In the era of big data, variable selection is a key technology for handling high-dimensional problems with a small sample size but a large number of covariables. Different variable selection methods were proposed for different models, such as linear model, logistic model and generalized linear model. However, fewer works focused on variable selection for single index models, especially, for single index logistic model, due to the difficulty arose from the unknown link function and the slow mixing rate of MCMC algorithm for traditional logistic model. In this paper, we proposed a Bayesian variable selection procedure for single index logistic model by taking the advantage of Gaussian process and data augmentation. Numerical results from simulations and real data analysis show the advantage of our method over the state of arts.
We consider Bayesian logistic regression models with group-structured covariates. In high-dimensional settings, it is often assumed that only small portion of groups are significant, thus consistent group selection is of significant importance. While consistent frequentist group selection methods have been proposed, theoretical properties of Bayesian group selection methods for logistic regression models have not been investigated yet. In this paper, we consider a hierarchical group spike and slab prior for logistic regression models in high-dimensional settings. Under mild conditions, we esta…
An accurately identified maximum tolerated dose (MTD) serves as the cornerstone of successful subsequent phases in oncology drug development. Bayesian logistic regression model (BLRM) is a popular and versatile model-based dose-finding design. However, BLRM with original overdose control strategy has been reported to be safe but "excessively conservative". In this manuscript, we investigate the reason for conservativeness and point out that a major reason could be the lack of appropriate underdose control. We propose designs that balance overdose and underdose control to improve the performanc…
Bayesian multinomial logistic-normal (MLN) models are popular for the analysis of sequence count data (e.g., microbiome or gene expression data) due to their ability to model multivariate count data with complex covariance structure. However, existing implementations of MLN models are limited to handling small data sets due to the non-conjugacy of the multinomial and logistic-normal distributions. We introduce MLN models which can be written as marginally latent matrix-t process (LTP) models. Marginally LTP models describe a flexible class of generalized linear regression, non-linear regressio…
This study aims to show the fundamental difference between logistic regression and Bayesian classifiers in the case of exponential and unexponential families of distributions, yielding the following findings. First, the logistic regression is a less general representation of a Bayesian classifier. Second, one should suppose distributions of classes for the correct specification of logistic regression equations. Third, in specific cases, there is no difference between predicted probabilities from correctly specified generative Bayesian classifier and discriminative logistic regression.
Consider a set of categorical variables where at least one of them is binary. The log-linear model that describes the counts in the resulting contingency table implies a specific logistic regression model, with the binary variable as the outcome. Within the Bayesian framework, the $g$-prior and mixtures of $g$-priors are commonly assigned to the parameters of a generalized linear model. We prove that assigning a $g$-prior (or a mixture of $g$-priors) to the parameters of a certain log-linear model designates a $g$-prior (or a mixture of $g$-priors) on the parameters of the corresponding logist…
This paper describes a method for a model-based analysis of clinical safety data called multivariate Bayesian logistic regression (MBLR). Parallel logistic regression models are fit to a set of medically related issues, or response variables, and MBLR allows information from the different issues to "borrow strength" from each other. The method is especially suited to sparse response data, as often occurs when fine-grained adverse events are collected from subjects in studies sized more for efficacy than for safety investigations. A combined analysis of data from multiple studies can be perform…
Recently, a very attractive logistic regression inference method for exponential family Gibbs spatial point processes was introduced. We combined it with the technique of quadratic tangential variational approximation and derived a new Bayesian technique for analysing spatial point patterns. The technique is described in detail, and demonstrated on numerical examples.
We introduce Bayesian additive regression trees (BART) for log-linear models including multinomial logistic regression and count regression with zero-inflation and overdispersion. BART has been applied to nonparametric mean regression and binary classification problems in a range of settings. However, existing applications of BART have been limited to models for Gaussian "data", either observed or latent. This is primarily because efficient MCMC algorithms are available for Gaussian likelihoods. But while many useful models are naturally cast in terms of latent Gaussian variables, many others …
We analyze binary data, available for a relatively large number (big data) of families (or households), which are within small areas, from a population-based survey. Inference is required for the finite population proportion of individuals with a specific character for each area. To accommodate the binary data and important features of all sampled individuals, we use a hierarchical Bayesian logistic regression model with each family (not area) having its own random effect. This modeling helps to correct for overshrinkage so common in small area estimation. Because there are numerous families, …
Partial Ordering Bayesian Logistic Regression Model for Phase I Combination Trials and Computationally Efficient Approach to Operational Prior Specification
MRC Biostatistics Unit, University of Cambridge（剑桥大学医学研究委员会生物统计学单元）
In logistic regression, separation occurs when a linear combination of the predictors can perfectly classify part or all of the observations in the sample, and as a result, finite maximum likelihood estimates of the regression coefficients do not exist. Gelman et al. (2008) recommended independent Cauchy distributions as default priors for the regression coefficients in logistic regression, even in the case of separation, and reported posterior modes in their analyses. As the mean does not exist for the Cauchy prior, a natural question is whether the posterior means of the regression coefficie…
In this article, we construct a two-block Gibbs sampler using Polson et al. (2013) data augmentation technique with Polya-Gamma latent variables for Bayesian logistic linear mixed models under proper priors. Furthermore, we prove the uniform ergodicity of this Gibbs sampler, which guarantees the existence of the central limit theorems for MCMC based estimators.
In professional tennis, it is often acknowledged that the server has an initial advantage. Indeed, the majority of points are won by the server, making the serve one of the most important elements in this sport. In this paper, we focus on the role of the serve advantage in winning a point as a function of the rally length. We propose a Bayesian isotonic logistic regression model for the probability of winning a point on serve. In particular, we decompose the logit of the probability of winning via a linear combination of B-splines basis functions, with athlete-specific basis function coefficie…
We develop a fully Bayesian, logistic tracking algorithm with the purpose of providing classification results that are unbiased when applied uniformly to individuals with differing sensitive variable values. Here, we consider bias in the form of differences in false prediction rates between the different sensitive variable groups. Given that the method is fully Bayesian, it is well suited for situations where group parameters or logistic regression coefficients are dynamic quantities. We illustrate our method, in comparison to others, on both simulated datasets and the well-known ProPublica CO…
SoftServe, Inc.（SoftServe 公司）；Ivan Franko National University of Lviv（利沃夫伊万·弗兰科国立大学）
In this work, we study the use of logistic regression in manufacturing failures detection. As a data set for the analysis, we used the data from Kaggle competition Bosch Production Line Performance. We considered the use of machine learning, linear and Bayesian models. For machine learning approach, we analyzed XGBoost tree based classifier to obtain high scored classification. Using the generalized linear model for logistic regression makes it possible to analyze the influence of the factors under study. The Bayesian approach for logistic regression gives the statistical distribution for the …
We present a class of sparse generalized linear models that include probit and logistic regression as special cases and offer some extra flexibility. We provide an EM algorithm for learning the parameters of these models from data. We apply our method in text classification and in simulated data and show that our method outperforms the logistic and probit models and also the elastic net, in general by a substantial margin.
High-dimensional feature selection arises in many areas of modern science. For example, in genomic research we want to find the genes that can be used to separate tissues of different classes (e.g. cancer and normal) from tens of thousands of genes that are active (expressed) in certain tissue cells. To this end, we wish to fit regression and classification models with a large number of features (also called variables, predictors). In the past decade, penalized likelihood methods for fitting regression models based on hyper-LASSO penalization have received increasing attention in the literatur…
We propose a new data-augmentation strategy for fully Bayesian inference in models with binomial likelihoods. The approach appeals to a new class of Polya-Gamma distributions, which are constructed in detail. A variety of examples are presented to show the versatility of the method, including logistic regression, negative binomial regression, nonlinear mixed-effects models, and spatial models for count data. In each case, our data-augmentation strategy leads to simple, effective methods for posterior inference that: (1) circumvent the need for analytic approximations, numerical integration, or…
The logistic regression model is the most popular model for analyzing binary data. In the absence of any prior information, an improper flat prior is often used for the regression coefficients in Bayesian logistic regression models. The resulting intractable posterior density can be explored by running Polson et al.'s (2013) data augmentation (DA) algorithm. In this paper, we establish that the Markov chain underlying Polson et al.'s (2013) DA algorithm is geometrically ergodic. Proving this theoretical result is practically important as it ensures the existence of central limit theorems (CLTs…
The logistic specification has been used extensively in non-Bayesian statistics to model the dependence of discrete outcomes on the values of specified covariates. Because the likelihood function is globally weakly concave estimation by maximum likelihood is generally straightforward even in commonly arising applications with scores or hundreds of parameters. In contrast Bayesian inference has proven awkward, requiring normal approximations to the likelihood or specialized adaptations of existing Markov chain Monte Carlo and data augmentation methods. This paper approaches Bayesian inference i…
Bayesian classification and regression with high order interactions is largely infeasible because Markov chain Monte Carlo (MCMC) would need to be applied with a great many parameters, whose number increases rapidly with the order. In this paper we show how to make it feasible by effectively reducing the number of parameters, exploiting the fact that many interactions have the same values for all training cases. Our method uses a single ``compressed'' parameter to represent the sum of all parameters associated with a set of patterns that have the same value for all training cases. Using symmet…
The logistic linear mixed model (LLMM) is one of the most widely used statistical models. Generally, Markov chain Monte Carlo algorithms are used to explore the posterior densities associated with the Bayesian LLMMs. Polson, Scott and Windle's (2013) Polya-Gamma data augmentation (DA) technique can be used to construct full Gibbs (FG) samplers for the LLMMs. Here, we develop efficient block Gibbs (BG) samplers for Bayesian LLMMs using the Polya-Gamma DA method. We compare the FG and BG samplers in the context of a real data example, as the correlation between the fixed effects and the random e…
The first investigation is made of designs for screening experiments where the response variable is approximated by a generalised linear model. A Bayesian information capacity criterion is defined for the selection of designs that are robust to the form of the linear predictor. For binomial data and logistic regression, the effectiveness of these designs for screening is assessed through simulation studies using all-subsets regression and model selection via maximum penalised likelihood and a generalised information criterion. For Poisson data and log-linear regression, similar assessments are…
We consider the problem of comparing two Poisson parameters from the Bayesian perspective. Kawasaki and Miyaoka (2012b) proposed the Bayesian index $P(λ_1 < λ_2 | X_1,X_2)$ and expressed it using the hypergeometric series. In this paper, under some conditions, we give four other expressions of the Bayesian index in terms of the cumulative distribution functions of beta, $F$, binomial, and negative binomial distribution. Next, we investigate the relationship between the Bayesian index and the $p$-value of the conditional test with the null hypothesis $H_0: λ_1 \geq λ_2 $ versus an alternative h…
For Bayesian D-optimal design, we define a singular prior distribution for the model parameters as a prior distribution such that the determinant of the Fisher information matrix has a prior geometric mean of zero for all designs. For such a prior distribution, the Bayesian D-optimality criterion fails to select a design. For the exponential decay model, we characterize singularity of the prior distribution in terms of the expectations of a few elementary transformations of the parameter. For a compartmental model and several multi-parameter generalized linear models, we establish sufficient c…
The transition density of a stochastic, logistic population growth model with multiplicative intrinsic noise is analytically intractable. Inferring model parameter values by fitting such stochastic differential equation (SDE) models to data therefore requires relatively slow numerical simulation. Where such simulation is prohibitively slow, an alternative is to use model approximations which do have an analytically tractable transition density, enabling fast inference. We introduce two such approximations, with either multiplicative or additive intrinsic noise, each derived from the linear noi…
Prevalence estimation in infectious diseases with imperfect tests: A comparison of Frequentist and Bayesian Logistic Regression methods with misclassification correction
Logistic regression models for binomial responses are routinely used in statistical practice. However, the maximum likelihood estimate may not exist due to data separability. We address this issue by considering a conjugate prior penalty which always produces finite estimates. Such a specification has a clear Bayesian interpretation and enjoys several invariance properties, making it an appealing prior choice. We show that the proposed method leads to an accurate approximation of the reduced-bias approach of Firth (1993), resulting in estimators with smaller asymptotic bias than the maximum-li…
Fitting cross-classified multilevel models with binary response is challenging. In this setting a promising method is Bayesian inference through Integrated Nested Laplace Approximations (INLA), which performs well in several latent variable models. Therefore we devise a systematic simulation study to assess the performance of INLA with cross-classified logistic data under different scenarios defined by the magnitude of the random effects variances, the number of observations, the number of clusters, and the degree of cross-classification. In the simulations INLA is systematically compared with…
Describing the complex dependence structure of extreme phenomena is particularly challenging. To tackle this issue we develop a novel statistical algorithm that describes extremal dependence taking advantage of the inherent hierarchical dependence structure of the max-stable nested logistic distribution and that identifies possible clusters of extreme variables using reversible jump Markov chain Monte Carlo techniques. Parsimonious representations are achieved when clusters of extreme variables are found to be completely independent. Moreover, we significantly decrease the computational comple…
Bayesian nonparametric modeling of dynamic pollution clusters through an autoregressive logistic-beta Stirling-gamma process
Research School of Finance, Actuarial Studies and Statistics, Australian National University（澳大利亚国立大学金融、精算与统计研究学院）；Department of Mathematics and Statistics, Virginia Commonwealth University（弗吉尼亚联邦大学数学与统计学系）
Mixed effects regression models are widely used by language researchers. However, these regressions are implemented with an algorithm which may not converge on a solution. While convergence issues in linear mixed effects models can often be addressed with careful experiment design and model building, logistic mixed effects models introduce the possibility of separation or quasi-separation, which can cause problems for model estimation that result in convergence errors or in unreasonable model estimates. These problems cannot be solved by experiment or model design. In this paper, we discuss (q…
In Oncology, trials evaluating drug combinations are becoming more common. While combination therapies bring the potential for greater efficacy, they also create unique challenges for ensuring drug safety. In Phase-I dose escalation trials of drug combinations, model-based approaches enable efficient use of information gathered, but the models need to account for trial complexities: appropriate modeling of interactions becomes increasingly important with growing numbers of drugs being tested simultaneously in a given trial. In principle, we can use data from multiple arms testing varying combi…
In this paper, we introduce the notion of Gaussian processes indexed by probability density functions for extending the Matérn family of covariance functions. We use some tools from information geometry to improve the efficiency and the computational aspects of the Bayesian learning model. We particularly show how a Bayesian inference with a Gaussian process prior (covariance parameters estimation and prediction) can be put into action on the space of probability density functions. Our framework has the capacity of classifiying and infering on data observations that lie on nonlinear subspaces.…
The problem of selecting the most useful features from a great many (eg, thousands) of candidates arises in many areas of modern sciences. An interesting problem from genomic research is that, from thousands of genes that are active (expressed) in certain tissue cells, we want to find the genes that can be used to separate tissues of different classes (eg. cancer and normal). In this paper, we report our empirical experiences of using Bayesian logistic regression based on heavy-tailed priors with moderately small degree freedom (such as 1) and very small scale, and using Hamiltonian Monte Carl…
The present work describes simulation studies to compare the performances of bayesian wavelet shrinkage methods in estimating component curves from aggregated functional data. To do so, five methods were considered: the bayesian shrinkage rule under logistic prior by Sousa (2020), bayesian shrinkage rule under beta prior by Sousa et al. (2020), Large Posterior Mode method by Cutillo et al. (2008), Amplitude-scale invariant Bayes Estimator by Figueiredo and Nowak (2001) and Bayesian Adaptive Multiresolution Smoother by Vidakovic and Ruggeri (2001). Further, the so called Donoho-Johnstone test f…
The use of Bayesian methods in large-scale data settings is attractive because of the rich hierarchical models, uncertainty quantification, and prior specification they provide. Standard Bayesian inference algorithms are computationally expensive, however, making their direct application to large datasets difficult or infeasible. Recent work on scaling Bayesian inference has focused on modifying the underlying algorithms to, for example, use only a random data subsample at each iteration. We leverage the insight that data is often redundant to instead obtain a weighted subset of the data (call…
Multinomial logistic regression is one of the most popular models for modelling the effect of explanatory variables on a subject choice between a set of specified options. This model has found numerous applications in machine learning, psychology or economy. Bayesian inference in this model is non trivial and requires, either to resort to a MetropolisHastings algorithm, or rejection sampling within a Gibbs sampler. In this paper, we propose an alternative model to multinomial logistic regression. The model builds on the Plackett-Luce model, a popular model for multiple comparisons. We show tha…
In this study we present an application which can be accessed via www.excellence-networks.net and which represents networks of scientific institutions worldwide. The application is based on papers (articles, reviews and conference papers) published between 2007 and 2011. It uses (network) data, on which the SCImago Institutions Ranking is based (Scopus data from Elsevier). Using this data, institutional networks have been estimated with statistical models (Bayesian multilevel logistic regression, BMLR) for a number of Scopus subject areas. Within single subject areas, we have investigated and …
We propose a model of brain atrophy as a function of high-dimensional genetic information and low dimensional covariates such as gender, age, APOE gene, and disease status. A nonparametric single-index Bayesian model of high dimension is proposed to model the relationship with B-spline series prior on the unknown functions and Dirichlet process scale mixture of centered normal prior on the distributions of the random effects. The posterior rate of contraction without the random effect is established for a fixed number of regions and time points with increasing sample size. We implement an effi…
