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arXiv 1909.09150eess.SPcs.LGstat.ML
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基于生成对抗网络的现实ECG合成

Synthesis of Realistic ECG using Generative Adversarial Networks

Dublin City University(都柏林城市大学);Insight Centre for Data Analytics(Insight数据分析中心)

Anne Marie Delaney, Eoin Brophy, Tomas E. Ward

摘要:

由于医疗数据的敏感性,其访问受到高度限制,阻止社区将这些数据用于研究或临床培训。为实现数据共享而实施的通用去身份化方法有时不足以保护数据中所包含的个人。在我们的研究中,我们研究了生成对抗网络(GANs)产生真实医疗时间序列数据的能力,这些数据可以在不考虑隐私的情况下使用。目的是生成代表正常ECG波形的合成ECG信号。GANs已成功用于生成高质量的合成时间序列,并已被证明可以防止重新识别单个记录。在这项工作中,开发了一系列GAN架构来生成合成正弦波和合成ECG。然后使用两个评估指标来定量评估合成数据是否适合现实世界的应用,如临床培训和数据分析。最后,我们讨论了与共享GANs产生的合成数据相关的隐私问题,并测试了它们抵御简单成员推断攻击的能力。我们第一次定量和定性地证明了GAN架构可以成功地生成时间序列信号,这些信号不仅在结构上与训练集相似,而且在生成的样本中具有多样性。我们还报告了它们抵御简单成员推断攻击的能力,保护了训练集的隐私。

英文摘要:

Access to medical data is highly restricted due to its sensitive nature, preventing communities from using this data for research or clinical training. Common methods of de-identification implemented to enable the sharing of data are sometimes inadequate to protect the individuals contained in the data. For our research, we investigate the ability of generative adversarial networks (GANs) to produce realistic medical time series data which can be used without concerns over privacy. The aim is to generate synthetic ECG signals representative of normal ECG waveforms. GANs have been used successfully to generate good quality synthetic time series and have been shown to prevent re-identification of individual records. In this work, a range of GAN architectures are developed to generate synthetic sine waves and synthetic ECG. Two evaluation metrics are then used to quantitatively assess how suitable the synthetic data is for real world applications such as clinical training and data analysis. Finally, we discuss the privacy concerns associated with sharing synthetic data produced by GANs and test their ability to withstand a simple membership inference attack. For the first time we both quantitatively and qualitatively demonstrate that GAN architecture can successfully generate time series signals that are not only structurally similar to the training sets but also diverse in nature across generated samples. We also report on their ability to withstand a simple membership inference attack, protecting the privacy of the training set.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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