活细胞中的异常亚扩散：通过合作挑战弥合实验与现实模型之间的差距
Anomalous subdiffusion in living cells: bridging the gap between experiments and realistic models through collaborative challenges
摘要：
细胞的生命是由高度动态的微观过程控制的。两个值得注意的例子是膜受体的扩散和控制基因表达速率的转录因子的动力学。出现了不同的荧光成像技术来研究分子动力学。其中，荧光相关光谱（FCS）和单粒子跟踪（SPT）已被证明有助于我们了解细胞动力学和功能。对小组委员会和FCS的分析是一项持续不断的工作，尽管进行了几十年的工作，但仍有许多工作要做。在本文中，我们给出了用于分析细胞中的异常扩散的现有技术的快速概述，并提出了一个合作的挑战，以促进国家的最先进的分析算法的发展。我们建议在公开和公平的挑战中向世界各地的竞争对手提供标记（培训）和未标记（评估）的模拟数据。目标是提供基于生物相关指标的统一数据基准，以便比较社区可用的扩散分析软件。
英文摘要：
The life of a cell is governed by highly dynamical microscopic processes. Two notable examples are the diffusion of membrane receptors and the kinetics of transcription factors governing the rates of gene expression. Different fluorescence imaging techniques have emerged to study molecular dynamics. Among them, fluorescence correlation spectroscopy (FCS) and single-particle tracking (SPT) have proven to be instrumental to our understanding of cell dynamics and function. The analysis of SPT and FCS is an ongoing effort, and despite decades of work, much progress remains to be done. In this paper, we give a quick overview of the existing techniques used to analyze anomalous diffusion in cells and propose a collaborative challenge to foster the development of state-of-the-art analysis algorithms. We propose to provide labelled (training) and unlabelled (evaluation) simulated data to competitors all over the world in an open and fair challenge. The goal is to offer unified data benchmarks based on biologically-relevant metrics in order to compare the diffusion analysis software available for the community.
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