This work presents a novel framework CISFA (Contrastive Image synthesis and Self-supervised Feature Adaptation)that builds on image domain translation and unsupervised feature adaptation for cross-modality biomedical image segmentation. Different from existing works, we use a one-sided generative model and add a weighted patch-wise contrastive loss between sampled patches of the input image and the corresponding synthetic image, which serves as shape constraints. Moreover, we notice that the generated images and input images share similar structural information but are in different modalities. As such, we enforce contrastive losses on the generated images and the input images to train the encoder of a segmentation model to minimize the discrepancy between paired images in the learned embedding space. Compared with existing works that rely on adversarial learning for feature adaptation, such a method enables the encoder to learn domain-independent features in a more explicit way. We extensively evaluate our methods on segmentation tasks containing CT and MRI images for abdominal cavities and whole hearts. Experimental results show that the proposed framework not only outputs synthetic images with less distortion of organ shapes, but also outperforms state-of-the-art domain adaptation methods by a large margin.
The Chinese University of Hong Kong（香港中文大学）；University of Michigan（密歇根大学）；Imsight Medical Technology Inc.（Imsight医疗科技公司）
Convolutional networks (ConvNets) have achieved great successes in various challenging vision tasks. However, the performance of ConvNets would degrade when encountering the domain shift. The domain adaptation is more significant while challenging in the field of biomedical image analysis, where cross-modality data have largely different distributions. Given that annotating the medical data is especially expensive, the supervised transfer learning approaches are not quite optimal. In this paper, we propose an unsupervised domain adaptation framework with adversarial learning for cross-modality…
With the advent of advancements in deep learning approaches, such as deep convolution neural network, residual neural network, adversarial network; U-Net architectures are most widely utilized in biomedical image segmentation to address the automation in identification and detection of the target regions or sub-regions. In recent studies, U-Net based approaches have illustrated state-of-the-art performance in different applications for the development of computer-aided diagnosis systems for early diagnosis and treatment of diseases such as brain tumor, lung cancer, alzheimer, breast cancer, et…
University of Notre Dame（圣母大学）；Guangdong Provincial People’s Hospital（广东省人民医院）
The success of deep learning methods in medical image segmentation tasks heavily depends on a large amount of labeled data to supervise the training. On the other hand, the annotation of biomedical images requires domain knowledge and can be laborious. Recently, contrastive learning has demonstrated great potential in learning latent representation of images even without any label. Existing works have explored its application to biomedical image segmentation where only a small portion of data is labeled, through a pre-training phase based on self-supervised contrastive learning without using a…
School of Medical Imaging, Xuzhou Medical University（徐州医科大学医学影像学院）；The Hong Kong Polytechnic University（香港理工大学）
With the widespread success of deep learning in biomedical image segmentation, domain shift becomes a critical and challenging problem, as the gap between two domains can severely affect model performance when deployed to unseen data with heterogeneous features. To alleviate this problem, we present a novel unsupervised domain adaptation network, for generalizing models learned from the labeled source domain to the unlabeled target domain for cross-modality biomedical image segmentation. Specifically, our approach consists of two key modules, a conditional domain discriminator~(CDD) and a cate…
Current point-cloud detection methods have difficulty detecting the open-vocabulary objects in the real world, due to their limited generalization capability. Moreover, it is extremely laborious and expensive to collect and fully annotate a point-cloud detection dataset with numerous classes of objects, leading to the limited classes of existing point-cloud datasets and hindering the model to learn general representations to achieve open-vocabulary point-cloud detection. As far as we know, we are the first to study the problem of open-vocabulary 3D point-cloud detection. Instead of seeking a p…
Nanyang Technological University（南洋理工大学）；National University of Singapore（新加坡国立大学）
Domain shift has been a long-standing issue for medical image segmentation. Recently, unsupervised domain adaptation (UDA) methods have achieved promising cross-modality segmentation performance by distilling knowledge from a label-rich source domain to a target domain without labels. In this work, we propose a multi-scale self-ensembling based UDA framework for automatic segmentation of two key brain structures i.e., Vestibular Schwannoma (VS) and Cochlea on high-resolution T2 images. First, a segmentation-enhanced contrastive unpaired image translation module is designed for image-level doma…
National Taiwan University（台湾大学）；GE Global Research（GE全球研究中心）
Deep learning models such as convolutional neural net- work have been widely used in 3D biomedical segmentation and achieve state-of-the-art performance. However, most of them often adapt a single modality or stack multiple modalities as different input channels. To better leverage the multi- modalities, we propose a deep encoder-decoder structure with cross-modality convolution layers to incorporate different modalities of MRI data. In addition, we exploit convolutional LSTM to model a sequence of 2D slices, and jointly learn the multi-modalities and convolutional LSTM in an end-to-end manner…
With the development of image segmentation in computer vision, biomedical image segmentation have achieved remarkable progress on brain tumor segmentation and Organ At Risk (OAR) segmentation. However, most of the research only uses single modality such as Computed Tomography (CT) scans while in real world scenario doctors often use multiple modalities to get more accurate result. To better leverage different modalities, we have collected a large dataset consists of 136 cases with CT and MR images which diagnosed with nasopharyngeal cancer. In this paper, we propose to use Generative Adversari…
The problem of cross-modality person re-identification has been receiving increasing attention recently, due to its practical significance. Motivated by the fact that human usually attend to the difference when they compare two similar objects, we propose a dual-path cross-modality feature learning framework which preserves intrinsic spatial strictures and attends to the difference of input cross-modality image pairs. Our framework is composed by two main components: a Dual-path Spatial-structure-preserving Common Space Network (DSCSN) and a Contrastive Correlation Network (CCN). The former em…
BioVLM: Routing Prompts, Not Parameters, for Cross-Modality Generalization in Biomedical VLMs
University of Trento（特伦托大学）；Carnegie Mellon University（卡内基梅隆大学）；LNMIIT Jaipur（贾伊普尔 LNMIIT）；MBZUAI；Sunandan Divatia School of Science（Sunandan Divatia 科学学院）；IIT Bombay（博伊斯大学）
Sensetime Research（商汤科技研究院）；The Hong Kong Polytechnic University（香港理工大学）
Video highlight detection is a crucial yet challenging problem that aims to identify the interesting moments in untrimmed videos. The key to this task lies in effective video representations that jointly pursue two goals, \textit{i.e.}, cross-modal representation learning and fine-grained feature discrimination. In this paper, these two challenges are tackled by not only enriching intra-modality and cross-modality relations for representation modeling but also shaping the features in a discriminative manner. Our proposed method mainly leverages the intra-modality encoding and cross-modality co…
Radboud University Medical Center（拉德堡德大学医学中心）；The Netherlands Cancer Institute（荷兰癌症研究所）；Nanjing University of Information Science and Technology（南京信息工程大学）
Domain adaptation has been widely adopted to transfer styles across multi-vendors and multi-centers, as well as to complement the missing modalities. In this challenge, we proposed an unsupervised domain adaptation framework for cross-modality vestibular schwannoma (VS) and cochlea segmentation and Koos grade prediction. We learn the shared representation from both ceT1 and hrT2 images and recover another modality from the latent representation, and we also utilize proxy tasks of VS segmentation and brain parcellation to restrict the consistency of image structures in domain adaptation. After …
Shanghai Jiao Tong University（上海交通大学）；Shanghai AI Laboratory（上海人工智能实验室）
Foundation models trained on large-scale dataset gain a recent surge in CV and NLP. In contrast, development in biomedical domain lags far behind due to data scarcity. To address this issue, we build and release PMC-OA, a biomedical dataset with 1.6M image-caption pairs collected from PubMedCentral's OpenAccess subset, which is 8 times larger than before. PMC-OA covers diverse modalities or diseases, with majority of the image-caption samples aligned at finer-grained level, i.e., subfigure and subcaption. While pretraining a CLIP-style model on PMC-OA, our model named PMC-CLIP achieves state-o…
In tissue characterization and cancer diagnostics, multimodal imaging has emerged as a powerful technique. Thanks to computational advances, large datasets can be exploited to discover patterns in pathologies and improve diagnosis. However, this requires efficient and scalable image retrieval methods. Cross-modality image retrieval is particularly challenging, since images of similar (or even the same) content captured by different modalities might share few common structures. We propose a new application-independent content-based image retrieval (CBIR) system for reverse (sub-)image search ac…
New York University（纽约大学）；Hyperfine Research（Hyperfine研究公司）；Yale University（耶鲁大学）
Establishing voxelwise semantic correspondence across distinct imaging modalities is a foundational yet formidable computer vision task. Current multi-modality registration techniques maximize hand-crafted inter-domain similarity functions, are limited in modeling nonlinear intensity-relationships and deformations, and may require significant re-engineering or underperform on new tasks, datasets, and domain pairs. This work presents ContraReg, an unsupervised contrastive representation learning approach to multi-modality deformable registration. By projecting learned multi-scale local patch fe…
Southern University of Science and Technology（南方科技大学）；The University of Hong Kong（香港大学）
Glaucoma is one of the ophthalmic diseases that may cause blindness, for which early detection and treatment are very important. Fundus images and optical coherence tomography (OCT) images are both widely-used modalities in diagnosing glaucoma. However, existing glaucoma grading approaches mainly utilize a single modality, ignoring the complementary information between fundus and OCT. In this paper, we propose an efficient multi-modality supervised contrastive learning framework, named COROLLA, for glaucoma grading. Through layer segmentation as well as thickness calculation and projection, re…
Contrastive Regularization over LoRA for Multimodal Biomedical Image Incremental Learning
School of Computer Science and Engineering, Central South University（计算机科学与工程学院，中南大学）；School of Automation, Central South University（自动化学院，中南大学）；School of Computer Science and Technology, Beijing Jiaotong University（计算机科学与技术学院，北京交通大学）
Weakly-supervised audio-visual violence detection aims to distinguish snippets containing multimodal violence events with video-level labels. Many prior works perform audio-visual integration and interaction in an early or intermediate manner, yet overlooking the modality heterogeneousness over the weakly-supervised setting. In this paper, we analyze the modality asynchrony and undifferentiated instances phenomena of the multiple instance learning (MIL) procedure, and further investigate its negative impact on weakly-supervised audio-visual learning. To address these issues, we propose a modal…
Large sparsely-activated models have obtained excellent performance in multiple domains. However, such models are typically trained on a single modality at a time. We present the Language-Image MoE, LIMoE, a sparse mixture of experts model capable of multimodal learning. LIMoE accepts both images and text simultaneously, while being trained using a contrastive loss. MoEs are a natural fit for a multimodal backbone, since expert layers can learn an appropriate partitioning of modalities. However, new challenges arise; in particular, training stability and balanced expert utilization, for which …
In this paper, we leverage the human perceiving process, that involves vision and language interaction, to generate a coherent paragraph description of untrimmed videos. We propose vision-language (VL) features consisting of two modalities, i.e., (i) vision modality to capture global visual content of the entire scene and (ii) language modality to extract scene elements description of both human and non-human objects (e.g. animals, vehicles, etc), visual and non-visual elements (e.g. relations, activities, etc). Furthermore, we propose to train our proposed VLCap under a contrastive learning V…
Columbia University（哥伦比亚大学）；Microsoft Cloud and AI（微软云与人工智能部门）；Microsoft Research（微软研究院）
Large-scale multi-modal contrastive pre-training has demonstrated great utility to learn transferable features for a range of downstream tasks by mapping multiple modalities into a shared embedding space. Typically, this has employed separate encoders for each modality. However, recent work suggests that transformers can support learning across multiple modalities and allow knowledge sharing. Inspired by this, we investigate a variety of Modality-Shared Contrastive Language-Image Pre-training (MS-CLIP) frameworks. More specifically, we question how many parameters of a transformer model can be…
A large amount of manual segmentation is typically required to train a robust segmentation network so that it can segment objects of interest in a new imaging modality. The manual efforts can be alleviated if the manual segmentation in one imaging modality (e.g., CT) can be utilized to train a segmentation network in another imaging modality (e.g., CBCT/MRI/PET). In this work, we developed an anatomy-constrained contrastive synthetic segmentation network (AccSeg-Net) to train a segmentation network for a target imaging modality without using its ground truth. Specifically, we proposed to use a…
University Of Texas at Arlington（德克萨斯大学阿灵顿分校）；Amazon（亚马逊）
Vision-language representation learning largely benefits from image-text alignment through contrastive losses (e.g., InfoNCE loss). The success of this alignment strategy is attributed to its capability in maximizing the mutual information (MI) between an image and its matched text. However, simply performing cross-modal alignment (CMA) ignores data potential within each modality, which may result in degraded representations. For instance, although CMA-based models are able to map image-text pairs close together in the embedding space, they fail to ensure that similar inputs from the same moda…
Is Contrastive Distillation Enough for Learning Comprehensive 3D Representations?
School of Mechatronic Engineering and Automation, Shanghai University, Shanghai, China（上海大学机械与自动化工程学院）；Department of Computer Science, City University of Hong Kong, Hong Kong SAR, China（香港城市大学计算机科学系）
RMIT University（皇家墨尔本理工大学）；University of New South Wales（新南威尔士大学）；Philips Research（飞利浦研究院）；Data61, CSIRO（澳大利亚联邦科学与工业研究组织Data61）
Self-Supervised Learning (SSL) is a new paradigm for learning discriminative representations without labelled data and has reached comparable or even state-of-the-art results in comparison to supervised counterparts. Contrastive Learning (CL) is one of the most well-known approaches in SSL that attempts to learn general, informative representations of data. CL methods have been mostly developed for applications in computer vision and natural language processing where only a single sensor modality is used. A majority of pervasive computing applications, however, exploit data from a range of dif…
We present modality gap, an intriguing geometric phenomenon of the representation space of multi-modal models. Specifically, we show that different data modalities (e.g. images and text) are embedded at arm's length in their shared representation in multi-modal models such as CLIP. Our systematic analysis demonstrates that this gap is caused by a combination of model initialization and contrastive learning optimization. In model initialization, we show empirically and theoretically that the representation of a common deep neural network is restricted to a narrow cone. As a consequence, in a mu…
LGE-Guided Cross-Modality Contrastive Learning for Gadolinium-Free Cardiomyopathy Screening in Cine CMR
School of Biomedical Engineering（生物医学工程学院）；State Key Laboratory of Advanced Medical Materials and Devices（先进医疗材料与设备国家重点实验室）；ShanghaiTech University（上海科技大学）；United Imaging Intelligence（联合影像智能）；Shanghai Clinical Research and Trial Center（上海临床研究与试验中心）；Capital Medical University（首都医科大学）；The First Hospital of Lanzhou University（兰州大学第一医院）
Google Research（谷歌研究院）；University of Michigan（密歇根大学）
The output of text-to-image synthesis systems should be coherent, clear, photo-realistic scenes with high semantic fidelity to their conditioned text descriptions. Our Cross-Modal Contrastive Generative Adversarial Network (XMC-GAN) addresses this challenge by maximizing the mutual information between image and text. It does this via multiple contrastive losses which capture inter-modality and intra-modality correspondences. XMC-GAN uses an attentional self-modulation generator, which enforces strong text-image correspondence, and a contrastive discriminator, which acts as a critic as well as …
CoCoNet: Coupled Contrastive Learning Network with Multi-level Feature Ensemble for Multi-modality Image Fusion
School of Software, Dalian University of Technology（大连理工大学软件学院）；Key Laboratory for Ubiquitous Network and Service Software of Liaoning Province（辽宁省普适网络与服务软件重点实验室）；Peng Cheng Laboratory（鹏城实验室）
A Modality-Tailored Graph Modeling Framework for Urban Region Representation via Contrastive Learning
Center for Applied Statistics, School of Statistics, Innovation Platform, Renmin University of China（应用统计中心、统计学院、创新平台、中国人民大学）；Harbin Institute of Technology, Shenzhen（哈尔滨工业大学深圳学院）
Unifying Visual and Vision-Language Tracking via Contrastive Learning
Deep Space Exploration Laboratory（深空探测实验室）；University of Science and Technology of China（中国科学技术大学）；Intelligent Science Technology Academy of CASIC（中国航天科工集团智能科学技术研究院）
Multimodal Medical Endoscopic Image Analysis via Progressive Disentangle-aware Contrastive Learning
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（深圳先进技术研究院，中国科学院）；First Affiliated Hospital, Sun Yat-sen University（中山大学第一附属医院）；College of Big Data and Internet, Shenzhen Technology University（深圳技术大学大数据与互联网学院）
Sun Yat-sen University（中山大学）；Beijing Jiaotong University（北京交通大学）；UiT The Arctic University of Norway（挪威UiT北极大学）；PengCheng Laboratory（鹏城实验室）；Alibaba Group（阿里巴巴集团）；Shenzhen Campus of Sun Yat-sen University（中山大学深圳校区）
Despite the potential of multi-modal pre-training to learn highly discriminative feature representations from complementary data modalities, current progress is being slowed by the lack of large-scale modality-diverse datasets. By leveraging the natural suitability of E-commerce, where different modalities capture complementary semantic information, we contribute a large-scale multi-modal pre-training dataset M5Product. The dataset comprises 5 modalities (image, text, table, video, and audio), covers over 6,000 categories and 5,000 attributes, and is 500 larger than the largest publicly availa…
SaliencyI2PLoc: saliency-guided image-point cloud localization using contrastive learning
State Key Laboratory of Information Engineering in Surveying, Mapping and Remote Sensing（测绘遥感信息工程国家重点实验室）；Wuhan University（武汉大学）；School of Electrical and Electronic Engineering（电气与电子工程学院）；Nanyang Technological University（南洋理工大学）；School of Geography and Environment（地理与环境学院）；Jiangxi Normal University（江西师范大学）
University of Electronic Science and Technology of China（电子科技大学）；Shanghai AI Lab（上海人工智能实验室）；ShanghaiTech University（上海科技大学）；Shanghai Jiao Tong University（上海交通大学）
Efficiently utilizing discriminative features is crucial for convolutional neural networks to achieve remarkable performance in medical image segmentation and is also important for model generalization across multiple domains, where letting model recognize domain-specific and domain-invariant information among multi-site datasets is a reasonable strategy for domain generalization. Unfortunately, most of the recent disentangle networks are not directly adaptable to unseen-domain datasets because of the limitations of offered data distribution. To tackle this deficiency, we propose Contrastive D…
CC-DCNet: Dynamic Convolutional Neural Network with Contrastive Constraints for Identifying Lung Cancer Subtypes on Multi-modality Images
Zhejiang Lab（之江实验室）；Institute of Computer Graphics and Vision（计算机图形与视觉研究所）；Graz University of Technology（格拉茨工业大学）；School of Computer Science and Engineering（计算机科学与工程学院）；Northwestern Polytechnical University（西北工业大学）；Zhejiang University School of Medicine（浙江大学医学院）；Sir Run Run Shaw Hospital（邵逸夫医院）；Shanghai Artificial Intelligence Laboratory（上海人工智能实验室）
