一个包含膜-皮层耦合和连接动力学的细胞起泡扩散界面模型
A Diffuse Interface Model for Cell Blebbing Including Membrane-Cortex Coupling with Linker Dynamics
摘要：
本文的目的是开发合适的模型，细胞起泡的现象，这使得计算预测的机械效应，包括细胞膜和肌动蛋白皮质的关键相互作用。为了这个原因，我们诉诸于一个两相场模型，该模型使用扩散的膜和皮质的描述，特别是允许通过连接蛋白密度的相互作用的一个合适的描述。除了详细的建模，我们讨论了一些充满活力的方面的模型，并提出了一个数值方案，它允许进行几个计算研究。在这些，我们证明，在实验中发现的几种效果可以重现，特别是水泡形成皮层破裂，这是不可能的，以前的模型没有连接动力学。
英文摘要：
The aim of this paper is to develop suitable models for the phenomenon of cell blebbing, which allow for computational predictions of mechanical effects including the crucial interaction of the cell membrane and the actin cortex. For this sake we resort to a two phase-field model that uses diffuse descriptions of both the membrane and the cortex, which in particular allows for a suitable description of the interaction via linker protein densities. Besides the detailed modelling we discuss some energetic aspects of the models and present a numerical scheme, which allows to carry out several computational studies. In those we demonstrate that several effects found in experiments can be reproduced, in particular bleb formation by cortex rupture, which was not possible by previous models without the linker dynamics.
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