The performance and diagnostic utility of magnetic resonance imaging (MRI) in pregnancy is fundamentally constrained by fetal motion. Motion of the fetus, which is unpredictable and rapid on the scale of conventional imaging times, limits the set of viable acquisition techniques to single-shot imaging with severe compromises in signal-to-noise ratio and diagnostic contrast, and frequently results in unacceptable image quality. Surprisingly little is known about the characteristics of fetal motion during MRI and here we propose and demonstrate methods that exploit a growing repository of MRI observations of the gravid abdomen that are acquired at low spatial resolution but relatively high temporal resolution and over long durations (10-30 minutes). We estimate fetal pose per frame in MRI volumes of the pregnant abdomen via deep learning algorithms that detect key fetal landmarks. Evaluation of the proposed method shows that our framework achieves quantitatively an average error of 4.47 mm and 96.4\% accuracy (with error less than 10 mm). Fetal pose estimation in MRI time series yields novel means of quantifying fetal movements in health and disease, and enables the learning of kinematic models that may enhance prospective mitigation of fetal motion artifacts during MRI acquisition.
MIT（麻省理工学院）；Boston Children’s Hospital（波士顿儿童医院）；Harvard Medical School（哈佛医学院）
Fetal MRI is heavily constrained by unpredictable and substantial fetal motion that causes image artifacts and limits the set of viable diagnostic image contrasts. Current mitigation of motion artifacts is predominantly performed by fast, single-shot MRI and retrospective motion correction. Estimation of fetal pose in real time during MRI stands to benefit prospective methods to detect and mitigate fetal motion artifacts where inferred fetal motion is combined with online slice prescription with low-latency decision making. Current developments of deep reinforcement learning (DRL), offer a nov…
Northeastern University（东北大学）；Boston Children’s Hospital（波士顿儿童医院）；Harvard Medical School（哈佛医学院）
Fetal brain segmentation is an important first step for slice-level motion correction and slice-to-volume reconstruction in fetal MRI. Fast and accurate segmentation of the fetal brain on fetal MRI is required to achieve real-time fetal head pose estimation and motion tracking for slice re-acquisition and steering. To address this critical unmet need, in this work we analyzed the speed-accuracy performance of a variety of deep neural network models, and devised a symbolically small convolutional neural network that combines spatial details at high resolution with context features extracted at …
Enhancing Generalized Fetal Brain MRI Segmentation using A Cascade Network with Depth-wise Separable Convolution and Attention Mechanism
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University（复旦大学类脑智能科学与技术研究院）；MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence（教育部计算神经科学与类脑智能重点实验室）；MOE Frontiers Center for Brain Science（教育部脑科学前沿中心）
The Hebrew University of Jerusalem（耶路撒冷希伯来大学）；Sagol Brain Institute, Tel Aviv Sourasky Medical Center（特拉维夫苏拉斯基医疗中心萨戈尔脑研究所）；Tel Aviv University（特拉维夫大学）；Tel Aviv Sourasky Medical Center（特拉维夫苏拉斯基医疗中心）；University of Ottawa（渥太华大学）；Children's Hospital of Eastern Ontario（东安大略儿童医院）；Shaare Zedek Medical Center（沙雷泽德克医疗中心）
Timely, accurate and reliable assessment of fetal brain development is essential to reduce short and long-term risks to fetus and mother. Fetal MRI is increasingly used for fetal brain assessment. Three key biometric linear measurements important for fetal brain evaluation are Cerebral Biparietal Diameter (CBD), Bone Biparietal Diameter (BBD), and Trans-Cerebellum Diameter (TCD), obtained manually by expert radiologists on reference slices, which is time consuming and prone to human error. The aim of this study was to develop a fully automatic method computing the CBD, BBD and TCD measurements…
Imperial College London（伦敦帝国学院）；King’s College London（伦敦国王学院）；FAU Erlangen-Nürnberg（埃尔朗根-纽伦堡大学）；Technical University of Munich（慕尼黑工业大学）
Fetal Magnetic Resonance Imaging (MRI) is used in prenatal diagnosis and to assess early brain development. Accurate segmentation of the different brain tissues is a vital step in several brain analysis tasks, such as cortical surface reconstruction and tissue thickness measurements. Fetal MRI scans, however, are prone to motion artifacts that can affect the correctness of both manual and automatic segmentation techniques. In this paper, we propose a novel network structure that can simultaneously generate conditional atlases and predict brain tissue segmentation, called CAS-Net. The condition…
DCRA-Net: Attention-Enabled Reconstruction Model for Dynamic Fetal Cardiac MRI
King’s College London（伦敦国王学院）；Evelina London Children’s Hospital（伊芙琳娜伦敦儿童医院）；Imperial College London（帝国理工学院）；Klinikum rechts der Isar, Technical University of Munich（慕尼黑工业大学右岸医院）
The Hebrew University of Jerusalem（耶路撒冷希伯来大学）；Sagol Brain Institute, Tel Aviv Sourasky Medical Center（特拉维夫苏拉斯基医疗中心萨戈尔脑研究所）；Tel Aviv University（特拉维夫大学）
Volumetric measurements of fetal structures in MRI are time consuming and error prone and therefore require automatic segmentation. Placenta segmentation and accurate fetal brain segmentation for gyrification assessment are particularly challenging because of the placenta fuzzy boundaries and the fetal brain cortex complex foldings. In this paper, we study the use of the Contour Dice loss for both problems and compare it to other boundary losses and to the combined Dice and Cross-Entropy loss. The loss is computed efficiently for each slice via erosion, dilation and XOR operators. We describe …
University of Electronic Science and Technology of China（电子科技大学）；King’s College London（伦敦国王学院）；University Hospitals KU Leuven（鲁汶大学附属医院）；University College London（伦敦大学学院）；SenseTime Research（商汤科技研究院）
Segmentation of the fetal brain from stacks of motion-corrupted fetal MRI slices is important for motion correction and high-resolution volume reconstruction. Although Convolutional Neural Networks (CNNs) have been widely used for automatic segmentation of the fetal brain, their results may still benefit from interactive refinement for challenging slices. To improve the efficiency of interactive refinement process, we propose an Uncertainty-Guided Interactive Refinement (UGIR) framework. We first propose a grouped convolution-based CNN to obtain multiple automatic segmentation predictions with…
Improving cross-domain brain tissue segmentation in fetal MRI with synthetic data
Lausanne University Hospital（洛桑大学医院）；University of Lausanne (UNIL)（洛桑大学）；CIBM Center for Biomedical Imaging（CIBM生物医学成像中心）；King’s College London（伦敦国王学院）；FAU Erlangen-Nuremberg（埃尔朗根-纽伦堡大学）
University Medical Center Utrecht（乌得勒支大学医学中心）；Wilhelmina Children’s Hospital（威廉明娜儿童医院）；Utrecht University（乌得勒支大学）
MR images of fetuses allow clinicians to detect brain abnormalities in an early stage of development. The cornerstone of volumetric and morphologic analysis in fetal MRI is segmentation of the fetal brain into different tissue classes. Manual segmentation is cumbersome and time consuming, hence automatic segmentation could substantially simplify the procedure. However, automatic brain tissue segmentation in these scans is challenging owing to artifacts including intensity inhomogeneity, caused in particular by spontaneous fetal movements during the scan. Unlike methods that estimate the bias f…
The Challenge of Fetal Cardiac MRI Reconstruction Using Deep Learning
King’s College London（伦敦国王学院）；Technical University of Munich（慕尼黑工业大学）；Imperial College London（帝国理工学院）；Guy’s & St. Thomas’ NHS Foundation Trust（盖伊和圣托马斯国民保健服务基金会信托）；Evelina London Children’s Hospital（伊夫琳娜伦敦儿童医院）
Fetal cortical plate segmentation is essential in quantitative analysis of fetal brain maturation and cortical folding. Manual segmentation of the cortical plate, or manual refinement of automatic segmentations is tedious and time-consuming. Automatic segmentation of the cortical plate, on the other hand, is challenged by the relatively low resolution of the reconstructed fetal brain MRI scans compared to the thin structure of the cortical plate, partial voluming, and the wide range of variations in the morphology of the cortical plate as the brain matures during gestation. To reduce the burde…
Equivariant symmetry-aware head pose estimation for fetal MRI
MIT Computer Science and Artificial Intelligence Laboratory（麻省理工学院计算机科学与人工智能实验室）；Boston Children's Hospital and Harvard Medical School（波士顿儿童医院和哈佛医学院）；Inria, Université Côte d'Azur（法国国家科学研究中心（Inria）、蔚蓝海岸大学）
Fetal brain magnetic resonance imaging (MRI) offers exquisite images of the developing brain but is not suitable for anomaly screening. For this ultrasound (US) is employed. While expert sonographers are adept at reading US images, MR images are much easier for non-experts to interpret. Hence in this paper we seek to produce images with MRI-like appearance directly from clinical US images. Our own clinical motivation is to seek a way to communicate US findings to patients or clinical professionals unfamiliar with US, but in medical image analysis such a capability is potentially useful, for in…
Quantitative analysis of fetal lung Diffusion-Weighted MRI (DWI) data shows potential in providing quantitative imaging biomarkers that indirectly reflect fetal lung maturation. However, fetal motion during the acquisition hampered quantitative analysis of the acquired DWI data and, consequently, reliable clinical utilization. We introduce qDWI-morph, an unsupervised deep-neural-network architecture for motion compensated quantitative DWI (qDWI) analysis. Our approach couples a registration sub-network with a quantitative DWI model fitting sub-network. We simultaneously estimate the qDWI param…
Evaluating Synthetic Data Generation for Domain Generalization in Fetal Brain MRI Segmentation
Department of Radiology, Lausanne University Hospital and University of Lausanne (UNIL)（拉沃斯大学医院放射科和洛桑大学（UNIL））；CIBM Center for Biomedical Imaging（生物医学成像中心）；Institute for Information Processing, Leibniz University Hannover（汉诺威莱比锡大学信息处理研究所）；Department of Biomedical Engineering, School of Biomedical Engineering & Imaging Sciences, King’s College London（伦敦国王学院生物医学工程系）；Department of Biomedical Imaging and Image-Guided Therapy, Division of Neuroradiology and Musculoskeletal Radiology, Medical University of Vienna（维也纳医学大学生物医学成像与影像引导治疗系）；Department of Biomedical Imaging and Image-guided Therapy, Computational Imaging Research Lab (CIR), Medical University of Vienna（维也纳医学大学生物医学成像与影像引导治疗系，计算成像研究实验室（CIR））；Christian Doppler Laboratory for Mathematical Modelling and Simulation of Next-Generation Medical Ultrasound Devices, Medical University of Vienna（维也纳医学大学下一代医学超声设备数学建模与仿真克里斯蒂安多普勒实验室）；Comprehensive Center for Artificial Intelligence in Medicine, Medical University of Vienna（维也纳医学大学人工智能在医学中的综合中心）；Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image–guided Therapy, Medical University of Vienna（维也纳医学大学生物医学成像与影像引导治疗系，神经放射学和骨科放射学系）
AtlasSeg: Atlas Prior Guided Dual-U-Net for Cortical Segmentation in Fetal Brain MRI
College of Biomedical Engineering & Instrument Science, Zhejiang University（浙江大学生物医学工程与仪器科学学院）；Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences（中国医学科学院北京医院国家老年医学中心老年医学研究所）；Shandong Provincial Hospital Affiliated to Shandong First Medical University（山东第一医科大学附属山东省立医院）；State Key Lab of CAD&CG, Zhejiang University（浙江大学CAD&CG国家重点实验室）
University Hospitals Leuven（鲁汶大学医院）；University Hospitals Tanta（坦塔大学医院）；University College London（伦敦大学学院）
Deep neural networks have increased the accuracy of automatic segmentation, however, their accuracy depends on the availability of a large number of fully segmented images. Methods to train deep neural networks using images for which some, but not all, regions of interest are segmented are necessary to make better use of partially annotated datasets. In this paper, we propose the first axiomatic definition of label-set loss functions that are the loss functions that can handle partially segmented images. We prove that there is one and only one method to convert a classical loss function for fu…
Towards contrast- and pathology-agnostic clinical fetal brain MRI segmentation using SynthSeg
University Children’s Hospital Zurich（苏黎世大学儿童医院）；ETH Zurich（苏黎世联邦理工学院）；University of Zurich（苏黎世大学）；Medical University of Vienna（维也纳医科大学）；CIBM Center for Biomedical Imaging（CIBM生物医学成像中心）；University of Lausanne（洛桑大学）；Lausanne University Hospital（洛桑大学医院）；King's College London（伦敦国王学院）；University Hospital Erlangen（埃尔朗根大学医院）；Spanish National Research Council (CSIC)（西班牙国家研究委员会）；Universitat Politècnica de València（瓦伦西亚理工大学）
SegQC: a segmentation network-based framework for multi-metric segmentation quality control and segmentation error detection in volumetric medical images
University of Haifa（海法大学）；Tel Aviv Sourasky Medical Center（特拉维夫苏拉斯基医疗中心）；Sackler Faculty of Medicine, Tel Aviv University（特拉维夫大学萨克勒医学院）；Tel Aviv University（特拉维夫大学）；Sagol Brain Institute（萨戈尔脑研究所）；Sagol School of Neuroscience, Tel Aviv University（特拉维夫大学萨戈尔神经科学学院）；School of Computer Science and Engineering, The Hebrew University of Jerusalem（希伯来大学计算机科学与工程学院）；The Hebrew University of Jerusalem（希伯来大学）；Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem（希伯来大学埃德蒙与莉莉·萨夫拉脑科学中心）
Universidad Politécnica de Madrid（马德里理工大学）；Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)（生物医学研究网络中心（生物工程、生物材料与纳米医学））；King’s College London（伦敦国王学院）
Magnetic resonance imaging of whole fetal body and placenta is limited by different sources of motion affecting the womb. Usual scanning techniques employ single-shot multi-slice sequences where anatomical information in different slices may be subject to different deformations, contrast variations or artifacts. Volumetric reconstruction formulations have been proposed to correct for these factors, but they must accommodate a non-homogeneous and non-isotropic sampling, so regularization becomes necessary. Thus, in this paper we propose a deep generative prior for robust volumetric reconstructi…
Aligning Fetal Anatomy with Kinematic Tree Log-Euclidean PolyRigid Transforms
Computer Science and Artificial Intelligence Lab, MIT, Cambridge, USA（麻省理工学院计算机科学与人工智能实验室）；California Institute of Technology, Pasadena, USA（加州理工学院）；Boston Children’s Hospital and Harvard Medical School, Boston, USA（哈佛医学院波士顿儿童医院）；The Hebrew University of Jerusalem, Jerusalem, Israel（耶路撒冷希伯来大学）
The Hebrew University of Jerusalem（耶路撒冷希伯来大学）；Sagol Brain Institute, Tel Aviv Medical Center（特拉维夫医疗中心萨戈尔脑研究所）；Tel Aviv Medical Center（特拉维夫医疗中心）；Tel Aviv University（特拉维夫大学）；Tel Aviv Sourasky Medical Center（特拉维夫苏拉斯基医疗中心）
Normal fetal adipose tissue (AT) development is essential for perinatal well-being. AT, or simply fat, stores energy in the form of lipids. Malnourishment may result in excessive or depleted adiposity. Although previous studies showed a correlation between the amount of AT and perinatal outcome, prenatal assessment of AT is limited by lacking quantitative methods. Using magnetic resonance imaging (MRI), 3D fat- and water-only images of the entire fetus can be obtained from two point Dixon images to enable AT lipid quantification. This paper is the first to present a methodology for developing …
Deep Learning-Based Fetal Lung Segmentation from Diffusion-weighted MRI Images and Lung Maturity Evaluation for Fetal Growth Restriction
School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK（生物医学工程与成像科学学院，伦敦国王学院）；Elizabeth Garrett Anderson Institute for Women’s Health, University College, London, UK（埃利扎贝塔·加德纳妇女健康研究所，大学学院，伦敦）；University College London Hospital NHS Foundation Trust, London, UK（伦敦大学学院医院国家健康服务信托基金）；Department of Medical Physics and Biomedical Engineering, University College London Hospitals, London, UK（医学物理与生物医学工程系，伦敦大学学院医院）；Department of Radiology, University College London Hospitals NHS Foundation Trust, London, United Kingdom（放射科，伦敦大学学院医院国家健康服务信托基金）
In this paper we present a novel method for the correction of motion artifacts that are present in fetal Magnetic Resonance Imaging (MRI) scans of the whole uterus. Contrary to current slice-to-volume registration (SVR) methods, requiring an inflexible anatomical enclosure of a single investigated organ, the proposed patch-to-volume reconstruction (PVR) approach is able to reconstruct a large field of view of non-rigidly deforming structures. It relaxes rigid motion assumptions by introducing a specific amount of redundant information that is exploited with parallelized patch-wise optimization…
Detailed delineation of the fetal brain in diffusion MRI via multi-task learning
Harvard Medical School（哈佛医学院）；Elmhurst Hospital Center（埃尔姆赫斯特医院中心）；Icahn School of Medicine at Mount Sinai（西奈山伊坎医学院）；Massachusetts General Hospital（麻省总医院）；University of California Irvine（加州大学欧文分校）
Department of Radiology, Massachusetts General Hospital（麻省总医院放射科）；Radiology, Perelman School of Medicine, University of Pennsylvania（宾夕法尼亚大学佩雷尔曼医学院放射科）
In fetal-brain MRI, head-pose changes between prescription and acquisition present a challenge to obtaining the standard sagittal, coronal and axial views essential to clinical assessment. As motion limits acquisitions to thick slices that preclude retrospective resampling, technologists repeat ~55-second stack-of-slices scans (HASTE) with incrementally reoriented field of view numerous times, deducing the head pose from previous stacks. To address this inefficient workflow, we propose a robust head-pose detection algorithm using full-uterus scout scans (EPI) which take ~5 seconds to acquire. …
A Dempster-Shafer approach to trustworthy AI with application to fetal brain MRI segmentation
University Hospitals Leuven（鲁汶大学医院）；Technical University Munich（慕尼黑工业大学）；University Hospital Zurich（苏黎世大学医院）；University of Zurich（苏黎世大学）；University College London（伦敦大学学院）；University Hospitals Tanta（坦塔大学医院）；Medical University of Vienna（维也纳医科大学）
School of Biomedical Engineering & Imaging Sciences, King’s College London, UK（伦敦国王学院生物医学工程与成像科学学院）；Department of Radiology, University Hospitals Leuven, Belgium（鲁汶大学医院放射科）；Institute for Women’s Health, University College London, UK（伦敦大学学院妇女健康研究所）；Department of Obstetrics and Gynaecology, University Hospitals Leuven, Belgium（鲁汶大学医院妇产科）；Department of Gynecology and Obstetrics, University Hospitals Tanta, Egypt（坦塔大学医院妇产科）；Department of Biomedical Imaging and Image-guided Therapy Medical University of Vienna, Austria（维也纳医科大学生物医学成像与图像引导治疗系）
The performance of deep neural networks typically increases with the number of training images. However, not all images have the same importance towards improved performance and robustness. In fetal brain MRI, abnormalities exacerbate the variability of the developing brain anatomy compared to non-pathological cases. A small number of abnormal cases, as is typically available in clinical datasets used for training, are unlikely to fairly represent the rich variability of abnormal developing brains. This leads machine learning systems trained by maximizing the average performance to be biased t…
Annotation-free deep learning for detection and segmentation of fetal germinal matrix-intraventricular hemorrhage in brain MRI
Department of Radiology, West China Second University Hospital, Sichuan University（四川大学华西第二医院放射科）；School of Biomedical Engineering, Tsinghua Medicine, Tsinghua University（清华大学医学院生物医学工程系）；Department of Radiology, Sichuan Provincial Woman’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College（四川省妇幼保健院放射科，成都医学院附属妇幼医院）；Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China（成都妇女儿童中央医院，电子科技大学医学院）；Department of Radiology, The Third Affiliated Hospital of Zhengzhou University（郑州大学第三附属医院放射科）；Qujing Maternal and Child Health Hospital, Qujing, China（曲靖 maternal and child health hospital, Qujing, China）
ResNet-34 with Lightweight Decoder for Accurate and Efficient Segmentation of Fetal Brain MRI
Department of Biomedical Physics and Technology, University of Dhaka（达卡大学生物医学物理与技术系）；Department of Electrical Engineering, College of Engineering, Qatar University（卡塔尔大学工程学院电气工程系）；Department of Biomedical Engineering, Jashore University of Science and Technology（贾沙尔大学科学与技术学院生物医学工程系）
Self-Supervised Slice-to-Volume Reconstruction with Gaussian Representations for Fetal MRI
Department of Electrical and Electronic Engineering and I-X, Imperial College London（伦敦帝国理工学院电气与电子工程系及I-X）；Trinity College Institute of Neuroscience, Trinity College Dublin（都柏林圣三一学院神经科学研究所）
Automated Fetal Brain MRI Biometry in Healthy and Pathological Cases
Faculty of Medicine, University of Ljubljana（卢布尔雅那大学医学院）；University Medical Centre Ljubljana（卢布尔雅那大学医学中心）；Faculty of Electrical Engineering, University of Ljubljana（卢布尔雅那大学电气工程学院）
Unsupervised Segmentation of Fetal Brain MRI using Deep Learning Cascaded Registration
Universitat Pompeu Fabra（庞培法布拉大学）；BCNatal；Institución Catalana de Investigación y Estudios Avanzados (ICREA)（加泰罗尼亚高级研究与发展研究院）；Centre for Biomedical Research on Rare Diseases (CIBERER)（罕见疾病生物医学研究中心）；European Commission, Joint Research Centre (JRC)（欧盟委员会联合研究中心）
Future Processing Healthcare（未来医疗处理公司）；Silesian University of Technology（西里西亚工业大学）；Medical University of Silesia in Katowice（卡托维兹西里西亚医科大学）；ZSM Chorzów（霍茹夫ZSM医院）；University Clinical Centre（大学临床中心）；Roche Pharmaceutical Research & Early Development（罗氏制药研究与早期开发部）
Tumor burden assessment by magnetic resonance imaging (MRI) is central to the evaluation of treatment response for glioblastoma. This assessment is complex to perform and associated with high variability due to the high heterogeneity and complexity of the disease. In this work, we tackle this issue and propose a deep learning pipeline for the fully automated end-to-end analysis of glioblastoma patients. Our approach simultaneously identifies tumor sub-regions, including the enhancing tumor, peritumoral edema and surgical cavity in the first step, and then calculates the volumetric and bidimens…
We present a robust method to correct for motion and deformations for in-utero volumetric MRI time series. Spatio-temporal analysis of dynamic MRI requires robust alignment across time in the presence of substantial and unpredictable motion. We make a Markov assumption on the nature of deformations to take advantage of the temporal structure in the image data. Forward message passing in the corresponding hidden Markov model (HMM) yields an estimation algorithm that only has to account for relatively small motion between consecutive frames. We demonstrate the utility of the temporal model by sh…
University of Science and Technology Beijing（北京科技大学）；University of Central Florida（中佛罗里达大学）
For 3D medical image (e.g. CT and MRI) segmentation, the difficulty of segmenting each slice in a clinical case varies greatly. Previous research on volumetric medical image segmentation in a slice-by-slice manner conventionally use the identical 2D deep neural network to segment all the slices of the same case, ignoring the data heterogeneity among image slices. In this paper, we focus on multi-modal 3D MRI brain tumor segmentation and propose a dynamic architecture network named Med-DANet based on adaptive model selection to achieve effective accuracy and efficiency trade-off. For each slice…
University of Brescia（布雷西亚大学）；University of Glasgow（格拉斯哥大学）
Many functional and structural neuroimaging studies call for accurate morphometric segmentation of different brain structures starting from image intensity values of MRI scans. Current automatic (multi-) atlas-based segmentation strategies often lack accuracy on difficult-to-segment brain structures and, since these methods rely on atlas-to-scan alignment, they may take long processing times. Recently, methods deploying solutions based on Convolutional Neural Networks (CNNs) are making the direct analysis of out-of-the-scanner data feasible. However, current CNN-based solutions partition the t…
Volumetrically Consistent Implicit Atlas Learning via Neural Diffeomorphic Flow for Placenta MRI
MIT Computer Science and Artificial Intelligence Laboratory（麻省理工学院计算机科学与人工智能实验室）；Massachusetts General Hospital, Harvard Medical School（哈佛医学院麻省总医院）；Boston Children’s Hospital, Harvard Medical School（哈佛医学院波士顿儿童医院）
OREHAS: A fully automated deep-learning pipeline for volumetric endolymphatic hydrops quantification in MRI
Bioengineering Department, Universidad Carlos III de Madrid（卡洛斯三世大学生物工程系）；Radiology Department, Clínica Universidad de Navarra（纳瓦拉大学医院放射科）；Otorhinolaryngology Department, Clínica Universidad de Navarra（纳瓦拉大学医院耳鼻喉科）
Vanderbilt University（范德堡大学）；Henry Jackson Foundation（亨利·杰克逊基金会）；University of Calgary（卡尔加里大学）；Vanderbilt University Medical Center（范德堡大学医学中心）
Generalizability is an important problem in deep neural networks, especially in the context of the variability of data acquisition in clinical magnetic resonance imaging (MRI). Recently, the Spatially Localized Atlas Network Tiles (SLANT) approach has been shown to effectively segment whole brain non-contrast T1w MRI with 132 volumetric labels. Enhancing generalizability of SLANT would enable broader application of volumetric assessment in multi-site studies. Transfer learning (TL) is commonly used to update the neural network weights for local factors; yet, it is commonly recognized to risk d…
Massachusetts Institute of Technology（麻省理工学院）；MGH/HST Martinos Center for Biomedical Imaging（麻省总医院/健康科学与技术部马蒂诺斯生物医学成像中心）；Harvard Medical School（哈佛医学院）；Boston Children’s Hospital（波士顿儿童医院）
Blood oxygen level dependent (BOLD) MRI with maternal hyperoxia can assess oxygen transport within the placenta and has emerged as a promising tool to study placental function. Measuring signal changes over time requires segmenting the placenta in each volume of the time series. Due to the large number of volumes in the BOLD time series, existing studies rely on registration to map all volumes to a manually segmented template. As the placenta can undergo large deformation due to fetal motion, maternal motion, and contractions, this approach often results in a large number of discarded volumes,…
Prostate cancer was the third most common cancer in 2020 internationally, coming after breast cancer and lung cancer. Furthermore, in recent years prostate cancer has shown an increasing trend. According to clinical experience, if this problem is detected and treated early, there can be a high chance of survival for the patient. One task that helps diagnose prostate cancer is prostate segmentation from magnetic resonance imaging. Manual segmentation performed by clinical experts has its drawbacks such as: the high time and concentration required from observers; and inter- and intra-observer va…
University of Copenhagen（哥本哈根大学）；Copenhagen University Hospital, Bispebjerg and Frederiksberg（哥本哈根大学医院比斯佩布杰格和弗雷德里克斯堡院区）
UNet has become the gold standard method for segmenting 2D medical images that any new method must be validated against. However, in recent years, several variations of the seminal UNet have been proposed with promising results. However, there is no clear consensus on the generalisability of these architectures, and UNet currently remains the methodological gold standard. The purpose of this study was to evaluate some of the most promising UNet-inspired architectures for 3D segmentation. For the segmentation of 3D scans, UNet-inspired methods are also dominant, but there is a larger variety ac…
