Automated Diabetic Retinopathy Grading using Deep Convolutional Neural Network
Department of Computer Science & Engineering, Priyadarshini Institute of Engineering & Technology（普里雅达希尼工程技术学院计算机科学与工程系）
Saket S. Chaturvedi, Kajol Gupta, Vaishali Ninawe, Prakash S. Prasad
备注：
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Diabetic Retinopathy is a global health problem, influences 100 million individuals worldwide, and in the next few decades, these incidences are expected to reach epidemic proportions. Diabetic Retinopathy is a subtle eye disease that can cause sudden, irreversible vision loss. The early-stage Diabetic Retinopathy diagnosis can be challenging for human experts, considering the visual complexity of fundus photography retinal images. However, Early Stage detection of Diabetic Retinopathy can significantly alter the severe vision loss problem. The competence of computer-aided detection systems to accurately detect the Diabetic Retinopathy had popularized them among researchers. In this study, we have utilized a pre-trained DenseNet121 network with several modifications and trained on APTOS 2019 dataset. The proposed method outperformed other state-of-the-art networks in early-stage detection and achieved 96.51% accuracy in severity grading of Diabetic Retinopathy for multi-label classification and achieved 94.44% accuracy for single-class classification method. Moreover, the precision, recall, f1-score, and quadratic weighted kappa for our network was reported as 86%, 87%, 86%, and 91.96%, respectively. Our proposed architecture is simultaneously very simple, accurate, and efficient concerning computational time and space.
Carnegie Mellon University（卡内基梅隆大学）；INESC TEC, Porto（波尔图INESC TEC研究所）；École de Tecnologie Superieure, Montreal（蒙特利尔高等技术学院）；Faculty of Engineering, University of Porto（波尔图大学工程学院）
Diabetic Retinopathy is the leading cause of blindness in the working-age population of the world. The main aim of this paper is to improve the accuracy of Diabetic Retinopathy detection by implementing a shadow removal and color correction step as a preprocessing stage from eye fundus images. For this, we rely on recent findings indicating that application of image dehazing on the inverted intensity domain amounts to illumination compensation. Inspired by this work, we propose a Shadow Removal Layer that allows us to learn the pre-processing function for a particular task. We show that learni…
COMSATS University Islamabad（伊斯兰堡 COMSATS 大学）；Deakin University（迪肯大学）；Victoria University（维多利亚大学）
Diabetic retinopathy refers to the pathology of the retina induced by diabetes and is one of the leading causes of preventable blindness in the world. Early detection of diabetic retinopathy is critical to avoid vision problem through continuous screening and treatment. In traditional clinical practice, the involved lesions are manually detected using photographs of the fundus. However, this task is cumbersome and time-consuming and requires intense effort due to the small size of lesion and low contrast of the images. Thus, computer-assisted diagnosis of diabetic retinopathy based on the dete…
Research and Technology Development Center（研究与技术开发中心）；Sharda University（夏尔达大学）
Early diagnosis of diabetic retinopathy for treatment of the disease has been failing to reach diabetic people living in rural areas. Shortage of trained ophthalmologists, limited availability of healthcare centers, and expensiveness of diagnostic equipment are among the reasons. Although many deep learning-based automatic diagnosis of diabetic retinopathy techniques have been implemented in the literature, these methods still fail to provide a point-of-care diagnosis. This raises the need for an independent diagnostic of diabetic retinopathy that can be used by a non-expert. Recently the usag…
Kasetsart University（泰国农业大学）；National Electronics and Computer Technology Centre（泰国国家电子与计算机技术中心）；Tokyo Institute of Technology（东京工业大学）
This research aims to develop an efficient system for screening of diabetic retinopathy. Diabetic retinopathy is the major cause of blindness. Severity of diabetic retinopathy is recognized by some features, such as blood vessel area, exudates, haemorrhages and microaneurysms. To grade the disease the screening system must efficiently detect these features. In this paper we are proposing a simple and fast method for detection of diabetic retinopathy. We do pre-processing of grey-scale image and find all labelled connected components (blobs) in an image regardless of whether it is haemorrhages,…
Although deep learning research and applications have grown rapidly over the past decade, it has shown limitation in healthcare applications and its reachability to people in remote areas. One of the challenges of incorporating deep learning in medical data classification or prediction is the shortage of annotated training data in the healthcare industry. Medical data sharing privacy issues and limited patient population size can be stated as some of the reasons for training data insufficiency in healthcare. Methods to exploit deep learning applications in healthcare have been proposed and imp…
Optical Coherence Tomography Angiography-OCTA dataset for the study of Diabetic Retinopathy
Symbiosis Institute of Technology, Symbiosis International (Deemed University)（共生国际（ deemed 大学）共生技术学院）；University of Technology Sydney（悉尼科技大学）；Natasha Eye Care（娜塔莎眼科护理中心）
Diabetic Retinopathy (DR) is a leading cause of blindness in working age adults. DR lesions can be challenging to identify in fundus images, and automatic DR detection systems can offer strong clinical value. Of the publicly available labeled datasets for DR, the Indian Diabetic Retinopathy Image Dataset (IDRiD) presents retinal fundus images with pixel-level annotations of four distinct lesions: microaneurysms, hemorrhages, soft exudates and hard exudates. We utilize the HEDNet edge detector to solve a semantic segmentation task on this dataset, and then propose an end-to-end system for pixel…
Introducing automated Diabetic Retinopathy (DR) diagnosis into Ethiopia is still a challenging task, despite recent reports that present trained Deep Learning (DL) based DR classifiers surpassing manual graders. This is mainly because of the expensive cost of conventional retinal imaging devices used in DL based classifiers. Current approaches that provide mobile based binary classification of DR, and the way towards a cheaper and offline multi-class classification of DR will be discussed in this paper.
Faculty of Computer Science and Information Technology, University of Al-Qadisiyah（阿尔卡迪西亚大学计算机科学与信息技术学院）
Diabetic Retinopathy DR is a popular disease for many people as a result of age or the diabetic, as a result, it can cause blindness. therefore, diagnosis of this disease especially in the early time can prevent its effect for a lot of patients. To achieve this diagnosis, eye retina must be examined continuously. Therefore, computer-aided tools can be used in the field based on computer vision techniques. Different works have been performed using various machine learning techniques. Convolutional Neural Network is one of the promise methods, so it was for Diabetic Retinopathy detection in this…
Technical University of Munich（慕尼黑工业大学）；Imperial College London（伦敦帝国理工学院）；Helmholtz Zentrum Muenchen（慕尼黑亥姆霍兹中心）
Recent studies suggest that early stages of diabetic retinopathy (DR) can be diagnosed by monitoring vascular changes in the deep vascular complex. In this work, we investigate a novel method for automated DR grading based on optical coherence tomography angiography (OCTA) images. Our work combines OCTA scans with their vessel segmentations, which then serve as inputs to task specific networks for lesion segmentation, image quality assessment and DR grading. For this, we generate synthetic OCTA images to train a segmentation network that can be directly applied on real OCTA data. We test our a…
Fudan University（复旦大学）；Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University（上海交通大学医学院附属上海市第一人民医院）
The ultra-wide optical coherence tomography angiography (OCTA) has become an important imaging modality in diabetic retinopathy (DR) diagnosis. However, there are few researches focusing on automatic DR analysis using ultra-wide OCTA. In this paper, we present novel and practical deep-learning solutions based on ultra-wide OCTA for the Diabetic Retinopathy Analysis Challenge (DRAC). In the segmentation of DR lesions task, we utilize UNet and UNet++ to segment three lesions with strong data augmentation and model ensemble. In the image quality assessment task, we create an ensemble of Inception…
Sun Yat-sen University（中山大学）；Southern University of Science and Technology（南方科技大学）
Manually annotating medical images is extremely expensive, especially for large-scale datasets. Self-supervised contrastive learning has been explored to learn feature representations from unlabeled images. However, unlike natural images, the application of contrastive learning to medical images is relatively limited. In this work, we propose a self-supervised framework, namely lesion-based contrastive learning for automated diabetic retinopathy (DR) grading. Instead of taking entire images as the input in the common contrastive learning scheme, lesion patches are employed to encourage the fea…
Detecting diabetic retinopathy severity through fundus images using an ensemble of classifiers
Technical University of Cluj-Napoca（克卢日-纳波卡技术大学）；“Iuliu Hatieganu” University of Medicine and Pharmacy（“尤利乌·哈采加努”医药大学）；Emergency County Hospital（急诊县医院）
Aalto University School of Science（阿尔托大学理学院）；Digifundus Ltd.（Digifundus有限公司）；Central Finland Central Hospital（中芬兰中心医院）
Diabetes is a globally prevalent disease that can cause visible microvascular complications such as diabetic retinopathy and macular edema in the human eye retina, the images of which are today used for manual disease screening. This labor-intensive task could greatly benefit from automatic detection using deep learning technique. Here we present a deep learning system that identifies referable diabetic retinopathy comparably or better than presented in the previous studies, although we use only a small fraction of images (<1/4) in training but are aided with higher image resolutions. We also …
University of Waterloo（滑铁卢大学）；University of Engineering and Management（工程与管理大学）；Medical Research Foundation（医学研究基金会）
Diabetic Retinopathy (DR) is a leading cause of vision loss in the world,. In the past few Diabetic Retinopathy (DR) is a leading cause of vision loss in the world. In the past few years, Artificial Intelligence (AI) based approaches have been used to detect and grade DR. Early detection enables appropriate treatment and thus prevents vision loss, Both fundus and optical coherence tomography (OCT) images are used to image the retina. With deep learning/machine learning apprroaches it is possible to extract features from the images and detect the presence of DR. Multiple strategies are implemen…
In this paper, we propose two distinct solutions to the problem of Diabetic Retinopathy (DR) classification. In the first approach, we introduce a shallow neural network architecture. This model performs well on classification of the most frequent classes while fails at classifying the less frequent ones. In the second approach, we use transfer learning to re-train the last modified layer of a very deep neural network to improve the generalization ability of the model to the less frequent classes. Our results demonstrate superior abilities of transfer learning in DR classification of less freq…
Diabetic retinopathy (DR) and diabetic macular edema (DME) are the leading causes of permanent blindness in the working-age population. Automatic grading of DR and DME helps ophthalmologists design tailored treatments to patients, thus is of vital importance in the clinical practice. However, prior works either grade DR or DME, and ignore the correlation between DR and its complication, i.e., DME. Moreover, the location information, e.g., macula and soft hard exhaust annotations, are widely used as a prior for grading. Such annotations are costly to obtain, hence it is desirable to develop aut…
Federated Learning for Diabetic Retinopathy Diagnosis: Enhancing Accuracy and Generalizability in Under-Resourced Regions
High Technology High School（高新技术高中）；Massachusetts Eye and Ear Harvard Medical School（马萨诸塞眼耳医院哈佛医学院）；Harvard Medical School（哈佛医学院）；Harvard Ophthalmology AI Lab（哈佛眼科人工智能实验室）
Technische Universität Kaiserslautern（凯泽斯劳滕工业大学）；German Research Center for Artificial Intelligence GmbH (DFKI)（德国人工智能研究中心（DFKI））；Osaka Prefecture University（大阪府立大学）；National University of Science and Technology (NUST)（国立科技大学（NUST））；Opthalmology Clinic（眼科诊所）
Visual artefacts of early diabetic retinopathy in retinal fundus images are usually small in size, inconspicuous, and scattered all over retina. Detecting diabetic retinopathy requires physicians to look at the whole image and fixate on some specific regions to locate potential biomarkers of the disease. Therefore, getting inspiration from ophthalmologist, we propose to combine coarse-grained classifiers that detect discriminating features from the whole images, with a recent breed of fine-grained classifiers that discover and pay particular attention to pathologically significant regions. To …
Netaji Subhas Institute of Technology（内塔吉·苏巴斯技术学院）；Pandit Deendayal Energy University（潘迪特·迪恩达亚尔能源大学）；National Institute of Technology Delhi（德里国立理工学院）；AMC MET Medical College（AMC MET医学院）
Patients with long-standing diabetes often fall prey to Diabetic Retinopathy (DR) resulting in changes in the retina of the human eye, which may lead to loss of vision in extreme cases. The aim of this study is two-fold: (a) create deep learning models that were trained to grade degraded retinal fundus images and (b) to create a browser-based application that will aid in diagnostic procedures by highlighting the key features of the fundus image. In this research work, we have emulated the images plagued by distortions by degrading the images based on multiple different combinations of Light Tr…
Cases of diabetes and related diabetic retinopathy (DR) have been increasing at an alarming rate in modern times. Early detection of DR is an important problem since it may cause permanent blindness in the late stages. In the last two decades, many different approaches have been applied in DR detection. Reviewing academic literature shows that deep neural networks (DNNs) have become the most preferred approach for DR detection. Among these DNN approaches, Convolutional Neural Network (CNN) models are the most used ones in the field of medical image classification. Designing a new CNN architect…
Universidad Nacional de Colombia（哥伦比亚国立大学）；Fundación Oftalmológica Nacional（国家眼科基金会）；Universidad del Rosario（罗萨里奥大学）
Diabetic retinopathy (DR) is the result of a complication of diabetes affecting the retina. It can cause blindness, if left undiagnosed and untreated. An ophthalmologist performs the diagnosis by screening each patient and analyzing the retinal lesions via ocular imaging. In practice, such analysis is time-consuming and cumbersome to perform. This paper presents a model for automatic DR classification on eye fundus images. The approach identifies the main ocular lesions related to DR and subsequently diagnoses the illness. The proposed method follows the same workflow as the clinicians, provid…
Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；Singapore Eye Research Institute（新加坡眼科研究所）；Duke-NUS Medical School（杜克-新加坡国立大学医学院）；Institute for Molecular and Clinical Ophthalmology（分子与临床眼科研究所）；National University of Singapore（新加坡国立大学）
In this paper, we propose an explainable and interpretable diabetic retinopathy (ExplainDR) classification model based on neural-symbolic learning. To gain explainability, a highlevel symbolic representation should be considered in decision making. Specifically, we introduce a human-readable symbolic representation, which follows a taxonomy style of diabetic retinopathy characteristics related to eye health conditions to achieve explainability. We then include humanreadable features obtained from the symbolic representation in the disease prediction. Experimental results on a diabetic retinopa…
UNIÃO DE ENSINO DO SUDOESTE DO PARANÁ – UNISEP（巴拉那州西南部教育联盟（UNISEP））；FACULDADE EDUCACIONAL DE FRANCISCO BELTRÃO – FEFB（弗朗西斯科贝尔特朗教育学院（FEFB））
Many people are affected by diabetes around the world. This disease may have type 1 and 2. Diabetes brings with it several complications including diabetic retinopathy, which is a disease that if not treated correctly can lead to irreversible damage in the patient's vision. The earlier it is detected, the better the chances that the patient will not lose vision. Methods of automating manual procedures are currently in evidence and the diagnostic process for retinopathy is manual with the physician analyzing the patient's retina on the monitor. The practice of image recognition can aid this det…
Heritage Institute of Technology（遗产理工学院）；Tata Consultancy Services（塔塔咨询服务公司）
Diabetic Retinopathy (DR) is a complication of long-standing, unchecked diabetes and one of the leading causes of blindness in the world. This paper focuses on improved and robust methods to extract some of the features of DR, viz. Blood Vessels and Exudates. Blood vessels are segmented using multiple morphological and thresholding operations. For the segmentation of exudates, k-means clustering and contour detection on the original images are used. Extensive noise reduction is performed to remove false positives from the vessel segmentation algorithm's results. The localization of Optic Disc …
Beijing Institute of Technology（北京理工大学）；Chongqing Innovation Center, Beijing Institute of Technology（北京理工大学重庆创新中心）
Automatic diabetic retinopathy (DR) lesions segmentation makes great sense of assisting ophthalmologists in diagnosis. Although many researches have been conducted on this task, most prior works paid too much attention to the designs of networks instead of considering the pathological association for lesions. Through investigating the pathogenic causes of DR lesions in advance, we found that certain lesions are closed to specific vessels and present relative patterns to each other. Motivated by the observation, we propose a relation transformer block (RTB) to incorporate attention mechanisms a…
Recently, diabetic retinopathy (DR) screening utilizing ultra-wide optical coherence tomography angiography (UW-OCTA) has been used in clinical practices to detect signs of early DR. However, developing a deep learning-based DR analysis system using UW-OCTA images is not trivial due to the difficulty of data collection and the absence of public datasets. By realistic constraints, a model trained on small datasets may obtain sub-par performance. Therefore, to help ophthalmologists be less confused about models' incorrect decisions, the models should be robust even in data scarcity settings. To …
Early detection of diabetic retinopathy prevents visual loss and blindness of a human eye. Based on the types of feature extraction method used, DR detection method can be broadly classified as Deep Convolutional Neural Network (CNN) based and traditional feature extraction (machine learning) based. This paper presents a comprehensive survey of existing feature extraction methods based on Deep CNN and conventional feature extraction for DR detection. In addition to that, this paper focuses on the severity scale measurement of the DR detection and to the best of our knowledge this is the first …
University of Georgia（佐治亚大学）；Florida International University（佛罗里达国际大学）
DRDr II is a hybrid of machine learning and deep learning worlds. It builds on the successes of its antecedent, namely, DRDr, that was trained to detect, locate, and create segmentation masks for two types of lesions (exudates and microaneurysms) that can be found in the eyes of the Diabetic Retinopathy (DR) patients; and uses the entire model as a solid feature extractor in the core of its pipeline to detect the severity level of the DR cases. We employ a big dataset with over 35 thousand fundus images collected from around the globe and after 2 phases of preprocessing alongside feature extra…
Inception Institute of Artificial Intelligence（因赛普申人工智能研究院）；Beijing BeYes Technology Co. Ltd.（北京贝叶斯科技有限公司）
Diabetic retinopathy (DR) is a complication of diabetes that severely affects eyes. It can be graded into five levels of severity according to international protocol. However, optimizing a grading model to have strong generalizability requires a large amount of balanced training data, which is difficult to collect particularly for the high severity levels. Typical data augmentation methods, including random flipping and rotation, cannot generate data with high diversity. In this paper, we propose a diabetic retinopathy generative adversarial network (DR-GAN) to synthesize high-resolution fundu…
Uncertainty-Aware Ordinal Deep Learning for cross-Dataset Diabetic Retinopathy Grading
Department of Computer Science & Engineering, Mississippi State University, MS, USA（计算机科学与工程系，密苏里州立大学）；Department of Mechanical Engineering, Mississippi State University, MS, USA（机械工程系，密苏里州立大学）；College of Engineering & Architecture, International University of Rabat（工程与建筑学院，拉巴特国际大学）
Isfahan University of Technology（伊斯法罕理工大学）；Seattle University（西雅图大学）；McMaster University（麦克马斯特大学）
Knowledge distillation allows transferring knowledge from a pre-trained model to another. However, it suffers from limitations, and constraints related to the two models need to be architecturally similar. Knowledge distillation addresses some of the shortcomings associated with transfer learning by generalizing a complex model to a lighter model. However, some parts of the knowledge may not be distilled by knowledge distillation sufficiently. In this paper, a novel knowledge distillation approach using transfer learning is proposed. The proposed method transfers the entire knowledge of a mode…
Detection and Classification of Diabetic Retinopathy using Deep Learning Algorithms for Segmentation to Facilitate Referral Recommendation for Test and Treatment Prediction
Diabetic retinopathy(DR) is the main cause of blindness in diabetic patients. However, DR can easily delay the occurrence of blindness through the diagnosis of the fundus. In view of the reality, it is difficult to collect a large amount of diabetic retina data in clinical practice. This paper proposes a few-shot learning model of a deep residual network based on Earth Mover's Distance algorithm to assist in diagnosing DR. We build training and validation classification tasks for few-shot learning based on 39 categories of 1000 sample data, train deep residual networks, and obtain experience m…
LaTIM UMR 1101, Inserm（法国国家健康与医学研究院LaTIM UMR 1101实验室）；University of Western Brittany（西布列塔尼大学）；University of Electronic Science and Technology of China（电子科技大学）；IMT Atlantique（大西洋国立高等矿业电信学院）
Diabetic Retinopathy (DR) is a severe complication of diabetes that can cause blindness. Although effective treatments exist (notably laser) to slow the progression of the disease and prevent blindness, the best treatment remains prevention through regular check-ups (at least once a year) with an ophthalmologist. Optical Coherence Tomography Angiography (OCTA) allows for the visualization of the retinal vascularization, and the choroid at the microvascular level in great detail. This allows doctors to diagnose DR with more precision. In recent years, algorithms for DR diagnosis have emerged al…
Institute for Infocomm Research, Agency for Science, Technology and Research（新加坡科技研究局资讯通信研究院）；Institute of Systems Science, National University of Singapore（新加坡国立大学系统科学研究院）
Diabetes is one of the most common disease in individuals. \textit{Diabetic retinopathy} (DR) is a complication of diabetes, which could lead to blindness. Automatic DR grading based on retinal images provides a great diagnostic and prognostic value for treatment planning. However, the subtle differences among severity levels make it difficult to capture important features using conventional methods. To alleviate the problems, a new deep learning architecture for robust DR grading is proposed, referred to as SEA-Net, in which, spatial attention and channel attention are alternatively carried o…
This paper proposes the importance of age and gender information in the diagnosis of diabetic retinopathy. We utilized Deep Residual Neural Networks (ResNet) and Densely Connected Convolutional Networks (DenseNet), which are proven effective on image classification problems and the diagnosis of diabetic retinopathy using the retinal fundus images. We used the ensemble of several classical networks and decentralized the training so that the network was simple and avoided overfitting. To observe whether the age and gender information could help enhance the performance, we added the information b…
There are extensive researches focusing on automated diabetic reti-nopathy (DR) detection from fundus images. However, the accuracy drop is ob-served when applying these models in real-world DR screening, where the fun-dus camera brands are different from the ones used to capture the training im-ages. How can we train a classification model on labeled fundus images ac-quired from only one camera brand, yet still achieves good performance on im-ages taken by other brands of cameras? In this paper, we quantitatively verify the impact of fundus camera brands related domain shift on the performanc…
Institute of Technical Education & Research, S‘O’A (Deemed to be University)（S‘O’A（被视为大学）技术教育与研究学院）
Blindness in diabetic patients caused by retinopathy (characterized by an increase in the diameter and new branches of the blood vessels inside the retina) is a grave concern. Many efforts have been made for the early detection of the disease using various image processing techniques on retinal images. However, most of the methods are plagued with the false detection of the blood vessel pixels. Given that, here, we propose a modified matched filter with the first derivative of Gaussian. The method uses the top-hat transform and contrast limited histogram equalization. Further, we segment the m…
ShanghaiTech University（上海科技大学）；Ningbo Institute of Materials Technology and Engineering（宁波材料技术与工程研究所）；Shanghai University（上海大学）
Diabetic Retinopathy (DR) is a non-negligible eye disease among patients with Diabetes Mellitus, and automatic retinal image analysis algorithm for the DR screening is in high demand. Considering the resolution of retinal image is very high, where small pathological tissues can be detected only with large resolution image and large local receptive field are required to identify those late stage disease, but directly training a neural network with very deep architecture and high resolution image is both time computational expensive and difficult because of gradient vanishing/exploding problem, …
Shanghai Jiao Tong University（上海交通大学）；The Hong Kong University of Science and Technology（香港科技大学）；Shanghai Jiao Tong University Affiliated Sixth People’s Hospital（上海交通大学附属第六人民医院）；VUNO Inc.（VUNO公司）；Johannes Kepler University Linz（林茨约翰·开普勒大学）；Fudan University（复旦大学）；Inserm（法国国家健康与医学研究院）；University of Western Brittany（西布列塔尼大学）
Commack High School（康马克高中）；Camp Illumina（Illumina 训练营）；Glenda Dawson High School（格伦达·道森高中）；Mira Loma High School（米拉洛马高中）；Ward Melville High School（沃德·梅尔维尔高中）
In this work, deep learning algorithms are used to classify fundus images in terms of diabetic retinopathy severity. Six different combinations of two model architectures, the Dense Convolutional Network-121 and the Residual Neural Network-50 and three image types, RGB, Green, and High Contrast, were tested to find the highest performing combination. We achieved an average validation loss of 0.17 and a max validation accuracy of 85 percent. By testing out multiple combinations, certain combinations of parameters performed better than others, though minimal variance was found overall. Green fil…
Much effort is being made by the researchers in order to detect and diagnose diabetic retinopathy (DR) accurately automatically. The disease is very dangerous as it can cause blindness suddenly if it is not continuously screened. Therefore, many computers aided diagnosis (CAD) systems have been developed to diagnose the various DR grades. Recently, many CAD systems based on deep learning (DL) methods have been adopted to get deep learning merits in diagnosing the pathological abnormalities of DR disease. In this paper, we present a full based-DL CAD system depending on multi-label classificati…
University of Texas Southwestern Medical Center（德克萨斯大学西南医学中心）；Indiana University-Purdue University（印第安纳大学-普渡大学）
Diabetes Mellitus (DM) can lead to significant microvasculature disruptions that eventually causes diabetic retinopathy (DR), or complications in the eye due to diabetes. If left unchecked, this disease can increase over time and eventually cause complete vision loss. The general method to detect such optical developments is through examining the vessels, optic nerve head, microaneurysms, haemorrhage, exudates, etc. from retinal images. Ultimately this is limited by the number of experienced ophthalmologists and the vastly growing number of DM cases. To enable earlier and efficient DR diagnosi…
Beihang University（北京航空航天大学）；Peng Cheng Laboratory（鹏城实验室）；RIKEN AIP（理化学研究所人工智能研究中心）；University of Tokyo（东京大学）；Ningbo Institute of Industrial Technology, CAS（中国科学院宁波工业技术研究院）
Though deep learning has shown successful performance in classifying the label and severity stage of certain diseases, most of them give few explanations on how to make predictions. Inspired by Koch's Postulates, the foundation in evidence-based medicine (EBM) to identify the pathogen, we propose to exploit the interpretability of deep learning application in medical diagnosis. By determining and isolating the neuron activation patterns on which diabetic retinopathy (DR) detector relies to make decisions, we demonstrate the direct relation between the isolated neuron activation and lesions for…
Institute of Systems Science, National University of Singapore（新加坡国立大学系统科学研究所）；University of Electronic Science and Technology of China（电子科技大学）；Wuhan University of Science and Technology（武汉科技大学）；Hubei Province Key Laboratory of Intelligent Information Processing and Real-time Industrial System（湖北省智能信息处理与实时工业系统重点实验室）
Diabetic retinopathy (DR) is a common retinal disease that leads to blindness. For diagnosis purposes, DR image grading aims to provide automatic DR grade classification, which is not addressed in conventional research methods of binary DR image classification. Small objects in the eye images, like lesions and microaneurysms, are essential to DR grading in medical imaging, but they could easily be influenced by other objects. To address these challenges, we propose a new deep learning architecture, called BiRA-Net, which combines the attention model for feature extraction and bilinear model fo…
Southern University of Science and Technology（南方科技大学）；The University of British Columbia（不列颠哥伦比亚大学）；The University of Hong Kong（香港大学）；The University of Queensland（昆士兰大学）
Although deep learning based diabetic retinopathy (DR) classification methods typically benefit from well-designed architectures of convolutional neural networks, the training setting also has a non-negligible impact on the prediction performance. The training setting includes various interdependent components, such as objective function, data sampling strategy and data augmentation approach. To identify the key components in a standard deep learning framework (ResNet-50) for DR grading, we systematically analyze the impact of several major components. Extensive experiments are conducted on a …
