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arXiv 2011.13624math.STstat.MEstat.TH

高维线性回归系数的两样本检验:基于互补草图方法

Two-sample testing of high-dimensional linear regression coefficients via complementary sketching

Fengnan Gao, Tengyao Wang

AI总结:

本文提出一种基于互补草图的高维线性回归系数两样本检验方法,无需系数可单独估计,在稀疏与稠密差异下具有最优渐近功效,并通过模拟和单细胞数据验证其有效性。

摘要:

我们提出了一种新的高维线性回归系数两样本检验方法,该方法不假设这些系数可单独估计。该过程首先将协变量矩阵和响应向量投影到在坐标子集中符号互补的方向上,我们称这一过程为“互补草图(complementary sketching)”。将投影后的协变量和响应聚合形成两个检验统计量,并证明在高斯设计下,当两个回归系数之差分别为稀疏和稠密时,这两个统计量具有本质上最优的渐近功效。模拟实验证实,我们的方法在广泛的情境下表现良好,并且应用于大规模单细胞RNA测序数据集展示了其在实际中的实用性。

英文摘要:

We introduce a new method for two-sample testing of high-dimensional linear regression coefficients without assuming that those coefficients are individually estimable. The procedure works by first projecting the matrices of covariates and response vectors along directions that are complementary in sign in a subset of the coordinates, a process which we call 'complementary sketching'. The resulting projected covariates and responses are aggregated to form two test statistics, which are shown to have essentially optimal asymptotic power under a Gaussian design when the difference between the two regression coefficients is sparse and dense respectively. Simulations confirm that our methods perform well in a broad class of settings and an application to a large single-cell RNA sequencing dataset demonstrates its utility in the real world.

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