With the development of image segmentation in computer vision, biomedical image segmentation have achieved remarkable progress on brain tumor segmentation and Organ At Risk (OAR) segmentation. However, most of the research only uses single modality such as Computed Tomography (CT) scans while in real world scenario doctors often use multiple modalities to get more accurate result. To better leverage different modalities, we have collected a large dataset consists of 136 cases with CT and MR images which diagnosed with nasopharyngeal cancer. In this paper, we propose to use Generative Adversarial Network to perform CT to MR transformation to synthesize MR images instead of aligning two modalities. The synthesized MR can be jointly trained with CT to achieve better performance. In addition, we use instance segmentation model to extend the OAR segmentation task to segment both organs and tumor region. The collected dataset will be made public soon.
Disentangled representation is a powerful technique to tackle domain shift problem in medical image analysis in unsupervised domain adaptation setting.However, previous methods only focus on exacting domain-invariant feature and ignore whether exacted feature is meaningful for downstream tasks.We propose a novel framework, called semantic-guided disentangled representation (SGDR), an effective method to exact semantically meaningful feature for segmentation task to improve performance of cross modality medical image segmentation in unsupervised domain adaptation setting. To exact the meaningfu…
Unsupervised domain adaptation (UDA) methods have shown their promising performance in the cross-modality medical image segmentation tasks. These typical methods usually utilize a translation network to transform images from the source domain to target domain or train the pixel-level classifier merely using translated source images and original target images. However, when there exists a large domain shift between source and target domains, we argue that this asymmetric structure could not fully eliminate the domain gap. In this paper, we present a novel deep symmetric architecture of UDA for …
With the advent of advancements in deep learning approaches, such as deep convolution neural network, residual neural network, adversarial network; U-Net architectures are most widely utilized in biomedical image segmentation to address the automation in identification and detection of the target regions or sub-regions. In recent studies, U-Net based approaches have illustrated state-of-the-art performance in different applications for the development of computer-aided diagnosis systems for early diagnosis and treatment of diseases such as brain tumor, lung cancer, alzheimer, breast cancer, et…
Nanyang Technological University（南洋理工大学）；National University of Singapore（新加坡国立大学）
Domain shift has been a long-standing issue for medical image segmentation. Recently, unsupervised domain adaptation (UDA) methods have achieved promising cross-modality segmentation performance by distilling knowledge from a label-rich source domain to a target domain without labels. In this work, we propose a multi-scale self-ensembling based UDA framework for automatic segmentation of two key brain structures i.e., Vestibular Schwannoma (VS) and Cochlea on high-resolution T2 images. First, a segmentation-enhanced contrastive unpaired image translation module is designed for image-level doma…
De-LightSAM: Modality-Decoupled Lightweight SAM for Generalizable Medical Segmentation
School of Computer Science, University of Nottingham Ningbo China（诺丁汉大学宁波校区计算机科学学院）；Department of Electronic Engineering, The Chinese University of Hong Kong（香港中文大学电子工程系）；School of School of Engineering & Physical Sciences, University of Lincoln（林肯大学工程与物理科学学院）；Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences（中国科学院香港科学与创新研究院）；School of Computer Science, University of Nottingham（诺丁汉大学计算机科学学院）；The Hong Kong Polytechnic University（香港理工大学）
Mix-modal Federated Learning for MRI Image Segmentation
School of Artificial Intelligence（人工智能学院）；School of Computer Science and Technology（计算机科学与技术学院）；State Key Laboratory of Opto-Electronic Information Acquisition and Protection Technology（光电信息采集与防护技术国家重点实验室）；Anhui Provincial Key Laboratory of Security Artificial Intelligence（安徽省安全人工智能重点实验室）；Anhui Provincial Key Laboratory of Multimodal Cognitive Computation（安徽省多模态认知计算重点实验室）
Double Banking on Knowledge: Customized Modulation and Prototypes for Multi-Modality Semi-supervised Medical Image Segmentation
College of Computer Science, Sichuan University（四川大学计算机学院）；Agency for Science, Technology and Research (A*STAR)（新加坡科技研究局）；College of Electrical Engineering, Sichuan University（四川大学电气工程学院）；School of Cyber Science and Engineering, Sichuan University（四川大学网络空间安全学院）
The Chinese University of Hong Kong（香港中文大学）；Imperial College Longdon（伦敦帝国理工学院）；Imsight Medical Technology Co. Ltd.（艾迈医疗科技有限公司）；The Hong Kong Polytechnic University（香港理工大学）；Chinese Academy of Sciences（中国科学院）
Accurate medical image segmentation commonly requires effective learning of the complementary information from multimodal data. However, in clinical practice, we often encounter the problem of missing imaging modalities. We tackle this challenge and propose a novel multimodal segmentation framework which is robust to the absence of imaging modalities. Our network uses feature disentanglement to decompose the input modalities into the modality-specific appearance code, which uniquely sticks to each modality, and the modality-invariant content code, which absorbs multimodal information for the s…
Heudiasyc（Heudiasyc实验室）；CNRS（法国国家科学研究中心）；Université de technologie de Compiègne（贡比涅技术大学）；Quantif（Quantif团队）；LITIS（LITIS实验室）；University of Rouen Normandy（鲁昂诺曼底大学）；Institut universitaire de France（法国大学研究院）；Henri Becquerel Cancer Center（亨利·贝克勒尔癌症中心）
As information sources are usually imperfect, it is necessary to take into account their reliability in multi-source information fusion tasks. In this paper, we propose a new deep framework allowing us to merge multi-MR image segmentation results using the formalism of Dempster-Shafer theory while taking into account the reliability of different modalities relative to different classes. The framework is composed of an encoder-decoder feature extraction module, an evidential segmentation module that computes a belief function at each voxel for each modality, and a multi-modality evidence fusion…
We present a method to address the challenging problem of segmentation of multi-modality isointense infant brain MR images into white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF). Our method is based on context-guided, multi-stream fully convolutional networks (FCN), which after training, can directly map a whole volumetric data to its volume-wise labels. In order to alleviate the poten-tial gradient vanishing problem during training, we designed multi-scale deep supervision. Furthermore, context infor-mation was used to further improve the performance of our method. Validated …
DMAF-Net: An Effective Modality Rebalancing Framework for Incomplete Multi-Modal Medical Image Segmentation
College of Computer Science and Engineering, Chongqing University of Technology（重庆理工大学计算机科学与工程学院）；School of Computer Science and Engineering, Southeast University（东南大学计算机科学与工程学院）
Université de Rouen Normandie（鲁昂诺曼底大学）；INSA Rouen（鲁昂应用科学学院）
Multi-modality is widely used in medical imaging, because it can provide multiinformation about a target (tumor, organ or tissue). Segmentation using multimodality consists of fusing multi-information to improve the segmentation. Recently, deep learning-based approaches have presented the state-of-the-art performance in image classification, segmentation, object detection and tracking tasks. Due to their self-learning and generalization ability over large amounts of data, deep learning recently has also gained great interest in multi-modal medical image segmentation. In this paper, we give an …
Scene depth information can help visual information for more accurate semantic segmentation. However, how to effectively integrate multi-modality information into representative features is still an open problem. Most of the existing work uses DCNNs to implicitly fuse multi-modality information. But as the network deepens, some critical distinguishing features may be lost, which reduces the segmentation performance. This work proposes a unified and efficient feature selectionand-fusion network (FSFNet), which contains a symmetric cross-modality residual fusion module used for explicit fusion o…
For medical image segmentation, imagine if a model was only trained using MR images in source domain, how about its performance to directly segment CT images in target domain? This setting, namely generalizable cross-modality segmentation, owning its clinical potential, is much more challenging than other related settings, e.g., domain adaptation. To achieve this goal, we in this paper propose a novel dual-normalization model by leveraging the augmented source-similar and source-dissimilar images during our generalizable segmentation. To be specific, given a single source domain, aiming to sim…
Nanyang Technological University（南洋理工大学）；Institute for Infocomm Research, A*STAR（新加坡科技研究局资讯通信研究院）
The success of deep convolutional neural networks (DCNNs) benefits from high volumes of annotated data. However, annotating medical images is laborious, expensive, and requires human expertise, which induces the label scarcity problem. Especially when encountering the domain shift, the problem becomes more serious. Although deep unsupervised domain adaptation (UDA) can leverage well-established source domain annotations and abundant target domain data to facilitate cross-modality image segmentation and also mitigate the label paucity problem on the target domain, the conventional UDA methods s…
The Chinese University of Hong Kong（香港中文大学）；University of Michigan（密歇根大学）；Imsight Medical Technology Inc.（Imsight医疗科技公司）
Convolutional networks (ConvNets) have achieved great successes in various challenging vision tasks. However, the performance of ConvNets would degrade when encountering the domain shift. The domain adaptation is more significant while challenging in the field of biomedical image analysis, where cross-modality data have largely different distributions. Given that annotating the medical data is especially expensive, the supervised transfer learning approaches are not quite optimal. In this paper, we propose an unsupervised domain adaptation framework with adversarial learning for cross-modality…
TUNI: Unifying Pre-training and Fine-tuning with Modality-Aware Mutual Learning and Rectification for RGB-T Semantic Segmentation
School of Automation, Beijing Institute of Technology（自动化学院，北京理工大学）；School of Computer Science, Wuhan University（计算机学院，武汉大学）；Great Wall Motor（长城汽车）；School of Information and Electronic Engineering, Zhejiang University of Science and Technology（信息电子工程学院，浙江理工大学）
École de Technologie Supérieure（高等技术学院）；Purdue University（普渡大学）
Weakly supervised learning has emerged as an appealing alternative to alleviate the need for large labeled datasets in semantic segmentation. Most current approaches exploit class activation maps (CAMs), which can be generated from image-level annotations. Nevertheless, resulting maps have been demonstrated to be highly discriminant, failing to serve as optimal proxy pixel-level labels. We present a novel learning strategy that leverages self-supervision in a multi-modal image scenario to significantly enhance original CAMs. In particular, the proposed method is based on two observations. Firs…
National Library of Medicine（国家医学图书馆）；National Institutes of Health（美国国立卫生研究院）；Saint Louis University（圣路易斯大学）
Deep learning (DL) has drawn tremendous attention in object localization and recognition for both natural and medical images. U-Net segmentation models have demonstrated superior performance compared to conventional handcrafted feature-based methods. Medical image modality-specific DL models are better at transferring domain knowledge to a relevant target task than those that are pretrained on stock photography images. This helps improve model adaptation, generalization, and class-specific region of interest (ROI) localization. In this study, we train chest X-ray (CXR) modality-specific U-Nets…
The University of Edinburgh（爱丁堡大学）；The Alan Turing Institute（艾伦·图灵研究所）；Cedars Sinai Medical Center（西达赛奈医疗中心）
Magnetic resonance (MR) protocols rely on several sequences to assess pathology and organ status properly. Despite advances in image analysis, we tend to treat each sequence, here termed modality, in isolation. Taking advantage of the common information shared between modalities (an organ's anatomy) is beneficial for multi-modality processing and learning. However, we must overcome inherent anatomical misregistrations and disparities in signal intensity across the modalities to obtain this benefit. We present a method that offers improved segmentation accuracy of the modality of interest (over…
Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）
Unsupervised domain adaptation (UDA) between two significantly disparate domains to learn high-level semantic alignment is a crucial yet challenging task.~To this end, in this work, we propose exploiting low-level edge information to facilitate the adaptation as a precursor task, which has a small cross-domain gap, compared with semantic segmentation.~The precise contour then provides spatial information to guide the semantic adaptation. More specifically, we propose a multi-task framework to learn a contouring adaptation network along with a semantic segmentation adaptation network, which tak…
SGMA: Semantic-Guided Modality-Aware Segmentation for Remote Sensing with Incomplete Multimodal Data
State Key Laboratory of Information Engineering in Surveying, Mapping and Remote Sensing, Wuhan University（武汉大学测绘遥感信息工程国家重点实验室）；Hangzhou Institute of Technology, Xidian University（西安电子科技大学杭州研究院）；School of Artificial Intelligence, Wuhan University（武汉大学人工智能学院）
Peking University（北京大学）；SenseTime Research（商汤科技研究院）；The Chinese University of Hong Kong（香港中文大学）
Depth information has proven to be a useful cue in the semantic segmentation of RGB-D images for providing a geometric counterpart to the RGB representation. Most existing works simply assume that depth measurements are accurate and well-aligned with the RGB pixels and models the problem as a cross-modal feature fusion to obtain better feature representations to achieve more accurate segmentation. This, however, may not lead to satisfactory results as actual depth data are generally noisy, which might worsen the accuracy as the networks go deeper. In this paper, we propose a unified and effici…
University of Liverpool（利物浦大学）；Xi’an Jiaotong-Liverpool University（西交利物浦大学）；Duke Kunshan University（昆山杜克大学）
Unsupervised cross-modality medical image adaptation aims to alleviate the severe domain gap between different imaging modalities without using the target domain label. A key in this campaign relies upon aligning the distributions of source and target domain. One common attempt is to enforce the global alignment between two domains, which, however, ignores the fatal local-imbalance domain gap problem, i.e., some local features with larger domain gap are harder to transfer. Recently, some methods conduct alignment focusing on local regions to improve the efficiency of model learning. While this…
BiXFormer: A Robust Framework for Maximizing Modality Effectiveness in Multi-Modal Semantic Segmentation
Graduate School of Informatics, Nagoya University（名古屋大学信息学研究科）；AI Thrust, The Hong Kong University of Science and Technology（香港科学与技术大学人工智能 thrust）；INSAIT, Sofia University（索菲亚大学INSAIT）
The Chinese University of Hong Kong（香港中文大学）；Imsight Medical Technology Co., Ltd.（影迈医疗科技有限公司）；The Hong Kong Polytechnic University（香港理工大学）；SIAT（深圳先进技术研究院）
This paper presents a novel unsupervised domain adaptation framework, called Synergistic Image and Feature Adaptation (SIFA), to effectively tackle the problem of domain shift. Domain adaptation has become an important and hot topic in recent studies on deep learning, aiming to recover performance degradation when applying the neural networks to new testing domains. Our proposed SIFA is an elegant learning diagram which presents synergistic fusion of adaptations from both image and feature perspectives. In particular, we simultaneously transform the appearance of images across domains and enha…
CM-MaskSD: Cross-Modality Masked Self-Distillation for Referring Image Segmentation
Institute of Automation, Chinese Academy of Sciences（中国科学院自动化研究所）；School of Artificial Intelligence, University of Chinese Academy of Science（中国科学院大学人工智能学院）；University of Science and Technology Beijing（北京科技大学）
Although many studies have successfully applied transfer learning to medical image segmentation, very few of them have investigated the selection strategy when multiple source tasks are available for transfer. In this paper, we propose a prior knowledge guided and transferability based framework to select the best source tasks among a collection of brain image segmentation tasks, to improve the transfer learning performance on the given target task. The framework consists of modality analysis, RoI (region of interest) analysis, and transferability estimation, such that the source task selectio…
Robust Multispectral Semantic Segmentation under Missing or Full Modalities via Structured Latent Projection
Department of Computer Engineering, Ankara University（安卡拉大学计算机工程系）；Department of Modeling and Simulation, Graduate School of Informatics, METU（信息学院建模与模拟系，METU）
STARS: Shared-specific Translation and Alignment for missing-modality Remote Sensing Semantic Segmentation
State Key Laboratory of information Engineering in Surveying, Mapping and Remote Sensing, Wuhan University（测绘遥感信息工程国家重点实验室，武汉大学）；Electronic Information School, Wuhan University（电子信息学院，武汉大学）；Hubei FreerTech Co. Ltd（湖北弗瑞特科技有限公司）
Ludwig Maximilians University（路德维希-马克西米利安大学）；Technical University Munich（慕尼黑工业大学）
The wide range of research in deep learning-based medical image segmentation pushed the boundaries in a multitude of applications. A clinically relevant problem that received less attention is the handling of scans with irregular anatomy, e.g., after organ resection. State-of-the-art segmentation models often lead to organ hallucinations, i.e., false-positive predictions of organs, which cannot be alleviated by oversampling or post-processing. Motivated by the increasing need to develop robust deep learning models, we propose HALOS for abdominal organ segmentation in MR images that handles cas…
Technical University Dresden（德累斯顿工业大学）；University of Twente（特文特大学）
This paper addresses the task of designing a modular neural network architecture that jointly solves different tasks. As an example we use the tasks of depth estimation and semantic segmentation given a single RGB image. The main focus of this work is to analyze the cross-modality influence between depth and semantic prediction maps on their joint refinement. While most previous works solely focus on measuring improvements in accuracy, we propose a way to quantify the cross-modality influence. We show that there is a relationship between final accuracy and cross-modality influence, although no…
