In this paper, we propose a fast transient hydrostatic stress analysis for electromigration (EM) failure assessment for multi-segment interconnects using generative adversarial networks (GANs). Our work leverages the image synthesis feature of GAN-based generative deep neural networks. The stress evaluation of multi-segment interconnects, modeled by partial differential equations, can be viewed as time-varying 2D-images-to-image problem where the input is the multi-segment interconnects topology with current densities and the output is the EM stress distribution in those wire segments at the given aging time. Based on this observation, we train conditional GAN model using the images of many self-generated multi-segment wires and wire current densities and aging time (as conditions) against the COMSOL simulation results. Different hyperparameters of GAN were studied and compared. The proposed algorithm, called {\it EM-GAN}, can quickly give accurate stress distribution of a general multi-segment wire tree for a given aging time, which is important for full-chip fast EM failure assessment. Our experimental results show that the EM-GAN shows 6.6\% averaged error compared to COMSOL simulation results with orders of magnitude speedup. It also delivers 8.3X speedup over state-of-the-art analytic based EM analysis solver.
While GANs have shown success in realistic image generation, the idea of using GANs for other tasks unrelated to synthesis is underexplored. Do GANs learn meaningful structural parts of objects during their attempt to reproduce those objects? In this work, we test this hypothesis and propose a simple and effective approach based on GANs for semantic part segmentation that requires as few as one label example along with an unlabeled dataset. Our key idea is to leverage a trained GAN to extract pixel-wise representation from the input image and use it as feature vectors for a segmentation networ…
Echocardiography (echo) is a common means of evaluating cardiac conditions. Due to the label scarcity, semi-supervised paradigms in automated echo analysis are getting traction. One of the most sought-after problems in echo is the segmentation of cardiac structures (e.g. chambers). Accordingly, we propose an echocardiogram generation approach using generative adversarial networks with a conditional patch-based discriminator. In this work, we validate the feasibility of GAN-enhanced echo generation with different conditions (segmentation masks), namely, the left ventricle, ventricular myocardiu…
University of Liverpool（利物浦大学）；Xi’an Jiaotong-Liverpool University（西交利物浦大学）；Duke Kunshan University（昆山杜克大学）
We consider unsupervised cell nuclei segmentation in this paper. Exploiting the recently-proposed unpaired image-to-image translation between cell nuclei images and randomly synthetic masks, existing approaches, e.g., CycleGAN, have achieved encouraging results. However, these methods usually take a two-stage pipeline and fail to learn end-to-end in cell nuclei images. More seriously, they could lead to the lossy transformation problem, i.e., the content inconsistency between the original images and the corresponding segmentation output. To address these limitations, we propose a novel end-to-…
Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histological sub-regions, i.e., peritumoral edema, necrotic core, enhancing and non-enhancing tumour core. Although brain tumours can easily be detected using multi-modal MRI, accurate tumor segmentation is a challenging task. Hence, using the data provided by the BraTS Challenge 2020, we propose a 3D volume-to-volume Generative Adversarial Network for segmentation of brain tumours. The model, called Vox2Vox, generates realistic segmentation outputs fro…
Panzhihua University（攀枝花学院）；Tsinghua University（清华大学）；Chinese Institute for Brain Research (CIBR)（中国脑科学研究中心（CIBR））
Recently, unsupervised learning has made impressive progress on various tasks. Despite the dominance of discriminative models, increasing attention is drawn to representations learned by generative models and in particular, Generative Adversarial Networks (GANs). Previous works on the interpretation of GANs reveal that GANs encode semantics in feature maps in a linearly separable form. In this work, we further find that GAN's features can be well clustered with the linear separability assumption. We propose a novel clustering algorithm, named KLiSH, which leverages the linear separability to c…
Deep generative models are a class of techniques that train deep neural networks to model the distribution of training samples. Research has fragmented into various interconnected approaches, each of which make trade-offs including run-time, diversity, and architectural restrictions. In particular, this compendium covers energy-based models, variational autoencoders, generative adversarial networks, autoregressive models, normalizing flows, in addition to numerous hybrid approaches. These techniques are compared and contrasted, explaining the premises behind each and how they are interrelated,…
Charité Universitätsmedizin Berlin（柏林夏里特医学院）；Technical University Berlin（柏林工业大学）；Birmingham City University（伯明翰城市大学）；Fraunhofer MEVIS（弗劳恩霍夫医学图像计算研究所）；Beuth University of Applied Sciences（拜伊特应用科学大学）
Anonymization and data sharing are crucial for privacy protection and acquisition of large datasets for medical image analysis. This is a big challenge, especially for neuroimaging. Here, the brain's unique structure allows for re-identification and thus requires non-conventional anonymization. Generative adversarial networks (GANs) have the potential to provide anonymous images while preserving predictive properties. Analyzing brain vessel segmentation, we trained 3 GANs on time-of-flight (TOF) magnetic resonance angiography (MRA) patches for image-label generation: 1) Deep convolutional GAN,…
Deep learning algorithms produces state-of-the-art results for different machine learning and computer vision tasks. To perform well on a given task, these algorithms require large dataset for training. However, deep learning algorithms lack generalization and suffer from over-fitting whenever trained on small dataset, especially when one is dealing with medical images. For supervised image analysis in medical imaging, having image data along with their corresponding annotated ground-truths is costly as well as time consuming since annotations of the data is done by medical experts manually. I…
MIT CSAIL（麻省理工学院计算机科学与人工智能实验室）；MIT-IBM Watson AI Lab（麻省理工学院-IBM沃森人工智能实验室）；The Chinese University of Hong Kong（香港中文大学）
Despite the success of Generative Adversarial Networks (GANs), mode collapse remains a serious issue during GAN training. To date, little work has focused on understanding and quantifying which modes have been dropped by a model. In this work, we visualize mode collapse at both the distribution level and the instance level. First, we deploy a semantic segmentation network to compare the distribution of segmented objects in the generated images with the target distribution in the training set. Differences in statistics reveal object classes that are omitted by a GAN. Second, given the identifie…
Shenzhen University（深圳大学）；Islamic Azad University（伊斯兰阿扎德大学）
Magnetic resonance imaging (MRI) provides varying tissue contrast images of internal organs based on a strong magnetic field. Despite the non-invasive advantage of MRI in frequent imaging, the low contrast MR images in the target area make tissue segmentation a challenging problem. This paper demonstrates the potential benefits of image-to-image translation techniques to generate synthetic high tissue contrast (HTC) images. Notably, we adopt a new cycle generative adversarial network (CycleGAN) with an attention mechanism to increase the contrast within underlying tissues. The attention block,…
University of Bourgogne Franche-Comte（勃艮第-弗朗什孔泰大学）；CASIS inc.（CASIS公司）；University of Sherbrooke（舍布鲁克大学）；University Hospital of Dijon（第戎大学医院）
Generative Adversarial Networks (GANs) have become increasingly powerful, generating mind-blowing photorealistic images that mimic the content of datasets they were trained to replicate. One recurrent theme in medical imaging is whether GANs can also be effective at generating workable medical data as they are for generating realistic RGB images. In this paper, we perform a multi-GAN and multi-application study to gauge the benefits of GANs in medical imaging. We tested various GAN architectures from basic DCGAN to more sophisticated style-based GANs on three medical imaging modalities and org…
Bosch Center for Artificial Intelligence（博世人工智能中心）；University of Tübingen（图宾根大学）；University of Bonn（波恩大学）
Joint synthesis of images and segmentation masks with generative adversarial networks (GANs) is promising to reduce the effort needed for collecting image data with pixel-wise annotations. However, to learn high-fidelity image-mask synthesis, existing GAN approaches first need a pre-training phase requiring large amounts of image data, which limits their utilization in restricted image domains. In this work, we take a step to reduce this limitation, introducing the task of one-shot image-mask synthesis. We aim to generate diverse images and their segmentation masks given only a single labelled…
Exploiting learning algorithms under scarce data regimes is a limitation and a reality of the medical imaging field. In an attempt to mitigate the problem, we propose a data augmentation protocol based on generative adversarial networks. We condition the networks at a pixel-level (segmentation mask) and at a global-level information (acquisition environment or lesion type). Such conditioning provides immediate access to the image-label pairs while controlling global class specific appearance of the synthesized images. To stimulate synthesis of the features relevant for the segmentation task, a…
Generative Adversarial Networks (GANs) are state of the art for image synthesis. Here, we present dapi2ck, a novel GAN-based approach to synthesize cytokeratin (CK) staining from immunofluorescent (IF) DAPI staining of nuclei in non-small cell lung cancer (NSCLC) images. We use the synthetic CK to segment epithelial regions, which, compared to expert annotations, yield equally good results as segmentation on stained CK. Considering the limited number of markers in a multiplexed IF (mIF) panel, our approach allows to replace CK by another marker addressing the complexity of the tumor micro-envi…
This review presents a comprehensive study on the role of GANs in addressing the challenges related to COVID-19 data scarcity and diagnosis. It is the first review that summarizes the different GANs methods and the lungs images datasets for COVID-19. It attempts to answer the questions related to applications of GANs, popular GAN architectures, frequently used image modalities, and the availability of source code. This review included 57 full-text studies that reported the use of GANs for different applications in COVID-19 lungs images data. Most of the studies (n=42) used GANs for data augmen…
COMSATS University Islamabad（COMSATS伊斯兰堡大学）；National University of Ireland, Galway（爱尔兰国立高威大学）；Umeå University（于默奥大学）
Chest X-ray (CXR) is a low-cost medical imaging technique. It is a common procedure for the identification of many respiratory diseases compared to MRI, CT, and PET scans. This paper presents the use of generative adversarial networks (GAN) to perform the task of lung segmentation on a given CXR. GANs are popular to generate realistic data by learning the mapping from one domain to another. In our work, the generator of the GAN is trained to generate a segmented mask of a given input CXR. The discriminator distinguishes between a ground truth and the generated mask, and updates the generator t…
King’s College London（伦敦国王学院）；University of Warwick（华威大学）
The clinical management of several cardiovascular conditions, such as pulmonary hypertension, require the assessment of the right ventricular (RV) function. This work addresses the fully automatic and robust access to one of the key RV biomarkers, its ejection fraction, from the gold standard imaging modality, MRI. The problem becomes the accurate segmentation of the RV blood pool from cine MRI sequences. This work proposes a solution based on Fully Convolutional Neural Networks (FCNN), where our first contribution is the optimal combination of three concepts (the convolution Gated Recurrent U…
Generative adversarial networks (GANs) have shown great success in applications such as image generation and inpainting. However, they typically require large datasets, which are often not available, especially in the context of prediction tasks such as image segmentation that require labels. Therefore, methods such as the CycleGAN use more easily available unlabelled data, but do not offer a way to leverage additional labelled data for improved performance. To address this shortcoming, we show how to factorise the joint data distribution into a set of lower-dimensional distributions along wit…
The University of Texas at Austin（德克萨斯大学奥斯汀分校）；Konkuk University（建国大学）
Generating wind power scenarios is very important for studying the impacts of multiple wind farms that are interconnected to the grid. We develop a graph convolutional generative adversarial network (GCGAN) approach by leveraging GAN's capability in generating large number of realistic scenarios without using statistical modeling. Unlike existing GAN-based wind power data generation approaches, we design GAN's hidden layers to match the underlying spatial and temporal characteristics. We advocate the use of graph filters to embed the spatial correlation among multiple wind farms, and a one-dim…
Transportation Research for Integrated Planning (TRIP) Lab（交通综合规划研究实验室）；Concordia University（康考迪亚大学）；Laboratory of Innovations in Transportation (LiTrans)（交通创新实验室）；Ryerson University（瑞尔森大学）
Semi-supervised Generative Adversarial Networks (GANs) are developed in the context of travel mode inference with uni-dimensional smartphone trajectory data. We use data from a large-scale smartphone travel survey in Montreal, Canada. We convert GPS trajectories into fixed-sized segments with five channels (variables). We develop different GANs architectures and compare their prediction results with Convolutional Neural Networks (CNNs). The best semi-supervised GANs model led to a prediction accuracy of 83.4%, while the best CNN model was able to achieve the prediction accuracy of 81.3%. The r…
Recently, social infrastructure is aging, and its predictive maintenance has become important issue. To monitor the state of infrastructures, bridge inspection is performed by human eye or bay drone. For diagnosis, primary damage region are recognized for repair targets. But, the degradation at worse level has rarely occurred, and the damage regions of interest are often narrow, so their ratio per image is extremely small pixel count, as experienced 0.6 to 1.5 percent. The both scarcity and imbalance property on the damage region of interest influences limited performance to detect damage. If …
Generative Adversarial Network (GAN) based localized image editing can suffer from ambiguity between semantic attributes. We thus present a novel objective function to evaluate the locality of an image edit. By introducing the supervision from a pre-trained segmentation network and optimizing the objective function, our framework, called Locally Effective Latent Space Direction (LELSD), is applicable to any dataset and GAN architecture. Our method is also computationally fast and exhibits a high extent of disentanglement, which allows users to interactively perform a sequence of edits on an im…
Existing GAN inversion and editing methods work well for aligned objects with a clean background, such as portraits and animal faces, but often struggle for more difficult categories with complex scene layouts and object occlusions, such as cars, animals, and outdoor images. We propose a new method to invert and edit such complex images in the latent space of GANs, such as StyleGAN2. Our key idea is to explore inversion with a collection of layers, spatially adapting the inversion process to the difficulty of the image. We learn to predict the "invertibility" of different image segments and pr…
Birla Institute of Technology and Science Pilani – KK Birla Goa Campus（贝拉理工学院皮拉尼分校–KK·贝拉果阿校区）；Indian Institute of Science Education and Research, Pune（印度科学教育与研究学院浦那分校）；Vellore Institute of Technology, Bhopal（韦洛尔理工学院博帕尔分校）
Biometric Authentication like Fingerprints has become an integral part of the modern technology for authentication and verification of users. It is pervasive in more ways than most of us are aware of. However, these fingerprint images deteriorate in quality if the fingers are dirty, wet, injured or when sensors malfunction. Therefore, extricating the original fingerprint by removing the noise and inpainting it to restructure the image is crucial for its authentication. Hence, this paper proposes a deep learning approach to address these issues using Generative (GAN) and Segmentation models. Qu…
The difficulty in obtaining labeled data relevant to a given task is among the most common and well-known practical obstacles to applying deep learning techniques to new or even slightly modified domains. The data volumes required by the current generation of supervised learning algorithms typically far exceed what a human needs to learn and complete a given task. We investigate ways to expand a given labeled corpus of remote sensed imagery into a larger corpus using Generative Adversarial Networks (GANs). We then measure how these additional synthetic data affect supervised machine learning p…
Fraunhofer Institute for Digital Medicine MEVIS（弗劳恩霍夫数字医学MEVIS研究所）
Generative networks are fundamentally different in their aim and methods compared to CNNs for classification, segmentation, or object detection. They have initially not been meant to be an image analysis tool, but to produce naturally looking images. The adversarial training paradigm has been proposed to stabilize generative methods, and has proven to be highly successful -- though by no means from the first attempt. This chapter gives a basic introduction into the motivation for Generative Adversarial Networks (GANs) and traces the path of their success by abstracting the basic task and worki…
University of Maryland, Baltimore County（马里兰大学巴尔的摩县分校）；University of Miami（迈阿密大学）；National Institutes of Health Clinical Center（美国国立卫生研究院临床中心）；Networking Health（网络健康）
We present a novel algorithm that is able to classify COVID-19 pneumonia from CT Scan slices using a very small sample of training images exhibiting COVID-19 pneumonia in tandem with a larger number of normal images. This algorithm is able to achieve high classification accuracy using as few as 10 positive training slices (from 10 positive cases), which to the best of our knowledge is one order of magnitude fewer than the next closest published work at the time of writing. Deep learning with extremely small positive training volumes is a very difficult problem and has been an important topic d…
Generative Adversarial Networks (GANs) are an arrange of two neural networks -- the generator and the discriminator -- that are jointly trained to generate artificial data, such as images, from random inputs. The quality of these generated images has recently reached such levels that can often lead both machines and humans into mistaking fake for real examples. However, the process performed by the generator of the GAN has some limitations when we want to condition the network to generate images from subcategories of a specific class. Some recent approaches tackle this \textit{conditional gene…
Generative adversarial networks (GANs) are recently highly successful in generative applications involving images and start being applied to time series data. Here we describe EEG-GAN as a framework to generate electroencephalographic (EEG) brain signals. We introduce a modification to the improved training of Wasserstein GANs to stabilize training and investigate a range of architectural choices critical for time series generation (most notably up- and down-sampling). For evaluation we consider and compare different metrics such as Inception score, Frechet inception distance and sliced Wasser…
Department of Biomedical Engineering, Yale University（耶鲁大学生物医学工程系）；Department of Radiology & Biomedical Imaging, Yale School of Medicine（耶鲁大学医学院放射科与生物医学成像系）；Department of Electrical Engineering, Yale University（耶鲁大学电气工程系）；Department of Statistics & Data Science, Yale University（耶鲁大学统计与数据科学系）；Yale School of Medicine（耶鲁大学医学院）
Domain Adaptation (DA) has the potential to greatly help the generalization of deep learning models. However, the current literature usually assumes to transfer the knowledge from the source domain to a specific known target domain. Domain Agnostic Learning (DAL) proposes a new task of transferring knowledge from the source domain to data from multiple heterogeneous target domains. In this work, we propose the Domain-Agnostic Learning framework with Anatomy-Consistent Embedding (DALACE) that works on both domain-transfer and task-transfer to learn a disentangled representation, aiming to not o…
TU Darmstadt（达姆施塔特工业大学）；TU Munich（慕尼黑工业大学）；Radboud University Medical Center（拉德堡德大学医学中心）
Generative Adversarial Networks (GANs) and their extensions have carved open many exciting ways to tackle well known and challenging medical image analysis problems such as medical image de-noising, reconstruction, segmentation, data simulation, detection or classification. Furthermore, their ability to synthesize images at unprecedented levels of realism also gives hope that the chronic scarcity of labeled data in the medical field can be resolved with the help of these generative models. In this review paper, a broad overview of recent literature on GANs for medical applications is given, th…
Eindhoven University of Technology（埃因霍温理工大学）；Philips Research Laboratories（飞利浦研究实验室）；Philips Healthcare（飞利浦医疗）
Generative adversarial networks (GANs) have provided promising data enrichment solutions by synthesizing high-fidelity images. However, generating large sets of labeled images with new anatomical variations remains unexplored. We propose a novel method for synthesizing cardiac magnetic resonance (CMR) images on a population of virtual subjects with a large anatomical variation, introduced using the 4D eXtended Cardiac and Torso (XCAT) computerized human phantom. We investigate two conditional image synthesis approaches grounded on a semantically-consistent mask-guided image generation techniqu…
Automatic analysis of spatio-temporal microscopy images is inevitable for state-of-the-art research in the life sciences. Recent developments in deep learning provide powerful tools for automatic analyses of such image data, but heavily depend on the amount and quality of provided training data to perform well. To this end, we developed a new method for realistic generation of synthetic 2D+t microscopy image data of fluorescently labeled cellular nuclei. The method combines spatiotemporal statistical shape models of different cell cycle stages with a conditional GAN to generate time series of …
We tackle the problem of object discovery, where objects are segmented for a given input image, and the system is trained without using any direct supervision whatsoever. A novel copy-pasting GAN framework is proposed, where the generator learns to discover an object in one image by compositing it into another image such that the discriminator cannot tell that the resulting image is fake. After carefully addressing subtle issues, such as preventing the generator from `cheating', this game results in the generator learning to select objects, as copy-pasting objects is most likely to fool the di…
Alibaba Group（阿里巴巴集团）；Huazhong University of Science and Technology（华中科技大学）；Xi’an International Studies University（西安外国语大学）
The behavior of malware threats is gradually increasing, heightened the need for malware detection. However, existing malware detection methods only target at the existing malicious samples, the detection of fresh malicious code and variants of malicious code is limited. In this paper, we propose a novel scheme that detects malware and its variants efficiently. Based on the idea of the generative adversarial networks (GANs), we obtain the `true' sample distribution that satisfies the characteristics of the real malware, use them to deceive the discriminator, thus achieve the defense against ma…
University of Wisconsin-Madison（威斯康星大学麦迪逊分校）；Adobe Research（奥多比研究院）
We propose a new approach for high resolution semantic image synthesis. It consists of one base image generator and multiple class-specific generators. The base generator generates high quality images based on a segmentation map. To further improve the quality of different objects, we create a bank of Generative Adversarial Networks (GANs) by separately training class-specific models. This has several benefits including -- dedicated weights for each class; centrally aligned data for each model; additional training data from other sources, potential of higher resolution and quality; and easy ma…
Network architecture search (NAS) achieves state-of-the-art results in various tasks such as classification and semantic segmentation. Recently, a reinforcement learning-based approach has been proposed for Generative Adversarial Networks (GANs) search. In this work, we propose an alternative strategy for GAN search by using a method called DEGAS (Differentiable Efficient GenerAtor Search), which focuses on efficiently finding the generator in the GAN. Our search algorithm is inspired by the differential architecture search strategy and the Global Latent Optimization (GLO) procedure. This lead…
Massachusetts Institute of Technology（麻省理工学院）；MIT-IBM Watson AI Lab（MIT-IBM沃森人工智能实验室）；IBM Research（IBM研究院）；The Chinese University of Hong Kong（香港中文大学）
Generative Adversarial Networks (GANs) have recently achieved impressive results for many real-world applications, and many GAN variants have emerged with improvements in sample quality and training stability. However, they have not been well visualized or understood. How does a GAN represent our visual world internally? What causes the artifacts in GAN results? How do architectural choices affect GAN learning? Answering such questions could enable us to develop new insights and better models. In this work, we present an analytic framework to visualize and understand GANs at the unit-, object-…
