Image modality recognition is essential for efficient imaging workflows in current clinical environments, where multiple imaging modalities are used to better comprehend complex diseases. Emerging biomarkers from novel, rare modalities are being developed to aid in such understanding, however the availability of these images is often limited. This scenario raises the necessity of recognising new imaging modalities without them being collected and annotated in large amounts. In this work, we present a few-shot learning model for limited training examples based on Deep Triplet Networks. We show that the proposed model is more accurate in distinguishing different modalities than a traditional Convolutional Neural Network classifier when limited samples are available. Furthermore, we evaluate the performance of both classifiers when presented with noisy samples and provide an initial inspection of how the proposed model can incorporate measures of uncertainty to be more robust against out-of-sample examples.
Guangzhou University（广州大学）；University of Macau（澳门大学）
Visible-Infrared cross-modality person re-identification (VI-ReID), whose aim is to match person images between visible and infrared modality, is a challenging cross-modality image retrieval task. Batch Hard Triplet loss is widely used in person re-identification tasks, but it does not perform well in the Visible-Infrared person re-identification task. Because it only optimizes the hardest triplet for each anchor image within the mini-batch, samples in the hardest triplet may all belong to the same modality, which will lead to the imbalance problem of modality optimization. To address this pro…
BrainAnytime: Anatomy-Aware Cross-Modal Pretraining for Brain Image Analysis with Arbitrary Modality Availability
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China（生物医学工程系，香港理工大学，香港特别行政区，中国）；Department of Technology Management for Innovation, The University of Tokyo, Japan（创新技术管理系，东京大学，日本）；Department of Data Science and Artificial Intelligence, The Hong Kong Polytechnic University, Hong Kong SAR, China（数据科学与人工智能系，香港理工大学，香港特别行政区，中国）
School of Mechano-Electronic Engineering, Xidian University（西安电子科技大学机电工程学院）；Computer Science Department, Aberystwyth University（阿伯里斯特威斯大学计算机科学系）；School of Automation, Northwestern Polytechnical University（西北工业大学自动化学院）；Deepwise AI Lab（深睿人工智能实验室）
Recent advances in machine learning and prevalence of digital medical images have opened up an opportunity to address the challenging brain tumor segmentation (BTS) task by using deep convolutional neural networks. However, different from the RGB image data that are very widespread, the medical image data used in brain tumor segmentation are relatively scarce in terms of the data scale but contain the richer information in terms of the modality property. To this end, this paper proposes a novel cross-modality deep feature learning framework to segment brain tumors from the multi-modality MRI d…
University of California, Los Angeles（加州大学洛杉矶分校）；National University of Singapore（新加坡国立大学）
Brain tumor is a common and fatal form of cancer which affects both adults and children. The classification of brain tumors into different types is hence a crucial task, as it greatly influences the treatment that physicians will prescribe. In light of this, medical imaging techniques, especially those applying deep convolutional networks followed by a classification layer, have been developed to make possible computer-aided classification of brain tumor types. In this paper, we present a novel approach of directly learning deep embeddings for brain tumor types, which can be used for downstrea…
This paper focuses on the visible-thermal cross-modality person re-identification (VT Re-ID) task, whose goal is to match person images between the daytime visible modality and the nighttime thermal modality. The two-stream network is usually adopted to address the cross-modality discrepancy, the most challenging problem for VT Re-ID, by learning the multi-modality person features. In this paper, we explore how many parameters of two-stream network should share, which is still not well investigated in the existing literature. By well splitting the ResNet50 model to construct the modality-speci…
We present a method to address the challenging problem of segmentation of multi-modality isointense infant brain MR images into white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF). Our method is based on context-guided, multi-stream fully convolutional networks (FCN), which after training, can directly map a whole volumetric data to its volume-wise labels. In order to alleviate the poten-tial gradient vanishing problem during training, we designed multi-scale deep supervision. Furthermore, context infor-mation was used to further improve the performance of our method. Validated …
Southern University of Science and Technology（南方科技大学）；The University of Hong Kong（香港大学）
Multi-modal magnetic resonance (MR) imaging provides great potential for diagnosing and analyzing brain gliomas. In clinical scenarios, common MR sequences such as T1, T2 and FLAIR can be obtained simultaneously in a single scanning process. However, acquiring contrast enhanced modalities such as T1ce requires additional time, cost, and injection of contrast agent. As such, it is clinically meaningful to develop a method to synthesize unavailable modalities which can also be used as additional inputs to downstream tasks (e.g., brain tumor segmentation) for performance enhancing. In this work, …
South China University of Technology（华南理工大学）；Rochester Institute of Technology（罗切斯特理工学院）
Due to the difficulties of obtaining multimodal paired images in clinical practice, recent studies propose to train brain tumor segmentation models with unpaired images and capture complementary information through modality translation. However, these models cannot fully exploit the complementary information from different modalities. In this work, we thus present a novel two-step (intra-modality and inter-modality) curriculum disentanglement learning framework to effectively utilize privileged semi-paired images, i.e. limited paired images that are only available in training, for brain tumor …
Huazhong University of Science and Technology（华中科技大学）；Baidu Research（百度研究院）
This paper tackles the Zero-Shot Sketch-Based Image Retrieval (ZS-SBIR) problem from the viewpoint of cross-modality metric learning. This task has two characteristics: 1) the zero-shot setting requires a metric space with good within-class compactness and the between-class discrepancy for recognizing the novel classes and 2) the sketch query and the photo gallery are in different modalities. The metric learning viewpoint benefits ZS-SBIR from two aspects. First, it facilitates improvement through recent good practices in deep metric learning (DML). By combining two fundamental learning approa…
Research Institute of Beihang University in Shenzhen（北京航空航天大学深圳研究院）；Beihang University（北京航空航天大学）；Chongqing University（重庆大学）；Microsoft Research（微软研究院）
We present a cross-modality generation framework that learns to generate translated modalities from given modalities in MR images without real acquisition. Our proposed method performs NeuroImage-to-NeuroImage translation (abbreviated as N2N) by means of a deep learning model that leverages conditional generative adversarial networks (cGANs). Our framework jointly exploits the low-level features (pixel-wise information) and high-level representations (e.g. brain tumors, brain structure like gray matter, etc.) between cross modalities which are important for resolving the challenging complexity…
Tianjin University（天津大学）；The University of Hong Kong（香港大学）；Huanhu Hospital（环湖医院）；The Hong Kong University of Science and Technology (Guangzhou)（香港科技大学（广州））；The Hong Kong University of Science and Technology（香港科技大学）
Multi-modal MR imaging is routinely used in clinical practice to diagnose and investigate brain tumors by providing rich complementary information. Previous multi-modal MRI segmentation methods usually perform modal fusion by concatenating multi-modal MRIs at an early/middle stage of the network, which hardly explores non-linear dependencies between modalities. In this work, we propose a novel Nested Modality-Aware Transformer (NestedFormer) to explicitly explore the intra-modality and inter-modality relationships of multi-modal MRIs for brain tumor segmentation. Built on the transformer-based…
Institute of Imaging and Computer Vision, RWTH Aachen University（亚琛工业大学成像与计算机视觉研究所）
Gliomas are one of the most prevalent types of primary brain tumours, accounting for more than 30\% of all cases and they develop from the glial stem or progenitor cells. In theory, the majority of brain tumours could well be identified exclusively by the use of Magnetic Resonance Imaging (MRI). Each MRI modality delivers distinct information on the soft tissue of the human brain and integrating all of them would provide comprehensive data for the accurate segmentation of the glioma, which is crucial for the patient's prognosis, diagnosis, and determining the best follow-up treatment. Unfortun…
Technical University of Denmark（丹麦技术大学）；Skåne University Hospital（斯科讷大学医院）；Danish Research Centre for Magnetic Resonance（丹麦磁共振研究中心）；Copenhagen University Hospital Hvidovre（哥本哈根大学医院维兹奥勒医院）；Copenhagen University Hospital Rigshospitalet（哥本哈根大学医院国立医院）；University College London（伦敦大学学院）；UCLH NHS Foundation Trust（伦敦大学学院医院NHS基金会信托）；National Hospital for Neurology and Neurosurgery（国立神经病学与神经外科医院）
In this paper we present a method for simultaneously segmenting brain tumors and an extensive set of organs-at-risk for radiation therapy planning of glioblastomas. The method combines a contrast-adaptive generative model for whole-brain segmentation with a new spatial regularization model of tumor shape using convolutional restricted Boltzmann machines. We demonstrate experimentally that the method is able to adapt to image acquisitions that differ substantially from any available training data, ensuring its applicability across treatment sites; that its tumor segmentation accuracy is compara…
Institute of Computing Technology, Chinese Academy of Sciences（中国科学院计算技术研究所）；University of Chinese Academy of Sciences（中国科学院大学）；Lenovo Research（联想研究院）
Automatic brain tumor segmentation from multi-modality Magnetic Resonance Images (MRI) using deep learning methods plays an important role in assisting the diagnosis and treatment of brain tumor. However, previous methods mostly ignore the latent relationship among different modalities. In this work, we propose a novel end-to-end Modality-Pairing learning method for brain tumor segmentation. Paralleled branches are designed to exploit different modality features and a series of layer connections are utilized to capture complex relationships and abundant information among modalities. We also us…
Disentangled Multimodal Brain MR Image Translation via Transformer-based Modality Infuser
Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School（马萨诸塞州总医院与哈佛医学院戈登医学影像中心）；Korea Advanced Institute of Science and Technology（韩国科学技术院）
A Foundation Model for Brain Lesion Segmentation with Mixture of Modality Experts
Imperial College London（帝国理工学院）；UK Dementia Research Institute（英国痴呆症研究所）；Beijing Institute of Technology（北京理工大学）；Capital Medical University（首都医科大学）；Beijing Tiantan Hospital（北京天坛医院）
Istanbul Technical University（伊斯坦布尔理工大学）；Université de Sousse（苏塞大学）；Ecole Nationale d’Ingénieurs de Sousse（苏塞国立工程师学院）
Synthesizing multimodality medical data provides complementary knowledge and helps doctors make precise clinical decisions. Although promising, existing multimodal brain graph synthesis frameworks have several limitations. First, they mainly tackle only one problem (intra- or inter-modality), limiting their generalizability to synthesizing inter- and intra-modality simultaneously. Second, while few techniques work on super-resolving low-resolution brain graphs within a single modality (i.e., intra), inter-modality graph super-resolution remains unexplored though this would avoid the need for c…
Magnetic Resonance (MR) images of different modalities can provide complementary information for clinical diagnosis, but whole modalities are often costly to access. Most existing methods only focus on synthesizing missing images between two modalities, which limits their robustness and efficiency when multiple modalities are missing. To address this problem, we propose a multi-modality generative adversarial network (MGAN) to synthesize three high-quality MR modalities (FLAIR, T1 and T1ce) from one MR modality T2 simultaneously. The experimental results show that the quality of the synthesize…
The Chinese University of Hong Kong（香港中文大学）；Imperial College Longdon（伦敦帝国理工学院）；Imsight Medical Technology Co. Ltd.（艾迈医疗科技有限公司）；The Hong Kong Polytechnic University（香港理工大学）；Chinese Academy of Sciences（中国科学院）
Accurate medical image segmentation commonly requires effective learning of the complementary information from multimodal data. However, in clinical practice, we often encounter the problem of missing imaging modalities. We tackle this challenge and propose a novel multimodal segmentation framework which is robust to the absence of imaging modalities. Our network uses feature disentanglement to decompose the input modalities into the modality-specific appearance code, which uniquely sticks to each modality, and the modality-invariant content code, which absorbs multimodal information for the s…
Université de Sousse（苏塞大学）；Ecole Nationale d’Ingénieurs de Sousse（苏塞国立工程师学院）；Istanbul Technical University（伊斯坦布尔理工大学）
Brain graph synthesis marked a new era for predicting a target brain graph from a source one without incurring the high acquisition cost and processing time of neuroimaging data. However, existing multi-modal graph synthesis frameworks have several limitations. First, they mainly focus on generating graphs from the same domain (intra-modality), overlooking the rich multimodal representations of brain connectivity (inter-modality). Second, they can only handle isomorphic graph generation tasks, limiting their generalizability to synthesizing target graphs with a different node size and topologi…
University of Pittsburgh（匹兹堡大学）；Arizona State University（亚利桑那州立大学）；University of California San Francisco（加州大学旧金山分校）；University of Illinois Chicago（伊利诺伊大学芝加哥分校）；University of Southern California（南加州大学）
MRI-based modeling of brain networks has been widely used to understand functional and structural interactions and connections among brain regions, and factors that affect them, such as brain development and disease. Graph mining on brain networks may facilitate the discovery of novel biomarkers for clinical phenotypes and neurodegenerative diseases. Since brain networks derived from functional and structural MRI describe the brain topology from different perspectives, exploring a representation that combines these cross-modality brain networks is non-trivial. Most current studies aim to extra…
South China University of Technology（华南理工大学）；Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences（广东省人民医院，广东省医学科学院）
Brain tumor segmentation (BTS) in magnetic resonance image (MRI) is crucial for brain tumor diagnosis, cancer management and research purposes. With the great success of the ten-year BraTS challenges as well as the advances of CNN and Transformer algorithms, a lot of outstanding BTS models have been proposed to tackle the difficulties of BTS in different technical aspects. However, existing studies hardly consider how to fuse the multi-modality images in a reasonable manner. In this paper, we leverage the clinical knowledge of how radiologists diagnose brain tumors from multiple MRI modalities…
University at Buffalo, The State University of New York（纽约州立大学布法罗分校）
Brain Tumor Segmentation from magnetic resonance imaging (MRI) is a critical technique for early diagnosis. However, rather than having complete four modalities as in BraTS dataset, it is common to have missing modalities in clinical scenarios. We design a brain tumor segmentation algorithm that is robust to the absence of any modality. Our network includes a channel-independent encoding path and a feature-fusion decoding path. We use self-supervised training through channel dropout and also propose a novel domain adaptation method on feature maps to recover the information from the missing ch…
Lehigh University（里海大学）；University of Pennsylvania（宾夕法尼亚大学）
Identification of brain regions related to the specific neurological disorders are of great importance for biomarker and diagnostic studies. In this paper, we propose an interpretable Graph Convolutional Network (GCN) framework for the identification and classification of Alzheimer's disease (AD) using multi-modality brain imaging data. Specifically, we extended the Gradient Class Activation Mapping (Grad-CAM) technique to quantify the most discriminative features identified by GCN from brain connectivity patterns. We then utilized them to find signature regions of interest (ROIs) by detecting…
ClusMFL: A Cluster-Enhanced Framework for Modality-Incomplete Multimodal Federated Learning in Brain Imaging Analysis
School of Science and Engineering, the Chinese University of Hong Kong, Shenzhen（香港中文大学（深圳）理工学院）；Department of Computer Science and Engineering, Lehigh University（利哈伊大学计算机科学与工程系）；Department of Computer Science, Emory University（埃默里大学计算机科学系）
Segmenting the fine structure of the mouse brain on magnetic resonance (MR) images is critical for delineating morphological regions, analyzing brain function, and understanding their relationships. Compared to a single MRI modality, multimodal MRI data provide complementary tissue features that can be exploited by deep learning models, resulting in better segmentation results. However, multimodal mouse brain MRI data is often lacking, making automatic segmentation of mouse brain fine structure a very challenging task. To address this issue, it is necessary to fuse multimodal MRI data to produ…
UniTriGen: Unified Triplet Generation of Aligned Visible-Infrared-Label for Few-Shot RGB-T Semantic Segmentation
School of Computer Science, Northwestern Polytechnical University（西北工业大学计算机学院）；School of Computer Science & Technology, Xi’an University of Posts & Telecommunications（西安邮电大学计算机科学与技术学院）；MMLab, The Chinese University of Hong Kong（香港中文大学MMLab）
Modality-Agnostic Input Channels Enable Segmentation of Brain lesions in Multimodal MRI with Sequences Unavailable During Training
Department of Engineering Science, University of Oxford, Oxford, UK（工程科学系，牛津大学，牛津，英国）；Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK（牛津大学临床神经科学系，牛津，英国）
INSA de Rouen（鲁昂国立应用科学学院）；Université de Rouen Normandie（鲁昂诺曼底大学）；Normandie Univ（诺曼底大学）；Henri Becquerel Cancer Center（亨利·贝克勒尔癌症中心）
Using multimodal Magnetic Resonance Imaging (MRI) is necessary for accurate brain tumor segmentation. The main problem is that not all types of MRIs are always available in clinical exams. Based on the fact that there is a strong correlation between MR modalities of the same patient, in this work, we propose a novel brain tumor segmentation network in the case of missing one or more modalities. The proposed network consists of three sub-networks: a feature-enhanced generator, a correlation constraint block and a segmentation network. The feature-enhanced generator utilizes the available modali…
Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）
Unsupervised domain adaptation (UDA) between two significantly disparate domains to learn high-level semantic alignment is a crucial yet challenging task.~To this end, in this work, we propose exploiting low-level edge information to facilitate the adaptation as a precursor task, which has a small cross-domain gap, compared with semantic segmentation.~The precise contour then provides spatial information to guide the semantic adaptation. More specifically, we propose a multi-task framework to learn a contouring adaptation network along with a semantic segmentation adaptation network, which tak…
Graduate School at Shenzhen, Tsinghua University（清华大学深圳研究生院）；The University of Texas at Arlington（德克萨斯大学阿灵顿分校）
Accurate segmentation of brain tissue in magnetic resonance images (MRI) is a diffcult task due to different types of brain abnormalities. Using information and features from multimodal MRI including T1, T1-weighted inversion recovery (T1-IR) and T2-FLAIR and differential geometric features including the Jacobian determinant(JD) and the curl vector(CV) derived from T1 modality can result in a more accurate analysis of brain images. In this paper, we use the differential geometric information including JD and CV as image characteristics to measure the differences between different MRI images, w…
Massachusetts General Hospital（马萨诸塞总医院）；Harvard Medical School（哈佛医学院）
Multimodal MRI provides complementary and clinically relevant information to probe tissue condition and to characterize various diseases. However, it is often difficult to acquire sufficiently many modalities from the same subject due to limitations in study plans, while quantitative analysis is still demanded. In this work, we propose a unified conditional disentanglement framework to synthesize any arbitrary modality from an input modality. Our framework hinges on a cycle-constrained conditional adversarial training approach, where it can extract a modality-invariant anatomical feature with …
Automated brain structure segmentation is important to many clinical quantitative analysis and diagnoses. In this work, we introduce MixNet, a 2D semantic-wise deep convolutional neural network to segment brain structure in multi-modality MRI images. The network is composed of our modified deep residual learning units. In the unit, we replace the traditional convolution layer with the dilated convolutional layer, which avoids the use of pooling layers and deconvolutional layers, reducing the number of network parameters. Final predictions are made by aggregating information from multiple scale…
Mind the Gap: Promoting Missing Modality Brain Tumor Segmentation with Alignment
School of Robotics Xi’an Jiaotong-Liverpool University Suzhou, China；School of Advanced Technology Xi'an Jiaotong-Liverpool University Suzhou, China；School of Advanced Technology Xi’an Jiaotong-Liverpool University Suzhou, China；Data Science Research Center Duke Kunshan University Suzhou, China
CCSD: Cross-Modal Compositional Self-Distillation for Robust Brain Tumor Segmentation with Missing Modalities
Shanghai Research Institute for Intelligent Autonomous Systems, Tongji University（上海智能自主系统研究院，同济大学）；College of Biomedical Engineering, Fudan University（生物医学工程学院，复旦大学）；School of Medicine, Tongji University（医学院，同济大学）；College of Information Engineering, China Jiliang University（信息工程学院，中国嘉兴大学）
Medical School of Nanjing University（南京大学医学院）；National Institute of Healthcare Data Science at Nanjing University（南京大学国家健康医疗大数据研究院）；State Key Laboratory for Novel Software Technology, Nanjing University（南京大学计算机软件新技术国家重点实验室）；School of Computer Science and Technology, Nanjing University of Science and Technology（南京理工大学计算机科学与技术学院）；Department of Radiology, Nanjing Drum Tower Hospital, Nanjing University Medical School（南京大学医学院附属鼓楼医院放射科）；School of Biomedical Engineering, ShanghaiTech University（上海科技大学生物医学工程学院）；Department of Research and Development, Shanghai United Imaging Intelligence Co., Ltd.（上海联影智能医疗科技有限公司研发部）；Department of Artificial Intelligence, Korea University（高丽大学人工智能系）
Accurate segmentation of brain tumors from multi-modal Magnetic Resonance (MR) images is essential in brain tumor diagnosis and treatment. However, due to the existence of domain shifts among different modalities, the performance of networks decreases dramatically when training on one modality and performing on another, e.g., train on T1 image while performing on T2 image, which is often required in clinical applications. This also prohibits a network from being trained on labeled data and then transferred to unlabeled data from a different domain. To overcome this, unsupervised domain adaptat…
University of Edinburgh（爱丁堡大学）；Imperial College London（帝国理工学院）；University of Essex（埃塞克斯大学）
Magnetic Resonance Imaging (MRI) typically recruits multiple sequences (defined here as "modalities"). As each modality is designed to offer different anatomical and functional clinical information, there are evident disparities in the imaging content across modalities. Inter- and intra-modality affine and non-rigid image registration is an essential medical image analysis process in clinical imaging, as for example before imaging biomarkers need to be derived and clinically evaluated across different MRI modalities, time phases and slices. Although commonly needed in real clinical scenarios, …
Wavelet-Fusion Diffusion Model for Multimodal Brain MRI Synthesis with Modality and Metadata Conditioning
Department of Psychology & Neuroscience, Auckland University of Technology（心理学与神经科学系，奥克兰技术大学）；Department of Psychiatry, University of Melbourne（精神病学系，墨尔本大学）
Synergistic Modality-and-Slice Memory Framework for Cross-Modal 3D Brain Tumor Segmentation
Graduate School of Information, Production and Systems, Waseda University, Japan（信息、生产与系统研究生院，早稻田大学，日本）；School of Computer Science, University of Lincoln, UK（林肯大学计算机科学学院，英国）；University of Nottingham, UK（诺丁汉大学，英国）；University of Nottingham Ningbo China, China（宁波诺丁汉大学，中国）；College of Electrical Engineering and Information, Northeast Agricultural University, Harbin, China（电气工程与信息学院，东北农业大学，中国）；College of Computer Science, Sichuan University, Chengdu, China（计算机科学学院，四川大学，中国）；Yale University, New Haven, CT 06510, USA（耶鲁大学，美国）；School of Engineering and Physical Science, University of Lincoln, Lincoln LN6 7TS, UK（工程与物理科学学院，林肯大学，英国）
Make-A-Volume: Leveraging Latent Diffusion Models for Cross-Modality 3D Brain MRI Synthesis
The University of Hong Kong（香港大学）；The Chinese University of Hong Kong（香港中文大学）；Qilu Hospital of Shandong University（山东大学齐鲁医院）；Nanyang Technological University（南洋理工大学）
