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arXiv physics/0310031physics.bio-phq-bio.TO
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在折返的一维心脏离子模型中双刺激协议后交替放大:从湮灭到双波准周期折返

Alternans amplification following a two-stimulations protocol in a one-dimensional cardiac ionic model of reentry: from annihilation to double-wave quasiperiodic reentry

Philippe Comtois, Alain Vinet

摘要:

电起搏是在实验和临床环境中用于研究和/或消除解剖折返的常见程序。在最近的一项研究中[Comtois and Vinet,Chaos 12,903(2002)],发现了使用仅由两个刺激组成的简单协议来终止一维再入的新方法。通过这些新的方案,湮灭再入活动的概率比通常的局部单向块的概率大得多。本文是以前研究的一个扩展,其中的新的方案的湮灭路径长度的敏感性进行了研究。由此可见,再入可以停止在一个有限的时间间隔的路径长度和增加的长度超过这个时间间隔的上限产量过渡到持续的双波再入。一个类似的动力学机制,标记交替放大,被认为是负责这两种行为。

英文摘要:

Electrical pacing is a common procedure that is used in both experimental and clinical settings for studying and/or annihilating anatomical reentry. In a recent study [Comtois and Vinet, Chaos 12, 903 (2002)], new ways to terminate the one-dimensional reentry using a simple protocol consisting of only two stimulations were discovered. The probability of annihilating the reentrant activity is much more probable by these new scenarios than by the usual local unidirectional block. This paper is an extension of the previous study in which the sensitivity of the new scenarios of annihilation to the pathway length is studied. It follows that reentry can be stopped over a limited interval of the pathway length and that increasing the length beyond the upper limit of this interval yields to a transition to sustained double-wave reentry. A similar dynamical mechanism, labeled alternans amplification, is found to be responsible for both behaviors.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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