Machine learning-based medical anomaly detection is an important problem that has been extensively studied. Numerous approaches have been proposed across various medical application domains and we observe several similarities across these distinct applications. Despite this comparability, we observe a lack of structured organisation of these diverse research applications such that their advantages and limitations can be studied. The principal aim of this survey is to provide a thorough theoretical analysis of popular deep learning techniques in medical anomaly detection. In particular, we contribute a coherent and systematic review of state-of-the-art techniques, comparing and contrasting their architectural differences as well as training algorithms. Furthermore, we provide a comprehensive overview of deep model interpretation strategies that can be used to interpret model decisions. In addition, we outline the key limitations of existing deep medical anomaly detection techniques and propose key research directions for further investigation.
The University of Tokyo Hospital（东京大学医院）；The University of Tokyo（东京大学）；RIKEN（理化学研究所）
Oversight in medical images is a crucial problem, and timely reporting of medical images is desired. Therefore, an all-purpose anomaly detection method that can detect virtually all types of lesions/diseases in a given image is strongly desired. However, few commercially available and versatile anomaly detection methods for medical images have been provided so far. Recently, anomaly detection methods built upon deep learning methods have been rapidly growing in popularity, and these methods seem to provide reasonable solutions to the problem. However, the workload to label the images necessary…
Towards Universal Unsupervised Anomaly Detection in Medical Imaging
Technical University of Munich（慕尼黑工业大学）；Helmholtz AI and Helmholtz Center Munich（亥姆霍兹人工智能与亥姆霍兹慕尼黑中心）；Klinikum Rechts der Isar（伊萨尔河右岸医院）；Imperial College London（伦敦帝国理工学院）
Obtaining ground truth data in medical imaging has difficulties due to the fact that it requires a lot of annotating time from the experts in the field. Also, when trained with supervised learning, it detects only the cases included in the labels. In real practice, we want to also open to other possibilities than the named cases while examining the medical images. As a solution, the need for anomaly detection that can detect and localize abnormalities by learning the normal characteristics using only normal images is emerging. With medical image data, we can design either 2D or 3D networks of …
City, University of London（伦敦大学城市学院）；Imperial College（帝国理工学院）
We propose a novel unsupervised out-of-distribution detection method for medical images based on implicit fields image representations. In our approach, an auto-decoder feed-forward neural network learns the distribution of healthy images in the form of a mapping between spatial coordinates and probabilities over a proxy for tissue types. At inference time, the learnt distribution is used to retrieve, from a given test image, a restoration, i.e. an image maximally consistent with the input one but belonging to the healthy distribution. Anomalies are localized using the voxel-wise probability p…
LPIXEL Inc.（LPIXEL公司）；University of Cambridge（剑桥大学）；National Institute of Informatics（国立信息学研究所）；National Center for Global Health and Medicine（国立国际医疗研究中心）；Juntendo University（顺天堂大学）；ELTE Eötvös Loránd University（厄特沃什·罗兰大学）；The University of Tokyo（东京大学）
Unsupervised learning can discover various unseen abnormalities, relying on large-scale unannotated medical images of healthy subjects. Towards this, unsupervised methods reconstruct a 2D/3D single medical image to detect outliers either in the learned feature space or from high reconstruction loss. However, without considering continuity between multiple adjacent slices, they cannot directly discriminate diseases composed of the accumulation of subtle anatomical anomalies, such as Alzheimer's Disease (AD). Moreover, no study has shown how unsupervised anomaly detection is associated with eith…
ShanghaiTech University（上海科技大学）；Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences（中国科学院上海微系统与信息技术研究所）；University of Chinese Academy of Sciences（中国科学院大学）；Shanghai Jiao Tong University（上海交通大学）；Institute of High Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR)（新加坡科技研究局高性能计算研究所）；Institute for Infocomm Research, Agency for Science, Technology and Research (A*STAR)（新加坡科技研究局资讯通信研究院）；Southern University of Science and Technology（南方科技大学）；Cixi Institute of Biomedical Engineering, Chinese Academy of Sciences（中国科学院慈溪生物医学工程研究所）
Anomaly detection in medical images refers to the identification of abnormal images with only normal images in the training set. Most existing methods solve this problem with a self-reconstruction framework, which tends to learn an identity mapping and reduces the sensitivity to anomalies. To mitigate this problem, in this paper, we propose a novel Proxy-bridged Image Reconstruction Network (ProxyAno) for anomaly detection in medical images. Specifically, we use an intermediate proxy to bridge the input image and the reconstructed image. We study different proxy types, and we find that the sup…
MadCLIP: Few-shot Medical Anomaly Detection with CLIP
Department of Computer Science, University of Verona（威尼斯大学计算机科学系）；AI for Good (AIGO) Research Unit, Istituto Italiano di Tecnologia（意大利技术研究院人工智能为善研究单元）
MADPOT: Medical Anomaly Detection with CLIP Adaptation and Partial Optimal Transport
Department of Computer Science, University of Verona（威尼斯大学计算机科学系）；AI for Good (AIGO) Research Unit, Istituto Italiano di Tecnologia（意大利技术研究院人工智能为善研究单元）
Ludwig-Maximilians-Universität München（慕尼黑大学）；Lehrstuhl für Datenbanksysteme und Data Mining（数据库系统与数据挖掘研究所）
Obtaining labels for medical (image) data requires scarce and expensive experts. Moreover, due to ambiguous symptoms, single images rarely suffice to correctly diagnose a medical condition. Instead, it often requires to take additional background information such as the patient's medical history or test results into account. Hence, instead of focusing on uninterpretable black-box systems delivering an uncertain final diagnosis in an end-to-end-fashion, we investigate how unsupervised methods trained on images without anomalies can be used to assist doctors in evaluating X-ray images of hands. …
Diverse Normal Prototypes-Guided Contrastive Reconstruction for Medical Anomaly Detection
School of Mathematics, Shandong University（山东大学数学学院）；Department of Interventional Medicine and Minimally Invasive Oncology, The Second Qilu Hospital of Shandong University（山东大学第二齐鲁医院介入医学与微创肿瘤科）；Department of Neurosurgery, The Second Qilu Hospital of Shandong University（山东大学第二齐鲁医院神经外科）
Anomaly detection is a significant problem faced in several research areas. Detecting and correctly classifying something unseen as anomalous is a challenging problem that has been tackled in many different manners over the years. Generative Adversarial Networks (GANs) and the adversarial training process have been recently employed to face this task yielding remarkable results. In this paper we survey the principal GAN-based anomaly detection methods, highlighting their pros and cons. Our contributions are the empirical validation of the main GAN models for anomaly detection, the increase of …
Computer Vision and Machine Intelligence Group University of the Philippines, Diliman（菲律宾大学迪利曼分校计算机视觉与机器智能研究组）；University of the Philippines, Diliman（菲律宾大学迪利曼分校）；Computer Vision and Machine Intelligence Group（计算机视觉与机器智能研究组）；University of the Philippines（菲律宾大学）；Diliman（迪利曼）
Anomaly detection in videos is a problem that has been studied for more than a decade. This area has piqued the interest of researchers due to its wide applicability. Because of this, there has been a wide array of approaches that have been proposed throughout the years and these approaches range from statistical-based approaches to machine learning-based approaches. Numerous surveys have already been conducted on this area but this paper focuses on providing an overview on the recent advances in the field of anomaly detection using Deep Learning. Deep Learning has been applied successfully in…
In recent years, anomaly detection has become an essential field in medical image analysis. Most current anomaly detection methods for medical images are based on image reconstruction. In this work, we propose a novel anomaly detection approach based on coordinate regression. Our method estimates the position of patches within a volume, and is trained only on data of healthy subjects. During inference, we can detect and localize anomalies by considering the error of the position estimate of a given patch. We apply our method to 3D CT volumes and evaluate it on patients with intracranial haemor…
The University of Sydney（悉尼大学）；Hamad bin Khalifa University（哈马德·本·哈利法大学）
Anomaly detection is an important problem that has been well-studied within diverse research areas and application domains. The aim of this survey is two-fold, firstly we present a structured and comprehensive overview of research methods in deep learning-based anomaly detection. Furthermore, we review the adoption of these methods for anomaly across various application domains and assess their effectiveness. We have grouped state-of-the-art research techniques into different categories based on the underlying assumptions and approach adopted. Within each category we outline the basic anomaly …
Anomaly detection for time-series data has been an important research field for a long time. Seminal work on anomaly detection methods has been focussing on statistical approaches. In recent years an increasing number of machine learning algorithms have been developed to detect anomalies on time-series. Subsequently, researchers tried to improve these techniques using (deep) neural networks. In the light of the increasing number of anomaly detection methods, the body of research lacks a broad comparative evaluation of statistical, machine learning and deep learning methods. This paper studies …
We present five methods to the problem of network anomaly detection. These methods cover most of the common techniques in the anomaly detection field, including Statistical Hypothesis Tests (SHT), Support Vector Machines (SVM) and clustering analysis. We evaluate all methods in a simulated network that consists of nominal data, three flow-level anomalies and one packet-level attack. Through analyzing the results, we point out the advantages and disadvantages of each method and conclude that combining the results of the individual methods can yield improved anomaly detection results.
Anomalies represent deviations from the intended system operation and can lead to decreased efficiency as well as partial or complete system failure. As the causes of anomalies are often unknown due to complex system dynamics, efficient anomaly detection is necessary. Conventional detection approaches rely on statistical and time-invariant methods that fail to address the complex and dynamic nature of anomalies. With advances in artificial intelligence and increasing importance for anomaly detection and prevention in various domains, artificial neural network approaches enable the detection of…
Indian Institute of Technology Bhubaneswar（布巴内斯瓦尔印度理工学院）
Computer vision has evolved in the last decade as a key technology for numerous applications replacing human supervision. In this paper, we present a survey on relevant visual surveillance related researches for anomaly detection in public places, focusing primarily on roads. Firstly, we revisit the surveys done in the last 10 years in this field. Since the underlying building block of a typical anomaly detection is learning, we emphasize more on learning methods applied on video scenes. We then summarize the important contributions made during last six years on anomaly detection primarily foc…
North Carolina State University（北卡罗来纳州立大学）；Mitsubishi Electric Research Labs (MERL)（三菱电机研究实验室）
This survey article summarizes research trends on the topic of anomaly detection in video feeds of a single scene. We discuss the various problem formulations, publicly available datasets and evaluation criteria. We categorize and situate past research into an intuitive taxonomy and provide a comprehensive comparison of the accuracy of many algorithms on standard test sets. Finally, we also provide best practices and suggest some possible directions for future research.
University of Chinese Academy of Sciences（中国科学院大学）
Visual anomaly detection is an important and challenging problem in the field of machine learning and computer vision. This problem has attracted a considerable amount of attention in relevant research communities. Especially in recent years, the development of deep learning has sparked an increasing interest in the visual anomaly detection problem and brought a great variety of novel methods. In this paper, we provide a comprehensive survey of the classical and deep learning-based approaches for visual anomaly detection in the literature. We group the relevant approaches in view of their unde…
Southern University on Science and Technology（南方科技大学）；University of Surrey（萨里大学）；Tencent（腾讯）；Bielefeld University（比勒费尔德大学）
Visual sensory anomaly detection (AD) is an essential problem in computer vision, which is gaining momentum recently thanks to the development of AI for good. Compared with semantic anomaly detection which detects anomaly at the label level (semantic shift), visual sensory AD detects the abnormal part of the sample (covariate shift). However, no thorough review has been provided to summarize this area for the computer vision community. In this survey, we are the first one to provide a comprehensive review of visual sensory AD and category into three levels according to the form of anomalies. F…
With the rapid increase in the integration of renewable energy generation and the wide adoption of various electric appliances, power grids are now faced with more and more challenges. One prominent challenge is to implement efficient anomaly detection for different types of anomalous behaviors within power grids. These anomalous behaviors might be induced by unusual consumption patterns of the users, faulty grid infrastructures, outages, external cyberattacks, or energy fraud. Identifying such anomalies is of critical importance for the reliable and efficient operation of modern power grids. …
Bridging Vision Foundation Model Priors with CLIP for Spatial-aware Few-shot Anomaly Detection in Medical Images
The Chinese University of Hong Kong（香港中文大学）；The University of Hong Kong（香港大学）；Institute of Medical Intelligence and XR, The Chinese University of Hong Kong（香港中文大学医学智能与扩展现实研究所）
VRVis Zentrum für Virtual Reality und Visualisierung Forschungs-GmbH（VRVis虚拟现实与可视化研究中心有限责任公司）；Aalto University（阿尔托大学）
Unsupervised anomaly detection models which are trained solely by healthy data, have gained importance in the recent years, as the annotation of medical data is a tedious task. Autoencoders and generative adversarial networks are the standard anomaly detection methods that are utilized to learn the data distribution. However, they fall short when it comes to inference and evaluation of the likelihood of test samples. We propose a novel combination of generative models and a probabilistic graphical model. After encoding image samples by autoencoders, the distribution of data is modeled by Rando…
Utah State University（犹他州立大学）；University of Arkansas（阿肯色大学）
Anomaly detection has a wide range of real-world applications, such as bank fraud detection and cyber intrusion detection. In the past decade, a variety of anomaly detection models have been developed, which lead to big progress towards accurately detecting various anomalies. Despite the successes, anomaly detection models still face many limitations. The most significant one is whether we can trust the detection results from the models. In recent years, the research community has spent a great effort to design trustworthy machine learning models, such as developing trustworthy classification …
With the development of medical imaging technology, medical images have become an important basis for doctors to diagnose patients. The brain structure in the collected data is complicated, thence, doctors are required to spend plentiful energy when diagnosing brain abnormalities. Aiming at the imbalance of brain tumor data and the rare amount of labeled data, we propose an innovative brain tumor abnormality detection algorithm. The semi-supervised anomaly detection model is proposed in which only healthy (normal) brain images are trained. Model capture the common pattern of the normal images …
Anomaly-Aware Vision-Language Adapters for Zero-Shot Anomaly Detection
Dept. of Engineering for Innovation Medicine, University of Verona, Italy（创新医学工程系，威尼斯大学，意大利）；School of Computer Science and Engineering, Beihang University, China（计算机科学与工程学院，北航大学，中国）；Dept. of Computer Science, Reykjavik University, Iceland（计算机科学系，雷克雅未克大学，冰岛）
Tsinghua University（清华大学）；Huazhong University of Science and Technology（华中科技大学）
This paper presents a novel framework, named Global-Local Correspondence Framework (GLCF), for visual anomaly detection with logical constraints. Visual anomaly detection has become an active research area in various real-world applications, such as industrial anomaly detection and medical disease diagnosis. However, most existing methods focus on identifying local structural degeneration anomalies and often fail to detect high-level functional anomalies that involve logical constraints. To address this issue, we propose a two-branch approach that consists of a local branch for detecting struc…
UltraAD: Fine-Grained Ultrasound Anomaly Classification via Few-Shot CLIP Adaptation
Computer Aided Medical Procedures (CAMP)（计算机辅助医疗程序）；TU Munich, Germany（慕尼黑工业大学）；Munich Center for Machine Learning (MCML)（慕尼黑机器学习中心）；The First Affiliated Hospital of Sun Yat-Sen University（中山大学附属第一医院）
Social media anomaly detection is of critical importance to prevent malicious activities such as bullying, terrorist attack planning, and fraud information dissemination. With the recent popularity of social media, new types of anomalous behaviors arise, causing concerns from various parties. While a large amount of work have been dedicated to traditional anomaly detection problems, we observe a surge of research interests in the new realm of social media anomaly detection. In this paper, we present a survey on existing approaches to address this problem. We focus on the new type of anomalous …
