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arXiv 1908.10208eess.IVcs.LGphysics.med-phstat.ML
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基于CT扫描的前列腺分割的跨模态知识传递

Cross-modality Knowledge Transfer for Prostate Segmentation from CT Scans

Columbia University Irving Medical Center(哥伦比亚大学欧文医学中心);University of Central Florida(中佛罗里达大学);Chung Yuan Christian University(中原大学);New York Presbyterian Hospital(纽约长老会医院);Weill Cornell Medical College(威尔康奈尔医学院)

Yucheng Liu, Naji Khosravan, Yulin Liu, Joseph Stember, Jonathan Shoag, Christopher E. Barbieri, Ulas Bagci, Sachin Jambawalikar

摘要:

创建大规模高质量注释是医学成像中的已知挑战。在这项工作中,基于CycleGAN算法,我们建议利用一种模态的注释在其他模态中是有用的。更具体地说,所提出的算法创建高度逼真的合成CT图像(SynCT)从前列腺MR图像使用不成对的数据集。通过使用SynCT图像(无分割标签)和MR图像(有可用的分割标签),我们训练了一个深度分割网络,用于从真实CT扫描中精确描绘前列腺。对于我们的CycleGAN中的发生器,循环一致性术语用于保证SynCT共享最初在MR图像上描绘的相同手动绘制的高质量掩模。此外,我们引入了一个基于结构相似性指数(SSIM)的代价函数,以提高真实图像和合成图像之间的解剖相似性。对于CycleGAN的SynCT生成之后的分割,通过2.5D残差U网实现自动描绘。定量评估表明,我们的SynCT和放射科医生绘制的掩模之间的分割结果具有可比性的真实CT图像,解决了一个重要的问题,在医学图像分割领域时,地面实况注释是不适用于感兴趣的模态。

英文摘要:

Creating large scale high-quality annotations is a known challenge in medical imaging. In this work, based on the CycleGAN algorithm, we propose leveraging annotations from one modality to be useful in other modalities. More specifically, the proposed algorithm creates highly realistic synthetic CT images (SynCT) from prostate MR images using unpaired data sets. By using SynCT images (without segmentation labels) and MR images (with segmentation labels available), we have trained a deep segmentation network for precise delineation of prostate from real CT scans. For the generator in our CycleGAN, the cycle consistency term is used to guarantee that SynCT shares the identical manually-drawn, high-quality masks originally delineated on MR images. Further, we introduce a cost function based on structural similarity index (SSIM) to improve the anatomical similarity between real and synthetic images. For segmentation followed by the SynCT generation from CycleGAN, automatic delineation is achieved through a 2.5D Residual U-Net. Quantitative evaluation demonstrates comparable segmentation results between our SynCT and radiologist drawn masks for real CT images, solving an important problem in medical image segmentation field when ground truth annotations are not available for the modality of interest.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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