The anatomical axis of long bones is an important reference line for guiding fracture reduction and assisting in the correct placement of guide pins, screws, and implants in orthopedics and trauma surgery. This study investigates an automatic approach for detection of such axes on X-ray images based on the segmentation contour of the bone. For this purpose, we use the medically established two-line method and translate it into a learning-based approach. The proposed method is evaluated on 38 clinical test images of the femoral and tibial bone and achieves a median angulation error of 0.19° and 0.33° respectively. An inter-rater study with three trauma surgery experts confirms reliability of the method and recommends further clinical application.
The University of Queensland（昆士兰大学）；Australian e-Health Research Centre（澳大利亚电子健康研究中心）；Commonwealth Scientific and Industrial Research Organisation（联邦科学与工业研究组织）
In medical image analysis, automated segmentation of multi-component anatomical structures, which often have a spectrum of potential anomalies and pathologies, is a challenging task. In this work, we develop a multi-step approach using U-Net-based neural networks to initially detect anomalies (bone marrow lesions, bone cysts) in the distal femur, proximal tibia and patella from 3D magnetic resonance (MR) images of the knee in individuals with varying grades of osteoarthritis. Subsequently, the extracted data are used for downstream tasks involving semantic segmentation of individual bone and c…
RSIP Vision（RSIP Vision 公司）；Weizmann Institute of Science（魏茨曼科学研究所）
We present an end-to-end Convolutional Neural Network (CNN) approach for 3D reconstruction of knee bones directly from two bi-planar X-ray images. Clinically, capturing the 3D models of the bones is crucial for surgical planning, implant fitting, and postoperative evaluation. X-ray imaging significantly reduces the exposure of patients to ionizing radiation compared to Computer Tomography (CT) imaging, and is much more common and inexpensive compared to Magnetic Resonance Imaging (MRI) scanners. However, retrieving 3D models from such 2D scans is extremely challenging. In contrast to the commo…
CT-based Subchondral Bone Microstructural Analysis in Knee Osteoarthritis via MR-Guided Distillation Learning
School of Biomedical Engineering, Shanghai Jiao Tong University（上海交通大学生物医学工程学院）；Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine（上海交通大学医学院附属第九人民医院）
Semi-Supervised Bone Marrow Lesion Detection from Knee MRI Segmentation Using Mask Inpainting Models
Gordon Center for Medical Imaging, Harvard Medical School and Massachusetts General Hospital（哈佛医学院与麻省总医院戈登医学成像中心）；Boston University（波士顿大学）；Seidenberg School of CSIS, Pace University（佩斯大学塞登伯格计算机科学与信息系统学院）；Ewha Womans University（梨花女子大学）
German Center for Neuro-degenerative Diseases（德国神经退行性疾病中心）；Technischer Universität Darmstadt（达姆施塔特工业大学）；University Düsseldorf（杜塞尔多夫大学）
Purpose: Accurate estimation of the position and orientation (pose) of surgical instruments is crucial for delicate minimally invasive temporal bone surgery. Current techniques lack in accuracy and/or line-of-sight constraints (conventional tracking systems) or expose the patient to prohibitive ionizing radiation (intra-operative CT). A possible solution is to capture the instrument with a c-arm at irregular intervals and recover the pose from the image. Methods: i3PosNet infers the position and orientation of instruments from images using a pose estimation network. Said framework considers lo…
University of Oulu（奥卢大学）；Oulu University Hospital（奥卢大学医院）；Erasmus MC, University Medical Center（伊拉斯谟医学中心大学医院）；Medical Research Center, University of Oulu and Oulu University Hospital（奥卢大学与奥卢大学医院医学研究中心）
The purposes of this study were to investigate: 1) the effect of placement of region-of-interest (ROI) for texture analysis of subchondral bone in knee radiographs, and 2) the ability of several texture descriptors to distinguish between the knees with and without radiographic osteoarthritis (OA). Bilateral posterior-anterior knee radiographs were analyzed from the baseline of OAI and MOST datasets. A fully automatic method to locate the most informative region from subchondral bone using adaptive segmentation was developed. We used an oversegmentation strategy for partitioning knee images int…
Friedrich-Alexander-Universität Erlangen-Nürnberg（弗里德里希-亚历山大-埃尔兰根-纽伦堡大学）；Siemens Healthcare GmbH（西门子医疗保健有限公司）；Hochschule Furtwangen（富特旺根应用技术大学）；BG Trauma Center Ludwigshafen（路德维希港BG创伤中心）
X-ray based measurement and guidance are commonly used tools in orthopaedic surgery to facilitate a minimally invasive workflow. Typically, a surgical planning is first performed using knowledge of bone morphology and anatomical landmarks. Information about bone location then serves as a prior for registration during overlay of the planning on intra-operative X-ray images. Performing these steps manually however is prone to intra-rater/inter-rater variability and increases task complexity for the surgeon. To remedy these issues, we propose an automatic framework for planning and subsequent ove…
The aim of this study was to investigate the influence of MRI and patient data on the prediction of knee osteoarthritis (OA) incidence using different deep learning architectures. Knee OA incidence within 24 months was predicted using the intermediate-weighted turbo spin-echo (IW-TSE) sequence of 593 patients from the Osteoarthritis Initiative. To extract a region of interest containing the knee joint from the IW-TSE sequence, a U-Net model was trained and used to segment bone on a dual echo steady state (DESS) sequence. Subsequently, IW-TSE and DESS sequences were registered and the DESS segm…
University of Oulu（奥卢大学）；Oulu University Hospital（奥卢大学医院）；Medical Research Center, University of Oulu and Oulu University Hospital（奥卢大学与奥卢大学医院医学研究中心）
Knee osteoarthritis (OA) is very common progressive and degenerative musculoskeletal disease worldwide creates a heavy burden on patients with reduced quality of life and also on society due to financial impact. Therefore, any attempt to reduce the burden of the disease could help both patients and society. In this study, we propose a fully automated novel method, based on combination of joint shape and convolutional neural network (CNN) based bone texture features, to distinguish between the knee radiographs with and without radiographic osteoarthritis. Moreover, we report the first attempt a…
Validation of musculoskeletal segmentation model with uncertainty estimation for bone and muscle assessment in hip-to-knee clinical CT images
Nara Institute of Science and Technology（奈良先端科学技术大学院大学）；Osaka University（大阪大学）；Keio University School of Medicine（庆应义塾大学医学部）；Hitachi Ltd.（日立制作所）；Ehime University（爱媛大学）
Johns Hopkins University（约翰斯·霍普金斯大学）；University of British Columbia（不列颠哥伦比亚大学）
Due to imaging artifacts and low signal-to-noise ratio in ultrasound images, automatic bone surface segmentation networks often produce fragmented predictions that can hinder the success of ultrasound-guided computer-assisted surgical procedures. Existing pixel-wise predictions often fail to capture the accurate topology of bone tissues due to a lack of supervision to enforce connectivity. In this work, we propose an orientation-guided graph convolutional network to improve connectivity while segmenting the bone surface. We also propose an additional supervision on the orientation of the bone …
3D Reconstruction from Arthroscopic Images using NeRF: a preliminary in-silico study
LaTIM - UMR 1101 INSERM（INSERM LaTIM联合研究单位）；University of Western Brittany（布列塔尼大学）；IMT Atlantique（大西洋理工大学）；Brest University Hospital（布雷斯特大学医院）；Universidad de Alcala（阿尔卡拉大学）；INSA Centre Val de Loire（卢瓦尔河谷国立应用科学学院）；Rennes University Hospital（雷恩大学医院）
Bones are always wrapped by soft tissues. As a result, bones in their X-ray images are obscured and become unclear. In this paper, we tackle this problem and propose a novel task to virtually decompose the soft tissue and bone by image processing algorithms. This task is fundamentally different from segmentation because the decomposed images share the same imaging domain. Our decomposition task is also fundamentally different from the conventional image enhancement. We propose a new mathematical model for such decomposition. Our model is ill-posed and thus it requires some priors. With proper …
Computer-Aided Osteoporosis Diagnosis Using Transfer Learning with Enhanced Features from Stacked Deep Learning Modules
Bangladesh Army University of Science and Technology（孟加拉国陆军科技大学）；Brac University（BRAC大学）；National Institute of Textile Engineering and Research (NITER)（国家纺织工程与研究所（NITER））；University of Dhaka（达卡大学）
Background: Object detection in radiograph computer vision has largely benefited from progress in deep convolutional neural networks and can, for example, annotate a radiograph with a box around a knee joint or intervertebral disc. Is deep learning capable of detect small (less than 1% of the image) in radiographs? And how many radiographs do we need use when re-training a deep learning model? Methods: We annotated 396 radiographs of left and right carpi dorsal 75 medial to palmarolateral oblique (DMPLO) projection with the location of radius, proximal row of carpal bones, distal row of carpal…
Time-efficient combined morphologic and quantitative joint MRI based on clinical image contrasts -- An exploratory in-situ study of standardized cartilage defects
Harbin Institute of Technology（哈尔滨工业大学）；the People's Liberation Army General Hospital（中国人民解放军总医院）
Cochlear implantation is currently the most effective treatment for patients with severe deafness, but mastering cochlear implantation is extremely challenging because the temporal bone has extremely complex and small three-dimensional anatomical structures, and it is important to avoid damaging the corresponding structures when performing surgery. The spatial location of the relevant anatomical tissues within the target area needs to be determined using CT prior to the procedure. Considering that the target structures are too small and complex, the time required for manual segmentation is too…
Image Sciences Institute, University Medical Center Utrecht（乌得勒支大学医学中心影像科学研究所）；Department of Orthopedics, University Medical Center Utrecht（乌得勒支大学医学中心骨科）；MRIguidance B.V.（MRIguidance有限公司（乌得勒支））；University Medical Center Utrecht（乌得勒支大学医学中心）
Purpose: To assess the feasibility of deep learning-based high resolution synthetic CT generation from MRI scans of the lower arm for orthopedic applications. Methods: A conditional Generative Adversarial Network was trained to synthesize CT images from multi-echo MR images. A training set of MRI and CT scans of 9 ex vivo lower arms was acquired and the CT images were registered to the MRI images. Three-fold cross-validation was applied to generate independent results for the entire dataset. The synthetic CT images were quantitatively evaluated with the mean absolute error metric, and Dice sim…
A solution for co-locating 2D histology images in 3D for histology-to-CT and MR image registration: closing the loop for bone sarcoma treatment planning
Deep Learning for Predicting Progression of Patellofemoral Osteoarthritis Based on Lateral Knee Radiographs, Demographic Data and Symptomatic Assessments
University of Oulu（奥卢大学）；Lund University（隆德大学）；Diakonhjemmet Hospital（迪亚科涅米特医院）；Juntendo University（顺天堂大学）；Oulu University Hospital（奥卢大学医院）
IMT Atlantique（大西洋国立高等矿业电信学院）；LaTIM UMR 1101, Inserm（法国国家健康与医学研究院LaTIM UMR 1101实验室）；CHRU de Brest（布雷斯特大学区域医院中心）；SCMIA, SIU（SIU SCMIA）
Statistical shape models (SSMs) are a popular tool to conduct morphological analysis of anatomical structures which is a crucial step in clinical practices. However, shape representations through SSMs are based on shape coefficients and lack an explicit one-to-one relationship with anatomical measures of clinical relevance. While a shape coefficient embeds a combination of anatomical measures, a formalized approach to find the relationship between them remains elusive in the literature. This limits the use of SSMs to subjective evaluations in clinical practices. We propose a novel SSM controll…
A knee cannot have lung disease: out-of-distribution detection with in-distribution voting using the medical example of chest X-ray classification
Munich Institute of Biomedical Engineering（慕尼黑生物医学工程研究所）；School of Computation, Information, and Technology（计算、信息与技术学院）；Technical University of Munich（慕尼黑工业大学）；Institute for History and Ethics in Medicine（医学史与医学伦理学研究所）；Munich School of Technology in Society（慕尼黑技术与社会学院）
From Variability To Accuracy: Conditional Bernoulli Diffusion Models with Consensus-Driven Correction for Thin Structure Segmentation
Department of Software Convergence, Seoul Women's University, Seoul, Republic of Korea（首尔女性大学软件融合系）；Department of Pediatric Neurosurgery, Craniofacial Reforming and Reconstruction Clinic, Yonsei University College of Medicine, Seoul, Republic of Korea（延世大学医学院小儿神经外科及颅面整复与重建诊所）
