Medical image processing is one of the most important topics in the field of the Internet of Medical Things (IoMT). Recently, deep learning methods have carried out state-of-the-art performances on medical image tasks. However, conventional deep learning have two main drawbacks: 1) insufficient training data and 2) the domain mismatch between the training data and the testing data. In this paper, we propose a distant domain transfer learning (DDTL) method for medical image classification. Moreover, we apply our methods to a recent issue (Coronavirus diagnose). Several current studies indicate that lung Computed Tomography (CT) images can be used for a fast and accurate COVID-19 diagnosis. However, the well-labeled training data cannot be easily accessed due to the novelty of the disease and a number of privacy policies. Moreover, the proposed method has two components: Reduced-size Unet Segmentation model and Distant Feature Fusion (DFF) classification model. It is related to a not well-investigated but important transfer learning problem, termed Distant Domain Transfer Learning (DDTL). DDTL aims to make efficient transfers even when the domains or the tasks are entirely different. In this study, we develop a DDTL model for COVID-19 diagnose using unlabeled Office-31, Catech-256, and chest X-ray image data sets as the source data, and a small set of COVID-19 lung CT as the target data. The main contributions of this study: 1) the proposed method benefits from unlabeled data collected from distant domains which can be easily accessed, 2) it can effectively handle the distribution shift between the training data and the testing data, 3) it has achieved 96\% classification accuracy, which is 13\% higher classification accuracy than "non-transfer" algorithms, and 8\% higher than existing transfer and distant transfer algorithms.
Deep learning has led to state-of-the-art results for many medical imaging tasks, such as segmentation of different anatomical structures. With the increased numbers of deep learning publications and openly available code, the approach to choosing a model for a new task becomes more complicated, while time and (computational) resources are limited. A possible solution to choosing a model efficiently is meta-learning, a learning method in which prior performance of a model is used to predict the performance for new tasks. We investigate meta-learning for segmentation across ten datasets of diff…
Nanyang Technological University（南洋理工大学）；City University of Hong Kong（香港城市大学）；Karolinska Institute（卡罗林斯卡学院）；Karolinska University Hospital（卡罗林斯卡大学医院）
Recently, we have witnessed great progress in the field of medical imaging classification by adopting deep neural networks. However, the recent advanced models still require accessing sufficiently large and representative datasets for training, which is often unfeasible in clinically realistic environments. When trained on limited datasets, the deep neural network is lack of generalization capability, as the trained deep neural network on data within a certain distribution (e.g. the data captured by a certain device vendor or patient population) may not be able to generalize to the data with a…
In this work we examine the performance enhancement in classification of medical imaging data when image features are combined with associated non-image data. We compare the performance of eight state-of-the-art deep neural networks in classification tasks when using only image features, compared to when these are combined with patient metadata. We utilise transfer learning with networks pretrained on ImageNet used directly as feature extractors and fine tuned on the target domain. Our experiments show that performance can be significantly enhanced with the inclusion of metadata and use interp…
Transfer learning from natural image datasets, particularly ImageNet, using standard large models and corresponding pretrained weights has become a de-facto method for deep learning applications to medical imaging. However, there are fundamental differences in data sizes, features and task specifications between natural image classification and the target medical tasks, and there is little understanding of the effects of transfer. In this paper, we explore properties of transfer learning for medical imaging. A performance evaluation on two large scale medical imaging tasks shows that surprisin…
Queensland University of Technology（昆士兰科技大学）；University of Jaen（哈恩大学）；The University of Queensland（昆士兰大学）；University of Sumer（苏美尔大学）；University of Baghdad（巴格达大学）；The University of Information Technology & Communications（信息与通信技术大学）；University of Missouri（密苏里大学）
Deep Learning (DL) requires a large amount of training data to provide quality outcomes. However, the field of medical imaging suffers from the lack of sufficient data for properly training DL models because medical images require manual labelling carried out by clinical experts thus the process is time-consuming, expensive, and error-prone. Recently, transfer learning (TL) was introduced to reduce the need for the annotation procedure by means of transferring the knowledge performed by a previous task and then fine-tuning the result using a relatively small dataset. Nowadays, multiple classif…
Jordan University of Science and Technology（约旦科技大学）
The scarcity of high-quality annotated medical imaging datasets is a major problem that collides with machine learning applications in the field of medical imaging analysis and impedes its advancement. Self-supervised learning is a recent training paradigm that enables learning robust representations without the need for human annotation which can be considered an effective solution for the scarcity of annotated medical data. This article reviews the state-of-the-art research directions in self-supervised learning approaches for image data with a concentration on their applications in the fiel…
While deep learning methods have shown great success in medical image analysis, they require a number of medical images to train. Due to data privacy concerns and unavailability of medical annotators, it is oftentimes very difficult to obtain a lot of labeled medical images for model training. In this paper, we study cross-modality data augmentation to mitigate the data deficiency issue in the medical imaging domain. We propose a discriminative unpaired image-to-image translation model which translates images in source modality into images in target modality where the translation task is condu…
Medical imaging AI systems such as disease classification and segmentation are increasingly inspired and transformed from computer vision based AI systems. Although an array of adversarial training and/or loss function based defense techniques have been developed and proved to be effective in computer vision, defending against adversarial attacks on medical images remains largely an uncharted territory due to the following unique challenges: 1) label scarcity in medical images significantly limits adversarial generalizability of the AI system; 2) vastly similar and dominant fore- and backgroun…
As a promising lensless imaging method for distance objects, intensity interferometry imaging (III) had been suffering from the unreliable phase retrieval process, hindering the development of III for decades. Recently, the introduction of the ptychographic detection in III overcame this challenge, and a method called ptychographic III (PIII) was proposed. We here experimentally demonstrate that PIII can image a dynamic distance object. A reasonable image for the moving object can be retrieved with only two speckle patterns for each probe, and only 10 to 20 iterations are needed. Meanwhile, PI…
This regularly updated survey provides an overview of public resources that offer medical images and metadata of COVID-19 cases. The purpose of this survey is to simplify the access to open COVID-19 image data resources for all scientists currently working on the coronavirus crisis.
Recent work has investigated the distributions of learned convolution filters through a large-scale study containing hundreds of heterogeneous image models. Surprisingly, on average, the distributions only show minor drifts in comparisons of various studied dimensions including the learned task, image domain, or dataset. However, among the studied image domains, medical imaging models appeared to show significant outliers through "spikey" distributions, and, therefore, learn clusters of highly specific filters different from other domains. Following this observation, we study the collected med…
This compendium gathers all the accepted extended abstracts from the Second International Conference on Medical Imaging with Deep Learning (MIDL 2019), held in London, UK, 8-10 July 2019. Note that only accepted extended abstracts are listed here, the Proceedings of the MIDL 2019 Full Paper Track are published as Volume 102 of the Proceedings of Machine Learning Research (PMLR) http://proceedings.mlr.press/v102/.
Microsoft Health and Life Sciences（微软健康与生命科学部）；Stanford Center for Artificial Intelligence in Medicine and Imaging（斯坦福医学与成像人工智能中心）
Clinical Artificial lntelligence (AI) applications are rapidly expanding worldwide, and have the potential to impact to all areas of medical practice. Medical imaging applications constitute a vast majority of approved clinical AI applications. Though healthcare systems are eager to adopt AI solutions a fundamental question remains: \textit{what happens after the AI model goes into production?} We use the CheXpert and PadChest public datasets to build and test a medical imaging AI drift monitoring workflow to track data and model drift without contemporaneous ground truth. We simulate drift in…
Recently, with the significant developments in deep learning techniques, solving underdetermined inverse problems has become one of the major concerns in the medical imaging domain. Typical examples include undersampled magnetic resonance imaging, interior tomography, and sparse-view computed tomography, where deep learning techniques have achieved excellent performances. Although deep learning methods appear to overcome the limitations of existing mathematical methods when handling various underdetermined problems, there is a lack of rigorous mathematical foundations that would allow us to el…
California Institute of Technology（加州理工学院）；Stanford University（斯坦福大学）
Magnetic Resonance Imaging (MRI) suffers from several artifacts, the most common of which are motion artifacts. These artifacts often yield images that are of non-diagnostic quality. To detect such artifacts, images are prospectively evaluated by experts for their diagnostic quality, which necessitates patient-revisits and rescans whenever non-diagnostic quality scans are encountered. This motivates the need to develop an automated framework capable of accessing medical image quality and detecting diagnostic and non-diagnostic images. In this paper, we explore several convolutional neural netw…
Institute of Computing Technology, Chinese Academy of Sciences（中国科学院计算技术研究所）；University of Arkansas（阿肯色大学）；University of Houston（休斯顿大学）；INRIA, Sophia Antipolis-Mediterranean Centre（法国国家信息与自动化研究所索菲亚·安蒂波利斯地中海中心）
Deep reinforcement learning (DRL) augments the reinforcement learning framework, which learns a sequence of actions that maximizes the expected reward, with the representative power of deep neural networks. Recent works have demonstrated the great potential of DRL in medicine and healthcare. This paper presents a literature review of DRL in medical imaging. We start with a comprehensive tutorial of DRL, including the latest model-free and model-based algorithms. We then cover existing DRL applications for medical imaging, which are roughly divided into three main categories: (I) parametric med…
We present three imaging modalities that live on the crossroads of seismic and medical imaging. Through the lens of extended source imaging, we can draw deep connections among the fields of wave-equation based seismic and medical imaging, despite first appearances. From the seismic perspective, we underline the importance to work with the correct physics and spatially varying velocity fields. Medical imaging, on the other hand, opens the possibility for new imaging modalities where outside stimuli, such as laser or radar pulses, can not only be used to identify endogenous optical or thermal co…
AI Alignment in Medical Imaging: Unveiling Hidden Biases Through Counterfactual Analysis
School of Computation, Information and Technology, Technical University of Munich（技术大学慕尼黑计算、信息与技术学院）；Department of Computer Science, University of Oxford（牛津大学计算机科学系）；Department of Engineering Science, University of Oxford（牛津大学工程科学系）；Helmholtz AI, Munich, Germany（海德堡人工智能研究所，德国慕尼黑）
Computer Aided Detection (CAD) is a valuable technique for precisely interpreting medical images and it has a global business opportunity of about USD 1.8 billion. The current aspects with reference to the four sub stages such as image pre-processing, segmentation, feature extraction and classification and the future scope of CAD in medical imaging has been discussed in this paper. Many reviewers have emphasized the need for synergy between engineers and medical professionals for successful development of CAD systems and the current work is a move in that direction. The engineering aspects of …
Multi-environment lifelong deep reinforcement learning for medical imaging
Rice University（莱斯大学）；The Johns Hopkins University（约翰斯·霍普金斯大学）；McGovern Medical School, UTHealth Houston（休斯顿UTHealth麦戈文医学院）；Johns Hopkins University School of Medicine（约翰斯·霍普金斯大学医学院）；University of Maryland Medical Intelligent Imaging (UM2ii)（马里兰大学医学智能成像中心）；University of Maryland School of Medicine（马里兰大学医学院）
University College London（伦敦大学学院）；King’s College London（伦敦国王学院）
Counting is a fundamental task in biomedical imaging and count is an important biomarker in a number of conditions. Estimating the uncertainty in the measurement is thus vital to making definite, informed conclusions. In this paper, we first compare a range of existing methods to perform counting in medical imaging and suggest ways of deriving predictive intervals from these. We then propose and test a method for calculating intervals as an output of a multi-task network. These predictive intervals are optimised to be as narrow as possible, while also enclosing a desired percentage of the data…
Image-based characterization and disease understanding involve integrative analysis of morphological, spatial, and topological information across biological scales. The development of graph convolutional networks (GCNs) has created the opportunity to address this information complexity via graph-driven architectures, since GCNs can perform feature aggregation, interaction, and reasoning with remarkable flexibility and efficiency. These GCNs capabilities have spawned a new wave of research in medical imaging analysis with the overarching goal of improving quantitative disease understanding, mon…
KU Leuven（鲁汶大学）；Vector Institute（向量研究所）；NVIDIA（英伟达）；University of Toronto（多伦多大学）；University of Leeds（利兹大学）
Labelling data is expensive and time consuming especially for domains such as medical imaging that contain volumetric imaging data and require expert knowledge. Exploiting a larger pool of labeled data available across multiple centers, such as in federated learning, has also seen limited success since current deep learning approaches do not generalize well to images acquired with scanners from different manufacturers. We aim to address these problems in a common, learning-based image simulation framework which we refer to as Federated Simulation. We introduce a physics-driven generative appro…
Stanford University（斯坦福大学）；Columbia University（哥伦比亚大学）；Stanford Artificial Intelligence in Medicine Center（斯坦福医学人工智能中心）
Advances in computing power, deep learning architectures, and expert labelled datasets have spurred the development of medical imaging artificial intelligence systems that rival clinical experts in a variety of scenarios. The National Institutes of Health in 2018 identified key focus areas for the future of artificial intelligence in medical imaging, creating a foundational roadmap for research in image acquisition, algorithms, data standardization, and translatable clinical decision support systems. Among the key issues raised in the report: data availability, need for novel computing archite…
This work provides a strong baseline for the problem of multi-source multi-target domain adaptation and generalization in medical imaging. Using a diverse collection of ten chest X-ray datasets, we empirically demonstrate the benefits of training medical imaging deep learning models on varied patient populations for generalization to out-of-sample domains.
Purdue University Northwest（普渡大学西北校区）；Michigan Technological University（密歇根理工大学）
Deep learning algorithms have seen acute growth of interest in their applications throughout several fields of interest in the last decade, with medical hyperspectral imaging being a particularly promising domain. So far, to the best of our knowledge, there is no review paper that discusses the implementation of deep learning for medical hyperspectral imaging, which is what this review paper aims to accomplish by examining publications that currently utilize deep learning to perform effective analysis of medical hyperspectral imagery. This paper discusses deep learning concepts that are releva…
Over the last years, deep learning methods have become an increasingly popular choice to solve tasks from the field of inverse problems. Many of these new data-driven methods have produced impressive results, although most only give point estimates for the reconstruction. However, especially in the analysis of ill-posed inverse problems, the study of uncertainties is essential. In our work, we apply generative flow-based models based on invertible neural networks to two challenging medical imaging tasks, i.e. low-dose computed tomography and accelerated medical resonance imaging. We test diffe…
Towards Universal Unsupervised Anomaly Detection in Medical Imaging
Technical University of Munich（慕尼黑工业大学）；Helmholtz AI and Helmholtz Center Munich（亥姆霍兹人工智能与亥姆霍兹慕尼黑中心）；Klinikum Rechts der Isar（伊萨尔河右岸医院）；Imperial College London（伦敦帝国理工学院）
Deep neural networks (DNN) have achieved unprecedented performance in computer-vision tasks almost ubiquitously in business, technology, and science. While substantial efforts are made to engineer highly accurate architectures and provide usable model explanations, most state-of-the-art approaches are first designed for natural vision and then translated to the medical domain. This dissertation seeks to address this gap by proposing novel architectures that integrate the domain-specific constraints of medical imaging into the DNN model and explanation design.
Institute for Systems and Robotics（系统与机器人研究所）；Interactive Technologies Institute（交互技术研究所）
This paper describes the field research, design and comparative deployment of a multimodal medical imaging user interface for breast screening. The main contributions described here are threefold: 1) The design of an advanced visual interface for multimodal diagnosis of breast cancer (BreastScreening); 2) Insights from the field comparison of single vs multimodality screening of breast cancer diagnosis with 31 clinicians and 566 images, and 3) The visualization of the two main types of breast lesions in the following image modalities: (i) MammoGraphy (MG) in both Craniocaudal (CC) and Mediolat…
University of Edinburgh（爱丁堡大学）；Samsung AI Centre, Cambridge（三星剑桥人工智能中心）
A multitude of work has shown that machine learning-based medical diagnosis systems can be biased against certain subgroups of people. This has motivated a growing number of bias mitigation algorithms that aim to address fairness issues in machine learning. However, it is difficult to compare their effectiveness in medical imaging for two reasons. First, there is little consensus on the criteria to assess fairness. Second, existing bias mitigation algorithms are developed under different settings, e.g., datasets, model selection strategies, backbones, and fairness metrics, making a direct comp…
This paper reviewed the deep learning-based studies for medical imaging synthesis and its clinical application. Specifically, we summarized the recent developments of deep learning-based methods in inter- and intra-modality image synthesis by listing and highlighting the proposed methods, study designs and reported performances with related clinical applications on representative studies. The challenges among the reviewed studies were summarized in the discussion part.
A Review of Uncertainty Estimation and its Application in Medical Imaging
Sichuan University（四川大学）；Tianjin University（天津大学）；Institute of High Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR)（新加坡科技研究局高性能计算研究所（IHPC））
Emory University（埃默里大学）；Winship Cancer Institute（温希普癌症研究所）；Emory University School of Medicine（埃默里大学医学院）
Medical imaging is widely used in cancer diagnosis and treatment, and artificial intelligence (AI) has achieved tremendous success in various tasks of medical image analysis. This paper reviews AI-based tumor subregion analysis in medical imaging. We summarize the latest AI-based methods for tumor subregion analysis and their applications. Specifically, we categorize the AI-based methods by training strategy: supervised and unsupervised. A detailed review of each category is presented, highlighting important contributions and achievements. Specific challenges and potential AI applications in t…
A central task in medical imaging is the reconstruction of an image or function from data collected by medical devices (e.g., CT, MRI, and PET scanners). We provide quantum algorithms for image reconstruction with exponential speedup over classical counterparts when data is input as a quantum state. Since outputs of our algorithms are stored in quantum states, individual pixels of reconstructed images may not be efficiently accessed classically; instead, we discuss various methods to extract information from outputs using a variety of quantum post-processing algorithms.
Neural Radiance Fields in Medical Imaging: A Survey
University at Albany, State University of New York（纽约州立大学奥尔巴尼分校）；Purdue University（普渡大学）；University of North Texas（北得克萨斯大学）；University of North Carolina at Chapel Hill（北卡罗来纳大学教堂山分校）
Deep learning models are now used in many different industries, while in certain domains safety is not a critical issue in the medical field it is a huge concern. Not only, we want the models to generalize well but we also want to know the models confidence respect to its decision and which features matter the most. Our team aims to develop a full pipeline in which not only displays the uncertainty of the models decision but also, the saliency map to show which sets of pixels of the input image contribute most to the predictions.
School of Biomedical Engineering, University of Science and Technology of China（中国科学技术大学生物医学工程学院）；Institute of Computing Technology, Chinese Academy of Sciences（中国科学院计算技术研究所）；Tel-Aviv University（特拉维夫大学）；University of Pennsylvania（宾夕法尼亚大学）；Yale University（耶鲁大学）；Radboud University Medical Center（拉德堡德大学医学中心）；Case Western Reserve University（凯斯西储大学）；Louis Stokes Cleveland Veterans Administration Medical Center（路易斯·斯托克斯克利夫兰退伍军人事务医疗中心）；Johns Hopkins University（约翰霍普金斯大学）；Klinikum rechts der Isar, TU Munich（慕尼黑工业大学右岸医院）；Imperial College（帝国理工学院）；National Institute of Health Clinical Center（美国国立卫生研究院临床中心）
Since its renaissance, deep learning has been widely used in various medical imaging tasks and has achieved remarkable success in many medical imaging applications, thereby propelling us into the so-called artificial intelligence (AI) era. It is known that the success of AI is mostly attributed to the availability of big data with annotations for a single task and the advances in high performance computing. However, medical imaging presents unique challenges that confront deep learning approaches. In this survey paper, we first present traits of medical imaging, highlight both clinical needs a…
Reconstructing medical images from partial measurements is an important inverse problem in Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Existing solutions based on machine learning typically train a model to directly map measurements to medical images, leveraging a training dataset of paired images and measurements. These measurements are typically synthesized from images using a fixed physical model of the measurement process, which hinders the generalization capability of models to unknown measurement processes. To address this issue, we propose a fully unsupervised techniq…
University of Central Florida（中佛罗里达大学）；Northwestern University（西北大学）；Mayo Clinic（梅奥诊所）；Sheikh Shakhbout Medical City（谢赫·沙赫布特医疗城）
Current data augmentation techniques and transformations are well suited for improving the size and quality of natural image datasets but are not yet optimized for medical imaging. We hypothesize that sub-optimal data augmentations can easily distort or occlude medical images, leading to false positives or negatives during patient diagnosis, prediction, or therapy/surgery evaluation. In our experimental results, we found that utilizing commonly used intensity-based data augmentation distorts the MRI scans and leads to texture information loss, thus negatively affecting the overall performance …
UQMIA: An Open, Hands-On Tutorial on Uncertainty Quantification in Medical Imaging Analysis with Large Language Model-Based Assessment of Educational Content
Mashhad University of Medical Sciences（马什哈德医科大学）；Northside Hospital（北院医院）；Mayo Clinic（梅奥诊所）；University of Pennsylvania（宾夕法尼亚大学）
INRIA（法国国家信息与自动化研究所）；IT University of Copenhagen（哥本哈根信息技术大学）
Medical imaging is an important research field with many opportunities for improving patients' health. However, there are a number of challenges that are slowing down the progress of the field as a whole, such optimizing for publication. In this paper we reviewed several problems related to choosing datasets, methods, evaluation metrics, and publication strategies. With a review of literature and our own analysis, we show that at every step, potential biases can creep in. On a positive note, we also see that initiatives to counteract these problems are already being started. Finally we provide…
Washington University in St. Louis（圣路易斯华盛顿大学）；University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）；Carle Foundation Hospital（卡尔基金会医院）
It has been advocated that medical imaging systems and reconstruction algorithms should be assessed and optimized by use of objective measures of image quality that quantify the performance of an observer at specific diagnostic tasks. One important source of variability that can significantly limit observer performance is variation in the objects to-be-imaged. This source of variability can be described by stochastic object models (SOMs). A SOM is a generative model that can be employed to establish an ensemble of to-be-imaged objects with prescribed statistical properties. In order to accurat…
A generalizable 3D framework and model for self-supervised learning in medical imaging
Department of Medical Biophysics, University of Toronto（多伦多大学医学生物物理学系）；Department of Computer Science, University of Toronto（多伦多大学计算机科学系）；Institute for Aerospace Studies, University of Toronto（多伦多大学航空航天研究所）；Physical Sciences Platform, Sunnybrook Research Institute（圣母医院研究学院物理科学平台）；Vector Institute, Toronto（多伦多向量研究所）；Department of Laboratory Medicine and Pathobiology, University of Toronto（多伦多大学实验室医学与病理学系）；Hurvitz Brain Sciences, Sunnybrook Health Sciences Centre（圣母医院健康科学中心Hurvitz脑科学）；Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre（圣母医院健康科学中心Harquail神经调制中心）
University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）；Food and Drug Administration（美国食品药品监督管理局）
Modern generative models, such as generative adversarial networks (GANs), hold tremendous promise for several areas of medical imaging, such as unconditional medical image synthesis, image restoration, reconstruction and translation, and optimization of imaging systems. However, procedures for establishing stochastic image models (SIMs) using GANs remain generic and do not address specific issues relevant to medical imaging. In this work, canonical SIMs that simulate realistic vessels in angiography images are employed to evaluate procedures for establishing SIMs using GANs. The GAN-based SIM …
