生物学和生物医学中微力学研究的布里渊成像：从当前最新技术水平到未来的临床应用
Brillouin imaging for studies of micromechanics in biology and biomedicine: from current state-of-the-art to future clinical translation
摘要：
布里渊成像技术是一种能够在微观尺度上对细胞和组织的力学特性进行非侵入性测量的强大技术。这为研究细胞机械生物学，细胞-基质相互作用，健康和疾病条件下的组织生物力学以及其他基本生物学问题提供了前所未有的工具。光学硬件的最新进展特别加速了该技术的发展，具有越来越精细的光谱分辨率和更强大的系统能力。我们设想，进一步的发展将使布里渊成像的翻译，以评估临床标本和样本的疾病筛查和监测。这篇综述的目的是总结国家的最先进的布里渊显微镜和成像与生物组织和细胞测量的具体重点。将讨论关键系统和操作要求，以促进布里渊成像的更广泛应用，以及当前将该技术转化为临床和医疗应用所面临的挑战。
英文摘要：
Brillouin imaging is increasingly recognized to be a powerful technique that enables non-invasive measurement of the mechanical properties of cells and tissues on a microscopic scale. This provides an unprecedented tool for investigating cell mechanobiology, cell-matrix interactions, tissue biomechanics in healthy and disease conditions and other fundamental biological questions. Recent advances in optical hardware have particularly accelerated the development of the technique, with increasingly finer spectral resolution and more powerful system capabilities. We envision that further developments will enable translation of Brillouin imaging to assess clinical specimens and samples for disease screening and monitoring. The purpose of this review is to summarize the state-of-the-art in Brillouin microscopy and imaging with a specific focus on biological tissue and cell measurements. Key system and operational requirements will be discussed to facilitate wider application of Brillouin imaging along with current challenges for translation of the technology for clinical and medical applications.
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