用于记录来自纳米粒子注入器的气相粒子束横向绝对密度分布的光片成像
Light-sheet imaging for the recording of transverse absolute density distributions of gas-phase particle-beams from nanoparticle injectors
摘要：
在气相中成像生物分子需要新的样品输送方法，通常必须对其进行表征和优化，以产生高密度粒子束。提出了一种非破坏性表征粒子束横向剖面的方法。它能够在收集例如X射线衍射图案的同时对粒子束进行表征。作为一种相当简单的实验方法，它需要使用柱面望远镜和显微镜产生一个小的激光片。该技术的工作原理被证明为220 nm的聚苯乙烯珠作为原型纳米粒子的流体动态聚焦行为的表征。粒子通量的测定和速度分布进行了校准使用米氏散射计算。
英文摘要：
Imaging biological molecules in the gas-phase requires novel sample delivery methods, which generally have to be characterized and optimized to produce high-density particle beams. A non-destructive characterization method of the transverse particle beam profile is presented. It enables the characterization of the particle beam in parallel to the collection of, for instance, x-ray-diffraction patterns. As a rather simple experimental method, it requires the generation of a small laser-light sheet using a cylindrical telescope and a microscope. The working principle of this technique was demonstrated for the characterization of the fluid-dynamic-focusing behavior of 220 nm polystyrene beads as prototypical nanoparticles. The particle flux was determined and the velocity distribution was calibrated using Mie-scattering calculations.
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