对Michael J. Saxton的论文的评论：“瞬态异常亚扩散的生物学解释。I.定性模型”
Comment to the Paper of Michael J. Saxton: "A Biological Interpretation of Transient Anomalous Subdiffusion. I. Qualitative Model"
摘要：
在最近的一篇论文中，Michael J. Saxton提出将均方位移（MSD）图中出现的明显瞬态亚扩散机制解释为异常扩散，MSD图是根据单粒子（或分子）跟踪技术（SPT或SMT）获得的活细胞中分子扩散的实验轨迹计算的。在这篇评论中，在不质疑亚扩散行为的存在的情况下，它肯定在生命系统中的许多机制中起着关键作用，我们指出，J.M.萨克斯顿也可以用一个简单的定律来拟合，这是由于在短时间内的受限扩散，在较长时间内叠加了较慢的自由扩散。当将MSD图可视化时，从尺寸为L的区域中的短期扩散到较慢的长期自由扩散的过渡可能与几个数量级的时间内的异常扩散相混淆。
英文摘要：
In a recent paper, Michael J. Saxton proposes to interpret as anomalous diffusion the occurrence of apparent transient sub-diffusive regimes in mean-squared displacements (MSD) plots, calculated from experimental trajectories of molecules diffusing in living cells, acquired by Single Particle (or Molecule) Tracking techniques (SPT or SMT). In this Comment, without questioning the existence of sub-diffusive behaviors, which certainly play a key role in numbers of mechanisms in living systems, we point out that the data used by J.M. Saxton can as well be fitted by a simple law, resulting from confined diffusion at short times, with a slower free diffusion superimposed at larger times. When visualizing MSD plots, the transition from short-term diffusion confined in domains of size L, to slower, longer-term free diffusion, can be confused with anomalous diffusion over several orders of magnitude of time.
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