发表机构
New York University Grossman School of Medicine; Siemens Shenzhen Magnetic Resonance Ltd.; New York University Tandon School of Engineering; Siemens Medical Solutions; Indiana University School of Medicine（纽约大学格罗斯曼医学院; 西门子深圳磁共振有限公司; 纽约大学坦顿工程学院; 西门子医疗解决方案; 印第安纳大学医学院）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
本文提出PROPELLER-DWI集成采集与重建框架，实现无畸变高分辨率前列腺弥散成像，在体模、志愿者和患者中验证了优于EPI-DWI的几何保真度，并保持定量ADC准确性。
AI 中文摘要
目的：开发并评估一种用于无畸变、高分辨率前列腺弥散加权成像（DWI）的集成采集与重建框架。方法：PROPELLER-DWI结合了脉冲梯度自旋回波弥散准备、具有黄金角叶片旋转的交错梯度与自旋回波PROPELLER采集，以及自监督联合重建与去噪。在NIST/QIBA弥散体模、25名志愿者和4名接受3T前列腺MRI的临床患者中，在三种空间分辨率设置和两个b值（50和1000 s/mm²）下，将其与常规NUFFT重建和MPPCA去噪进行了比较。阅片研究比较了几何保真度、图像质量和总体偏好，并与临床单次激发EPI-DWI进行了对比。结果：在EPI-DWI显示磁化率诱导畸变、信号丢失和金属相关伪影的病例中，PROPELLER-DWI保持了前列腺几何形态。自监督重建改善了噪声抑制，在更高空间分辨率下获益最大。在所有分辨率下，PROPELLER-DWI的几何保真度显著高于EPI-DWI，且放射科医生的偏好随EPI畸变严重程度而增加。ADC测量值在各分辨率下保持一致，并与临床EPI-DWI相当，而EPI-DWI的ADC随分辨率增加而变化。回顾性减少采集次数重建也支持缩短扫描时间。结论：PROPELLER-DWI能够在保持定量弥散测量的同时实现无畸变、高分辨率的前列腺DWI，为技术上具有挑战性的前列腺MRI及需要提高几何保真度的应用提供了实用替代方案。
英文摘要
Purpose: To develop and evaluate an integrated acquisition and reconstruction framework for distortion-free, high-resolution prostate diffusion-weighted imaging (DWI). Methods: PROPELLER-DWI combines pulsed-gradient spin-echo diffusion preparation, an interleaved gradient-and-spin-echo PROPELLER acquisition with golden-angle blade rotation, and self-supervised joint reconstruction and denoising. It was compared with conventional NUFFT reconstruction and MPPCA denoising in a NIST/QIBA diffusion phantom, 25 volunteers, and 4 clinical patients undergoing 3T prostate MRI across three spatial-resolution settings and two b-values (50 and 1000 s/mm2). Reader studies compared geometric fidelity, image quality, and overall preference with clinical single-shot EPI-DWI. Results: PROPELLER-DWI preserved prostate geometry in cases where EPI-DWI showed susceptibility-induced distortion, signal loss, and metal-related artifacts. Self-supervised reconstruction improved noise suppression, with the greatest benefit at higher spatial resolution. Across all resolutions, PROPELLER-DWI had significantly higher geometric fidelity than EPI-DWI, and radiologist preference increased with the severity of EPI distortion. ADC measurements remained consistent across resolutions and comparable to clinical EPI-DWI, whereas EPI-DWI ADC varied with increasing resolution. Retrospective reduced-shot reconstruction also supported shorter scan times. Conclusion: PROPELLER-DWI enables distortion-free, high-resolution prostate DWI while preserving quantitative diffusion measurements, providing a practical alternative for technically challenging prostate MRI and applications requiring improved geometric fidelity.
Comments37 pages, 10 figures
