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arXiv 1811.04662cs.LGeess.SPq-bio.NCstat.ML
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自动多导睡眠图分析检测REM睡眠行为障碍

Detection of REM Sleep Behaviour Disorder by Automated Polysomnography Analysis

University of Oxford(牛津大学);Oxford University Hospitals(牛津大学医院)

Navin Cooray, Fernando Andreotti, Christine Lo, Mkael Symmonds, Michele T. M. Hu, Maarten De Vos

摘要:

有证据表明,快速眼动(REM)睡眠行为障碍(RBD)是帕金森病的早期预测因子。这项研究提出了一个全自动的RBD检测框架,包括自动睡眠分期,然后进行RBD识别。使用有限的多导睡眠图蒙太奇对53名RBD参与者和53名年龄匹配的健康对照者进行分析。使用随机森林(RF)分类器和从脑电图(EEG)、眼电图(EOG)和肌电图(EMG)通道中提取的156个特征实现睡眠阶段分类。对于RBD检测,结合已建立的技术来训练RF分类器,以量化肌肉张力与结合睡眠结构和EMG分形指数的附加特征。自动多状态睡眠分期达到0.62科恩的Kappa评分。当使用手动注释的睡眠分期时,RBD检测准确性提高了10%至96%(与单独建立的指标相比)。当使用自动睡眠分期时,准确性仍然很高(92%)。这项研究优于既定的指标,并表明结合睡眠结构和睡眠阶段转换可以有利于RBD检测。这项研究还实现了自动睡眠分期,其准确度与手动注释相当。这项研究验证了一个易于处理的,全自动的,敏感的RBD识别管道,可以转化为可穿戴带回家的技术。

英文摘要:

Evidence suggests Rapid-Eye-Movement (REM) Sleep Behaviour Disorder (RBD) is an early predictor of Parkinson's disease. This study proposes a fully-automated framework for RBD detection consisting of automated sleep staging followed by RBD identification. Analysis was assessed using a limited polysomnography montage from 53 participants with RBD and 53 age-matched healthy controls. Sleep stage classification was achieved using a Random Forest (RF) classifier and 156 features extracted from electroencephalogram (EEG), electrooculogram (EOG) and electromyogram (EMG) channels. For RBD detection, a RF classifier was trained combining established techniques to quantify muscle atonia with additional features that incorporate sleep architecture and the EMG fractal exponent. Automated multi-state sleep staging achieved a 0.62 Cohen's Kappa score. RBD detection accuracy improved by 10% to 96% (compared to individual established metrics) when using manually annotated sleep staging. Accuracy remained high (92%) when using automated sleep staging. This study outperforms established metrics and demonstrates that incorporating sleep architecture and sleep stage transitions can benefit RBD detection. This study also achieved automated sleep staging with a level of accuracy comparable to manual annotation. This study validates a tractable, fully-automated, and sensitive pipeline for RBD identification that could be translated to wearable take-home technology.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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