Sleep disorder is one of many neurological diseases that can affect greatly the quality of daily life. It is very burdensome to manually classify the sleep stages to detect sleep disorders. Therefore, the automatic sleep stage classification techniques are needed. However, the previous automatic sleep scoring methods using raw signals are still low classification performance. In this study, we proposed an end-to-end automatic sleep staging framework based on optimal spectral-temporal sleep features using a sleep-edf dataset. The input data were modified using a bandpass filter and then applied to a convolutional neural network model. For five sleep stage classification, the classification performance 85.6% and 91.1% using the raw input data and the proposed input, respectively. This result also shows the highest performance compared to conventional studies using the same dataset. The proposed framework has shown high performance by using optimal features associated with each sleep stage, which may help to find new features in the automatic sleep stage method.
In this paper, we propose a novel method and a practical approach to predicting early onsets of sleep syndromes, including restless leg syndrome, insomnia, based on an algorithm that is comprised of two modules. A Fast Fourier Transform is applied to 30 seconds long epochs of EEG recordings to provide localized time-frequency information, and a deep convolutional LSTM neural network is trained for sleep stage classification. Automating sleep stages detection from EEG data offers great potential to tackling sleep irregularities on a daily basis. Thereby, a novel approach for sleep stage classif…
The detection of human sleep stages is widely used in the diagnosis and intervention of neurological and psychiatric diseases. Some patients with deep brain stimulator implanted could have their neural activities recorded from the deep brain. Sleep stage classification based on deep brain recording has great potential to provide more precise treatment for patients. The accuracy and generalizability of existing sleep stage classifiers based on local field potentials are still limited. We proposed an applicable cross-modal transfer learning method for sleep stage classification with implanted de…
Humans have been aware for thousands of years that sleep comes in many forms, accompanied by different kinds of mental content. We review the first-person report literature on the frequency and type of content experienced in various stages of sleep, showing that different sleep stages are dissociable at the subjective level. We then relate these subjective differences to the growing literature differentiating the various sleep stages at the neurophysiological level, including evidence from electrophysiology, neurochemistry, and functional neuroimaging. We suggest that there is emerging evidenc…
Despite continued advancement in machine learning algorithms and increasing availability of large data sets, there is still no universally acceptable solution for automatic sleep staging of human sleep recordings. One reason is that a skilled neurophysiologist scoring brain recordings of a sleeping person implicitly adapts his/her staging to the individual characteristics present in the brain recordings. Trying to incorporate this adaptation step in an automatic scoring algorithm, we introduce in this paper a method for personalizing a general sleep scoring model. Starting from a general convo…
Study Objective: Sleep is reflected not only in the electroencephalogram but also in heart rhythms and breathing patterns. Therefore, we hypothesize that it is possible to accurately stage sleep based on the electrocardiogram (ECG) and respiratory signals. Methods: Using a dataset including 8,682 polysomnographs, we develop deep neural networks to stage sleep from ECG and respiratory signals. Five deep neural networks consisting of convolutional networks and long short-term memory networks are trained to stage sleep using heart and breathing, including the timing of R peaks from ECG, abdominal…
CITIC Universidade da Coruña（拉科鲁尼亚大学CITIC）；Sleep Center & Clinical Neurophysiology Haaglanden Medisch Centrum（海牙兰登医疗中心睡眠中心与临床神经生理学）
Sleep stages classification is a crucial task in the context of sleep studies. It involves the simultaneous analysis of multiple signals recorded during sleep. However, it is complex and tedious, and even the trained expert can spend several hours scoring a single night recording. Multiple automatic methods have tried to solve these problems in the past, most of them by classifying a feature vector that is engineered for a specific dataset. In this work, we avoid this bias using a deep learning model that learns relevant features without human intervention. Particularly, we propose an ensemble…
Vidyasirimedhi Institute of Science & Technology（维迪亚西里梅迪科学技术学院）；Chulalongkorn University（朱拉隆功大学）；King Chulalongkorn Memorial Hospital（朱拉隆功国王纪念医院）；Thai Red Cross Society（泰国红十字会）；Fudan University（复旦大学）
Identifying bio-signals based-sleep stages requires time-consuming and tedious labor of skilled clinicians. Deep learning approaches have been introduced in order to challenge the automatic sleep stage classification conundrum. However, the difficulties can be posed in replacing the clinicians with the automatic system due to the differences in many aspects found in individual bio-signals, causing the inconsistency in the performance of the model on every incoming individual. Thus, we aim to explore the feasibility of using a novel approach, capable of assisting the clinicians and lessening th…
Automatic sleep staging is a challenging problem and state-of-the-art algorithms have not yet reached satisfactory performance to be used instead of manual scoring by a sleep technician. Much research has been done to find good feature representations that extract the useful information to correctly classify each epoch into the correct sleep stage. While many useful features have been discovered, the amount of features have grown to an extent that a feature reduction step is necessary in order to avoid the curse of dimensionality. One reason for the need of such a large feature set is that man…
Stimulation of target neuronal populations using optogenetic techniques during specific sleep stages has begun to elucidate the mechanisms and effects of sleep. To conduct closed-loop optogenetic sleep studies in untethered animals, we designed a fully integrated, low-power system-on-chip (SoC) for real-time sleep stage classification and stage-specific optical stimulation. The SoC consists of a 4-channel analog front-end for recording polysomnography signals, a mixed-signal machine-learning (ML) core, and a 16-channel optical stimulation back-end. A novel ML algorithm and innovative circuit d…
This paper proposes a practical approach to addressing limitations posed by use of single active electrodes in applications for sleep stage classification. Electroencephalography (EEG)-based characterizations of sleep stage progression contribute the diagnosis and monitoring of the many pathologies of sleep. Several prior reports have explored ways of automating the analysis of sleep EEG and of reducing the complexity of the data needed for reliable discrimination of sleep stages in order to make it possible to perform sleep studies at lower cost in the home (rather than only in specialized cl…
Cortical arousals are transient events of disturbed sleep that occur spontaneously or in response to stimuli such as apneic events. The gold standard for arousal detection in human polysomnographic recordings (PSGs) is manual annotation by expert human scorers, a method with significant interscorer variability. In this study, we developed an automated method, the Multimodal Arousal Detector (MAD), to detect arousals using deep learning methods. The MAD was trained on 2,889 PSGs to detect both cortical arousals and wakefulness in 1 second intervals. Furthermore, the relationship between MAD-pre…
This paper proposes a practical approach for automatic sleep stage classification based on a multi-level feature learning framework and Recurrent Neural Network (RNN) classifier using heart rate and wrist actigraphy derived from a wearable device. The feature learning framework is designed to extract low- and mid-level features. Low-level features capture temporal and frequency domain properties and mid-level features learn compositions and structural information of signals. Since sleep staging is a sequential problem with long-term dependencies, we take advantage of RNNs with Bidirectional Lo…
University of Oxford（牛津大学）；Oxford University Hospitals（牛津大学医院）
Evidence suggests Rapid-Eye-Movement (REM) Sleep Behaviour Disorder (RBD) is an early predictor of Parkinson's disease. This study proposes a fully-automated framework for RBD detection consisting of automated sleep staging followed by RBD identification. Analysis was assessed using a limited polysomnography montage from 53 participants with RBD and 53 age-matched healthy controls. Sleep stage classification was achieved using a Random Forest (RF) classifier and 156 features extracted from electroencephalogram (EEG), electrooculogram (EOG) and electromyogram (EMG) channels. For RBD detection, …
Rythm（Rythm公司）；Laboratoire Traitement et Communication de l'Information (LTCI), Telecom ParisTech, Université Paris-Saclay（巴黎高科电信学院，巴黎萨克雷大学，信息处理与通信实验室）；Ecole Normale Supérieure（巴黎高等师范学院）；Inria, Université Paris-Saclay（法国国家信息与自动化研究所，巴黎萨克雷大学）；CEA, Université Paris-Saclay（法国原子能与替代能源委员会，巴黎萨克雷大学）
Sleep stage classification constitutes an important preliminary exam in the diagnosis of sleep disorders. It is traditionally performed by a sleep expert who assigns to each 30s of signal a sleep stage, based on the visual inspection of signals such as electroencephalograms (EEG), electrooculograms (EOG), electrocardiograms (ECG) and electromyograms (EMG). We introduce here the first deep learning approach for sleep stage classification that learns end-to-end without computing spectrograms or extracting hand-crafted features, that exploits all multivariate and multimodal Polysomnography (PSG) …
Automated sleep stage classification using heart-rate variability is an active field of research. In this work limitations of the current state-of-the-art are addressed through the use of deep learning techniques and their efficacy is demonstrated. First, a temporal model is proposed for the inference of sleep stages from electrocardiography using a deep long- and short-term (LSTM) classifier and it is shown that this model outperforms previous approaches which were often limited to non-temporal or Markovian classifiers on a comprehensive benchmark data set (292 participants, 541214 samples) c…
