超扩散事件表明SARS-CoV-2通过在封闭空间中的累积进行气溶胶传播
Superspreading events suggest aerosol transmission of SARS-CoV-2 by accumulation in enclosed spaces
摘要：
病毒传播途径对公共安全具有深远的影响;因此，必须全面了解可行的传染途径。越来越多的证据表明，SARS-CoV-2可以通过空气传播;然而，这一点尚未得到证实。在这里，我们定量分析病毒粒子的积累占雾化病毒粒子的排放和不稳定。在此框架内分析的报告的超级传播事件指向气溶胶介导的SARS-CoV-2传播。发现为这些事件计算的病毒体暴露追踪到一个单一值，表明通过气溶胶的通用最小感染剂量（MID）与其他呼吸道病毒测量的MID相当;因此，一致的感染暴露水平及其与已知气溶胶MID的相似性确立了SARS-CoV-2气溶胶传播的相似性。以超过雾化SARS-CoV-2的不稳定速率使用过滤可以将暴露降低到低于该感染剂量。
英文摘要：
Viral transmission pathways have profound implications for public safety; it is thus imperative to establish a complete understanding of viable infectious avenues. Mounting evidence suggests SARS-CoV-2 can be transmitted via the air; however, this has not yet been demonstrated. Here we quantitatively analyze virion accumulation by accounting for aerosolized virion emission and destabilization. Reported superspreading events analyzed within this framework point towards aerosol mediated transmission of SARS-CoV-2. Virion exposure calculated for these events is found to trace out a single value, suggesting a universal minimum infective dose (MID) via aerosol that is comparable to the MIDs measured for other respiratory viruses; thus, the consistent infectious exposure levels and their commensurability to known aerosol-MIDs establishes the plausibility of aerosol transmission of SARS-CoV-2. Using filtration at a rate exceeding the destabilization rate of aerosolized SARS-CoV-2 can reduce exposure below this infective dose.
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