利用布里渊显微镜测量角膜的力学各向异性
Measuring mechanical anisotropy of the cornea with Brillouin microscopy
摘要：
承重组织通常由蛋白质纤维网络强化，通常具有优先取向。这种纤维结构赋予组织方向依赖性的机械性能，以支持特定的外部负载。为了准确地建模和预测组织的力学响应，必须在微观尺度上表征各向异性。以前，它一直难以测量的完整组织的机械性能非侵入性。在这里，我们使用布里渊光学显微镜可视化和量化的角膜组织在不同的长度尺度的各向异性的机械性能。我们推导出胶原纤维的层状网络的刚度张量，并使用角度分辨布里渊测量来确定纵向刚度系数（纵向模量）描述的离体猪角膜作为横向各向同性材料。最后，我们观察到显着的机械各向异性的人角膜在体内，突出了离轴布里渊显微镜的临床应用的潜力。
英文摘要：
Load-bearing tissues are typically fortified by networks of protein fibers, often with preferential orientations. This fiber structure imparts the tissues with direction-dependent mechanical properties optimized to support specific external loads. To accurately model and predict tissues' mechanical response, it is essential to characterize the anisotropy on a microstructural scale. Previously, it has been difficult to measure the mechanical properties of intact tissues noninvasively. Here, we use Brillouin optical microscopy to visualize and quantify the anisotropic mechanical properties of corneal tissues at different length scales. We derive the stiffness tensor for a lamellar network of collagen fibrils and use angle-resolved Brillouin measurements to determine the longitudinal stiffness coefficients (longitudinal moduli) describing the ex vivo porcine cornea as a transverse isotropic material. Lastly, we observe significant mechanical anisotropy of the human cornea in vivo, highlighting the potential for clinical applications of off-axis Brillouin microscopy.
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