public benchmark dataset, and the experimental results show that th…
Shanghai University（上海大学）；Shanghai Jiao Tong University（上海交通大学）；University of Chinese Academy of Sciences（中国科学院大学）；Northeastern University（东北大学）
Liver tumor segmentation in CT images is a critical step in the diagnosis, surgical planning and postoperative evaluation of liver disease. An automatic liver and tumor segmentation method can greatly relieve physicians of the heavy workload of examining CT images and better improve the accuracy of diagnosis. In the last few decades, many modifications based on U-Net model have been proposed in the literature. However, there are relatively few improvements for the advanced UNet++ model. In our paper, we propose an encoding feature supervised UNet++(ES-UNet++) and apply it to the liver and tumo…
University at Buffalo, The State University of New York（纽约州立大学布法罗分校）
Brain Tumor Segmentation from magnetic resonance imaging (MRI) is a critical technique for early diagnosis. However, rather than having complete four modalities as in BraTS dataset, it is common to have missing modalities in clinical scenarios. We design a brain tumor segmentation algorithm that is robust to the absence of any modality. Our network includes a channel-independent encoding path and a feature-fusion decoding path. We use self-supervised training through channel dropout and also propose a novel domain adaptation method on feature maps to recover the information from the missing ch…
Non-invasive techniques such as magnetic resonance imaging (MRI) are widely employed in brain tumor diagnostics. However, manual segmentation of brain tumors from 3D MRI volumes is a time-consuming task that requires trained expert radiologists. Due to the subjectivity of manual segmentation, there is low inter-rater reliability which can result in diagnostic discrepancies. As the success of many brain tumor treatments depends on early intervention, early detection is paramount. In this context, a fully automated segmentation method for brain tumor segmentation is necessary as an efficient and…
Vingroup Big Data Institute (VinBigdata)（越南 VinBigdata 大数据研究院）；Hanoi University of Science and Technology (HUST)（河内科技大学）；University of Engineering and Technology (UET), VNU（越南国立大学工程技术大学）
Brain tumor segmentation plays an essential role in medical image analysis. In recent studies, deep convolution neural networks (DCNNs) are extremely powerful to tackle tumor segmentation tasks. We propose in this paper a novel training method that enhances the segmentation results by adding an additional classification branch to the network. The whole network was trained end-to-end on the Multimodal Brain Tumor Segmentation Challenge (BraTS) 2020 training dataset. On the BraTS's validation set, it achieved an average Dice score of 78.43%, 89.99%, and 84.22% respectively for the enhancing tumo…
Research & Development Institute of Northwestern Polytechnical University in Shenzhen（西北工业大学深圳研究院）；Northwestern Polytechnical University（西北工业大学）；University of Pittsburgh（匹兹堡大学）；University of Sydney（悉尼大学）；JD Finance America Corporation（京东金融美国公司）
In this paper, we propose a Hybrid High-resolution and Non-local Feature Network (H2NF-Net) to segment brain tumor in multimodal MR images. Our H2NF-Net uses the single and cascaded HNF-Nets to segment different brain tumor sub-regions and combines the predictions together as the final segmentation. We trained and evaluated our model on the Multimodal Brain Tumor Segmentation Challenge (BraTS) 2020 dataset. The results on the test set show that the combination of the single and cascaded models achieved average Dice scores of 0.78751, 0.91290, and 0.85461, as well as Hausdorff distances ($95\%$…
School of Biomedical Engineering（生物医学工程学院）；Universidad Autónoma de Ciudad Juárez（华雷斯自治大学）
The brain is a complex organ controlling cognitive process and physical functions. Tumors in the brain are accelerated cell growths affecting the normal function and processes in the brain. MRI scans provides detailed images of the body being one of the most common tests to diagnose brain tumors. The process of segmentation of brain tumors from magnetic resonance imaging can provide a valuable guide for diagnosis, treatment planning and prediction of results. Here we consider the problem brain tumor segmentation using a Deep learning architecture for use in tumor segmentation. Although the pro…
Shenzhen University（深圳大学）；Huazhong University of Science and Technology（华中科技大学）
The brain tumor segmentation task aims to classify tissue into the whole tumor (WT), tumor core (TC), and enhancing tumor (ET) classes using multimodel MRI images. Quantitative analysis of brain tumors is critical for clinical decision making. While manual segmentation is tedious, time-consuming, and subjective, this task is at the same time very challenging to automatic segmentation methods. Thanks to the powerful learning ability, convolutional neural networks (CNNs), mainly fully convolutional networks, have shown promising brain tumor segmentation. This paper further boosts the performance…
University of Leicester（莱斯特大学）；University of Lancaster（兰卡斯特大学）；Queen Mary, University of London（伦敦大学玛丽女王学院）；Xidian University（西安电子科技大学）；Bielefeld University（比勒费尔德大学）
Brain tumor segmentation is one of the most challenging problems in medical image analysis. The goal of brain tumor segmentation is to generate accurate delineation of brain tumor regions. In recent years, deep learning methods have shown promising performance in solving various computer vision problems, such as image classification, object detection and semantic segmentation. A number of deep learning based methods have been applied to brain tumor segmentation and achieved promising results. Considering the remarkable breakthroughs made by state-of-the-art technologies, we use this survey to …
Northwestern University（西北大学）；University of Chicago（芝加哥大学）
Head and Neck (H\&N) organ-at-risk (OAR) and tumor segmentations are essential components of radiation therapy planning. The varying anatomic locations and dimensions of H\&N nodal Gross Tumor Volumes (GTVn) and H\&N primary gross tumor volume (GTVp) are difficult to obtain due to lack of accurate and reliable delineation methods. The downstream effect of incorrect segmentation can result in unnecessary irradiation of normal organs. Towards a fully automated radiation therapy planning algorithm, we explore the efficacy of multi-scale fusion based deep learning architectures for accurately segm…
Automatic segmentation of brain tumors is an essential but challenging step for extracting quantitative imaging biomarkers for accurate tumor detection, diagnosis, prognosis, treatment planning and assessment. Multimodal Brain Tumor Segmentation Challenge 2020 (BraTS 2020) provides a common platform for comparing different automatic algorithms on multi-parametric Magnetic Resonance Imaging (mpMRI) in tasks of 1) Brain tumor segmentation MRI scans; 2) Prediction of patient overall survival (OS) from pre-operative MRI scans; 3) Distinction of true tumor recurrence from treatment related effects …
Huazhong University of Science and Technology（华中科技大学）；Shenzhen University（深圳大学）
Deep convolutional neural network (CNN) achieves remarkable performance for medical image analysis. UNet is the primary source in the performance of 3D CNN architectures for medical imaging tasks, including brain tumor segmentation. The skip connection in the UNet architecture concatenates features from both encoder and decoder paths to extract multi-contextual information from image data. The multi-scaled features play an essential role in brain tumor segmentation. However, the limited use of features can degrade the performance of the UNet approach for segmentation. In this paper, we propose…
Automatic segmentation of liver tumors in medical images is crucial for the computer-aided diagnosis and therapy. It is a challenging task, since the tumors are notoriously small against the background voxels. This paper proposes a new three-stage curriculum learning approach for training deep networks to tackle this small object segmentation problem. The learning in the first stage is performed on the whole input to obtain an initial deep network for tumor segmenta-tion. Then the second stage of learning focuses the strength-ening of tumor specific features by continuing training the network …
This paper proposes an adversarial learning based training approach for brain tumor segmentation task. In this concept, the 3D segmentation network learns from dual reciprocal adversarial learning approaches. To enhance the generalization across the segmentation predictions and to make the segmentation network robust, we adhere to the Virtual Adversarial Training approach by generating more adversarial examples via adding some noise on original patient data. By incorporating a critic that acts as a quantitative subjective referee, the segmentation network learns from the uncertainty informatio…
Intracranial tumors are groups of cells that usually grow uncontrollably. One out of four cancer deaths is due to brain tumors. Early detection and evaluation of brain tumors is an essential preventive medical step that is performed by magnetic resonance imaging (MRI). Many segmentation techniques exist for this purpose. Low segmentation accuracy is the main drawback of existing methods. In this paper, we use a deep learning method to boost the accuracy of tumor segmentation in MR images. Cascade approach is used with multiple scales of images to induce both local and global views and help the…
Gliomas are among the most aggressive and deadly brain tumors. This paper details the proposed Deep Neural Network architecture for brain tumor segmentation from Magnetic Resonance Images. The architecture consists of a cascade of three Deep Layer Aggregation neural networks, where each stage elaborates the response using the feature maps and the probabilities of the previous stage, and the MRI channels as inputs. The neuroimaging data are part of the publicly available Brain Tumor Segmentation (BraTS) 2020 challenge dataset, where we evaluated our proposal in the BraTS 2020 Validation and Tes…
School of Computer Science and Technology, Harbin Institute of Technology（哈尔滨工业大学计算机科学与技术学院）
Automatic brain tumor segmentation method plays an extremely important role in the whole process of brain tumor diagnosis and treatment. In this paper, we propose a multi-step cascaded network which takes the hierarchical topology of the brain tumor substructures into consideration and segments the substructures from coarse to fine .During segmentation, the result of the former step is utilized as the prior information for the next step to guide the finer segmentation process. The whole network is trained in an end-to-end fashion. Besides, to alleviate the gradient vanishing issue and reduce o…
The Hospital for Sick Children（病童医院）；University of Toronto（多伦多大学）；Vector Institute（矢量研究所）
Brain tumor segmentation is a critical task for tumor volumetric analyses and AI algorithms. However, it is a time-consuming process and requires neuroradiology expertise. While there has been extensive research focused on optimizing brain tumor segmentation in the adult population, studies on AI guided pediatric tumor segmentation are scarce. Furthermore, MRI signal characteristics of pediatric and adult brain tumors differ, necessitating the development of segmentation algorithms specifically designed for pediatric brain tumors. We developed a segmentation model trained on magnetic resonance…
Another year of the multimodal brain tumor segmentation challenge (BraTS) 2021 provides an even larger dataset to facilitate collaboration and research of brain tumor segmentation methods, which are necessary for disease analysis and treatment planning. A large dataset size of BraTS 2021 and the advent of modern GPUs provide a better opportunity for deep-learning based approaches to learn tumor representation from the data. In this work, we maintained an encoder-decoder based segmentation network, but focused on a modification of network training process that minimizes redundancy under perturb…
Accurate visualization of liver tumors and their surrounding blood vessels is essential for noninvasive diagnosis and prognosis prediction of tumors. In medical image segmentation, there is still a lack of in-depth research on the simultaneous segmentation of liver tumors and peritumoral blood vessels. To this end, we collect the first liver tumor, and vessel segmentation benchmark datasets containing 52 portal vein phase computed tomography images with liver, liver tumor, and vessel annotations. In this case, we propose a 3D U-shaped Cross-Attention Network (UCA-Net) that utilizes a tailored …
Tumor treating fields (TTFields) is an FDA approved therapy for the treatment of Gliobastoma Multiform (GBM) and currently being investigated for additional tumor types. TTFields are delivered to the tumor through the placement of transducer arrays (TAs) placed on the patient scalp. The positions of the TAs are associated with treatment outcomes via simulations of the electric fields. Therefore, we are currently developing a method for recommending optimal placement of TAs. A key step to achieve this goal is to correctly segment the head into tissues of similar electrical properties. Visual in…
Institute of Computing Technology, Chinese Academy of Sciences（中国科学院计算技术研究所）；University of Chinese Academy of Sciences（中国科学院大学）；Lenovo Research（联想研究院）
Automatic brain tumor segmentation from multi-modality Magnetic Resonance Images (MRI) using deep learning methods plays an important role in assisting the diagnosis and treatment of brain tumor. However, previous methods mostly ignore the latent relationship among different modalities. In this work, we propose a novel end-to-end Modality-Pairing learning method for brain tumor segmentation. Paralleled branches are designed to exploit different modality features and a series of layer connections are utilized to capture complex relationships and abundant information among modalities. We also us…
College of Biomedical Engineering, Rangsit University（兰实大学生物医学工程学院）
Automated medical image segmentation is a priority research area for computational methods. In particular, detection of cancerous tumors represents a current challenge in this area with potential for real-world impact. This paper describes a method developed in response to the 2019 Kidney Tumor Segmentation Challenge (KiTS19). Axial computed tomography (CT) scans from 210 kidney cancer patients were used to develop and evaluate this automatic segmentation method based on a logical ensemble of fully-convolutional network (FCN) architectures, followed by volumetric validation. Data was pre-proce…
College of Physics and Information Engineering, Fuzhou University（福州大学物理与信息工程学院）；School of Data Science, Fudan University（复旦大学数据科学学院）；School of Biomedical Engineering, Shanghai Jiao Tong University（上海交通大学生物医学工程学院）；School of Biomedical Engineering and Imaging Sciences, King’s College London（伦敦国王学院生物医学工程与成像科学学院）
Delineating the brain tumor from magnetic resonance (MR) images is critical for the treatment of gliomas. However, automatic delineation is challenging due to the complex appearance and ambiguous outlines of tumors. Considering that multi-modal MR images can reflect different tumor biological properties, we develop a novel multi-modal tumor segmentation network (MMTSN) to robustly segment brain tumors based on multi-modal MR images. The MMTSN is composed of three sub-branches and a main branch. Specifically, the sub-branches are used to capture different tumor features from multi-modal images,…
Recently deep learning has been playing a major role in the field of computer vision. One of its applications is the reduction of human judgment in the diagnosis of diseases. Especially, brain tumor diagnosis requires high accuracy, where minute errors in judgment may lead to disaster. For this reason, brain tumor segmentation is an important challenge for medical purposes. Currently several methods exist for tumor segmentation but they all lack high accuracy. Here we present a solution for brain tumor segmenting by using deep learning. In this work, we studied different angles of brain MR ima…
Deep learning algorithms are preferable for rectal tumor segmentation. However, it is still a challenge task to accurately segment and identify the locations and sizes of rectal tumors by using deep learning methods. To increase the capability of extracting enough feature information for rectal tumor segmentation, we propose a Covariance Self-Attention Dual Path UNet (CSA-DPUNet). The proposed network mainly includes two improvements on UNet: 1) modify UNet that has only one path structure to consist of two contracting path and two expansive paths (nam new network as DPUNet), which can help ex…
In the past few years, deep learning (DL) models have drawn great attention and shown superior performance on brain tumor and subregion segmentation tasks. However, the success is limited to segmentation of adult gliomas, where sufficient data have been collected, manually labeled, and published for training DL models. It is still challenging to segment pediatric tumors, because the appearances are different from adult gliomas. Hence, directly applying a pretained DL model on pediatric data usually generates unacceptable results. Because pediatric data is very limited, both labeled and unlabel…
ARTORG Center for Biomedical Engineering Research, University of Bern（伯尔尼大学生物医学工程研究中心）
Each year, there are about 400'000 new cases of kidney cancer worldwide causing around 175'000 deaths. For clinical decision making it is important to understand the morphometry of the tumor, which involves the time-consuming task of delineating tumor and kidney in 3D CT images. Automatic segmentation could be an important tool for clinicians and researchers to also study the correlations between tumor morphometry and clinical outcomes. We present a segmentation method which combines the popular U-Net convolutional neural network architecture with post-processing based on statistical constrain…
Head and neck tumor segmentation challenge (HECKTOR) 2022 offers a platform for researchers to compare their solutions to segmentation of tumors and lymph nodes from 3D CT and PET images. In this work, we describe our solution to HECKTOR 2022 segmentation task. We re-sample all images to a common resolution, crop around head and neck region, and train SegResNet semantic segmentation network from MONAI. We use 5-fold cross validation to select best model checkpoints. The final submission is an ensemble of 15 models from 3 runs. Our solution (team name NVAUTO) achieves the 1st place on the HECKT…
Nanjing University of Science and Technology（南京理工大学）；Nanjing University（南京大学）
Automatic segmentation of head and neck tumors plays an important role in radiomics analysis. In this short paper, we propose an automatic segmentation method for head and neck tumors from PET and CT images based on the combination of convolutional neural networks (CNNs) and hybrid active contours. Specifically, we first introduce a multi-channel 3D U-Net to segment the tumor with the concatenated PET and CT images. Then, we estimate the segmentation uncertainty by model ensembles and define a segmentation quality score to select the cases with high uncertainties. Finally, we develop a hybrid …
Lumbar Spine Tumor Segmentation and Localization in T2 MRI Images Using AI
A. K. Choudhury School of Information Technology, University of Calcutta（加尔各答大学A.K.乔杜里信息技术学院）；Rammohan College, University of Calcutta（加尔各答大学拉莫汉学院）；Indian Statistical Institute（印度统计研究院）
Federal University of Santa Catarina（圣卡塔琳娜联邦大学）；Santa Luzia Hospital（圣卢西亚医院）
State-of-the-art brain tumor segmentation is based on deep learning models applied to multi-modal MRIs. Currently, these models are trained on images after a preprocessing stage that involves registration, interpolation, brain extraction (BE, also known as skull-stripping) and manual correction by an expert. However, for clinical practice, this last step is tedious and time-consuming and, therefore, not always feasible, resulting in skull-stripping faults that can negatively impact the tumor segmentation quality. Still, the extent of this impact has never been measured for any of the many diff…
Institute of Computing Technology, Chinese Academy of Sciences（中国科学院计算技术研究所）；University of Chinese Academy of Sciences（中国科学院大学）；Southeast University（东南大学）；Lenovo Research（联想研究院）
Automated segmentation of kidney and tumor from 3D CT scans is necessary for the diagnosis, monitoring, and treatment planning of the disease. In this paper, we describe a two-stage framework for kidney and tumor segmentation based on 3D fully convolutional network (FCN). The first stage preliminarily locate the kidney and cut off the irrelevant background to reduce class imbalance and computation cost. Then the second stage precisely segment the kidney and tumor on the cropped patch. The proposed method ranks the 4th place out of 105 competitive teams in MICCAI 2019 KiTS Challenge with a Comp…
Institute of Computing Technology, Chinese Academy of Sciences（中国科学院计算技术研究所）；University of Chinese Academy of Sciences（中国科学院大学）；Lenovo Research（联想研究院）
Liver tumor segmentation plays an important role in hepatocellular carcinoma diagnosis and surgical planning. In this paper, we propose a novel Semantic Feature Attention Network (SFAN) for liver tumor segmentation from Computed Tomography (CT) volumes, which exploits the impact of both low-level and high-level features. In the SFAN, a Semantic Attention Transmission (SAT) module is designed to select discriminative low-level localization details with the guidance of neighboring high-level semantic information. Furthermore, a Global Context Attention (GCA) module is proposed to effectively fus…
Adaptable Segmentation Pipeline for Diverse Brain Tumors with Radiomic-Guided Subtyping and Lesion-Wise Model Ensemble
Sheikh Zayed Institute for Pediatric Surgical Innovation（Sheikh Zayed儿童外科创新研究所）；Children’s National Hospital（儿童医院）；University of Washington（华盛顿大学）；Universidad Politécnica de Madrid（马德里理工大学）；CIBER-BBN；ISCIII；School of Medicine and Health Sciences（医学与健康科学学院）
Rowan University（罗文大学）；University of Alabama at Birmingham（阿拉巴马大学伯明翰分校）
Magnetic resonance imaging (MRI) is routinely used for brain tumor diagnosis, treatment planning, and post-treatment surveillance. Recently, various models based on deep neural networks have been proposed for the pixel-level segmentation of tumors in brain MRIs. However, the structural variations, spatial dissimilarities, and intensity inhomogeneity in MRIs make segmentation a challenging task. We propose a new end-to-end brain tumor segmentation architecture based on U-Net that integrates Inception modules and dilated convolutions into its contracting and expanding paths. This allows us to ex…
National Institutes of Health Clinical Center（美国国立卫生研究院临床中心）；Ping An Insurance Company of China（中国平安保险公司）
Developing an effective liver and liver tumor segmentation model from CT scans is very important for the success of liver cancer diagnosis, surgical planning and cancer treatment. In this work, we propose a two-stage framework for 2D liver and tumor segmentation. The first stage is a coarse liver segmentation network, while the second stage is an edge enhanced network (E$^2$Net) for more accurate liver and tumor segmentation. E$^2$Net explicitly models complementary objects (liver and tumor) and their edge information within the network to preserve the organ and lesion boundaries. We introduce…
Mask-Enhanced Segment Anything Model for Tumor Lesion Semantic Segmentation
Beihang University（北京航空航天大学）；Hangzhou Innovation Institute, Beihang University（北京航空航天大学杭州创新研究院）；Institute of Information Engineering, Chinese Academy of Sciences（中国科学院信息工程研究所）；The Chinese University of Hong Kong（香港中文大学）；Sun Yat-sen University（中山大学）；Peking University Cancer Hospital & Institute（北京大学肿瘤医院暨研究所）；Nanjing University（南京大学）
Research & Development Institute of Northwestern Polytechnical University in Shenzhen（西北工业大学深圳研究院）；Northwestern Polytechnical University（西北工业大学）；University of Pittsburgh（匹兹堡大学）；University of Sydney（悉尼大学）；JD Finance America Corporation（京东金融美国公司）
In our previous work, $i.e.$, HNF-Net, high-resolution feature representation and light-weight non-local self-attention mechanism are exploited for brain tumor segmentation using multi-modal MR imaging. In this paper, we extend our HNF-Net to HNF-Netv2 by adding inter-scale and intra-scale semantic discrimination enhancing blocks to further exploit global semantic discrimination for the obtained high-resolution features. We trained and evaluated our HNF-Netv2 on the multi-modal Brain Tumor Segmentation Challenge (BraTS) 2021 dataset. The result on the test set shows that our HNF-Netv2 achieved…
German Cancer Research Center (DKFZ)（德国癌症研究中心）；Heidelberg University Hospital（海德堡大学医院）
We apply nnU-Net to the segmentation task of the BraTS 2020 challenge. The unmodified nnU-Net baseline configuration already achieves a respectable result. By incorporating BraTS-specific modifications regarding postprocessing, region-based training, a more aggressive data augmentation as well as several minor modifications to the nnUNet pipeline we are able to improve its segmentation performance substantially. We furthermore re-implement the BraTS ranking scheme to determine which of our nnU-Net variants best fits the requirements imposed by it. Our final ensemble took the first place in the…
Kavli Institute for Systems Neuroscience, NTNU（挪威科技大学卡弗里系统神经科学研究所）
Early diagnosis and accurate segmentation of brain tumors are imperative for successful treatment. Unfortunately, manual segmentation is time consuming, costly and despite extensive human expertise often inaccurate. Here, we present an MRI-based tumor segmentation framework using an autoencoder-regularized 3D-convolutional neural network. We trained the model on manually segmented structural T1, T1ce, T2, and Flair MRI images of 335 patients with tumors of variable severity, size and location. We then tested the model using independent data of 125 patients and successfully segmented brain tumo…
Image Sciences Institute, UMC Utrecht, Utrecht University（乌得勒支大学医学中心影像科学研究所）
This paper assesses whether using clinical characteristics in addition to imaging can improve automated segmentation of kidney cancer on contrast-enhanced computed tomography (CT). A total of 300 kidney cancer patients with contrast-enhanced CT scans and clinical characteristics were included. A baseline segmentation of the kidney cancer was performed using a 3D U-Net. Input to the U-Net were the contrast-enhanced CT images, output were segmentations of kidney, kidney tumors, and kidney cysts. A cognizant sampling strategy was used to leverage clinical characteristics for improved segmentation…
Sichuan University（四川大学）；Institute of High Performance Computing, A*STAR（新加坡科技研究局高性能计算研究所）
Despite recent improvements in the accuracy of brain tumor segmentation, the results still exhibit low levels of confidence and robustness. Uncertainty estimation is one effective way to change this situation, as it provides a measure of confidence in the segmentation results. In this paper, we propose a trusted brain tumor segmentation network which can generate robust segmentation results and reliable uncertainty estimations without excessive computational burden and modification of the backbone network. In our method, uncertainty is modeled explicitly using subjective logic theory, which tr…
Shanghai United Imaging Intelligence Co. Ltd（上海联影智能医疗科技有限公司）；Southern Medical University（南方医科大学）
In brain tumor diagnosis and surgical planning, segmentation of tumor regions and accurate analysis of surrounding normal tissues are necessary for physicians. Pathological variability often renders difficulty to register a well-labeled normal atlas to such images and to automatic segment/label surrounding normal brain tissues. In this paper, we propose a new registration approach that first segments brain tumor using a U-Net and then simulates missed normal tissues within the tumor region using a partial convolutional network. Then, a standard normal brain atlas image is registered onto such …
University of Electronic Science and Technology of China（电子科技大学）；New Jersey Institute of Technology（新泽西理工学院）
Past few years have witnessed the prevalence of deep learning in many application scenarios, among which is medical image processing. Diagnosis and treatment of brain tumors requires an accurate and reliable segmentation of brain tumors as a prerequisite. However, such work conventionally requires brain surgeons significant amount of time. Computer vision techniques could provide surgeons a relief from the tedious marking procedure. In this paper, a 3D U-net based deep learning model has been trained with the help of brain-wise normalization and patching strategies for the brain tumor segmenta…
Brain tumor segmentation is a critical task for patient's disease management. In order to automate and standardize this task, we trained multiple U-net like neural networks, mainly with deep supervision and stochastic weight averaging, on the Multimodal Brain Tumor Segmentation Challenge (BraTS) 2020 training dataset. Two independent ensembles of models from two different training pipelines were trained, and each produced a brain tumor segmentation map. These two labelmaps per patient were then merged, taking into account the performance of each ensemble for specific tumor subregions. Our perf…
