心脏机电动力学不稳定
Cardiac Mechano-Electrical Dynamical Instability
摘要：
在计算研究中，我们揭示了一种新的动力学不稳定性的激励波在心肌。这种不稳定性表现为动作电位持续时间的局部逐渐增加，从而导致螺旋波的形成和超弯曲。该机制是由牵张激活电流引起的，牵张激活电流会引起波的前后碰撞，以及由于双兴奋性而导致的动作电位时程的逐拍延长。我们讨论了不稳定性对心律失常的发生和动力学的重要性。
英文摘要：
In a computational study we reveal a novel dynamical instability of excitation waves in the heartmuscle. The instability manifests itself as gradual local increase in the duration of the actionpotential which causes formation and hypermeandering of spiral waves. The mechanism is causedby stretch-activated currents that cause wave front-tail collisions and beat to beat elongation of theaction potential duration due to biexcitability. We discuss the importance of the instability for theonset and dynamics of cardiac arrhythmias.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
