自发性收缩介导的皮层血流在三维环境中产生细胞迁移
Spontaneous contractility--mediated cortical flow generates cell migration in 3-dimensional environments
摘要：
我们提出了一个通用模型的细胞运动产生的肌动蛋白收缩的细胞皮质。我们确定分析动力学不稳定的皮质，并表明，它们触发自发的皮质流，这反过来又可以诱导细胞迁移在3维（3D）的环境，以及水泡形成。这种收缩性为基础的机制，广泛独立的肌动蛋白酶铣，出现作为一种替代的经典图片lamellipodial运动平面基板上。理论预测相比，肿瘤细胞迁移在3D matrigel的实验数据，并建议，这种机制可能是一个一般模式的细胞迁移在3D环境中。
英文摘要：
We present a generic model of cell motility generated by acto-myosin contraction of the cell cortex. We identify analytically dynamical instabilities of the cortex and show that they trigger spontaneous cortical flows which in turn can induce cell migration in 3-dimensional (3D) environments as well as bleb formation. This contractility--based mechanism, widely independent of actin treadmilling, appears as an alternative to the classical picture of lamellipodial motility on flat substrates. Theoretical predictions are compared to experimental data of tumor cells migrating in 3D matrigel and suggest that this mechanism could be a general mode of cell migration in 3D environments.
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