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arXiv 2002.02903stat.MLcs.LG
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大规模回归数据特征选择的子采样Winner算法

Subsampling Winner Algorithm for Feature Selection in Large Regression Data

Cleveland State University(克利夫兰州立大学);George Mason University(乔治梅森大学)

Yiying Fan, Jiayang Sun

摘要:

在回归分析中,从大量协变量(又名特征)中选择特征仍然是数据科学中的一个挑战,特别是在其扩展到不断扩大的数据并找到一组有科学意义的特征方面。例如,为了开发卵巢癌的新的响应性药物靶标,实际特征选择程序的实际错误发现率(FDR)也必须与靶标FDR匹配。当真实特征稀疏时,常用的特征选择方法是使用惩罚似然或收缩估计,如LASSO、SCAD、弹性网或MCP过程(称之为基准过程)。我们提出了一种不同的方法,使用一种新的子采样方法,称为子采样赢家算法(SWA)。SWA的中心思想类似于美国国家优秀学者的选择。SWA使用"基本程序"来分析每个子样本,根据来自所有子样本分析的每个特征的表现计算所有特征的得分,基于所得得分获得"半决赛选手",然后确定"决赛选手",即,最重要的特征。由于其子采样性质,SWA原则上可以扩展到任何维度的数据。与基准程序和randomForest相比,SWA还具有最佳控制的实际FDR,同时具有竞争力的真实特征发现率。我们还建议实用的附加策略,SWA或没有惩罚基准程序,以进一步确保“真正”的发现的机会。我们将SWA应用于Broad研究所的卵巢浆液性囊腺癌标本,揭示了功能重要的基因和途径,我们通过其他基因组学工具进行了验证。这个第二阶段的研究对于当前讨论P值的正确使用是必不可少的。

英文摘要:

Feature selection from a large number of covariates (aka features) in a regression analysis remains a challenge in data science, especially in terms of its potential of scaling to ever-enlarging data and finding a group of scientifically meaningful features. For example, to develop new, responsive drug targets for ovarian cancer, the actual false discovery rate (FDR) of a practical feature selection procedure must also match the target FDR. The popular approach to feature selection, when true features are sparse, is to use a penalized likelihood or a shrinkage estimation, such as a LASSO, SCAD, Elastic Net, or MCP procedure (call them benchmark procedures). We present a different approach using a new subsampling method, called the Subsampling Winner algorithm (SWA). The central idea of SWA is analogous to that used for the selection of US national merit scholars. SWA uses a "base procedure" to analyze each of the subsamples, computes the scores of all features according to the performance of each feature from all subsample analyses, obtains the "semifinalist" based on the resulting scores, and then determines the "finalists," i.e., the most important features. Due to its subsampling nature, SWA can scale to data of any dimension in principle. The SWA also has the best-controlled actual FDR in comparison with the benchmark procedures and the randomForest, while having a competitive true-feature discovery rate. We also suggest practical add-on strategies to SWA with or without a penalized benchmark procedure to further assure the chance of "true" discovery. Our application of SWA to the ovarian serous cystadenocarcinoma specimens from the Broad Institute revealed functionally important genes and pathways, which we verified by additional genomics tools. This second-stage investigation is essential in the current discussion of the proper use of P-values.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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