Learning non-rigid registration in an end-to-end manner is challenging due to the inherent high degrees of freedom and the lack of labeled training data. In this paper, we resolve these two challenges simultaneously. First, we propose to represent the non-rigid transformation with a point-wise combination of several rigid transformations. This representation not only makes the solution space well-constrained but also enables our method to be solved iteratively with a recurrent framework, which greatly reduces the difficulty of learning. Second, we introduce a differentiable loss function that measures the 3D shape similarity on the projected multi-view 2D depth images so that our full framework can be trained end-to-end without ground truth supervision. Extensive experiments on several different datasets demonstrate that our proposed method outperforms the previous state-of-the-art by a large margin. The source codes are available at https://github.com/WanquanF/RMA-Net.
Brain extraction and registration are important preprocessing steps in neuroimaging data analysis, where the goal is to extract the brain regions from MRI scans (i.e., extraction step) and align them with a target brain image (i.e., registration step). Conventional research mainly focuses on developing methods for the extraction and registration tasks separately under supervised settings. The performance of these methods highly depends on the amount of training samples and visual inspections performed by experts for error correction. However, in many medical studies, collecting voxel-level lab…
Domain adaptation (DA) mitigates the domain shift problem when transferring knowledge from one annotated domain to another similar but different unlabeled domain. However, existing models often utilize one of the ImageNet models as the backbone without exploring others, and fine-tuning or retraining the backbone ImageNet model is also time-consuming. Moreover, pseudo-labeling has been used to improve the performance in the target domain, while how to generate confident pseudo labels and explicitly align domain distributions has not been well addressed. In this paper, we show how to efficiently…
Rethinking Barely-Supervised Volumetric Medical Image Segmentation from an Unsupervised Domain Adaptation Perspective
School of Computer Science and Engineering, Northeastern University（东北大学计算机科学与工程学院）；Alberta Machine Intelligence Institute, University of Alberta（阿尔伯塔大学阿尔伯塔机器智能研究所）
Computer Science and Artificial Intelligence Lab, MIT（麻省理工学院计算机科学与人工智能实验室）；Martinos Center for Biomedical Imaging, Massachusetts General Hospital, HMS（哈佛医学院麻省总医院马蒂诺生物医学成像中心）；School of Electrical and Computer Engineering, Cornell University（康奈尔大学电子与计算机工程学院）
Traditional deformable registration techniques achieve impressive results and offer a rigorous theoretical treatment, but are computationally intensive since they solve an optimization problem for each image pair. Recently, learning-based methods have facilitated fast registration by learning spatial deformation functions. However, these approaches use restricted deformation models, require supervised labels, or do not guarantee a diffeomorphic (topology-preserving) registration. Furthermore, learning-based registration tools have not been derived from a probabilistic framework that can offer …
Classical deformable registration techniques achieve impressive results and offer a rigorous theoretical treatment, but are computationally intensive since they solve an optimization problem for each image pair. Recently, learning-based methods have facilitated fast registration by learning spatial deformation functions. However, these approaches use restricted deformation models, require supervised labels, or do not guarantee a diffeomorphic (topology-preserving) registration. Furthermore, learning-based registration tools have not been derived from a probabilistic framework that can offer un…
We propose a registration algorithm for 2D CT/MRI medical images with a new unsupervised end-to-end strategy using convolutional neural networks. The contributions of our algorithm are threefold: (1) We transplant traditional image registration algorithms to an end-to-end convolutional neural network framework, while maintaining the unsupervised nature of image registration problems. The image-to-image integrated framework can simultaneously learn both image features and transformation matrix for registration. (2) Training with additional data without any label can further improve the registra…
Multi-modality image registration is one of the most underlined processes in medical image analysis. Recently, convolutional neural networks (CNNs) have shown significant potential in deformable registration. However, the lack of voxel-wise ground truth challenges the training of CNNs for an accurate registration. In this work, we propose a cross-modality similarity metric, based on the KL-divergence of image variables, and implement an efficient estimation method using a CNN. This estimation network, referred to as KLDivNet, can be trained unsupervisedly. We then embed the KLDivNet into a reg…
New York University（纽约大学）；NYU Abu Dhabi（纽约大学阿布扎比分校）；NYU Tandon School of Engineering（纽约大学坦登工程学院）
Given new pairs of source and target point sets, standard point set registration methods often repeatedly conduct the independent iterative search of desired geometric transformation to align the source point set with the target one. This limits their use in applications to handle the real-time point set registration with large volume dataset. This paper presents a novel method, named coherent point drift networks (CPD-Net), for the unsupervised learning of geometric transformation towards real-time non-rigid point set registration. In contrast to previous efforts (e.g. coherent point drift), …
Image registration is a fundamental building block for various applications in medical image analysis. To better explore the correlation between the fixed and moving images and improve registration performance, we propose a novel deep learning network, Co-Attention guided Registration Network (CAR-Net). CAR-Net employs a co-attention block to learn a new representation of the inputs, which drives the registration of the fixed and moving images. Experiments on UK Biobank cardiac cine-magnetic resonance image data demonstrate that CAR-Net obtains higher registration accuracy and smoother deforma…
Aligning partial views of a scene into a single whole is essential to understanding one's environment and is a key component of numerous robotics tasks such as SLAM and SfM. Recent approaches have proposed end-to-end systems that can outperform traditional methods by leveraging pose supervision. However, with the rising prevalence of cameras with depth sensors, we can expect a new stream of raw RGB-D data without the annotations needed for supervision. We propose UnsupervisedR&R: an end-to-end unsupervised approach to learning point cloud registration from raw RGB-D video. The key idea is to l…
Medical image segmentation is a relevant task as it serves as the first step for several diagnosis processes, thus it is indispensable in clinical usage. Whilst major success has been reported using supervised techniques, they assume a large and well-representative labelled set. This is a strong assumption in the medical domain where annotations are expensive, time-consuming, and inherent to human bias. To address this problem, unsupervised techniques have been proposed in the literature yet it is still an open problem due to the difficulty of learning any transformation pattern. In this work,…
Deformable registration is one of the most challenging task in the field of medical image analysis, especially for the alignment between different sequences and modalities. In this paper, a non-rigid registration method is proposed for 3D medical images leveraging unsupervised learning. To the best of our knowledge, this is the first attempt to introduce gradient loss into deep-learning-based registration. The proposed gradient loss is robust across sequences and modals for large deformation. Besides, adversarial learning approach is used to transfer multi-modal similarity to mono-modal simila…
Image Sciences Institute, University Medical Center Utrecht and Utrecht University（乌得勒支大学医学中心与乌得勒支大学影像科学研究所）；Division of Image Processing of the Leiden University Medical Center（莱顿大学医学中心图像处理部）
Image registration, the process of aligning two or more images, is the core technique of many (semi-)automatic medical image analysis tasks. Recent studies have shown that deep learning methods, notably convolutional neural networks (ConvNets), can be used for image registration. Thus far training of ConvNets for registration was supervised using predefined example registrations. However, obtaining example registrations is not trivial. To circumvent the need for predefined examples, and thereby to increase convenience of training ConvNets for image registration, we propose the Deep Learning Im…
Image registration is an essential but challenging task in medical image computing, especially for echocardiography, where the anatomical structures are relatively noisy compared to other imaging modalities. Traditional (non-learning) registration approaches rely on the iterative optimization of a similarity metric which is usually costly in time complexity. In recent years, convolutional neural network (CNN) based image registration methods have shown good effectiveness. In the meantime, recent studies show that the attention-based model (e.g., Transformer) can bring superior performance in p…
MINES ParisTech（巴黎高等矿业学院）；PSL University（巴黎文理研究大学）；Centre for Robotics（机器人中心）
We propose a method for generalizing deep learning for 3D point cloud registration on new, totally different datasets. It is based on two components, MS-SVConv and UDGE. Using Multi-Scale Sparse Voxel Convolution, MS-SVConv is a fast deep neural network that outputs the descriptors from point clouds for 3D registration between two scenes. UDGE is an algorithm for transferring deep networks on unknown datasets in a unsupervised way. The interest of the proposed method appears while using the two components, MS-SVConv and UDGE, together as a whole, which leads to state-of-the-art results on real…
An unsupervised, iterative point-set registration algorithm for an unlabeled (i.e. correspondence between points is unknown) N-dimensional Euclidean point-cloud is proposed. It is based on linear least squares, and considers all possible point pairings and iteratively aligns the two sets until the number of point pairs does not exceed the maximum number of allowable one-to-one pairings.
Institute for Interdisciplinary Information Sciences, Tsinghua University（清华大学交叉信息研究院）；Beihang University（北京航空航天大学）；Microsoft Research（微软研究院）
3D medical image registration is of great clinical importance. However, supervised learning methods require a large amount of accurately annotated corresponding control points (or morphing), which are very difficult to obtain. Unsupervised learning methods ease the burden of manual annotation by exploiting unlabeled data without supervision. In this paper, we propose a new unsupervised learning method using convolutional neural networks under an end-to-end framework, Volume Tweening Network (VTN), for 3D medical image registration. We propose three innovative technical components: (1) An end-t…
CuraCloud corporation（库拉云公司）；Chengdu University of Information Technology（成都信息工程大学）
The crucial components of a conventional image registration method are the choice of the right feature representations and similarity measures. These two components, although elaborately designed, are somewhat handcrafted using human knowledge. To this end, these two components are tackled in an end-to-end manner via reinforcement learning in this work. Specifically, an artificial agent, which is composed of a combined policy and value network, is trained to adjust the moving image toward the right direction. We train this network using an asynchronous reinforcement learning algorithm, where a…
Image Sciences Institute, University Medical Center Utrecht（乌得勒支大学医学中心图像科学研究所）；Division of Image Processing, Leiden University Medical Center（莱顿大学医学中心图像处理部）
In this work we propose a deep learning network for deformable image registration (DIRNet). The DIRNet consists of a convolutional neural network (ConvNet) regressor, a spatial transformer, and a resampler. The ConvNet analyzes a pair of fixed and moving images and outputs parameters for the spatial transformer, which generates the displacement vector field that enables the resampler to warp the moving image to the fixed image. The DIRNet is trained end-to-end by unsupervised optimization of a similarity metric between input image pairs. A trained DIRNet can be applied to perform registration …
We present a new unsupervised learning algorithm, "FAIM", for 3D medical image registration. With a different architecture than the popular "U-net", the network takes a pair of full image volumes and predicts the displacement fields needed to register source to target. Compared with "U-net" based registration networks such as VoxelMorph, FAIM has fewer trainable parameters but can achieve higher registration accuracy as judged by Dice score on region labels in the Mindboggle-101 dataset. Moreover, with the proposed penalty loss on negative Jacobian determinants, FAIM produces deformations with…
Imperial College London（帝国理工学院）；Siemens Healthineers（西门子医疗）
We propose a fully unsupervised multi-modal deformable image registration method (UMDIR), which does not require any ground truth deformation fields or any aligned multi-modal image pairs during training. Multi-modal registration is a key problem in many medical image analysis applications. It is very challenging due to complicated and unknown relationships between different modalities. In this paper, we propose an unsupervised learning approach to reduce the multi-modal registration problem to a mono-modal one through image disentangling. In particular, we decompose images of both modalities …
NYU Multimedia and Visual Computing Lab, NYU Tandon（纽约大学坦登工程学院多媒体与视觉计算实验室）；NYU Abu Dhabi（纽约大学阿布扎比分校）；Department of Electrical and Computer Engineering, NYU Tandon（纽约大学坦登工程学院电气与计算机工程系）；Department of Electrical and Computer Engineering, NYU Abu Dhabi（纽约大学阿布扎比分校电气与计算机工程系）
We propose a self-supervised method for partial point set registration. While recent proposed learning-based methods have achieved impressive registration performance on the full shape observations, these methods mostly suffer from performance degradation when dealing with partial shapes. To bridge the performance gaps between partial point set registration with full point set registration, we proposed to incorporate a shape completion network to benefit the registration process. To achieve this, we design a latent code for each pair of shapes, which can be regarded as a geometric encoding of …
Brain image registration transforms a pair of images into one system with the matched imaging contents, which is of essential importance for brain image analysis. This paper presents a novel framework for unsupervised 3D brain image registration by capturing the feature-level transformation relationships between the unaligned image and reference image. To achieve this, we develop a feature-level probabilistic model to provide the direct regularization to the hidden layers of two deep convolutional neural networks, which are constructed from two input images. This model design is developed into…
We propose a deformable registration algorithm based on unsupervised learning of a low-dimensional probabilistic parameterization of deformations. We model registration in a probabilistic and generative fashion, by applying a conditional variational autoencoder (CVAE) network. This model enables to also generate normal or pathological deformations of any new image based on the probabilistic latent space. Most recent learning-based registration algorithms use supervised labels or deformation models, that miss important properties such as diffeomorphism and sufficiently regular deformation field…
We present a fast learning-based algorithm for deformable, pairwise 3D medical image registration. Current registration methods optimize an objective function independently for each pair of images, which can be time-consuming for large data. We define registration as a parametric function, and optimize its parameters given a set of images from a collection of interest. Given a new pair of scans, we can quickly compute a registration field by directly evaluating the function using the learned parameters. We model this function using a convolutional neural network (CNN), and use a spatial transf…
Unsupervised training of keypoint-agnostic descriptors for flexible retinal image registration
Grupo VARPA, Instituto de Investigacion Biomédica de A Coruña (INIBIC), Universidade da Coruña（VARPA组，阿维拉生物医学研究所（INIBIC），科鲁纳大学）；Departamento de Ciencias de la Computación y Tecnologías de la Información, Universidade da Coruña（计算机科学与信息技术部门，科鲁纳大学）
Deformable image registration is widely utilized in medical image analysis, but most proposed methods fail in the situation of complex deformations. In this paper, we pre-sent a cascaded feature warping network to perform the coarse-to-fine registration. To achieve this, a shared-weights encoder network is adopted to generate the feature pyramids for the unaligned images. The feature warping registration module is then used to estimate the deformation field at each level. The coarse-to-fine manner is implemented by cascading the module from the bottom level to the top level. Furthermore, the m…
University of Southern California（南加州大学）；Tencent Media Lab（腾讯媒体实验室）；Tencent America（腾讯美国）
An unsupervised point cloud registration method, called salient points analysis (SPA), is proposed in this work. The proposed SPA method can register two point clouds effectively using only a small subset of salient points. It first applies the PointHop++ method to point clouds, finds corresponding salient points in two point clouds based on the local surface characteristics of points and performs registration by matching the corresponding salient points. The SPA method offers several advantages over the recent deep learning based solutions for registration. Deep learning methods such as Point…
South China University of Technology（华南理工大学）；Rochester Institute of Technology（罗切斯特理工学院）
In clinical practice, well-aligned multi-modal images, such as Magnetic Resonance (MR) and Computed Tomography (CT), together can provide complementary information for image-guided therapies. Multi-modal image registration is essential for the accurate alignment of these multi-modal images. However, it remains a very challenging task due to complicated and unknown spatial correspondence between different modalities. In this paper, we propose a novel translation-based unsupervised deformable image registration approach to convert the multi-modal registration problem to a mono-modal one. Specifi…
Korea Advanced Institute of Science and Technology（韩国科学技术院）；University of Ulsan College of Medicine（蔚山大学医学院）；Asan Medical Center（峨山医学中心）
Medical image registration is one of the key processing steps for biomedical image analysis such as cancer diagnosis. Recently, deep learning based supervised and unsupervised image registration methods have been extensively studied due to its excellent performance in spite of ultra-fast computational time compared to the classical approaches. In this paper, we present a novel unsupervised medical image registration method that trains deep neural network for deformable registration of 3D volumes using a cycle-consistency. Thanks to the cycle consistency, the proposed deep neural networks can t…
Nanjing University of Science and Technology（南京理工大学）
Unsupervised point cloud registration algorithm usually suffers from the unsatisfied registration precision in the partially overlapping problem due to the lack of effective inlier evaluation. In this paper, we propose a neighborhood consensus based reliable inlier evaluation method for robust unsupervised point cloud registration. It is expected to capture the discriminative geometric difference between the source neighborhood and the corresponding pseudo target neighborhood for effective inlier distinction. Specifically, our model consists of a matching map refinement module and an inlier ev…
Technion – Israel Institute of Technology（以色列理工学院）
Unsupervised deep-learning (DL) models were recently proposed for deformable image registration tasks. In such models, a neural-network is trained to predict the best deformation field by minimizing some dissimilarity function between the moving and the target images. After training on a dataset without reference deformation fields available, such a model can be used to rapidly predict the deformation field between newly seen moving and target images. Currently, the training process effectively provides a point-estimate of the network weights rather than characterizing their entire posterior d…
University of Basel（巴塞尔大学）；University of Basel Hospital（巴塞尔大学医院）；Inselspital, Bern University Hospital（伯尔尼大学医院 Inselspital）；University of Bern（伯尔尼大学）
Parametric spatial transformation models have been successfully applied to image registration tasks. In such models, the transformation of interest is parameterized by a fixed set of basis functions as for example B-splines. Each basis function is located on a fixed regular grid position among the image domain, because the transformation of interest is not known in advance. As a consequence, not all basis functions will necessarily contribute to the final transformation which results in a non-compact representation of the transformation. We reformulate the pairwise registration problem as a re…
Image registration is a crucial task in signal processing, but it often encounters issues with stability and efficiency. Non-learning registration approaches rely on optimizing similarity metrics between fixed and moving images, which can be expensive in terms of time and space complexity. This problem can be exacerbated when the images are large or there are significant deformations between them. Recently, deep learning, specifically convolutional neural network (CNN)-based methods, have been explored as an effective solution to the weaknesses of non-learning approaches. To further advance le…
Registration networks have shown great application potentials in medical image analysis. However, supervised training methods have a great demand for large and high-quality labeled datasets, which is time-consuming and sometimes impractical due to data sharing issues. Unsupervised image registration algorithms commonly employ intensity-based similarity measures as loss functions without any manual annotations. These methods estimate the parameterized transformations between pairs of moving and fixed images through the optimization of the network parameters during training. However, these metho…
Tel Aviv University（特拉维夫大学）；Elbit Systems（埃尔比特系统公司）
Many applications, such as autonomous driving, heavily rely on multi-modal data where spatial alignment between the modalities is required. Most multi-modal registration methods struggle computing the spatial correspondence between the images using prevalent cross-modality similarity measures. In this work, we bypass the difficulties of developing cross-modality similarity measures, by training an image-to-image translation network on the two input modalities. This learned translation allows training the registration network using simple and reliable mono-modality metrics. We perform multi-mod…
New York University Abu Dhabi（纽约大学阿布扎比分校）；NYU Tandon School of Engineering（纽约大学坦登工程学院）
Point cloud registration is the process of aligning a pair of point sets via searching for a geometric transformation. Unlike classical optimization-based methods, recent learning-based methods leverage the power of deep learning for registering a pair of point sets. In this paper, we propose to develop a novel model that organically integrates the optimization to learning, aiming to address the technical challenges in 3D registration. More specifically, in addition to the deep transformation decoding network, our framework introduce an optimizable deep \underline{S}patial \underline{C}orrelat…
Medical image registration is a fundamental and critical task in medical image analysis. With the rapid development of deep learning, convolutional neural networks (CNN) have dominated the medical image registration field. Due to the disadvantage of the local receptive field of CNN, some recent registration methods have focused on using transformers for non-local registration. However, the standard Transformer has a vast number of parameters and high computational complexity, which causes Transformer can only be applied at the bottom of the registration models. As a result, only coarse informa…
Northwestern Polytechnical University（西北工业大学）；Baidu Research（百度研究院）；National Engineering Laboratory of Deep Learning Technology and Application（深度学习技术及应用国家工程实验室）
3D point cloud registration in remote sensing field has been greatly advanced by deep learning based methods, where the rigid transformation is either directly regressed from the two point clouds (correspondences-free approaches) or computed from the learned correspondences (correspondences-based approaches). Existing correspondences-free methods generally learn the holistic representation of the entire point cloud, which is fragile for partial and noisy point clouds. In this paper, we propose a correspondences-free unsupervised point cloud registration (UPCR) method from the representation se…
University of Cambridge（剑桥大学）；Cancer Research UK Cambridge Centre（英国癌症研究中心剑桥中心）；Medical University Vienna（维也纳医科大学）；Cambridge University Hospitals National Health Service (NHS) Foundation Trust（剑桥大学医院国民保健服务基金会信托）；Eindhoven University of Technology（埃因霍温理工大学）；Leiden University（莱顿大学）；University College London（伦敦大学学院）；Cancer Research UK Cambridge Institute（英国癌症研究中心剑桥研究所）
This study investigates the use of the unsupervised deep learning framework VoxelMorph for deformable registration of longitudinal abdominopelvic CT images acquired in patients with bone metastases from breast cancer. The CT images were refined prior to registration by automatically removing the CT table and all other extra-corporeal components. To improve the learning capabilities of VoxelMorph when only a limited amount of training data is available, a novel incremental training strategy is proposed based on simulated deformations of consecutive CT images. In a 4-fold cross-validation scheme…
University of Technology Sydney（悉尼科技大学）；Facebook Reality Labs（脸书现实实验室）
In this paper, we present supervision-by-registration, an unsupervised approach to improve the precision of facial landmark detectors on both images and video. Our key observation is that the detections of the same landmark in adjacent frames should be coherent with registration, i.e., optical flow. Interestingly, the coherency of optical flow is a source of supervision that does not require manual labeling, and can be leveraged during detector training. For example, we can enforce in the training loss function that a detected landmark at frame$_{t-1}$ followed by optical flow tracking from fr…
Medical image registration and segmentation are critical tasks for several clinical procedures. Manual realisation of those tasks is time-consuming and the quality is highly dependent on the level of expertise of the physician. To mitigate that laborious task, automatic tools have been developed where the majority of solutions are supervised techniques. However, in medical domain, the strong assumption of having a well-representative ground truth is far from being realistic. To overcome this challenge, unsupervised techniques have been investigated. However, they are still limited in performan…
College of Physics and Information Engineering, Fuzhou University（福州大学物理与信息工程学院）；School of Data Science, Fudan University（复旦大学大数据学院）；School of Biomedical Engineering, Shanghai Jiao Tong University（上海交通大学生物医学工程学院）
Multi-modality medical images can provide relevant or complementary information for a target (organ, tumor or tissue). Registering multi-modality images to a common space can fuse these comprehensive information, and bring convenience for clinical application. Recently, neural networks have been widely investigated to boost registration methods. However, it is still challenging to develop a multi-modality registration network due to the lack of robust criteria for network training. In this work, we propose a multi-modality registration network (MMRegNet), which can perform registration between…
Deformable image registration is a fundamental task in medical image analysis, aiming to establish a dense and non-linear correspondence between a pair of images. Previous deep-learning studies usually employ supervised neural networks to directly learn the spatial transformation from one image to another, requiring task-specific ground-truth registration for model training. Due to the difficulty in collecting precise ground-truth registration, implementation of these supervised methods is practically challenging. Although several unsupervised networks have been recently developed, these metho…
New York University（纽约大学）；Hyperfine Research（Hyperfine研究公司）；Yale University（耶鲁大学）
Establishing voxelwise semantic correspondence across distinct imaging modalities is a foundational yet formidable computer vision task. Current multi-modality registration techniques maximize hand-crafted inter-domain similarity functions, are limited in modeling nonlinear intensity-relationships and deformations, and may require significant re-engineering or underperform on new tasks, datasets, and domain pairs. This work presents ContraReg, an unsupervised contrastive representation learning approach to multi-modality deformable registration. By projecting learned multi-scale local patch fe…
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）
Deformable image registration is one of the fundamental tasks in medical imaging. Classical registration algorithms usually require a high computational cost for iterative optimizations. Although deep-learning-based methods have been developed for fast image registration, it is still challenging to obtain realistic continuous deformations from a moving image to a fixed image with less topological folding problem. To address this, here we present a novel diffusion-model-based image registration method, called DiffuseMorph. DiffuseMorph not only generates synthetic deformed images through revers…
New York University Abu Dhabi（纽约大学阿布扎比分校）；New York University（纽约大学）；NYU Tandon School of Engineering（纽约大学坦登工程学院）
Global registration of point clouds aims to find an optimal alignment of a sequence of 2D or 3D point sets. In this paper, we present a novel method that takes advantage of current deep learning techniques for unsupervised learning of global registration from a temporal sequence of point clouds. Our key novelty is that we introduce a deep Spatio-Temporal REPresentation (STREP) feature, which describes the geometric essence of both temporal and spatial relationship of the sequence of point clouds acquired with sensors in an unknown environment. In contrast to the previous practice that treats e…
Institute of Medical Informatics, Universität zu Lübeck（吕贝克大学医学信息学研究所）
Multimodal image registration is a very challenging problem for deep learning approaches. Most current work focuses on either supervised learning that requires labelled training scans and may yield models that bias towards annotated structures or unsupervised approaches that are based on hand-crafted similarity metrics and may therefore not outperform their classical non-trained counterparts. We believe that unsupervised domain adaptation can be beneficial in overcoming the current limitations for multimodal registration, where good metrics are hard to define. Domain adaptation has so far been…
Cluster of Excellence – ML for Science（卓越集群——科学机器学习）；University of Tübingen（蒂宾根大学）；Faculty of Health Sciences and Medicine, University of Lucerne（卢塞恩大学健康科学与医学院）；University of Lübeck（吕贝克大学）
PCA Lab, Nanjing University of Science and Technology（南京理工大学PCA实验室）
In this paper, by modeling the point cloud registration task as a Markov decision process, we propose an end-to-end deep model embedded with the cross-entropy method (CEM) for unsupervised 3D registration. Our model consists of a sampling network module and a differentiable CEM module. In our sampling network module, given a pair of point clouds, the sampling network learns a prior sampling distribution over the transformation space. The learned sampling distribution can be used as a "good" initialization of the differentiable CEM module. In our differentiable CEM module, we first propose a ma…
Tsinghua University（清华大学）；Shenzhen International Graduate School（深圳国际研究生院）；Harvard Medical School（哈佛医学院）；Brigham and Women’s Hospital（布莱根和妇女医院）
Multimodal image registration (MIR) is a fundamental procedure in many image-guided therapies. Recently, unsupervised learning-based methods have demonstrated promising performance over accuracy and efficiency in deformable image registration. However, the estimated deformation fields of the existing methods fully rely on the to-be-registered image pair. It is difficult for the networks to be aware of the mismatched boundaries, resulting in unsatisfactory organ boundary alignment. In this paper, we propose a novel multimodal registration framework, which leverages the deformation fields estima…
