We introduce equivalence testing procedures for linear regression analyses. Such tests can be very useful for confirming the lack of a meaningful association between a continuous outcome and a continuous or binary predictor. Specifically, we propose an equivalence test for unstandardized regression coefficients and an equivalence test for semipartial correlation coefficients. We review how to define valid hypotheses, how to calculate p-values, and how these tests compare to an alternative Bayesian approach with applications to examples in the literature.
In this study, we propose a two-stage procedure for hypothesis testing, where the first stage is conventional hypothesis testing and the second is an equivalence testing procedure using an introduced Empirical Equivalence Bound. In 2016, the American Statistical Association released a policy statement on P-values to clarify the proper use and interpretation in response to the criticism of reproducibility and replicability in scientific findings. A recent solution to improve reproducibility and transparency in statistical hypothesis testing is to integrate P-values (or confidence intervals) wit…
In order to determine whether or not an effect is absent based on a statistical test, the recommended frequentist tool is the equivalence test. Typically, it is expected that an appropriate equivalence margin has been specified before any data are observed. Unfortunately, this can be a difficult task. If the margin is too small, then the test's power will be substantially reduced. If the margin is too large, any claims of equivalence will be meaningless. Moreover, it remains unclear how defining the margin afterwards will bias one's results. In this short article, we consider a series of hypot…
We propose a goodness-of-fit test for the distribution of errors from a multivariate indirect regression model. The test statistic is based on the Khmaladze transformation of the empirical process of standardized residuals. This goodness-of-fit test is consistent at the root-n rate of convergence, and the test can maintain power against local alternatives converging to the null at a root-n rate.
In clinical trials the comparison of two different populations is a frequently addressed problem. Non-linear (parametric) regression models are commonly used to describe the relationship between covariates as the dose and a response variable in the two groups. In some situations it is reasonable to assume some model parameters to be the same, for instance the placebo effect or the maximum treatment effect. In this paper we develop a (parametric) bootstrap test to establish the similarity of two regression curves sharing some common parameters. We show by theoretical arguments and by means of a…
In this paper we discuss how to evaluate the differences between fitted logistic regression models across sub-populations. Our motivating example is in studying computerized diagnosis for learning disabilities, where sub-populations based on gender may or may not require separate models. In this context, significance tests for hypotheses of no difference between populations may provide perverse incentives, as larger variances and smaller samples increase the probability of not-rejecting the null. We argue that equivalence testing for a prespecified tolerance level on population differences inc…
This paper presents a goodness-of-fit test for parametric regression models with scalar response and directional predictor, that is, a vector on a sphere of arbitrary dimension. The testing procedure is based on the weighted squared distance between a smooth and a parametric regression estimator, where the smooth regression estimator is obtained by a projected local approach. Asymptotic behavior of the test statistic under the null hypothesis and local alternatives is provided, jointly with a consistent bootstrap algorithm for application in practice. A simulation study illustrates the perform…
Heteroscedasticity testing is of importance in regression analysis. Existing local smoothing tests suffer severely from curse of dimensionality even when the number of covariates is moderate because of use of nonparametric estimation. In this paper, a dimension reduction-based model adaptive test is proposed which behaves like a local smoothing test as if the number of covariates were equal to the number of their linear combinations in the mean regression function, in particular, equal to 1 when the mean function contains a single index. The test statistic is asymptotically normal under the nu…
Regression is one of the most commonly used statistical techniques. However, testing regression systems is a great challenge because of the absence of test oracle in general. In this paper, we show that Metamorphic Testing is an effective approach to test multiple linear regression systems. In doing so, we identify intrinsic mathematical properties of linear regression, and then propose 11 Metamorphic Relations to be used for testing. Their effectiveness is examined using mutation analysis with a range of different regression programs. We further look at how the testing could be adopted in a m…
In this paper we propose a new test of heteroscedasticity for parametric regression models and partial linear regression models in high dimensional settings. When the dimension of covariates is large, existing tests of heteroscedasticity perform badly due to the \curse of dimensionality". To attack this problem, we construct a test of heteroscedasticity by using a projection-based empirical process. We study the asymptotic properties of the test statistic under the null hypothesis and alternative hypotheses. It is shown that the test can detect local alternatives departure from the null hypoth…
Testing heteroscedasticity of the errors is a major challenge in high-dimensional regressions where the number of covariates is large compared to the sample size. Traditional procedures such as the White and the Breusch-Pagan tests typically suffer from low sizes and powers. This paper proposes two new test procedures based on standard OLS residuals. Using the theory of random Haar orthogonal matrices, the asymptotic normality of both test statistics is obtained under the null when the degree of freedom tends to infinity. This encompasses both the classical low-dimensional setting where the nu…
We develop a maximum-likelihood based method for regression in a setting where the dependent variable is a random graph and covariates are available on a graph-level. The model generalizes the well-known $β$-model for random graphs by replacing the constant model parameters with regression functions. Cramér-Rao bounds are derived for the undirected $β$-model, the directed $β$-model, and the generalized $β$-model. The corresponding maximum likelihood estimators are compared to the bounds by means of simulations. Moreover, examples are given on how to use the presented maximum likelihood estimat…
Recently a distribution free approach for testing parametric hypotheses based on unitary transformations has been suggested in \cite{Khm13, Khm16, Khm17} and further studied in \cite{Ngu17} and \cite{Rob19}. In this note we show that the transformation takes extremely simple form in distribution free testing of linear regression. Then we extend it to general parametric regression with vector-valued covariates.
In the high dimensional regression analysis when the number of predictors is much larger than the sample size, an important question is to select the important variable which are relevant to the response variable of interest. Variable selection and the multiple testing are both tools to address this issue. However, there is little discussion on the connection of these two areas. When the signal strength is strong enough such that the selection consistency is achievable, it seems to be unnecessary to control the false discovery rate. In this paper, we consider the regime where the signals are b…
A formal likelihood ratio hypothesis test for the validity of a parametric regression function is proposed, using a large-dimensional, nonparametric double cone alternative. For example, the test against a constant function uses the alternative of increasing or decreasing regression functions, and the test against a linear function uses the convex or concave alternative. The proposed test is exact, unbiased and the critical value is easily computed. The power of the test increases to one as the sample size increases, under very mild assumptions -- even when the alternative is mis-specified. Th…
Gene expression and phenotype association can be affected by potential unmeasured confounders from multiple sources, leading to biased estimates of the associations. Since genetic variants largely explain gene expression variations, they can be used as instruments in studying the association between gene expressions and phenotype in the framework of high dimensional instrumental variable (IV) regression. However, because the dimensions of both genetic variants and gene expressions are often larger than the sample size, statistical inferences such as hypothesis testing for such high dimensional…
High-dimensional logistic regression is widely used in analyzing data with binary outcomes. In this paper, global testing and large-scale multiple testing for the regression coefficients are considered in both single- and two-regression settings. A test statistic for testing the global null hypothesis is constructed using a generalized low-dimensional projection for bias correction and its asymptotic null distribution is derived. A lower bound for the global testing is established, which shows that the proposed test is asymptotically minimax optimal over some sparsity range. For testing the in…
This paper studies the high-dimensional mixed linear regression (MLR) where the output variable comes from one of the two linear regression models with an unknown mixing proportion and an unknown covariance structure of the random covariates. Building upon a high-dimensional EM algorithm, we propose an iterative procedure for estimating the two regression vectors and establish their rates of convergence. Based on the iterative estimators, we further construct debiased estimators and establish their asymptotic normality. For individual coordinates, confidence intervals centered at the debiased …
This paper presents a selective survey of recent developments in statistical inference and multiple testing for high-dimensional regression models, including linear and logistic regression. We examine the construction of confidence intervals and hypothesis tests for various low-dimensional objectives such as regression coefficients and linear and quadratic functionals. The key technique is to generate debiased and desparsified estimators for the targeted low-dimensional objectives and estimate their uncertainty. In addition to covering the motivations for and intuitions behind these statistica…
We propose a kernel machine based hypothesis testing procedure in nonlinear function-on-scalar regression model. Our research is motivated by the Newborn Epigenetic Study (NEST) where the question of interest is whether a pre-specified group of toxic metals or methylation at any of 9 differentially methylated regions (DMRs) is associated with child growth. We take the child growth trajectory as the functional response, and model the toxic metal measurements jointly using a nonlinear function. We use a kernel machine approach to model the unknown function and transform the hypothesis of no effe…
Asymptotic equivalence theory developed in the literature so far are only for bounded loss functions. This limits the potential applications of the theory because many commonly used loss functions in statistical inference are unbounded. In this paper we develop asymptotic equivalence results for robust nonparametric regression with unbounded loss functions. The results imply that all the Gaussian nonparametric regression procedures can be robustified in a unified way. A key step in our equivalence argument is to bin the data and then take the median of each bin. The asymptotic equivalence resu…
Determining a lack of association between an outcome variable and a number of different explanatory variables is frequently necessary in order to disregard a proposed model (i.e., to confirm the lack of an association between an outcome and predictors). Despite this, the literature rarely offers information about, or technical recommendations concerning, the appropriate statistical methodology to be used to accomplish this task. This paper introduces non-inferiority tests for ANOVA and linear regression analyses, that correspond to the standard widely used $F$-test for $\hatη^2$ and $R^{2}$, r…
We consider the related problems of estimating the $l_2$-norm and the squared $l_2$-norm in sparse linear regression with unknown variance, as well as the problem of testing the hypothesis that the regression parameter is null under sparse alternatives with $l_2$ separation. We establish the minimax optimal rates of estimation (respectively, testing) in these three problems.
We propose a new testing procedure of heteroskedasticity in high-dimensional linear regression, where the number of covariates can be larger than the sample size. Our testing procedure is based on residuals of the Lasso. We demonstrate that our test statistic has asymptotic normality under the null hypothesis of homoskedasticity. Simulation results show that the proposed testing procedure obtains accurate empirical sizes and powers. We also present results of real economic data applications.
We derive adjusted signed likelihood ratio statistics for a general class of extreme value regression models. The adjustments reduce the error in the standard normal approximation to the distribution of the signed likelihood ratio statistic. We use Monte Carlo simulations to compare the finite-sample performance of the different tests. Our simulations suggest that the signed likelihood ratio test tends to be liberal when the sample size is not large, and that the adjustments are effective in shrinking the size distortion. Two real data applications are presented and discussed.
We consider the statistical experiment of functional linear regression (FLR). Furthermore, we introduce a white noise model where one observes an Ito process, which contains the covariance operator of the corresponding FLR model in its construction. We prove asymptotic equivalence of FLR and this white noise model in LeCam's sense under known design distribution. Moreover, we show equivalence of FLR and an empirical version of the white noise model for finite sample sizes. As an application, we derive sharp minimax constants in the FLR model which are still valid in the case of unknown design …
In this paper, we are concerned with nonparametric estimation of the multivariate regression function in the presence of right censored data. More precisely, we propose a statistic that is shown to be asymptotically normally distributed under the additive assumption, and that could be used to test for additivity in the censored regression setting.
We consider the problem of testing the hypothesis that the parameter of linear regression model is 0 against an s-sparse alternative separated from 0 in the l2-distance. We show that, in Gaussian linear regression model with p < n, where p is the dimension of the parameter and n is the sample size, the non-asymptotic minimax rate of testing has the form sqrt((s/n) log(1 + sqrt(p)/s )). We also show that this is the minimax rate of estimation of the l2-norm of the regression parameter.
We consider the problem of testing significance of predictors in multivariate nonparametric quantile regression. A stochastic process is proposed, which is based on a comparison of the responses with a nonparametric quantile regression estimate under the null hypothesis. It is demonstrated that under the null hypothesis this process converges weakly to a centered Gaussian process and the asymptotic properties of the test under fixed and local alternatives are also discussed. In particular we show, that - in contrast to the nonparametric approach based on estimation of $L^2$-distances - the new…
We propose a novel test statistic for testing exogeneity in the functional linear regression model. In contrast to Hausman-type tests in finite dimensional linear regression setups, a direct extension to the functional linear regression model is not possible. Instead, we propose a test statistic based on the sum of the squared difference of projections of the two estimators for testing the null hypothesis of exogeneity in the functional linear regression model. We derive asymptotic normality under the null and consistency under general alternatives. Moreover, we prove bootstrap consistency res…
In this paper we propose a general methodology, based on multiple testing, for testing that the mean of a Gaussian vector in R^n belongs to a convex set. We show that the test achieves its nominal level, and characterize a class of vectors over which the tests achieve a prescribed power. In the functional regression model this general methodology is applied to test some qualitative hypotheses on the regression function. For example, we test that the regression function is positive, increasing, convex, or more generally, satisfies a differential inequality. Uniform separation rates over classes…
We consider a regression model with errors that are a.s. negative. Thus the regression function is not the expected value of the observations but the right endpoint of their support. We develop two goodness-of-fit tests for the hypotheses that the regression function is an affine function, study the asymptotic distributions of the test statistics in order to approximately fix the sizes of the tests, derive their finite-sample properties based on simulations and apply them to life expectancy data.
We study the portfolio problem of maximizing the outperformance probability over a random benchmark through dynamic trading with a fixed initial capital. Under a general incomplete market framework, this stochastic control problem can be formulated as a composite pure hypothesis testing problem. We analyze the connection between this pure testing problem and its randomized counterpart, and from latter we derive a dual representation for the maximal outperformance probability. Moreover, in a complete market setting, we provide a closed-form solution to the problem of beating a leveraged exchang…
We consider the problem of inference on a regression function at a point when the entire function satisfies a sign or shape restriction under the null. We propose a test that achieves the optimal minimax rate adaptively over a range of Hölder classes, up to a $\log\log n$ term, which we show to be necessary for adaptation. We apply the results to adaptive one-sided tests for the regression discontinuity parameter under a monotonicity restriction, the value of a monotone regression function at the boundary and the proportion of true null hypotheses in a multiple testing problem.
In this paper, we establish a uniform error rate of a Bahadur representation for local polynomial estimators of quantile regression functions. The error rate is uniform over a range of quantiles, a range of evaluation points in the regressors, and over a wide class of probabilities for observed random variables. Most of the existing results on Bahadur representations for local polynomial quantile regression estimators apply to the fixed data generating process. In the context of testing monotonicity where the null hypothesis is of a complex composite hypothesis, it is particularly relevant to …
In this paper we propose a new test for the hypothesis of a constant coefficient of variation in the common nonparametric regression model. The test is based on an estimate of the $L^2$-distance between the square of the regression function and variance function. We prove asymptotic normality of a standardized estimate of this distance under the null hypothesis and fixed alternatives and the finite sample properties of a corresponding bootstrap test are investigated by means of a simulation study. The results are applicable to stationary processes with the common mixing conditions and are used…
In this paper we consider the construction of optimal tests of equivalence hypotheses. Specifically, assume X_1,..., X_n are i.i.d. with distribution P_θ, with θ\in R^k. Let g(θ) be some real-valued parameter of interest. The null hypothesis asserts g(θ)\notin (a,b) versus the alternative g(θ)\in (a,b). For example, such hypotheses occur in bioequivalence studies where one may wish to show two drugs, a brand name and a proposed generic version, have the same therapeutic effect. Little optimal theory is available for such testing problems, and it is the purpose of this paper to provide an asymp…
We discuss nonparametric tests for parametric specifications of regression quantiles. The test is based on the comparison of parametric and nonparametric fits of these quantiles. The nonparametric fit is a Nadaraya-Watson quantile smoothing estimator. An asymptotic treatment of the test statistic requires the development of new mathematical arguments. An approach that makes only use of plugging in a Bahadur expansion of the nonparametric estimator is not satisfactory. It requires too strong conditions on the dimension and the choice of the bandwidth. Our alternative mathematical approach requi…
We consider a nonlinear polynomial regression model in which we wish to test the null hypothesis of structural stability in the regression parameters against the alternative of a break at an unknown time. We derive the extreme value distribution of a maximum-type test statistic which is asymptotically equivalent to the maximally selected likelihood ratio. The resulting test is easy to apply and has good size and power, even in small samples.
This is a comment on Economic Letters DOI http://dx.doi.org/10.1016/j.econlet.2015.10.015. We show that due to some methodological aspects the main conclusions of the above mentioned paper should be a little bit altered.
Measuring interdependence between probabilities of default (PDs) in different industry sectors of an economy plays a crucial role in financial stress testing. Thereby, regression approaches may be employed to model the impact of stressed industry sectors as covariates on other response sectors. We identify vine copula based quantile regression as an eligible tool for conducting such stress tests as this method has good robustness properties, takes into account potential nonlinearities of conditional quantile functions and ensures that no quantile crossing effects occur. We illustrate its perfo…
We consider the problem of sparsity testing in the high-dimensional linear regression model. The problem is to test whether the number of non-zero components (aka the sparsity) of the regression parameter $θ^*$ is less than or equal to $k_0$. We pinpoint the minimax separation distances for this problem, which amounts to quantifying how far a $k_1$-sparse vector $θ^*$ has to be from the set of $k_0$-sparse vectors so that a test is able to reject the null hypothesis with high probability. Two scenarios are considered. In the independent scenario, the covariates are i.i.d. normally distributed …
We consider the problem of testing a particular type of composite null hypothesis under a nonparametric multivariate regression model. For a given quadratic functional $Q$, the null hypothesis states that the regression function $f$ satisfies the constraint $Q[f]=0$, while the alternative corresponds to the functions for which $Q[f]$ is bounded away from zero. On the one hand, we provide minimax rates of testing and the exact separation constants, along with a sharp-optimal testing procedure, for diagonal and nonnegative quadratic functionals. We consider smoothness classes of ellipsoidal form…
In this paper we compare two regression curves by measuring their difference by the area between the two curves, represented by their $L^1$-distance. We develop asymptotic confidence intervals for this measure and statistical tests to investigate the similarity/equivalence of the two curves. Bootstrap methodology specifically designed for equivalence testing is developed to obtain procedures with good finite sample properties and its consistency is rigorously proved. The finite sample properties are investigated by means of a small simulation study.
We find the asymptotic distribution of the multi-dimensional multi-scale and kernel estimators for high-frequency financial data with microstructure. Sampling times are allowed to be asynchronous and endogenous. In the process, we show that the classes of multi-scale and kernel estimators for smoothing noise perturbation are asymptotically equivalent in the sense of having the same asymptotic distribution for corresponding kernel and weight functions. The theory leads to multi-dimensional stable central limit theorems and feasible versions. Hence they allow to draw statistical inference for a …
We introduce a publication policy that incorporates conditional equivalence testing (CET), a two-stage testing scheme in which standard NHST is followed conditionally by testing for equivalence. The idea of CET is carefully considered as it has the potential to address recent concerns about reproducibility and the limited publication of null results. In this paper we detail the implementation of CET, investigate similarities with a Bayesian testing scheme, and outline the basis for how a scientific journal could proceed to reduce publication bias while remaining relevant.
Explicitly accounting for all applicable independent variables, even when the model being tested does not, is critical in testing goodness-of-fit for logistic regression. This can increase statistical power by orders of magnitude.
We propose a new approach for sparse regression and marginal testing, for data with correlated features. Our procedure first clusters the features, and then chooses as the cluster prototype the most informative feature in that cluster. Then we apply either sparse regression (lasso) or marginal significance testing to these prototypes. While this kind of strategy is not entirely new, a key feature of our proposal is its use of the post-selection inference theory of Taylor et al. (2014) and Lee et al. (2014) to compute exact p-values and confidence intervals that properly account for the selecti…
This paper investigates type I error violations that occur when blinded sample size reviews are applied in equivalence testing. We give a derivation which explains why such violations are more pronounced in equivalence testing than in the case of superiority testing. In addition, the amount of type I error inflation is quantified by simulation as well as by some theoretical considerations. Non-negligible type I error violations arise when blinded interim re-assessments of sample sizes are performed particularly if sample sizes are small, but within the range of what is practically relevant.
There has been strong recent interest in testing interval null hypothesis for improved scientific inference. For example, Lakens et al (2018) and Lakens and Harms (2017) use this approach to study if there is a pre-specified meaningful treatment effect in gerontology and clinical trials, which is different from the more traditional point null hypothesis that tests for any treatment effect. Two popular Bayesian approaches are available for interval null hypothesis testing. One is the standard Bayes factor and the other is the Region of Practical Equivalence (ROPE) procedure championed by Krusch…
