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arXiv 2505.02787cs.CV
无监督训练的键点无关描述符用于灵活的视网膜图像配准
Unsupervised training of keypoint-agnostic descriptors for flexible retinal image registration
Grupo VARPA, Instituto de Investigacion Biomédica de A Coruña (INIBIC), Universidade da Coruña（VARPA组，阿维拉生物医学研究所（INIBIC），科鲁纳大学）；Departamento de Ciencias de la Computación y Tecnologías de la Información, Universidade da Coruña（计算机科学与信息技术部门，科鲁纳大学）
David Rivas-Villar, Álvaro S. Hervella, José Rouco, Jorge Novo
Current color fundus image registration approaches are limited, among other things, by the lack of labeled data, which is even more significant in the medical domain, motivating the use of unsupervised learning. Therefore, in this work, we develop a novel unsupervised descriptor learning method that does not rely on keypoint detection. This enables the resulting descriptor network to be agnostic to the keypoint detector used during the registration inference.
To validate this approach, we perform an extensive and comprehensive comparison on the reference public retinal image registration dataset. Additionally, we test our method with multiple keypoint detectors of varied nature, even proposing some novel ones. Our results demonstrate that the proposed approach offers accurate registration, not incurring in any performance loss versus supervised methods. Additionally, it demonstrates accurate performance regardless of the keypoint detector used. Thus, this work represents a notable step towards leveraging unsupervised learning in the medical domain.
In ophthalmological imaging, multiple imaging systems, such as color fundus, infrared, fluorescein angiography, optical coherence tomography (OCT) or OCT angiography, are often involved to make a diagnosis of retinal disease. Multi-modal retinal registration techniques can assist ophthalmologists by providing a pixel-based comparison of aligned vessel structures in images from different modalities or acquisition times. To this end, we propose an end-to-end trainable deep learning method for multi-modal retinal image registration. Our method extracts convolutional features from the vessel struc…
Progressive Retinal Image Registration via Global and Local Deformable Transformations
School of Computer Science Wuhan University Wuhan, China；School of Computer Science The University of Sydney Sydney, Australia；School of Computer Science Wuhan University Wuhan, China yuliang\；Institute for Infocomm Research A STAR Singapore cheng\
A Robust and Interpretable Deep Learning Framework for Multi-modal Registration via Keypoints
Cornell University（康奈尔大学）；Cornell Tech（康奈尔理工学院）；Weill Cornell Medical School（威尔康奈尔医学院）；Iterative Scopes（Iterative Scopes公司）；Massachusetts Institute of Technology（麻省理工学院）；Massachusetts General Hospital（麻省总医院）
ConKeD++ -- Improving descriptor learning for retinal image registration: A comprehensive study of contrastive losses
Instituto de Investigacion Biomédica de A Coruña (INIBIC)（拉科鲁尼亚生物医学研究所）；Universidade da Coruña（拉科鲁尼亚大学）；Departamento de Ciencias de la Computación y Tecnologías de la Información（计算机科学与信息技术系）；Grupo VARPA（VARPA团队）
Fraunhofer MEVIS（弗劳恩霍夫医学图像计算研究所（MEVIS））；University of Lübeck（吕贝克大学）；Anthropics Technology Ltd.（Anthropics科技有限公司）
We present a novel algorithm for the registration of pulmonary CT scans. Our method is designed for large respiratory motion by integrating sparse keypoint correspondences into a dense continuous optimization framework. The detection of keypoint correspondences enables robustness against large deformations by jointly optimizing over a large number of potential discrete displacements, whereas the dense continuous registration achieves subvoxel alignment with smooth transformations. Both steps are driven by the same normalized gradient fields data term. We employ curvature regularization and a v…
Pattern Recognition Lab, FAU Erlangen-Nürnberg（埃尔朗根-纽伦堡大学模式识别实验室）；Department of Ophthalmology, Universitätsklinikum Erlangen（埃尔朗根大学医院眼科）
Ophthalmological imaging utilizes different imaging systems, such as color fundus, infrared, fluorescein angiography, optical coherence tomography (OCT) or OCT angiography. Multiple images with different modalities or acquisition times are often analyzed for the diagnosis of retinal diseases. Automatically aligning the vessel structures in the images by means of multi-modal registration can support the ophthalmologists in their work. Our method uses a convolutional neural network to extract features of the vessel structure in multi-modal retinal images. We jointly train a keypoint detection an…
A 3D Cross-modal Keypoint Descriptor for MR-US Matching and Registration
Harvard Medical School（哈佛医学院）；Brigham and Women’s Hospital（布莱根妇女医院）；Inria（法国国家信息与自动化研究所）；Sorbonne Université（索邦大学）；Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, AP-HP, Hôpital de la Pitié Salpêtrière（巴黎大脑研究所 - ICM, 法国国家科学研究中心, 法国国家健康与医学研究院, 巴黎公立医院集团, 皮提耶-萨勒佩特里医院）；Technical University of Munich（慕尼黑工业大学）
The majority of current research in deep learning based image registration addresses inter-patient brain registration with moderate deformation magnitudes. The recent Learn2Reg medical registration benchmark has demonstrated that single-scale U-Net architectures, such as VoxelMorph that directly employ a spatial transformer loss, often do not generalise well beyond the cranial vault and fall short of state-of-the-art performance for abdominal or intra-patient lung registration. Here, we propose two straightforward steps that greatly reduce this gap in accuracy. First, we employ keypoint self-s…
Unsupervised Deep Learning-based Keypoint Localization Estimating Descriptor Matching Performance
Grupo VARPA（VARPA组）；Instituto de Investigacion Biomédica de A Coruña (INIBIC)（阿罗纳生物医学研究所（INIBIC））；Universidade da Coruña（科鲁纳大学）；Departamento de Ciencias de la Computación y Tecnologías de la Información（计算机科学与信息技术部门）
We present INSPIRE, a top-performing general-purpose method for deformable image registration. INSPIRE brings distance measures which combine intensity and spatial information into an elastic B-splines-based transformation model and incorporates an inverse inconsistency penalization supporting symmetric registration performance. We introduce several theoretical and algorithmic solutions which provide high computational efficiency and thereby applicability of the proposed framework in a wide range of real scenarios. We show that INSPIRE delivers highly accurate, as well as stable and robust reg…
École Polytechnique de Montréal（蒙特利尔高等理工学院）；École de technologie supérieure（高等工程技术学院）
In this paper, an automatic method is proposed to perform image registration in visible and infrared pair of video sequences for multiple targets. In multimodal image analysis like image fusion systems, color and IR sensors are placed close to each other and capture a same scene simultaneously, but the videos are not properly aligned by default because of different fields of view, image capturing information, working principle and other camera specifications. Because the scenes are usually not planar, alignment needs to be performed continuously by extracting relevant common information. In th…
COph100: A comprehensive fundus image registration dataset from infants constituting the "RIDIRP" database
Department of Computer Science and Engineering, Southern University of Science and Technology（南方科技大学计算机科学与工程系）；Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University（首都医科大学附属北京同仁医院北京同仁眼科中心）；Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）
RetinaRegNet: A Zero-Shot Approach for Retinal Image Registration
University of Florida（佛罗里达大学）；Stanford University（斯坦福大学）；University of Iowa（爱荷华大学）；University of California, Santa Cruz（加州大学圣克鲁兹分校）；Intelligent Clinical Care Center, University of Florida（佛罗里达大学智能临床护理中心）
David R. Cheriton School of Computer Science（大卫·R·切里顿计算机科学学院）；University of Waterloo（滑铁卢大学）
Analysis of retinal fundus images is essential for eye-care physicians in the diagnosis, care and treatment of patients. Accurate fundus and/or retinal vessel maps give rise to longitudinal studies able to utilize multimedia image registration and disease/condition status measurements, as well as applications in surgery preparation and biometrics. The segmentation of retinal morphology has numerous applications in assessing ophthalmologic and cardiovascular disease pathologies. The early detection of many such conditions is often the most effective method for reducing patient risk. Computer ai…
Renmin University of China（中国人民大学）；Visionary Intelligence Ltd（远见智能有限公司）；Tongren Hospital（同仁医院）
For retinal image matching (RIM), we propose SuperRetina, the first end-to-end method with jointly trainable keypoint detector and descriptor. SuperRetina is trained in a novel semi-supervised manner. A small set of (nearly 100) images are incompletely labeled and used to supervise the network to detect keypoints on the vascular tree. To attack the incompleteness of manual labeling, we propose Progressive Keypoint Expansion to enrich the keypoint labels at each training epoch. By utilizing a keypoint-based improved triplet loss as its description loss, SuperRetina produces highly discriminativ…
Fraunhofer Institute for Digital Medicine MEVIS（弗劳恩霍夫数字医学研究所MEVIS）；Radboud University Medical Center（拉德堡德大学医学中心）
Deep-learning-based registration methods emerged as a fast alternative to conventional registration methods. However, these methods often still cannot achieve the same performance as conventional registration methods because they are either limited to small deformation or they fail to handle a superposition of large and small deformations without producing implausible deformation fields with foldings inside. In this paper, we identify important strategies of conventional registration methods for lung registration and successfully developed the deep-learning counterpart. We employ a Gaussian-py…
Automatic Registration of SHG and H&E Images with Feature-based Initial Alignment and Intensity-based Instance Optimization: Contribution to the COMULIS Challenge
AGH University of Krakow（克拉科夫AGH科技大学）；University of Applied Sciences Western Switzerland (HES-SO Valais-Wallis)（瑞士西部应用科学大学（瓦莱州-瓦利斯））；University of Geneva（日内瓦大学）
Medical Image Registration and Its Application in Retinal Images: A Review
Southern University of Science and Technology（南方科技大学）；Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；Singapore Eye Research Institute（新加坡眼科研究所）
Indian Institute of Technology Madras（印度理工学院马德拉斯分校）
In this report we present an unsupervised image registration framework, using a pre-trained deep neural network as a feature extractor. We refer this to zero-shot learning, due to nonoverlap between training and testing dataset (none of the network modules in the processing pipeline were trained specifically for the task of medical image registration). Highlights of our technique are: (a) No requirement of a training dataset (b) Keypoints i.e.locations of important features are automatically estimated (c) The number of key points in this model is fixed and can possibly be tuned as a hyperparam…
Unsupervised Deformable Image Registration with Structural Nonparametric Smoothing
Cornell University（康奈尔大学）；Hunan University（湖南大学）；University of Pennsylvania（宾夕法尼亚大学）；Johns Hopkins University（约翰霍普金斯大学）；Shanghai Jiao Tong University（上海交通大学）；University of Birmingham（伯明翰大学）；University of Manchester（曼彻斯特大学）
CITIC-Research Center of Information and Communication Technologies, University of A Coruña（科蒂克信息与通信技术研究中心，拉科鲁尼亚大学）；Department of Computer Science, University of A Coruña（拉科鲁尼亚大学计算机科学系）；University of A Coruña（拉科鲁尼亚大学）；CITIC-Research Center of Information and Communication Technologies（科蒂克信息与通信技术研究中心）
The analysis of different image modalities is frequently performed in ophthalmology as it provides complementary information for the diagnosis and follow-up of relevant diseases, like hypertension or diabetes. This work presents a hybrid method for the multimodal registration of color fundus retinography and fluorescein angiography. The proposed method combines a feature-based approach, using domain-specific landmarks, with an intensity-based approach that employs a domain-adapted similarity metric. The methodology is tested on a dataset of 59 image pairs containing both healthy and pathologic…
A Novel Streamline-based diffusion MRI Tractography Registration Method with Probabilistic Keypoint Detection
University of Electronic Science and Technology of China（电子科技大学）；Nanjing University of Science and Technology（南京理工大学）；Harvard Medical School（哈佛医学院）；Brigham and Women’s Hospital（布莱根和妇女医院）
Institute of Medical Informatics, University of Lübeck（吕贝克大学医学信息学研究所）
Recent deep learning-based methods for medical image registration achieve results that are competitive with conventional optimization algorithms at reduced run times. However, deep neural networks generally require plenty of labeled training data and are vulnerable to domain shifts between training and test data. While typical intensity shifts can be mitigated by keypoint-based registration, these methods still suffer from geometric domain shifts, for instance, due to different fields of view. As a remedy, in this work, we present a novel approach to geometric domain adaptation for image regis…
2D-3D Deformable Image Registration of Histology Slide and Micro-CT with ML-based Initialization
ImFusion GmbH（ImFusion有限公司）；Technical University of Munich（慕尼黑工业大学）；Institute of Pathology, Heinrich Heine University and University Hospital of Düsseldorf（海因里希·海涅大学与杜塞尔多夫大学医院病理研究所）；Fraunhofer Institute for High-Speed Dynamics, Ernst-Mach-Institut（弗劳恩霍夫高速动力学研究所（恩斯特·马赫研究所））
Tongji University（同济大学）；Technische Universität München（慕尼黑工业大学）；ETH Zurich（苏黎世联邦理工学院）；Westwell lab（西井实验室）
Point cloud registration is a fundamental problem in 3D computer vision. Outdoor LiDAR point clouds are typically large-scale and complexly distributed, which makes the registration challenging. In this paper, we propose an efficient hierarchical network named HRegNet for large-scale outdoor LiDAR point cloud registration. Instead of using all points in the point clouds, HRegNet performs registration on hierarchically extracted keypoints and descriptors. The overall framework combines the reliable features in deeper layer and the precise position information in shallower layers to achieve robu…
University of Pennsylvania（宾夕法尼亚大学）；University of Minnesota（明尼苏达大学）
This paper presents a semi-supervised learning framework to train a keypoint detector using multiview image streams given the limited labeled data (typically $<$4\%). We leverage the complementary relationship between multiview geometry and visual tracking to provide three types of supervisionary signals to utilize the unlabeled data: (1) keypoint detection in one view can be supervised by other views via the epipolar geometry; (2) a keypoint moves smoothly over time where its optical flow can be used to temporally supervise consecutive image frames to each other; (3) visible keypoint in one v…
Université de Lyon（里昂大学）；INSA Lyon（里昂国立应用科学学院）；Université Claude Bernard Lyon 1（里昂第一大学）；UJM-Saint Etienne（圣艾蒂安让·莫内大学）；CNRS（法国国家科学研究中心）；Inserm（法国国家健康与医学研究院）；Hospices Civils de Lyon（里昂民用医院集团）
We present a novel algorithm for Fast Registration Of image Groups (FROG), applied to large 3D image groups. Our approach extracts 3D SURF keypoints from images, computes matched pairs of keypoints and registers the group by minimizing pair distances in a hubless way i.e. without computing any central mean image. Using keypoints significantly reduces the problem complexity compared to voxel-based approaches, and enables us to provide an in-core global optimization, similar to the Bundle Adjustment for 3D reconstruction. As we aim to register images of different patients, the matching step yiel…
BrainMorph: A Foundational Keypoint Model for Robust and Flexible Brain MRI Registration
Department of Radiology, Weill Cornell Medicine, New York City, NY, USA（韦尔·科恩医学中心放射科）；School of Electrical and Computer Engineering, Cornell University, Ithaca, NY, USA（康奈尔大学电气与计算机工程学院）；Computer Science and Artificial Intelligence Lab at the Massachusetts Institute of Technology, Cambridge, MA, USA（麻省理工学院计算机科学与人工智能实验室）
本文提出基于 KeyMorph 的 BrainMorph 关键点基础模型，利用超十万个 3D 脑 MRI 体积训练，实现鲁棒、可解释、快速可控的多模态成对与组级刚性、仿射及非线性配准。
Shanghai Jiao Tong University（上海交通大学）；Qing Yuan Research Institute（清源研究院）；Shanghai Qi Zhi Institute（上海期智研究院）
Keypoint detection is an essential component for the object registration and alignment. In this work, we reckon keypoint detection as information compression, and force the model to distill out irrelevant points of an object. Based on this, we propose UKPGAN, a general self-supervised 3D keypoint detector where keypoints are detected so that they could reconstruct the original object shape. Two modules: GAN-based keypoint sparsity control and salient information distillation modules are proposed to locate those important keypoints. Extensive experiments show that our keypoints align well with …
Deformable registration continues to be one of the key challenges in medical image analysis. While iconic registration methods have started to benefit from the recent advances in medical deep learning, the same does not yet apply for the registration of point sets, e.g. registration based on surfaces, keypoints or landmarks. This is mainly due to the restriction of the convolution operator in modern CNNs to densely gridded input. However, with the newly developed methods from the field of geometric deep learning suitable tools are now emerging, which enable powerful analysis of medical data on…
DGIST（大邱庆北科学技术院）；Yeungnam University College of Medicine（岭南大学医学院）；Yeungnam University Hospital（岭南大学医院）
Non-rigid registration is a necessary but challenging task in medical imaging studies. Recently, unsupervised registration models have shown good performance, but they often require a large-scale training dataset and long training times. Therefore, in real world application where only dozens to hundreds of image pairs are available, existing models cannot be practically used. To address these limitations, we propose a novel unsupervised registration model which is integrated with a gradient-based meta learning framework. In particular, we train a meta learner which finds an initialization poin…
To deform or not: treatment-aware longitudinal registration for breast DCE-MRI during neoadjuvant chemotherapy via unsupervised keypoints detection
Radboud University Medical Centre（拉德堡德大学医学中心）；The Netherlands Cancer Institute（荷兰癌症研究所）；Macao Polytechnic University（澳门理工大学）；Maastricht University Medical Centre（马斯特里赫特大学医学中心）
Registration by Regression (RbR): a framework for interpretable and flexible atlas registration
Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；Danish Research Centre for Magnetic Resonance（丹麦磁共振研究中心）；Copenhagen University Hospital（哥本哈根大学医院）；Centre for Medical Image Computing（医学图像计算中心）；University College London（伦敦大学学院）；Computer Science and AI Laboratory（计算机科学与人工智能实验室）；Massachusetts Institute of Technology（麻省理工学院）
Tongji University（同济大学）；Technische Universität München（慕尼黑工业大学）；ETH Zurich（苏黎世联邦理工学院）
Keypoint detector and descriptor are two main components of point cloud registration. Previous learning-based keypoint detectors rely on saliency estimation for each point or farthest point sample (FPS) for candidate points selection, which are inefficient and not applicable in large scale scenes. This paper proposes Random Sample-based Keypoint Detector and Descriptor Network (RSKDD-Net) for large scale point cloud registration. The key idea is using random sampling to efficiently select candidate points and using a learning-based method to jointly generate keypoints and descriptors. To tackl…
Technische Universität München（慕尼黑工业大学）；Google（谷歌）
3D Point clouds are a rich source of information that enjoy growing popularity in the vision community. However, due to the sparsity of their representation, learning models based on large point clouds is still a challenge. In this work, we introduce Graphite, a GRAPH-Induced feaTure Extraction pipeline, a simple yet powerful feature transform and keypoint detector. Graphite enables intensive down-sampling of point clouds with keypoint detection accompanied by a descriptor. We construct a generic graph-based learning scheme to describe point cloud regions and extract salient points. To this en…
Conventional approaches to image registration consist of time consuming iterative methods. Most current deep learning (DL) based registration methods extract deep features to use in an iterative setting. We propose an end-to-end DL method for registering multimodal images. Our approach uses generative adversarial networks (GANs) that eliminates the need for time consuming iterative methods, and directly generates the registered image with the deformation field. Appropriate constraints in the GAN cost function produce accurately registered images in less than a second. Experiments demonstrate t…
A variety of computer vision applications depend on the efficiency of image matching algorithms used. Various descriptors are designed to detect and match features in images. Deployment of this algorithms in mobile applications creates a need for low computation time. Binary descriptors requires less computation time than float-point based descriptors because of the intensity comparison between pairs of sample points and comparing after creating a binary string. In order to decrease time complexity, quality of keypoints matched is often compromised. We propose a keypoint descriptor named Morph…
Istituto Italiano di Tecnologia（意大利理工学院）；Politecnico di Milano（米兰理工大学）；University College London（伦敦大学学院）；University College London Hospital（伦敦大学学院医院）；University Hospital Leuven（鲁汶大学医院）；Istituto "Giannina Gaslini"（詹尼娜·加斯利尼研究所）；Scuola Superiore Sant’Anna（圣安娜高等学校）
In Twin-to-Twin Transfusion Syndrome (TTTS), abnormal vascular anastomoses in the monochorionic placenta can produce uneven blood flow between the two fetuses. In the current practice, TTTS is treated surgically by closing abnormal anastomoses using laser ablation. This surgery is minimally invasive and relies on fetoscopy. Limited field of view makes anastomosis identification a challenging task for the surgeon. To tackle this challenge, we propose a learning-based framework for in-vivo fetoscopy frame registration for field-of-view expansion. The novelties of this framework relies on a learn…
University of Washington（华盛顿大学）；Magic Leap Inc.（Magic Leap公司）
Retinal template matching and registration is an important challenge in teleophthalmology with low-cost imaging devices. However, the images from such devices generally have a small field of view (FOV) and image quality degradations, making matching difficult. In this work, we develop an efficient and accurate retinal matching technique that combines dimension reduction and mutual information (MI), called RetinaMatch. The dimension reduction initializes the MI optimization as a coarse localization process, which narrows the optimization domain and avoids local optima. The effectiveness of Reti…
