细胞肌动蛋白皮质的力学：从信号传导到形状变化
Mechanics of the cellular actin cortex: from signalling to shape change
摘要：
肌动蛋白皮层是一层薄薄的肌动蛋白、肌球蛋白和肌动蛋白结合蛋白，位于大多数动物细胞膜的下面。它是高度动态的，并且由于蛋白质周转和肌球蛋白介导的收缩，可以在数十秒的时间尺度上进行重塑。皮层使细胞能够抵抗外部机械应力，控制细胞形状，并允许细胞对其邻居施加力。因此，其机械性能是其生理功能的关键。在这里，我们给出了一个概述皮层的组成，结构和动力学控制皮层力学和细胞形状。我们使用有丝分裂作为一个例子来说明如何全球和局部调节皮质力学引起一系列复杂的细胞形状的变化。
英文摘要：
The actin cortex is a thin layer of actin, myosin, and actin binding proteins that underlies the membrane of most animal cells. It is highly dynamic and can undergo remodelling on time-scales of tens of seconds thanks to protein turnover and myosin-mediated contractions. The cortex enables cells to resist external mechanical stresses, controls cell shape, and allows cells to exert forces on their neighbours. Thus, its mechanical properties are key to its physiological function. Here, we give an overview of how cortex composition, structure, and dynamics control cortex mechanics and cell shape. We use mitosis as an example to illustrate how global and local regulation of cortex mechanics give rise to a complex series of cell shape changes.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
