Mask-Enhanced Segment Anything Model for Tumor Lesion Semantic Segmentation
Beihang University（北京航空航天大学）；Hangzhou Innovation Institute, Beihang University（北京航空航天大学杭州创新研究院）；Institute of Information Engineering, Chinese Academy of Sciences（中国科学院信息工程研究所）；The Chinese University of Hong Kong（香港中文大学）；Sun Yat-sen University（中山大学）；Peking University Cancer Hospital & Institute（北京大学肿瘤医院暨研究所）；Nanjing University（南京大学）
Hairong Shi, Songhao Han, Shaofei Huang, Yue Liao, Guanbin Li, Xiangxing Kong, Hua Zhu, Xiaomu Wang, Si Liu
Tumor lesion segmentation on CT or MRI images plays a critical role in cancer diagnosis and treatment planning. Considering the inherent differences in tumor lesion segmentation data across various medical imaging modalities and equipment, integrating medical knowledge into the Segment Anything Model (SAM) presents promising capability due to its versatility and generalization potential. Recent studies have attempted to enhance SAM with medical expertise by pre-training on large-scale medical segmentation datasets. However, challenges still exist in 3D tumor lesion segmentation owing to tumor complexity and the imbalance in foreground and background regions. Therefore, we introduce Mask-Enhanced SAM (M-SAM), an innovative architecture tailored for 3D tumor lesion segmentation. We propose a novel Mask-Enhanced Adapter (MEA) within M-SAM that enriches the semantic information of medical images with positional data from coarse segmentation masks, facilitating the generation of more precise segmentation masks. Furthermore, an iterative refinement scheme is implemented in M-SAM to refine the segmentation masks progressively, leading to improved performance. Extensive experiments on seven tumor lesion segmentation datasets indicate that our M-SAM not only achieves high segmentation accuracy but also exhibits robust generalization. The code is available at https://github.com/nanase1025/M-SAM.
Multi-Sequence Parotid Gland Lesion Segmentation via Expert Text-Guided Segment Anything Model
Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University（中山大学附属第一医院放射科）；Department of Radiology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center（中山大学南方学院肿瘤学国家重点实验室、癌症医学创新中心、中山大学肿瘤中心放射科）；Department of Radiology, Shantou Central Hospital（汕头市中心医院放射科）；Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University（广东省恶性肿瘤表观遗传学与基因调控重点实验室、中山大学附属第一医院医学研究中心、中山大学）；Department of Radiology, Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University（中山大学附属山田医院放射科）
Comparative Analysis of Segment Anything Model and U-Net for Breast Tumor Detection in Ultrasound and Mammography Images
Florida Atlantic University（佛罗里达大西洋大学）；University of Massachusetts Lowell（马萨诸塞大学洛厄尔分校）；Shahid Beheshti University of Medical Sciences（沙希德·贝赫什提医科大学）；Missouri University of Science and Technology（密苏里科技大学）；Florida International University（佛罗里达国际大学）
Duke University（杜克大学）；Vanderbilt University（范德堡大学）
Lesion detection in digital breast tomosynthesis (DBT) is an important and a challenging problem characterized by a low prevalence of images containing tumors. Due to the label scarcity problem, large deep learning models and computationally intensive algorithms are likely to fail when applied to this task. In this paper, we present a practical yet lightweight backbone to improve the accuracy of tumor detection. Specifically, we propose a novel modification of visual transformer (ViT) on image feature patches to connect the feature patches of a tumor with healthy backgrounds of breast images a…
NVIDIA AI Technology Center（英伟达人工智能技术中心）；Nanyang Technological University（南洋理工大学）；Monash University（莫纳什大学）
Lesion detection from computed tomography (CT) scans is challenging compared to natural object detection because of two major reasons: small lesion size and small inter-class variation. Firstly, the lesions usually only occupy a small region in the CT image. The feature of such small region may not be able to provide sufficient information due to its limited spatial feature resolution. Secondly, in CT scans, the lesions are often indistinguishable from the background since the lesion and non-lesion areas may have very similar appearances. To tackle both problems, we need to enrich the feature …
National Institutes of Health（美国国立卫生研究院）；National Institute of Diabetes and Digestive and Kidney Diseases（国家糖尿病、消化和肾脏疾病研究所）
Finding small lesions is very challenging due to lack of noticeable features, severe class imbalance, as well as the size itself. One approach to improve small lesion segmentation is to reduce the region of interest and inspect it at a higher sensitivity rather than performing it for the entire region. It is usually implemented as sequential or joint segmentation of organ and lesion, which requires additional supervision on organ segmentation. Instead, we propose to utilize an intensity distribution of a target lesion at no additional labeling cost to effectively separate regions where the les…
Automatic segmentation of tumor lesions is a critical initial processing step for quantitative PET/CT analysis. However, numerous tumor lesion with different shapes, sizes, and uptake intensity may be distributed in different anatomical contexts throughout the body, and there is also significant uptake in healthy organs. Therefore, building a systemic PET/CT tumor lesion segmentation model is a challenging task. In this paper, we propose a novel training strategy to build deep learning models capable of systemic tumor segmentation. Our method is validated on the training set of the AutoPET 202…
University of California, Santa Barbara（加利福尼亚大学圣巴巴拉分校）；University of California, Irvine（加利福尼亚大学欧文分校）
We propose a novel, simple and effective method to integrate lesion prior and a 3D U-Net for improving brain tumor segmentation. First, we utilize the ground-truth brain tumor lesions from a group of patients to generate the heatmaps of different types of lesions. These heatmaps are used to create the volume-of-interest (VOI) map which contains prior information about brain tumor lesions. The VOI map is then integrated with the multimodal MR images and input to a 3D U-Net for segmentation. The proposed method is evaluated on a public benchmark dataset, and the experimental results show that th…
Adapting Segment Anything Model 3 for Concept-Driven Lesion Segmentation in Medical Images: An Experimental Study
The Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, University of Texas Southwestern Medical Center（德克萨斯大学西南医学中心放射肿瘤学系医学人工智能与自动化（MAIA）实验室）；Medical Image Processing Group, Department of Radiology, University of Pennsylvania（宾夕法尼亚大学放射学系医学图像处理组）；Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center（德克萨斯大学西南医学中心内科学系消化与肝脏疾病科）
Adaptable Segmentation Pipeline for Diverse Brain Tumors with Radiomic-Guided Subtyping and Lesion-Wise Model Ensemble
Sheikh Zayed Institute for Pediatric Surgical Innovation（Sheikh Zayed儿童外科创新研究所）；Children’s National Hospital（儿童医院）；University of Washington（华盛顿大学）；Universidad Politécnica de Madrid（马德里理工大学）；CIBER-BBN；ISCIII；School of Medicine and Health Sciences（医学与健康科学学院）
University of Science and Technology of China（中国科学技术大学）；University of Miami（迈阿密大学）；the First Affiliated Hospital of USTC（中国科学技术大学附属第一医院）
Automatic deep learning segmentation models has been shown to improve both the segmentation efficiency and the accuracy. However, training a robust segmentation model requires considerably large labeled training samples, which may be impractical. This study aimed to develop a deep learning framework for generating synthetic lesions that can be used to enhance network training. The lesion synthesis network is a modified generative adversarial network (GAN). Specifically, we innovated a partial convolution strategy to construct an Unet-like generator. The discriminator is designed using Wasserst…
ASLseg: Adapting SAM in the Loop for Semi-supervised Liver Tumor Segmentation
Southern University of Science and Technology（南方科技大学）；The University of Hong Kong（香港大学）；Jiaxing Research Institute, Southern University of Science and Technology（南方科技大学嘉兴研究院）
Automatic segmentation of tumor lesions is a critical initial processing step for quantitative PET/CT analysis. However, numerous tumor lesions with different shapes, sizes, and uptake intensity may be distributed in different anatomical contexts throughout the body, and there is also significant uptake in healthy organs. Therefore, building a systemic PET/CT tumor lesion segmentation model is a challenging task. In this paper, we propose a novel step-by-step 3D segmentation method to address this problem. We achieved Dice score of 0.92, false positive volume of 0.89 and false negative volume …
University of Science and Technology of China（中国科学技术大学）；Rensselaer Polytechnic Institute（伦斯勒理工学院）
Liver lesion segmentation is a difficult yet critical task for medical image analysis. Recently, deep learning based image segmentation methods have achieved promising performance, which can be divided into three categories: 2D, 2.5D and 3D, based on the dimensionality of the models. However, 2.5D and 3D methods can have very high complexity and 2D methods may not perform satisfactorily. To obtain competitive performance with low complexity, in this paper, we propose a Feature-fusion Encoder-Decoder Network (FED-Net) based 2D segmentation model to tackle the challenging problem of liver lesion…
Deep Learning is the newest and the current trend of the machine learning field that paid a lot of the researchers' attention in the recent few years. As a proven powerful machine learning tool, deep learning was widely used in several applications for solving various complex problems that require extremely high accuracy and sensitivity, particularly in the medical field. In general, brain tumor is one of the most common and aggressive malignant tumor diseases which is leading to a very short expected life if it is diagnosed at higher grade. Based on that, brain tumor grading is a very critica…
KTH Royal Institute of Technology（瑞典皇家理工学院）；Karolinska Institutet（卡罗林斯卡学院）
Tumor segmentation in PET-CT images is challenging due to the dual nature of the acquired information: low metabolic information in CT and low spatial resolution in PET. U-Net architecture is the most common and widely recognized approach when developing a fully automatic image segmentation method in the medical field. We proposed a two-step approach, aiming to refine and improve the segmentation performances of tumoral lesions in PET-CT. The first step generates a prior tumor appearance map from the PET-CT volumes, regarded as prior tumor information. The second step, consisting of a standard…
The Segment Anything foundation model achieves favorable brain tumor autosegmentation accuracy on MRI to support radiotherapy treatment planning
Universitätsklinikum Erlangen（埃尔兰根大学医院）；Friedrich-Alexander-Universität Erlangen-Nürnberg（埃尔朗根-纽伦堡弗里德里希·亚历山大大学）；Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN)（埃尔兰根-欧洲分子神经科学网络综合癌症中心）
Accurate liver and lesion segmentation from computed tomography (CT) images are highly demanded in clinical practice for assisting the diagnosis and assessment of hepatic tumor disease. However, automatic liver and lesion segmentation from contrast-enhanced CT volumes is extremely challenging due to the diversity in contrast, resolution, and quality of images. Previous methods based on UNet for 2D slice-by-slice or 3D volume-by-volume segmentation either lack sufficient spatial contexts or suffer from high GPU computational cost, which limits the performance. To tackle these issues, we propose…
Shenzhen University（深圳大学）；Guangdong Province Traditional Chinese Medical Hospital（广东省中医院）
Automated breast ultrasound (ABUS) is a new and promising imaging modality for breast cancer detection and diagnosis, which could provide intuitive 3D information and coronal plane information with great diagnostic value. However, manually screening and diagnosing tumors from ABUS images is very time-consuming and overlooks of abnormalities may happen. In this study, we propose a novel two-stage 3D detection network for locating suspected lesion areas and further classifying lesions as benign or malignant tumors. Specifically, we propose a 3D detection network rather than frequently-used segme…
Towards SAMBA: Segment Anything Model for Brain Tumor Segmentation in Sub-Sharan African Populations
Nile University（尼罗大学）；Friedrich-Alexander-Universität（埃尔朗根-纽伦堡大学）；Makerere University（马凯雷雷大学）；Malawi University of Science and Technology（马拉维科技大学）；Medical Artificial Intelligence Laboratory (MAI Lab)（医学人工智能实验室（MAI Lab））；Lawson Health Research Institute（劳森健康研究院）；University of British Columbia（不列颠哥伦比亚大学）；Montreal Neurological Institute, McGill University（麦吉尔大学蒙特利尔神经学研究所）；University of Cape Town（开普敦大学）
National Institutes of Health Clinical Center（美国国立卫生研究院临床中心）；Ping An Insurance Company of China（中国平安保险公司）
In clinical trials, one of the radiologists' routine work is to measure tumor sizes on medical images using the RECIST criteria (Response Evaluation Criteria In Solid Tumors). However, manual measurement is tedious and subject to inter-observer variability. We propose a unified framework named SEENet for semi-automatic lesion \textit{SE}gmentation and RECIST \textit{E}stimation on a variety of lesions over the entire human body. The user is only required to provide simple guidance by clicking once near the lesion. SEENet consists of two main parts. The first one extracts the lesion of interest…
ViPSAM: Visual Prompting Medical Image Segmentation Using Segment Anything Model
Department of Artificial Intelligence, Sungkyunkwan University, Republic of Korea（人工智能系，成均馆大学，大韩民国）；Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea（放射肿瘤科，三星医疗中心，成均馆大学医学院，大韩民国）；Department of MetaBioHealth, Sungkyunkwan University, Republic of Korea（元生物健康系，成均馆大学，大韩民国）
South Central University for Nationalities（中南民族大学）；Nanjing Eastern Theater General Hospital（南京东部战区总医院）
Wireless Capsule Endoscopy(WCE) has been widely used for the screening of gastrointestinal(GI) diseases, especially the small intestine, due to its advantages of non-invasive and painless imaging of the entire digestive tract.However, the huge amount of image data captured by WCE makes manual reading a process that requires a huge amount of tasks and can easily lead to missed detection and false detection of lesions.Therefore, In this paper, we propose a \textbf{T}wo-stage \textbf{M}ulti-scale \textbf{F}eature-fusion learning network(\textbf{TMFNet}) to automatically detect small intestinal po…
Exploiting learning algorithms under scarce data regimes is a limitation and a reality of the medical imaging field. In an attempt to mitigate the problem, we propose a data augmentation protocol based on generative adversarial networks. We condition the networks at a pixel-level (segmentation mask) and at a global-level information (acquisition environment or lesion type). Such conditioning provides immediate access to the image-label pairs while controlling global class specific appearance of the synthesized images. To stimulate synthesis of the features relevant for the segmentation task, a…
Multilevel Perception Boundary-guided Network for Breast Lesion Segmentation in Ultrasound Images
Guizhou University（贵州大学）；College of Computer Science and Technology, Guizhou University（贵州大学计算机科学与技术学院）；Engineering Research Center of Text Computing & Cognitive Intelligence, Ministry of Education（教育部文本计算与认知智能工程研究中心）；Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province（贵州省智能医学影像分析与精准诊断重点实验室）；State Key Laboratory of Public Big Data（公共大数据国家重点实验室）
Charles Stark Draper Laboratory（查尔斯·斯塔克·德拉普尔实验室）；Stanford Medicine（斯坦福医学）；Bracco Diagnostics Corporation（布拉科诊断公司）
Molecularly targeted contrast enhanced ultrasound (mCEUS) is a clinically promising approach for early cancer detection through targeted imaging of VEGFR2 (KDR) receptors. We have developed computational enhancement techniques for mCEUS tailored to address the unique challenges of imaging contrast accumulation in humans. These techniques utilize dynamic analysis to distinguish molecularly bound contrast agent from other contrast-mode signal sources, enabling analysis of contrast agent accumulation to be performed during contrast bolus arrival when the signal due to molecular binding is stronge…
Shanghai AI Lab（上海人工智能实验室）；Shanghai Jiao Tong University（上海交通大学）；University of Surrey（萨里大学）；University of Electronic Science and Technology of China（电子科技大学）；Tongji University（同济大学）
Tumor lesion segmentation is one of the most important tasks in medical image analysis. In clinical practice, Fluorodeoxyglucose Positron-Emission Tomography~(FDG-PET) is a widely used technique to identify and quantify metabolically active tumors. However, since FDG-PET scans only provide metabolic information, healthy tissue or benign disease with irregular glucose consumption may be mistaken for cancer. To handle this challenge, PET is commonly combined with Computed Tomography~(CT), with the CT used to obtain the anatomic structure of the patient. The combination of PET-based metabolic and…
Case Western Reserve University（凯斯西储大学）；Cleveland Clinic（克利夫兰诊所）
A significant challenge in Glioblastoma (GBM) management is identifying pseudo-progression (PsP), a benign radiation-induced effect, from tumor recurrence, on routine imaging following conventional treatment. Previous studies have linked tumor lobar presence and laterality to GBM outcomes, suggesting that disease etiology and progression in GBM may be impacted by tumor location. Hence, in this feasibility study, we seek to investigate the following question: Can tumor location on treatment-naïve MRI provide early cues regarding likelihood of a patient developing pseudo-progression versus tumor…
PAII Inc.（PAII公司）；Ping An Technology（平安科技）；Beijing United Family Hospital（北京和睦家医院）；Chang Gung Memorial Hospital（长庚纪念医院）
Measuring lesion size is an important step to assess tumor growth and monitor disease progression and therapy response in oncology image analysis. Although it is tedious and highly time-consuming, radiologists have to work on this task by using RECIST criteria (Response Evaluation Criteria In Solid Tumors) routinely and manually. Even though lesion segmentation may be the more accurate and clinically more valuable means, physicians can not manually segment lesions as now since much more heavy laboring will be required. In this paper, we present a prior-guided dual-path network (PDNet) to segme…
Recent progress in automated PET/CT lesion segmentation using deep learning methods has demonstrated the feasibility of this task. However, tumor lesion detection and segmentation in whole-body PET/CT is still a chal-lenging task. To promote research on machine learning-based automated tumor lesion segmentation on whole-body FDG-PET/CT data, Automated Lesion Segmentation in Whole-Body FDG-PET/CT (autoPET) challenge is held, and a large, publicly available training dataset is provided. In this report, we present our solution to the autoPET challenge. We employ multi-modal residual U-Net with de…
Automatically measuring lesion/tumor size with RECIST (Response Evaluation Criteria In Solid Tumors) diameters and segmentation is important for computer-aided diagnosis. Although it has been studied in recent years, there is still space to improve its accuracy and robustness, such as (1) enhancing features by incorporating rich contextual information while keeping a high spatial resolution and (2) involving new tasks and losses for joint optimization. To reach this goal, this paper proposes a transformer-based network (MeaFormer, Measurement transFormer) for lesion RECIST diameter prediction …
Brain tumor imaging has been part of the clinical routine for many years to perform non-invasive detection and grading of tumors. Tumor segmentation is a crucial step for managing primary brain tumors because it allows a volumetric analysis to have a longitudinal follow-up of tumor growth or shrinkage to monitor disease progression and therapy response. In addition, it facilitates further quantitative analysis such as radiomics. Deep learning models, in particular CNNs, have been a methodology of choice in many applications of medical image analysis including brain tumor segmentation. In this …
MSWAL: 3D Multi-class Segmentation of Whole Abdominal Lesions Dataset
Shanghai AI Lab（上海人工智能实验室）；University of Liverpool（利物浦大学）；Columbia university（哥伦比亚大学）；Monash University（墨尔本大学）；Xi'an Jiaotong-Liverpool University（西安交通大学利物浦大学）；MBZUAI（穆斯林人工智能研究所）；People's Hospital of Gong'an County（公安县人民医院）
本文提出首个 3D 全腹部病变多类分割数据集 MSWAL，覆盖七类常见病变，并提出 Inception nnU-Net 框架，在分割性能上显著优于现有方法。
Heidelberg University（海德堡大学）；University Medical Center Mannheim（曼海姆大学医学中心）
At present, lesion segmentation is still performed manually (or semi-automatically) by medical experts. To facilitate this process, we contribute a fully-automatic lesion segmentation pipeline. This work proposes a method as a part of the LiTS (Liver Tumor Segmentation Challenge) competition for ISBI 17 and MICCAI 17 comparing methods for automatics egmentation of liver lesions in CT scans. By utilizing cascaded, densely connected 2D U-Nets and a Tversky-coefficient based loss function, our framework achieves very good shape extractions with high detection sensitivity, with competitive scores …
University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）；Mayo Clinic（梅奥诊所）；Washington University in St. Louis（圣路易斯华盛顿大学）；Beckman Institute, University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校贝克曼研究所）
Automatic breast lesion detection and classification is an important task in computer-aided diagnosis, in which breast ultrasound (BUS) imaging is a common and frequently used screening tool. Recently, a number of deep learning-based methods have been proposed for joint localization and classification of breast lesions using BUS images. In these methods, features extracted by a shared network trunk are appended by two independent network branches to achieve classification and localization. Improper information sharing might cause conflicts in feature optimization in the two branches and leads …
Medical Faculty Mannheim（曼海姆医学院）；Heidelberg University（海德堡大学）；Tooploox
We propose a novel procedure to improve liver and lesion segmentation from CT scans for U-Net based models. Our method extends standard segmentation pipelines to focus on higher target recall or reduction of noisy false-positive predictions, boosting overall segmentation performance. To achieve this, we include segmentation errors into a new learning process appended to the main training setup, allowing the model to find features which explain away previous errors. We evaluate this on semantically distinct architectures: cascaded two- and three-dimensional as well as combined learning setups f…
Numerous oncology indications have extensively quantified metabolically active tumors using positron emission tomography (PET) and computed tomography (CT). F-fluorodeoxyglucose-positron emission tomography (FDG-PET) is frequently utilized in clinical practice and clinical drug research to detect and measure metabolically active malignancies. The assessment of tumor burden using manual or computer-assisted tumor segmentation in FDG-PET images is widespread. Deep learning algorithms have also produced effective solutions in this area. However, there may be a need to improve the performance of a…
College of Medicine and Biological Information Engineering, Northeastern University（东北大学生物医学与信息工程学院）；Department of Electrical and Computer Engineering, Steven Institute of Technology（史蒂文斯理工学院电气与计算机工程系）；Key Laboratory of Intelligent Computing in Medical Image, Ministry of Education（医学影像智能计算教育部重点实验室）
Whole-body PET/CT scan is an important tool for diagnosing various malignancies (e.g., malignant melanoma, lymphoma, or lung cancer), and accurate segmentation of tumors is a key part for subsequent treatment. In recent years, CNN-based segmentation methods have been extensively investigated. However, these methods often give inaccurate segmentation results, such as over-segmentation and under-segmentation. Therefore, to address such issues, we propose a post-processing method based on a graph convolutional neural network (GCN) to refine inaccurate segmentation parts and improve the overall se…
MedSAM2: Segment Anything in 3D Medical Images and Videos
University Health Network（多伦多大学健康网络）；Vector Institute（向量研究院）；Harvard Medical School（哈佛医学院）；Harvard University（哈佛大学）；University of Toronto（多伦多大学）；Peter Munk Cardiac Centre（彼得·芒克心脏中心）；AI Hub（人工智能中心）
提出MedSAM2，通过微调Segment Anything Model 2构建3D医学图像和视频分割基础模型，结合人在回路流程显著降低标注成本并提升分割性能。
Precise Liver Tumor Segmentation in CT Using a Hybrid Deep Learning-Radiomics Framework
School of Information Science & Engineering, Shandong Normal University（信息科学与工程学院，山东师范大学）；Tajik State University of Law, Business and Politics（塔吉克国立法律、商业与政治大学）
Transfer learning and joint learning approaches are extensively used to improve the performance of Convolutional Neural Networks (CNNs). In medical imaging applications in which the target dataset is typically very small, transfer learning improves feature learning while joint learning has shown effectiveness in improving the network's generalization and robustness. In this work, we study the combination of these two approaches for the problem of liver lesion segmentation and classification. For this purpose, 332 abdominal CT slices containing lesion segmentation and classification of three le…
Background: A crucial initial processing step for quantitative PET/CT analysis is the segmentation of tumor lesions enabling accurate feature ex-traction, tumor characterization, oncologic staging, and image-based therapy response assessment. Manual lesion segmentation is however associated with enormous effort and cost and is thus infeasible in clinical routine. Goal: The goal of this study was to report the performance of a deep neural network designed to automatically segment regions suspected of cancer in whole-body 18F-FDG PET/CT images in the context of the AutoPET challenge. Method: A c…
Instituto de Investigación e Innovación en Bioingeniería, Universitat Politècnica de València（瓦伦西亚理工大学生物工程研究与创新研究所）；Pathology Department. Hospital Clínico Universitario de Valencia, Universidad de Valencia（瓦伦西亚大学临床大学医院病理科）
Melanoma is an aggressive neoplasm responsible for the majority of deaths from skin cancer. Specifically, spitzoid melanocytic tumors are one of the most challenging melanocytic lesions due to their ambiguous morphological features. The gold standard for its diagnosis and prognosis is the analysis of skin biopsies. In this process, dermatopathologists visualize skin histology slides under a microscope, in a high time-consuming and subjective task. In the last years, computer-aided diagnosis (CAD) systems have emerged as a promising tool that could support pathologists in daily clinical practic…
