G1020: A Benchmark Retinal Fundus Image Dataset for Computer-Aided Glaucoma Detection
Technische Universität Kaiserslautern（凯泽斯劳滕工业大学）；German Research Center for Artificial Intelligence GmbH (DFKI)（德国人工智能研究中心）；Opthalmology Clinic（眼科诊所）；National University of Science and Technology (NUST)（国立科技大学）；National Center of Artificial Intelligence（国家人工智能中心）；Smart Data and Knowledge Services（智能数据与知识服务部）
Muhammad Naseer Bajwa, Gur Amrit Pal Singh, Wolfgang Neumeier, Muhammad Imran Malik, Andreas Dengel, Sheraz Ahmed
Scarcity of large publicly available retinal fundus image datasets for automated glaucoma detection has been the bottleneck for successful application of artificial intelligence towards practical Computer-Aided Diagnosis (CAD). A few small datasets that are available for research community usually suffer from impractical image capturing conditions and stringent inclusion criteria. These shortcomings in already limited choice of existing datasets make it challenging to mature a CAD system so that it can perform in real-world environment. In this paper we present a large publicly available retinal fundus image dataset for glaucoma classification called G1020. The dataset is curated by conforming to standard practices in routine ophthalmology and it is expected to serve as standard benchmark dataset for glaucoma detection. This database consists of 1020 high resolution colour fundus images and provides ground truth annotations for glaucoma diagnosis, optic disc and optic cup segmentation, vertical cup-to-disc ratio, size of neuroretinal rim in inferior, superior, nasal and temporal quadrants, and bounding box location for optic disc. We also report baseline results by conducting extensive experiments for automated glaucoma diagnosis and segmentation of optic disc and optic cup.
Observing retinal fundus images by an ophthalmologist is a major diagnosis approach for glaucoma. However, it is still difficult to distinguish the features of the lesion solely through manual observations, especially, in glaucoma early phase. In this paper, we present two deep learning-based automated algorithms for glaucoma detection and optic disc and cup segmentation. We utilize the attention mechanism to learn pixel-wise features for accurate prediction. In particular, we present two convolutional neural networks that can focus on learning various pixel-wise level features. In addition, w…
Shanghai Jiao Tong University（上海交通大学）；the Second Affiliated Hospital of Zhejiang University, College of Medicine（浙江大学医学院附属第二医院）
The early diagnosis and screening of glaucoma are important for patients to receive treatment in time and maintain eyesight. Nowadays, deep learning (DL) based models have been successfully used for computer-aided diagnosis (CAD) of glaucoma from retina fundus images. However, a DL model pre-trained using a dataset from one hospital center may have poor performance on a dataset from another new hospital center and therefore its applications in the real scene are limited. In this paper, we propose a self-adaptive transfer learning (SATL) strategy to fill the domain gap between multicenter datas…
GrInAdapt: Scaling Retinal Vessel Structural Map Segmentation Through Grounding, Integrating and Adapting Multi-device, Multi-site, and Multi-modal Fundus Domains
Department of Bioengineering, University of Washington（华盛顿大学生物工程系）；Department of Electrical and Computer Engineering, University of Washington（华盛顿大学电气与计算机工程系）；Department of Ophthalmology, University of Washington（华盛顿大学眼科系）
Airdoc LLC（爱丁堡医疗科技有限公司）；Monash University（莫纳什大学）；Nanjing University of Posts and Telecommunications（南京邮电大学）
For decades, advances in retinal imaging technology have enabled effective diagnosis and management of retinal disease using fundus cameras. Recently, ultra-wide-field (UWF) fundus imaging by Optos camera is gradually put into use because of its broader insights on fundus for some lesions that are not typically seen in traditional fundus images. Research on traditional fundus images is an active topic but studies on UWF fundus images are few. One of the most important reasons is that UWF fundus images are hard to obtain. In this paper, for the first time, we explore domain adaptation from the …
Harvard Glaucoma Fairness: A Retinal Nerve Disease Dataset for Fairness Learning and Fair Identity Normalization
Harvard Medical School（哈佛医学院）；Massachusetts Eye and Ear（麻省眼耳医院）；Schepens Eye Research Institute（谢彭斯眼科研究所）；Eye and Vision Research Institute（眼科与视觉研究所）；Icahn School of Medicine at Mount Sinai（西奈山伊坎医学院）
McGill University（麦吉尔大学）；University of British Columbia（不列颠哥伦比亚大学）；University of Ottawa（渥太华大学）
Deep learning has seen tremendous interest in medical imaging, particularly in the use of convolutional neural networks (CNNs) for developing automated diagnostic tools. The facility of its non-invasive acquisition makes retinal fundus imaging amenable to such automated approaches. Recent work in analyzing fundus images using CNNs relies on access to massive data for training and validation - hundreds of thousands of images. However, data residency and data privacy restrictions stymie the applicability of this approach in medical settings where patient confidentiality is a mandate. Here, we sh…
PALM: Open Fundus Photograph Dataset with Pathologic Myopia Recognition and Anatomical Structure Annotation
Baidu Inc.（百度公司）；Sun Yat-sen University（中山大学）；Agency for Science, Technology and Research（新加坡科技研究局）；CONICET（阿根廷国家科学与技术研究理事会）；UNICEN（阿根廷国立中央大学）；Medical University of Vienna（维也纳医科大学）
Early detection of retinal diseases is one of the most important means of preventing partial or permanent blindness in patients. In this research, a novel multi-label classification system is proposed for the detection of multiple retinal diseases, using fundus images collected from a variety of sources. First, a new multi-label retinal disease dataset, the MuReD dataset, is constructed, using a number of publicly available datasets for fundus disease classification. Next, a sequence of post-processing steps is applied to ensure the quality of the image data and the range of diseases, present …
MultiEYE: Dataset and Benchmark for OCT-Enhanced Retinal Disease Recognition from Fundus Images
Hong Kong University of Science and Technology（香港科技大学）；Guangdong Weiren Meditech Co., Ltd.（广东伟仁医疗科技有限公司）；Yunnan United Vision Innovations Technology Co., Ltd.（云南联合视力创新科技有限公司）；Guangdong Hospital of Integrated Traditional Chinese and Western Medicine（广东省中西医结合医院）；Second People’s Hospital of Foshan（佛山市第二人民医院）
RVD: A Handheld Device-Based Fundus Video Dataset for Retinal Vessel Segmentation
The University of Queensland（昆士兰大学）；University of Technology Sydney（悉尼科技大学）；Australian National University（澳大利亚国立大学）；University of New South Wales（新南威尔士大学）；Victoria University（维多利亚大学）；Deakin University（迪肯大学）
The Chinese University of Hong Kong（香港中文大学）；Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）
Glaucoma is a leading cause of irreversible blindness. Accurate segmentation of the optic disc (OD) and cup (OC) from fundus images is beneficial to glaucoma screening and diagnosis. Recently, convolutional neural networks demonstrate promising progress in joint OD and OC segmentation. However, affected by the domain shift among different datasets, deep networks are severely hindered in generalizing across different scanners and institutions. In this paper, we present a novel patchbased Output Space Adversarial Learning framework (pOSAL) to jointly and robustly segment the OD and OC from diffe…
Renmin University of China（中国人民大学）；Visionary Intelligence Ltd.（远景智能有限公司）
Glaucoma is a severe blinding disease, for which automatic detection methods are urgently needed to alleviate the scarcity of ophthalmologists. Many works have proposed to employ deep learning methods that involve the segmentation of optic disc and cup for glaucoma detection, in which the segmentation process is often considered merely as an upstream sub-task. The relationship between fundus images and segmentation masks in terms of joint decision-making in glaucoma assessment is rarely explored. We propose a novel segmentation-based information extraction and amalgamation method for the task …
Tampere University（坦佩雷大学）；Izmir University of Economics（伊兹密尔经济大学）；Qatar University（卡塔尔大学）；Eskişehir Osmangazi University（埃斯基谢希尔奥斯曼加齐大学）
Glaucoma leads to permanent vision disability by damaging the optical nerve that transmits visual images to the brain. The fact that glaucoma does not show any symptoms as it progresses and cannot be stopped at the later stages, makes it critical to be diagnosed in its early stages. Although various deep learning models have been applied for detecting glaucoma from digital fundus images, due to the scarcity of labeled data, their generalization performance was limited along with high computational complexity and special hardware requirements. In this study, compact Self-Organized Operational N…
Segmenting blood vessels in fundus imaging plays an important role in medical diagnosis. Many algorithms have been proposed. While deep Neural Networks have been attracting enormous attention from computer vision community recent years and several novel works have been done in terms of its application in retinal blood vessel segmentation, most of them are based on supervised learning which requires amount of labeled data, which is both scarce and expensive to obtain. We leverage the power of Deep Convolutional Neural Networks (DCNN) in feature learning, in this work, to achieve this ultimate g…
One of the leading causes of blindness is glaucoma, which is challenging to detect since it remains asymptomatic until the symptoms are severe. Thus, diagnosis is usually possible until the markers are easy to identify, i.e., the damage has already occurred. Early identification of glaucoma is generally made based on functional, structural, and clinical assessments. However, due to the nature of the disease, researchers still debate which markers qualify as a consistent glaucoma metric. Deep learning methods have partially solved this dilemma by bypassing the marker identification stage and an…
With the advancement of powerful image processing and machine learning techniques, CAD has become ever more prevalent in all fields of medicine including ophthalmology. Since optic disc is the most important part of retinal fundus image for glaucoma detection, this paper proposes a two-stage framework that first detects and localizes optic disc and then classifies it into healthy or glaucomatous. The first stage is based on RCNN and is responsible for localizing and extracting optic disc from a retinal fundus image while the second stage uses Deep CNN to classify the extracted disc into health…
University of Engineering and Technology Taxila（塔克西拉工程技术大学）
Glaucoma is a severe eye disease that is known to deteriorate optic never fibers, causing cup size to increase, which could result in permanent loss of vision. Glaucoma is the second leading cause of blindness after cataract, but glaucoma being more dangerous as it is not curable. Early diagnoses and treatment of glaucoma can help to slow the progression of glaucoma and its damages. For the detection of glaucoma, the Cup to Disc ratio (CDR) provides significant information. The CDR depends heavily on the accurate segmentation of cup and disc regions. In this paper, we have proposed a modified …
Cameron Heights Collegiate Institute（卡梅伦高地学院）；University of Waterloo（滑铁卢大学）
We propose a new method for training convolutional neural networks which integrates reinforcement learning along with supervised learning and use ti for transfer learning for classification of glaucoma from colored fundus images. The training method uses hill climbing techniques via two different climber types, viz "random movment" and "random detection" integrated with supervised learning model though stochastic gradient descent with momentum (SGDM) model. The model was trained and tested using the Drishti GS and RIM-ONE-r2 datasets having glaucomatous and normal fundus images. The performanc…
Mohamed bin Zayed University of Artificial Intelligence（穆罕默德·本·扎耶德人工智能大学）
Glaucoma is one of the most severe eye diseases, characterized by rapid progression and leading to irreversible blindness. It is often the case that diagnostics is carried out when one's sight has already significantly degraded due to the lack of noticeable symptoms at early stage of the disease. Regular glaucoma screenings of the population shall improve early-stage detection, however the desirable frequency of etymological checkups is often not feasible due to the excessive load imposed by manual diagnostics on limited number of specialists. Considering the basic methodology to detect glauco…
KU Leuven（鲁汶大学）；UZ Leuven（鲁汶大学医院）；University of Porto（波尔图大学）；Centro Hospitalar e Universitário São João（圣若昂大学医院中心）；Hasselt University（哈瑟尔特大学）；University of Antwerp（安特卫普大学）；Flemish Institute for Technological Research（弗拉芒技术研究院）
Although unprecedented sensitivity and specificity values are reported, recent glaucoma detection deep learning models lack in decision transparency. Here, we propose a methodology that advances explainable deep learning in the field of glaucoma detection and vertical cup-disc ratio (VCDR), an important risk factor. We trained and evaluated deep learning models using fundus images that underwent a certain cropping policy. We defined the crop radius as a percentage of image size, centered on the optic nerve head (ONH), with an equidistant spaced range from 10%-60% (ONH crop policy). The inverse…
National University of Sciences and Technology（国立科技大学）；Khalifa University（哈利法大学）
Objective: Glaucoma is the second leading cause of blindness worldwide. Glaucomatous progression can be easily monitored by analyzing the degeneration of retinal ganglion cells (RGCs). Many researchers have screened glaucoma by measuring cup-to-disc ratios from fundus and optical coherence tomography scans. However, this paper presents a novel strategy that pays attention to the RGC atrophy for screening glaucomatous pathologies and grading their severity. Methods: The proposed framework encompasses a hybrid convolutional network that extracts the retinal nerve fiber layer, ganglion cell with …
Sun Yat-sen University（中山大学）；Baidu Inc.（百度公司）；Agency for Science, Technology and Research（新加坡科技研究局）；CONICET（阿根廷国家科学技术研究委员会）；UNICEN（阿根廷中央国立大学）；Medical University of Vienna（维也纳医科大学）；VUNO Inc.（VUNO公司）；Tencent（腾讯）
With the rapid development of artificial intelligence (AI) in medical image processing, deep learning in color fundus photography (CFP) analysis is also evolving. Although there are some open-source, labeled datasets of CFPs in the ophthalmology community, large-scale datasets for screening only have labels of disease categories, and datasets with annotations of fundus structures are usually small in size. In addition, labeling standards are not uniform across datasets, and there is no clear information on the acquisition device. Here we release a multi-annotation, multi-quality, and multi-dev…
Southern University of Science and Technology（南方科技大学）；The University of Hong Kong（香港大学）
Glaucoma is one of the ophthalmic diseases that may cause blindness, for which early detection and treatment are very important. Fundus images and optical coherence tomography (OCT) images are both widely-used modalities in diagnosing glaucoma. However, existing glaucoma grading approaches mainly utilize a single modality, ignoring the complementary information between fundus and OCT. In this paper, we propose an efficient multi-modality supervised contrastive learning framework, named COROLLA, for glaucoma grading. Through layer segmentation as well as thickness calculation and projection, re…
Inception Institute of Artificial Intelligence（人工智能起源研究所）
Retinal fundus images are widely used for the clinical screening and diagnosis of eye diseases. However, fundus images captured by operators with various levels of experience have a large variation in quality. Low-quality fundus images increase uncertainty in clinical observation and lead to the risk of misdiagnosis. However, due to the special optical beam of fundus imaging and structure of the retina, natural image enhancement methods cannot be utilized directly to address this. In this paper, we first analyze the ophthalmoscope imaging system and simulate a reliable degradation of major inf…
University of Nevada, Reno（内华达大学里诺分校）；Deakin University（迪肯大学）；Houston Eye Associates（休斯顿眼科协会）；University of Nevada School of Medicine（内华达大学医学院）
Carrying out clinical diagnosis of retinal vascular degeneration using Fluorescein Angiography (FA) is a time consuming process and can pose significant adverse effects on the patient. Angiography requires insertion of a dye that may cause severe adverse effects and can even be fatal. Currently, there are no non-invasive systems capable of generating Fluorescein Angiography images. However, retinal fundus photography is a non-invasive imaging technique that can be completed in a few seconds. In order to eliminate the need for FA, we propose a conditional generative adversarial network (GAN) to…
University of California, Santa Barbara（加利福尼亚大学圣巴巴拉分校）
Fundus photography has routinely been used to document the presence and severity of retinal degenerative diseases such as age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR) in clinical practice, for which the fovea and optic disc (OD) are important retinal landmarks. However, the occurrence of lesions, drusen, and other retinal abnormalities during retinal degeneration severely complicates automatic landmark detection and segmentation. Here we propose HBA-U-Net: a U-Net backbone enriched with hierarchical bottleneck attention. The network consists of a novel bottle…
Tsinghua-Berkeley Shenzhen Institute（清华-伯克利深圳学院）；University of California, Berkeley（加州大学伯克利分校）；Affiliated Eye Hospital of Nanchang University（南昌大学附属眼科医院）
Retinopathy of prematurity (ROP) is an abnormal blood vessel development in the retina of a prematurely-born infant or an infant with low birth weight. ROP is one of the leading causes for infant blindness globally. Early detection of ROP is critical to slow down and avert the progression to vision impairment caused by ROP. Yet there is limited awareness of ROP even among medical professionals. Consequently, dataset for ROP is limited if ever available, and is in general extremely imbalanced in terms of the ratio between negative images and positive ones. In this study, we formulate the proble…
Eindhoven University of Technology（埃因霍温理工大学）；Maastricht University Medical Center+（马斯特里赫特大学医学中心+）
Type 2 Diabetes (T2D) is a chronic metabolic disorder that can lead to blindness and cardiovascular disease. Information about early stage T2D might be present in retinal fundus images, but to what extent these images can be used for a screening setting is still unknown. In this study, deep neural networks were employed to differentiate between fundus images from individuals with and without T2D. We investigated three methods to achieve high classification performance, measured by the area under the receiver operating curve (ROC-AUC). A multi-target learning approach to simultaneously output r…
Technical University of Munich（慕尼黑工业大学）；Heritage Institute of Technology（印度传统理工学院）
Automatic evaluation of the retinal fundus image is emerging as one of the most important tools for early detection and treatment of progressive eye diseases like Glaucoma. Glaucoma results to a progressive degeneration of vision and is characterized by the deformation of the shape of optic cup and the degeneration of the blood vessels resulting in the formation of a notch along the neuroretinal rim. In this paper, we propose a deep learning-based pipeline for automatic segmentation of optic disc (OD) and optic cup (OC) regions from Digital Fundus Images (DFIs), thereby extracting distinct fea…
In recent years, several automatic segmentation methods have been proposed for blood vessels in retinal fundus images, ranging from using cheap and fast trainable filters to complicated neural networks and even deep learning. One example of a filted-based segmentation method is B-COSFIRE. In this approach the image filter is trained with example prototype patterns, to which the filter becomes selective by finding points in a Difference of Gaussian response on circles around the center with large intensity variation. In this paper we discuss and evaluate several of these vessel segmentation met…
Baidu, Healthcare Group（百度医疗健康集团）；State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University（中山大学中山眼科中心眼科学国家重点实验室）；Institute of High Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR)（新加坡科技研究局高性能计算研究所）
GAMMA Challenge is organized to encourage the AI models to screen the glaucoma from a combination of 2D fundus image and 3D optical coherence tomography volume, like the ophthalmologists.
Generation of Structurally Realistic Retinal Fundus Images with Diffusion Models
Seoul National University College of Medicine（首尔大学医学院）；Seoul National University Bundang Hospital（首尔大学盆唐医院）；VUNO, Inc.（VUNO公司）；Kookmin University（国民大学）
Indian Institute of Science（印度科学学院）；University of Southern California（南加州大学）
Optic disc (OD) and optic cup (OC) are regions of prominent clinical interest in a retinal fundus image. They are the primary indicators of a glaucomatous condition. With the advent and success of deep learning for healthcare research, several approaches have been proposed for the segmentation of important features in retinal fundus images. We propose a novel approach for the simultaneous segmentation of the OD and OC using a residual encoder-decoder network (REDNet) based regional convolutional neural network (RCNN). The RED-RCNN is motivated by the Mask RCNN (MRCNN). Performance comparisons …
Explainable Convolutional Neural Networks for Retinal Fundus Classification and Cutting-Edge Segmentation Models for Retinal Blood Vessels from Fundus Images
Ahsanullah University of Science and Technology（阿萨努拉科技大学）
Fundus-Enhanced Disease-Aware Distillation Model for Retinal Disease Classification from OCT Images
The Hong Kong University of Science and Technology（香港科技大学）；Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine（广东省中西医结合医院）；Guangdong Weiren Meditech Co., Ltd（广东唯仁医疗科技有限公司）
Singapore Eye Research Institute, Singapore National Eye Centre（新加坡眼科研究所，新加坡国家眼科中心）；National University of Singapore（新加坡国立大学）；Vilnius University（维尔纽斯大学）；Vilnius University Hospital Santaros Klinikos（维尔纽斯大学桑塔罗斯诊所医院）；Aravind Eye Care Systems（阿拉文眼科医疗系统）；Duke-NUS Medical School（杜克-新加坡国立大学医学院）；Institute for Molecular and Clinical Ophthalmology（分子与临床眼科研究所）
Purpose: To assess whether the three-dimensional (3D) structural configuration of the central retinal vessel trunk and its branches (CRVT&B) could be used as a diagnostic marker for glaucoma. Method: We trained a deep learning network to automatically segment the CRVT&B from the B-scans of the optical coherence tomography (OCT) volume of the optic nerve head (ONH). Subsequently, two different approaches were used for glaucoma diagnosis using the structural configuration of the CRVT&B as extracted from the OCT volumes. In the first approach, we aimed to provide a diagnosis using only 3D CNN and…
University of Nevada, Reno（内华达大学雷诺分校）；Deakin University（迪肯大学）；Houston Eye Associates（休斯顿眼科协会）
Fluorescein Angiography (FA) is a technique that employs the designated camera for Fundus photography incorporating excitation and barrier filters. FA also requires fluorescein dye that is injected intravenously, which might cause adverse effects ranging from nausea, vomiting to even fatal anaphylaxis. Currently, no other fast and non-invasive technique exists that can generate FA without coupling with Fundus photography. To eradicate the need for an invasive FA extraction procedure, we introduce an Attention-based Generative network that can synthesize Fluorescein Angiography from Fundus imag…
Accurate measurements of abnormalities like Artery-Vein ratio and tortuosity in fundus images is an actively researched task. Most of the research seems to compute such features independently. However, in this work, we have devised a fully automated technique to measure any vascular abnormalities. This paper is a follow-up paper on vessel topology estimation and extraction, we use the extracted topology to perform A-V state-of-the-art Artery-Vein classification, AV ratio calculation, and vessel tortuosity measurement, all fully automated. Existing techniques tend to only work on the partial re…
Beijing University of Posts and Telecommunications（北京邮电大学）
Accurate retinal vessel segmentation is a challenging problem in color fundus image analysis. An automatic retinal vessel segmentation system can effectively facilitate clinical diagnosis and ophthalmological research. Technically, this problem suffers from various degrees of vessel thickness, perception of details, and contextual feature fusion. For addressing these challenges, a deep learning based method has been proposed and several customized modules have been integrated into the well-known encoder-decoder architecture U-net, which is mainly employed in medical image segmentation. Structu…
University of Calgary（卡尔加里大学）；Istanbul Medipol University（伊斯坦布尔梅迪波尔大学）；University of Southern Denmark（南丹麦大学）
The vascular structure of blood vessels is important in diagnosing retinal conditions such as glaucoma and diabetic retinopathy. Accurate segmentation of these vessels can help in detecting retinal objects such as the optic disc and optic cup and hence determine if there are damages to these areas. Moreover, the structure of the vessels can help in diagnosing glaucoma. The rapid development of digital imaging and computer-vision techniques has increased the potential for developing approaches for segmenting retinal vessels. In this paper, we propose an approach for segmenting retinal vessels t…
University of California, Berkeley（加利福尼亚大学伯克利分校）；International Computer Science Institute（国际计算机科学研究所）；University of California, Davis（加利福尼亚大学戴维斯分校）
Many diseases are classified based on human-defined rubrics that are prone to bias. Supervised neural networks can automate the grading of retinal fundus images, but require labor-intensive annotations and are restricted to the specific trained task. Here, we employed an unsupervised network with Non-Parametric Instance Discrimination (NPID) to grade age-related macular degeneration (AMD) severity using fundus photographs from the Age-Related Eye Disease Study (AREDS). Our unsupervised algorithm demonstrated versatility across different AMD classification schemes without retraining, and achiev…
Universidad Nacional de Colombia（哥伦比亚国立大学）；Fundación Oftalmológica Nacional（国家眼科基金会）；Universidad del Rosario（罗萨里奥大学）
Diabetic retinopathy (DR) is the result of a complication of diabetes affecting the retina. It can cause blindness, if left undiagnosed and untreated. An ophthalmologist performs the diagnosis by screening each patient and analyzing the retinal lesions via ocular imaging. In practice, such analysis is time-consuming and cumbersome to perform. This paper presents a model for automatic DR classification on eye fundus images. The approach identifies the main ocular lesions related to DR and subsequently diagnoses the illness. The proposed method follows the same workflow as the clinicians, provid…
Ultra-widefield (UWF) imaging is a promising modality that captures a larger retinal field of view compared to traditional fundus photography. Previous studies showed that deep learning (DL) models are effective for detecting retinal disease in UWF images, but primarily considered individual diseases under less-than-realistic conditions (excluding images with other diseases, artefacts, comorbidities, or borderline cases; and balancing healthy and diseased images) and did not systematically investigate which regions of the UWF images are relevant for disease detection. We first improve on the s…
Adaptive Multiscale Retinal Diagnosis: A Hybrid Trio-Model Approach for Comprehensive Fundus Multi-Disease Detection Leveraging Transfer Learning and Siamese Networks
