Diabetic Retinopathy (DR) is one of the microvascular complications of Diabetes Mellitus, which remains as one of the leading causes of blindness worldwide. Computational models based on Convolutional Neural Networks represent the state of the art for the automatic detection of DR using eye fundus images. Most of the current work address this problem as a binary classification task. However, including the grade estimation and quantification of predictions uncertainty can potentially increase the robustness of the model. In this paper, a hybrid Deep Learning-Gaussian process method for DR diagnosis and uncertainty quantification is presented. This method combines the representational power of deep learning, with the ability to generalize from small datasets of Gaussian process models. The results show that uncertainty quantification in the predictions improves the interpretability of the method as a diagnostic support tool. The source code to replicate the experiments is publicly available at https://github.com/stoledoc/DLGP-DR-Diagnosis.
Beihang University（北京航空航天大学）；Peng Cheng Laboratory（鹏城实验室）；RIKEN AIP（理化学研究所人工智能研究中心）；University of Tokyo（东京大学）；Ningbo Institute of Industrial Technology, CAS（中国科学院宁波工业技术研究院）
Though deep learning has shown successful performance in classifying the label and severity stage of certain diseases, most of them give few explanations on how to make predictions. Inspired by Koch's Postulates, the foundation in evidence-based medicine (EBM) to identify the pathogen, we propose to exploit the interpretability of deep learning application in medical diagnosis. By determining and isolating the neuron activation patterns on which diabetic retinopathy (DR) detector relies to make decisions, we demonstrate the direct relation between the isolated neuron activation and lesions for…
Tsinghua-Berkeley Shenzhen Institute（清华-伯克利深圳学院）；University of California, Berkeley（加州大学伯克利分校）；Affiliated Eye Hospital of Nanchang University（南昌大学附属眼科医院）
Retinal vascular diseases affect the well-being of human body and sometimes provide vital signs of otherwise undetected bodily damage. Recently, deep learning techniques have been successfully applied for detection of diabetic retinopathy (DR). The main obstacle of applying deep learning techniques to detect most other retinal vascular diseases is the limited amount of data available. In this paper, we propose a transfer learning technique that aims to utilize the feature similarities for detecting retinal vascular diseases. We choose the well-studied DR detection as a source task and identify…
Department of Computer Science & Engineering, Priyadarshini Institute of Engineering & Technology（普里达尔希尼工程技术学院计算机科学与工程系）
Diabetic Retinopathy is a critical health problem influences 100 million individuals worldwide, and these figures are expected to rise, particularly in Asia. Diabetic Retinopathy is a chronic eye disease which can lead to irreversible vision loss. Considering the visual complexity of retinal images, the early-stage diagnosis of Diabetic Retinopathy can be challenging for human experts. However, Early detection of Diabetic Retinopathy can significantly help to avoid permanent vision loss. The capability of computer-aided detection systems to accurately and efficiently detect the diabetic retino…
Introducing automated Diabetic Retinopathy (DR) diagnosis into Ethiopia is still a challenging task, despite recent reports that present trained Deep Learning (DL) based DR classifiers surpassing manual graders. This is mainly because of the expensive cost of conventional retinal imaging devices used in DL based classifiers. Current approaches that provide mobile based binary classification of DR, and the way towards a cheaper and offline multi-class classification of DR will be discussed in this paper.
Department of Computer Science, Aalto University（阿尔托大学计算机科学系）；The Alan Turing Institute（艾伦图灵研究所）；University of Warwick（华威大学）；University College London（伦敦大学学院）；Department of Electrical Engineering and Automation, Aalto University（阿尔托大学电气工程与自动化系）；Central Finland Health Care District（芬兰中部医疗保健区）
Automatic classification of diabetic retinopathy from retinal images has been widely studied using deep neural networks with impressive results. However, there is a clinical need for estimation of the uncertainty in the classifications, a shortcoming of modern neural networks. Recently, approximate Bayesian deep learning methods have been proposed for the task but the studies have only considered the binary referable/non-referable diabetic retinopathy classification applied to benchmark datasets. We present novel results by systematically investigating a clinical dataset and a clinically relev…
Manipal Institute of Technology（马尼帕尔理工学院）；Manipal Academy of Higher Education（马尼帕尔高等教育学院）
Deep Ensemble Convolutional Neural Networks has become a methodology of choice for analyzing medical images with a diagnostic performance comparable to a physician, including the diagnosis of Diabetic Retinopathy. However, commonly used techniques are deterministic and are therefore unable to provide any estimate of predictive uncertainty. Quantifying model uncertainty is crucial for reducing the risk of misdiagnosis. A reliable architecture should be well-calibrated to avoid over-confident predictions. To address this, we propose a UATTA-ENS: Uncertainty-Aware Test-Time Augmented Ensemble Tec…
Detecting diabetic retinopathy severity through fundus images using an ensemble of classifiers
Technical University of Cluj-Napoca（克卢日-纳波卡技术大学）；“Iuliu Hatieganu” University of Medicine and Pharmacy（“尤利乌·哈采加努”医药大学）；Emergency County Hospital（急诊县医院）
Aalto University School of Science（阿尔托大学理学院）；Digifundus Ltd.（Digifundus有限公司）；Central Finland Central Hospital（中芬兰中心医院）
Diabetes is a globally prevalent disease that can cause visible microvascular complications such as diabetic retinopathy and macular edema in the human eye retina, the images of which are today used for manual disease screening. This labor-intensive task could greatly benefit from automatic detection using deep learning technique. Here we present a deep learning system that identifies referable diabetic retinopathy comparably or better than presented in the previous studies, although we use only a small fraction of images (<1/4) in training but are aided with higher image resolutions. We also …
In this paper, we propose two distinct solutions to the problem of Diabetic Retinopathy (DR) classification. In the first approach, we introduce a shallow neural network architecture. This model performs well on classification of the most frequent classes while fails at classifying the less frequent ones. In the second approach, we use transfer learning to re-train the last modified layer of a very deep neural network to improve the generalization ability of the model to the less frequent classes. Our results demonstrate superior abilities of transfer learning in DR classification of less freq…
Federated Learning for Diabetic Retinopathy Diagnosis: Enhancing Accuracy and Generalizability in Under-Resourced Regions
High Technology High School（高新技术高中）；Massachusetts Eye and Ear Harvard Medical School（马萨诸塞眼耳医院哈佛医学院）；Harvard Medical School（哈佛医学院）；Harvard Ophthalmology AI Lab（哈佛眼科人工智能实验室）
Technische Universität Kaiserslautern（凯泽斯劳滕工业大学）；German Research Center for Artificial Intelligence GmbH (DFKI)（德国人工智能研究中心（DFKI））；Osaka Prefecture University（大阪府立大学）；National University of Science and Technology (NUST)（国立科技大学（NUST））；Opthalmology Clinic（眼科诊所）
Visual artefacts of early diabetic retinopathy in retinal fundus images are usually small in size, inconspicuous, and scattered all over retina. Detecting diabetic retinopathy requires physicians to look at the whole image and fixate on some specific regions to locate potential biomarkers of the disease. Therefore, getting inspiration from ophthalmologist, we propose to combine coarse-grained classifiers that detect discriminating features from the whole images, with a recent breed of fine-grained classifiers that discover and pay particular attention to pathologically significant regions. To …
Deep learning-based models are developed to automatically detect if a retina image is `referable' in diabetic retinopathy (DR) screening. However, their classification accuracy degrades as the input images distributionally shift from their training distribution. Further, even if the input is not a retina image, a standard DR classifier produces a high confident prediction that the image is `referable'. Our paper presents a Dirichlet Prior Network-based framework to address this issue. It utilizes an out-of-distribution (OOD) detector model and a DR classification model to improve generalizabil…
Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；Singapore Eye Research Institute（新加坡眼科研究所）；Duke-NUS Medical School（杜克-新加坡国立大学医学院）；Institute for Molecular and Clinical Ophthalmology（分子与临床眼科研究所）；National University of Singapore（新加坡国立大学）
In this paper, we propose an explainable and interpretable diabetic retinopathy (ExplainDR) classification model based on neural-symbolic learning. To gain explainability, a highlevel symbolic representation should be considered in decision making. Specifically, we introduce a human-readable symbolic representation, which follows a taxonomy style of diabetic retinopathy characteristics related to eye health conditions to achieve explainability. We then include humanreadable features obtained from the symbolic representation in the disease prediction. Experimental results on a diabetic retinopa…
UNIÃO DE ENSINO DO SUDOESTE DO PARANÁ – UNISEP（巴拉那州西南部教育联盟（UNISEP））；FACULDADE EDUCACIONAL DE FRANCISCO BELTRÃO – FEFB（弗朗西斯科贝尔特朗教育学院（FEFB））
Many people are affected by diabetes around the world. This disease may have type 1 and 2. Diabetes brings with it several complications including diabetic retinopathy, which is a disease that if not treated correctly can lead to irreversible damage in the patient's vision. The earlier it is detected, the better the chances that the patient will not lose vision. Methods of automating manual procedures are currently in evidence and the diagnostic process for retinopathy is manual with the physician analyzing the patient's retina on the monitor. The practice of image recognition can aid this det…
Research and Technology Development Center（研究与技术开发中心）；Sharda University（夏尔达大学）
Early diagnosis of diabetic retinopathy for treatment of the disease has been failing to reach diabetic people living in rural areas. Shortage of trained ophthalmologists, limited availability of healthcare centers, and expensiveness of diagnostic equipment are among the reasons. Although many deep learning-based automatic diagnosis of diabetic retinopathy techniques have been implemented in the literature, these methods still fail to provide a point-of-care diagnosis. This raises the need for an independent diagnostic of diabetic retinopathy that can be used by a non-expert. Recently the usag…
Manarat International University（玛纳拉特国际大学）；Bangladesh University of Engineering and Technology（孟加拉国工程技术大学）
Diabetic Retinopathy (DR) is a constantly deteriorating disease, being one of the leading causes of vision impairment and blindness. Subtle distinction among different grades and existence of many significant small features make the task of recognition very challenging. In addition, the present approach of retinopathy detection is a very laborious and time-intensive task, which heavily relies on the skill of a physician. Automated detection of diabetic retinopathy is essential to tackle these problems. Early-stage detection of diabetic retinopathy is also very important for diagnosis, which ca…
Recently, diabetic retinopathy (DR) screening utilizing ultra-wide optical coherence tomography angiography (UW-OCTA) has been used in clinical practices to detect signs of early DR. However, developing a deep learning-based DR analysis system using UW-OCTA images is not trivial due to the difficulty of data collection and the absence of public datasets. By realistic constraints, a model trained on small datasets may obtain sub-par performance. Therefore, to help ophthalmologists be less confused about models' incorrect decisions, the models should be robust even in data scarcity settings. To …
University of Georgia（佐治亚大学）；Florida International University（佛罗里达国际大学）
DRDr II is a hybrid of machine learning and deep learning worlds. It builds on the successes of its antecedent, namely, DRDr, that was trained to detect, locate, and create segmentation masks for two types of lesions (exudates and microaneurysms) that can be found in the eyes of the Diabetic Retinopathy (DR) patients; and uses the entire model as a solid feature extractor in the core of its pipeline to detect the severity level of the DR cases. We employ a big dataset with over 35 thousand fundus images collected from around the globe and after 2 phases of preprocessing alongside feature extra…
Deep neural network models have been proven to be very successful in image classification tasks, also for medical diagnosis, but their main concern is its lack of interpretability. They use to work as intuition machines with high statistical confidence but unable to give interpretable explanations about the reported results. The vast amount of parameters of these models make difficult to infer a rationale interpretation from them. In this paper we present a diabetic retinopathy interpretable classifier able to classify retine images into the different levels of disease severity and of explaini…
Rochester Institute of Technology（罗切斯特理工学院）；Drexel University（德雷塞尔大学）；University of Rochester（罗切斯特大学）
Widespread outreach programs using remote retinal imaging have proven to decrease the risk from diabetic retinopathy, the leading cause of blindness in the US. However, this process still requires manual verification of image quality and grading of images for level of disease by a trained human grader and will continue to be limited by the lack of such scarce resources. Computer-aided diagnosis of retinal images have recently gained increasing attention in the machine learning community. In this paper, we introduce a set of neural networks for diabetic retinopathy classification of fundus reti…
Department of Computer Science & Engineering, Priyadarshini Institute of Engineering & Technology（普里雅达希尼工程技术学院计算机科学与工程系）
Diabetic Retinopathy is a global health problem, influences 100 million individuals worldwide, and in the next few decades, these incidences are expected to reach epidemic proportions. Diabetic Retinopathy is a subtle eye disease that can cause sudden, irreversible vision loss. The early-stage Diabetic Retinopathy diagnosis can be challenging for human experts, considering the visual complexity of fundus photography retinal images. However, Early Stage detection of Diabetic Retinopathy can significantly alter the severe vision loss problem. The competence of computer-aided detection systems to…
Diabetic retinopathy(DR) is the main cause of blindness in diabetic patients. However, DR can easily delay the occurrence of blindness through the diagnosis of the fundus. In view of the reality, it is difficult to collect a large amount of diabetic retina data in clinical practice. This paper proposes a few-shot learning model of a deep residual network based on Earth Mover's Distance algorithm to assist in diagnosing DR. We build training and validation classification tasks for few-shot learning based on 39 categories of 1000 sample data, train deep residual networks, and obtain experience m…
Carnegie Mellon University（卡内基梅隆大学）；INESC TEC, Porto（波尔图INESC TEC研究所）；École de Tecnologie Superieure, Montreal（蒙特利尔高等技术学院）；Faculty of Engineering, University of Porto（波尔图大学工程学院）
Diabetic Retinopathy is the leading cause of blindness in the working-age population of the world. The main aim of this paper is to improve the accuracy of Diabetic Retinopathy detection by implementing a shadow removal and color correction step as a preprocessing stage from eye fundus images. For this, we rely on recent findings indicating that application of image dehazing on the inverted intensity domain amounts to illumination compensation. Inspired by this work, we propose a Shadow Removal Layer that allows us to learn the pre-processing function for a particular task. We show that learni…
LaTIM UMR 1101, Inserm（法国国家健康与医学研究院LaTIM UMR 1101实验室）；University of Western Brittany（西布列塔尼大学）；University of Electronic Science and Technology of China（电子科技大学）；IMT Atlantique（大西洋国立高等矿业电信学院）
Diabetic Retinopathy (DR) is a severe complication of diabetes that can cause blindness. Although effective treatments exist (notably laser) to slow the progression of the disease and prevent blindness, the best treatment remains prevention through regular check-ups (at least once a year) with an ophthalmologist. Optical Coherence Tomography Angiography (OCTA) allows for the visualization of the retinal vascularization, and the choroid at the microvascular level in great detail. This allows doctors to diagnose DR with more precision. In recent years, algorithms for DR diagnosis have emerged al…
Diabetic Retinopathy (DR) has become one of the leading causes of vision impairment in working-aged people and is a severe problem worldwide. However, most of the works ignored the ordinal information of labels. In this project, we propose a novel design MTCSNN, a Multi-task Clinical Siamese Neural Network for Diabetic Retinopathy severity prediction task. The novelty of this project is to utilize the ordinal information among labels and add a new regression task, which can help the model learn more discriminative feature embedding for fine-grained classification tasks. We perform comprehensiv…
The conventional spatial convolution layers in the Convolutional Neural Networks (CNNs) are computationally expensive at the point where the training time could take days unless the number of layers, the number of training images or the size of the training images are reduced. The image size of 256x256 pixels is commonly used for most of the applications of CNN, but this image size is too small for applications like Diabetic Retinopathy (DR) classification where the image details are important for accurate classification. This research proposed Frequency Domain Convolution (FDC) and Frequency …
We proposed a deep learning method for interpretable diabetic retinopathy (DR) detection. The visual-interpretable feature of the proposed method is achieved by adding the regression activation map (RAM) after the global averaging pooling layer of the convolutional networks (CNN). With RAM, the proposed model can localize the discriminative regions of an retina image to show the specific region of interest in terms of its severity level. We believe this advantage of the proposed deep learning model is highly desired for DR detection because in practice, users are not only interested with high …
German Research Center for Artificial Intelligence (DFKI)（德国人工智能研究中心）；Dongguk University（东国大学）；Stanford University（斯坦福大学）；Oldenburg University（奥尔登堡大学）
This paper investigates the problem of domain adaptation for diabetic retinopathy (DR) grading. We learn invariant target-domain features by defining a novel self-supervised task based on retinal vessel image reconstructions, inspired by medical domain knowledge. Then, a benchmark of current state-of-the-art unsupervised domain adaptation methods on the DR problem is provided. It can be shown that our approach outperforms existing domain adaption strategies. Furthermore, when utilizing entire training data in the target domain, we are able to compete with several state-of-the-art approaches in…
Universidad Nacional de Colombia（哥伦比亚国立大学）；Universidad del Rosario（罗萨里奥大学）
Diabetic retinopathy (DR) is one of the leading causes of blindness in the working-age population of developed countries, caused by a side effect of diabetes that reduces the blood supply to the retina. Deep neural networks have been widely used in automated systems for DR classification on eye fundus images. However, these models need a large number of annotated images. In the medical domain, annotations from experts are costly, tedious, and time-consuming; as a result, a limited number of annotated images are available. This paper presents a semi-supervised method that leverages unlabeled im…
This paper addresses the problem of identifying two main types of lesions - Exudates and Microaneurysms - caused by Diabetic Retinopathy (DR) in the eyes of diabetic patients. We make use of Convolutional Neural Networks (CNNs) and Transfer Learning to locate and generate high-quality segmentation mask for each instance of the lesion that can be found in the patients' fundus images. We create our normalized database out of e-ophtha EX and e-ophtha MA and tweak Mask R-CNN to detect small lesions. Moreover, we employ data augmentation and the pre-trained weights of ResNet101 to compensate for ou…
In this paper, an ensemble-based method for the screening of diabetic retinopathy (DR) is proposed. This approach is based on features extracted from the output of several retinal image processing algorithms, such as image-level (quality assessment, pre-screening, AM/FM), lesion-specific (microaneurysms, exudates) and anatomical (macula, optic disc) components. The actual decision about the presence of the disease is then made by an ensemble of machine learning classifiers. We have tested our approach on the publicly available Messidor database, where 90% sensitivity, 91% specificity and 90% a…
The Chinese University of Hong Kong（香港中文大学）；Tsing Hua University（清华大学）；SenseTime Group Limited（商汤集团有限公司）；Sir Run Run Shaw Hospital（邵逸夫医院）
We propose a convolution neural network based algorithm for simultaneously diagnosing diabetic retinopathy and highlighting suspicious regions. Our contributions are two folds: 1) a network termed Zoom-in-Net which mimics the zoom-in process of a clinician to examine the retinal images. Trained with only image-level supervisions, Zoomin-Net can generate attention maps which highlight suspicious regions, and predicts the disease level accurately based on both the whole image and its high resolution suspicious patches. 2) Only four bounding boxes generated from the automatically learned attentio…
Institute of Technical Education & Research, S‘O’A (Deemed to be University)（S‘O’A（被视为大学）技术教育与研究学院）
Blindness in diabetic patients caused by retinopathy (characterized by an increase in the diameter and new branches of the blood vessels inside the retina) is a grave concern. Many efforts have been made for the early detection of the disease using various image processing techniques on retinal images. However, most of the methods are plagued with the false detection of the blood vessel pixels. Given that, here, we propose a modified matched filter with the first derivative of Gaussian. The method uses the top-hat transform and contrast limited histogram equalization. Further, we segment the m…
COMSATS University Islamabad（伊斯兰堡 COMSATS 大学）；Deakin University（迪肯大学）；Victoria University（维多利亚大学）
Diabetic retinopathy refers to the pathology of the retina induced by diabetes and is one of the leading causes of preventable blindness in the world. Early detection of diabetic retinopathy is critical to avoid vision problem through continuous screening and treatment. In traditional clinical practice, the involved lesions are manually detected using photographs of the fundus. However, this task is cumbersome and time-consuming and requires intense effort due to the small size of lesion and low contrast of the images. Thus, computer-assisted diagnosis of diabetic retinopathy based on the dete…
Shanghai Jiao Tong University（上海交通大学）；The Hong Kong University of Science and Technology（香港科技大学）；Shanghai Jiao Tong University Affiliated Sixth People’s Hospital（上海交通大学附属第六人民医院）；VUNO Inc.（VUNO公司）；Johannes Kepler University Linz（林茨约翰·开普勒大学）；Fudan University（复旦大学）；Inserm（法国国家健康与医学研究院）；University of Western Brittany（西布列塔尼大学）
Commack High School（康马克高中）；Camp Illumina（Illumina 训练营）；Glenda Dawson High School（格伦达·道森高中）；Mira Loma High School（米拉洛马高中）；Ward Melville High School（沃德·梅尔维尔高中）
In this work, deep learning algorithms are used to classify fundus images in terms of diabetic retinopathy severity. Six different combinations of two model architectures, the Dense Convolutional Network-121 and the Residual Neural Network-50 and three image types, RGB, Green, and High Contrast, were tested to find the highest performing combination. We achieved an average validation loss of 0.17 and a max validation accuracy of 85 percent. By testing out multiple combinations, certain combinations of parameters performed better than others, though minimal variance was found overall. Green fil…
Much effort is being made by the researchers in order to detect and diagnose diabetic retinopathy (DR) accurately automatically. The disease is very dangerous as it can cause blindness suddenly if it is not continuously screened. Therefore, many computers aided diagnosis (CAD) systems have been developed to diagnose the various DR grades. Recently, many CAD systems based on deep learning (DL) methods have been adopted to get deep learning merits in diagnosing the pathological abnormalities of DR disease. In this paper, we present a full based-DL CAD system depending on multi-label classificati…
Indian Institute of Technology Kharagpur（印度理工学院卡拉格普尔分校）
Diabetic retinopathy (DR) is the most common form of diabetic eye disease. Retinopathy can affect all diabetic patients and becomes particularly dangerous, increasing the risk of blindness, if it is left untreated. The success rate of its curability solemnly depends on diagnosis at an early stage. The development of automated computer aided disease diagnosis tools could help in faster detection of symptoms with a wider reach and reasonable cost. This paper proposes a method for the automated segmentation of retinal lesions and optic disk in fundus images using a deep fully convolutional neural…
Source-free Active Domain Adaptation for Diabetic Retinopathy Grading Based on Ultra-wide-field Fundus Image
Southwest University（西南大学）；Taiyuan University（太原学院）；Taiyuan University of Technology（太原理工大学）；Shanxi Eye Hospital（山西省眼科医院）；Nanjing University of Information Science and Technology（南京信息工程大学）
In this manuscript, we automate the procedure of grading of diabetic retinopathy and macular edema from fundus images using an ensemble of convolutional neural networks. The availability of limited amount of labeled data to perform supervised learning was circumvented by using transfer learning approach. The models in the ensemble were pre-trained on a large dataset comprising natural images and were later fine-tuned with the limited data for the task of choice. For an image, the ensemble of classifiers generate multiple predictions, and a max-voting based approach was utilized to attain the f…
The automatic grading of diabetic retinopathy (DR) facilitates medical diagnosis for both patients and physicians. Existing researches formulate DR grading as an image classification problem. As the stages/categories of DR correlate with each other, the relationship between different classes cannot be explicitly described via a one-hot label because it is empirically estimated by different physicians with different outcomes. This class correlation limits existing networks to achieve effective classification. In this paper, we propose a Graph REsidual rE-ranking Network (GREEN) to introduce a c…
Kasetsart University（泰国农业大学）；National Electronics and Computer Technology Centre（泰国国家电子与计算机技术中心）；Tokyo Institute of Technology（东京工业大学）
This research aims to develop an efficient system for screening of diabetic retinopathy. Diabetic retinopathy is the major cause of blindness. Severity of diabetic retinopathy is recognized by some features, such as blood vessel area, exudates, haemorrhages and microaneurysms. To grade the disease the screening system must efficiently detect these features. In this paper we are proposing a simple and fast method for detection of diabetic retinopathy. We do pre-processing of grey-scale image and find all labelled connected components (blobs) in an image regardless of whether it is haemorrhages,…
Google Research（谷歌研究院）；Palo Alto Medical Foundation（帕洛阿尔托医疗基金会）；Oregon Eye Consultants（俄勒冈眼科顾问公司）
Diabetic retinopathy (DR) and diabetic macular edema are common complications of diabetes which can lead to vision loss. The grading of DR is a fairly complex process that requires the detection of fine features such as microaneurysms, intraretinal hemorrhages, and intraretinal microvascular abnormalities. Because of this, there can be a fair amount of grader variability. There are different methods of obtaining the reference standard and resolving disagreements between graders, and while it is usually accepted that adjudication until full consensus will yield the best reference standard, the …
Institute of Systems Science, National University of Singapore（新加坡国立大学系统科学研究所）；University of Electronic Science and Technology of China（电子科技大学）；Wuhan University of Science and Technology（武汉科技大学）；Hubei Province Key Laboratory of Intelligent Information Processing and Real-time Industrial System（湖北省智能信息处理与实时工业系统重点实验室）
Diabetic retinopathy (DR) is a common retinal disease that leads to blindness. For diagnosis purposes, DR image grading aims to provide automatic DR grade classification, which is not addressed in conventional research methods of binary DR image classification. Small objects in the eye images, like lesions and microaneurysms, are essential to DR grading in medical imaging, but they could easily be influenced by other objects. To address these challenges, we propose a new deep learning architecture, called BiRA-Net, which combines the attention model for feature extraction and bilinear model fo…
Although deep learning research and applications have grown rapidly over the past decade, it has shown limitation in healthcare applications and its reachability to people in remote areas. One of the challenges of incorporating deep learning in medical data classification or prediction is the shortage of annotated training data in the healthcare industry. Medical data sharing privacy issues and limited patient population size can be stated as some of the reasons for training data insufficiency in healthcare. Methods to exploit deep learning applications in healthcare have been proposed and imp…
