We present an end-to-end Convolutional Neural Network (CNN) approach for 3D reconstruction of knee bones directly from two bi-planar X-ray images. Clinically, capturing the 3D models of the bones is crucial for surgical planning, implant fitting, and postoperative evaluation. X-ray imaging significantly reduces the exposure of patients to ionizing radiation compared to Computer Tomography (CT) imaging, and is much more common and inexpensive compared to Magnetic Resonance Imaging (MRI) scanners. However, retrieving 3D models from such 2D scans is extremely challenging. In contrast to the common approach of statistically modeling the shape of each bone, our deep network learns the distribution of the bones' shapes directly from the training images. We train our model with both supervised and unsupervised losses using Digitally Reconstructed Radiograph (DRR) images generated from CT scans. To apply our model to X-Ray data, we use style transfer to transform between X-Ray and DRR modalities. As a result, at test time, without further optimization, our solution directly outputs a 3D reconstruction from a pair of bi-planar X-ray images, while preserving geometric constraints. Our results indicate that our deep learning model is very efficient, generalizes well and produces high quality reconstructions.
The University of Queensland（昆士兰大学）；Australian e-Health Research Centre（澳大利亚电子健康研究中心）；Commonwealth Scientific and Industrial Research Organisation（联邦科学与工业研究组织）
In medical image analysis, automated segmentation of multi-component anatomical structures, which often have a spectrum of potential anomalies and pathologies, is a challenging task. In this work, we develop a multi-step approach using U-Net-based neural networks to initially detect anomalies (bone marrow lesions, bone cysts) in the distal femur, proximal tibia and patella from 3D magnetic resonance (MR) images of the knee in individuals with varying grades of osteoarthritis. Subsequently, the extracted data are used for downstream tasks involving semantic segmentation of individual bone and c…
The anatomical axis of long bones is an important reference line for guiding fracture reduction and assisting in the correct placement of guide pins, screws, and implants in orthopedics and trauma surgery. This study investigates an automatic approach for detection of such axes on X-ray images based on the segmentation contour of the bone. For this purpose, we use the medically established two-line method and translate it into a learning-based approach. The proposed method is evaluated on 38 clinical test images of the femoral and tibial bone and achieves a median angulation error of 0.19° and…
CT-based Subchondral Bone Microstructural Analysis in Knee Osteoarthritis via MR-Guided Distillation Learning
School of Biomedical Engineering, Shanghai Jiao Tong University（上海交通大学生物医学工程学院）；Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine（上海交通大学医学院附属第九人民医院）
Semi-Supervised Bone Marrow Lesion Detection from Knee MRI Segmentation Using Mask Inpainting Models
Gordon Center for Medical Imaging, Harvard Medical School and Massachusetts General Hospital（哈佛医学院与麻省总医院戈登医学成像中心）；Boston University（波士顿大学）；Seidenberg School of CSIS, Pace University（佩斯大学塞登伯格计算机科学与信息系统学院）；Ewha Womans University（梨花女子大学）
University of Oulu（奥卢大学）；Oulu University Hospital（奥卢大学医院）；Erasmus MC, University Medical Center（伊拉斯谟医学中心大学医院）；Medical Research Center, University of Oulu and Oulu University Hospital（奥卢大学与奥卢大学医院医学研究中心）
The purposes of this study were to investigate: 1) the effect of placement of region-of-interest (ROI) for texture analysis of subchondral bone in knee radiographs, and 2) the ability of several texture descriptors to distinguish between the knees with and without radiographic osteoarthritis (OA). Bilateral posterior-anterior knee radiographs were analyzed from the baseline of OAI and MOST datasets. A fully automatic method to locate the most informative region from subchondral bone using adaptive segmentation was developed. We used an oversegmentation strategy for partitioning knee images int…
Validation of musculoskeletal segmentation model with uncertainty estimation for bone and muscle assessment in hip-to-knee clinical CT images
Nara Institute of Science and Technology（奈良先端科学技术大学院大学）；Osaka University（大阪大学）；Keio University School of Medicine（庆应义塾大学医学部）；Hitachi Ltd.（日立制作所）；Ehime University（爱媛大学）
Johns Hopkins University（约翰斯·霍普金斯大学）；University of British Columbia（不列颠哥伦比亚大学）
Due to imaging artifacts and low signal-to-noise ratio in ultrasound images, automatic bone surface segmentation networks often produce fragmented predictions that can hinder the success of ultrasound-guided computer-assisted surgical procedures. Existing pixel-wise predictions often fail to capture the accurate topology of bone tissues due to a lack of supervision to enforce connectivity. In this work, we propose an orientation-guided graph convolutional network to improve connectivity while segmenting the bone surface. We also propose an additional supervision on the orientation of the bone …
Friedrich-Alexander-Universität Erlangen-Nürnberg（弗里德里希-亚历山大-埃尔兰根-纽伦堡大学）；Siemens Healthcare GmbH（西门子医疗保健有限公司）；Hochschule Furtwangen（富特旺根应用技术大学）；BG Trauma Center Ludwigshafen（路德维希港BG创伤中心）
X-ray based measurement and guidance are commonly used tools in orthopaedic surgery to facilitate a minimally invasive workflow. Typically, a surgical planning is first performed using knowledge of bone morphology and anatomical landmarks. Information about bone location then serves as a prior for registration during overlay of the planning on intra-operative X-ray images. Performing these steps manually however is prone to intra-rater/inter-rater variability and increases task complexity for the surgeon. To remedy these issues, we propose an automatic framework for planning and subsequent ove…
Computer-Aided Osteoporosis Diagnosis Using Transfer Learning with Enhanced Features from Stacked Deep Learning Modules
Bangladesh Army University of Science and Technology（孟加拉国陆军科技大学）；Brac University（BRAC大学）；National Institute of Textile Engineering and Research (NITER)（国家纺织工程与研究所（NITER））；University of Dhaka（达卡大学）
UMedNeRF: Uncertainty-aware Single View Volumetric Rendering for Medical Neural Radiance Fields
Chengdu University of Information Technology（成都信息工程大学）；Purdue University（普渡大学）；University at Buffalo, State University of New York（纽约州立大学布法罗分校）；University at Albany, State University of New York（纽约州立大学奥尔巴尼分校）
The aim of this study was to investigate the influence of MRI and patient data on the prediction of knee osteoarthritis (OA) incidence using different deep learning architectures. Knee OA incidence within 24 months was predicted using the intermediate-weighted turbo spin-echo (IW-TSE) sequence of 593 patients from the Osteoarthritis Initiative. To extract a region of interest containing the knee joint from the IW-TSE sequence, a U-Net model was trained and used to segment bone on a dual echo steady state (DESS) sequence. Subsequently, IW-TSE and DESS sequences were registered and the DESS segm…
Magnetic Resonance Images (MRIs) are extremely used in the medical field to detect and better understand diseases. In order to fasten automatic processing of scans and enhance medical research, this project focuses on automatically segmenting targeted parts of MRIs and generating new MRI datasets from random noise. More specifically, a Deep Neural Network architecture called U-net is used to segment bones and cartilages of Knee MRIs, and several Generative Adversarial Networks (GANs) are compared and tuned to create new realistic and high quality brain MRIs that can be used as training set for…
University of Westminster（威斯敏斯特大学）；Calico Life Sciences LLC（Calico生命科学有限责任公司）
An end-to-end image analysis pipeline is presented for the abdominal MRI protocol used in the UK Biobank on the first 38,971 participants. Emphasis is on the processing steps necessary to ensure a high-level of data quality and consistency is produced in order to prepare the datasets for downstream quantitative analysis, such as segmentation and parameter estimation. Quality control procedures have been incorporated to detect and, where possible, correct issues in the raw data. Detection of fat-water swaps in the Dixon series is performed by a deep learning model and corrected automatically. B…
Deep Learning for Predicting Progression of Patellofemoral Osteoarthritis Based on Lateral Knee Radiographs, Demographic Data and Symptomatic Assessments
University of Oulu（奥卢大学）；Lund University（隆德大学）；Diakonhjemmet Hospital（迪亚科涅米特医院）；Juntendo University（顺天堂大学）；Oulu University Hospital（奥卢大学医院）
A knee cannot have lung disease: out-of-distribution detection with in-distribution voting using the medical example of chest X-ray classification
Munich Institute of Biomedical Engineering（慕尼黑生物医学工程研究所）；School of Computation, Information, and Technology（计算、信息与技术学院）；Technical University of Munich（慕尼黑工业大学）；Institute for History and Ethics in Medicine（医学史与医学伦理学研究所）；Munich School of Technology in Society（慕尼黑技术与社会学院）
Purpose: To present a computational procedure for accelerated, calibrationless magnetic resonance image (Cl-MRI) reconstruction that is fast, memory efficient, and scales to high-dimensional imaging. Theory and Methods: Cl-MRI methods can enable high acceleration rates and flexible sampling patterns, but their clinical application is limited by computational complexity and large memory footprint. The proposed computational procedure, HIgh-dimensional fast ConvolU-tional framework (HICU), provides fast, memory-efficient recovery of unsampled k-space points. For demonstration, HICU is applied to…
