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arXiv 2006.069682020-06-12eess.IVcs.CVcs.LG

Early Detection of Retinopathy of Prematurity (ROP) in Retinal Fundus Images Via Convolutional Neural Networks

Tsinghua-Berkeley Shenzhen Institute（清华-伯克利深圳学院）；University of California, Berkeley（加州大学伯克利分校）；Affiliated Eye Hospital of Nanchang University（南昌大学附属眼科医院）

Xin Guo, Yusuke Kikuchi, Guan Wang, Jinglin Yi, Qiong Zou, Rui Zhou

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Retinopathy of prematurity (ROP) is an abnormal blood vessel development in the retina of a prematurely-born infant or an infant with low birth weight. ROP is one of the leading causes for infant blindness globally. Early detection of ROP is critical to slow down and avert the progression to vision impairment caused by ROP. Yet there is limited awareness of ROP even among medical professionals. Consequently, dataset for ROP is limited if ever available, and is in general extremely imbalanced in terms of the ratio between negative images and positive ones. In this study, we formulate the problem of detecting ROP in retinal fundus images in an optimization framework, and apply state-of-art convolutional neural network techniques to solve this problem. Experimental results based on our models achieve 100 percent sensitivity, 96 percent specificity, 98 percent accuracy, and 96 percent precision. In addition, our study shows that as the network gets deeper, more significant features can be extracted for better understanding of ROP.

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