Detection of Myocardial Infarction Based on Novel Deep Transfer Learning Methods for Urban Healthcare in Smart Cities
University of Jeddah（吉达大学）；Menoufia University（米努菲亚大学）；University of Bradford（布拉德福德大学）；Sejong University（世宗大学）；Misr Higher Institute of Commerce and Computers（米斯尔高等商业与计算机学院）；Nile University（尼罗河大学）；Harbin Institute of Technology（哈尔滨工业大学）
Ahmed Alghamdi, Mohamed Hammad, Hassan Ugail, Asmaa Abdel-Raheem, Khan Muhammad, Hany S. Khalifa, Ahmed A. Abd El-Latif
. In this paper, an effective computer-aided diagnosis (CAD) system is presented to detect MI signals using the convolution neural network (CNN) for urban healthcare in smart cities. Two types of transfer learning techniques are employed to retrain the pre-trained VGG-Net (Fine-tuning and VGG-Net as fixed feature extractor) and obtained two new networks VGG-MI1 and VGG-MI2. In the VGG-MI1 model, the last layer of the VGG-Net model is replaced with a specific layer according to our requirements and various functions are optimized to reduce overfitting. In the VGG-MI2 model, one layer of the VGG-Net model is selected as a feature descriptor of the ECG images to describe it with informative features. Considering the limited availability of dataset, ECG data is augmented which has increased the classification performance. Physikalisch-technische bundesanstalt (PTB) Diagnostic ECG database is used for experimentation, which has been widely employed in MI detection studies. In case of using VGG-MI1, we achieved an accuracy, sensitivity, and specificity of 99.02%, 98.76%, and 99.17%, respectively and we achieved an accuracy of 99.22%, a sensitivity of 99.15%, and a specificity of 99.49% with VGG-MI2 model. Experimental results validate the efficiency of the proposed system in terms of accuracy sensitivity, and specificity.
IBM Research - Africa（IBM非洲研究院）；University of Oxford（牛津大学）；Guangdong Cardiovascular Institute（广东省心血管病研究所）
Myocardial Infarction (MI) has the highest mortality of all cardiovascular diseases (CVDs). Detection of MI and information regarding its occurrence-time in particular, would enable timely interventions that may improve patient outcomes, thereby reducing the global rise in CVD deaths. Electrocardiogram (ECG) recordings are currently used to screen MI patients. However, manual inspection of ECGs is time-consuming and prone to subjective bias. Machine learning methods have been adopted for automated ECG diagnosis, but most approaches require extraction of ECG beats or consider leads independentl…
University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）；Beckman Institute for Advanced Science and Technology（贝克曼先进科学技术研究所）；Carle Illinois College of Medicine（卡尔伊利诺伊医学院）
Myocardial infarction is the leading cause of death worldwide. In this paper, we design domain-inspired neural network models to detect myocardial infarction. First, we study the contribution of various leads. This systematic analysis, first of its kind in the literature, indicates that out of 15 ECG leads, data from the v6, vz, and ii leads are critical to correctly identify myocardial infarction. Second, we use this finding and adapt the ConvNetQuake neural network model--originally designed to identify earthquakes--to attain state-of-the-art classification results for myocardial infarction,…
Florida State University（佛罗里达州立大学）；University of Florida（佛罗里达大学）
Heart disease remains the leading cause of death in the United States. Compared with risk assessment guidelines that require manual calculation of scores, machine learning-based prediction for disease outcomes such as mortality can be utilized to save time and improve prediction accuracy. This study built and evaluated various machine learning models to predict one-year mortality in patients diagnosed with acute myocardial infarction or post myocardial infarction syndrome in the MIMIC-III database. The results of the best performing shallow prediction models were compared to a deep feedforward…
Florida State University（佛罗里达州立大学）；University of Florida（佛罗里达大学）
Predicting the risk of mortality for patients with acute myocardial infarction (AMI) using electronic health records (EHRs) data can help identify risky patients who might need more tailored care. In our previous work, we built computational models to predict one-year mortality of patients admitted to an intensive care unit (ICU) with AMI or post myocardial infarction syndrome. Our prior work only used the structured clinical data from MIMIC-III, a publicly available ICU clinical database. In this study, we enhanced our work by adding the word embedding features from free-text discharge summar…
Fraunhofer Heinrich Hertz Institute（弗劳恩霍夫海因里希·赫兹研究所）；University Medical Center Schleswig-Holstein（石勒苏益格-荷尔斯泰因大学医学中心）
Objective: We aim to provide an algorithm for the detection of myocardial infarction that operates directly on ECG data without any preprocessing and to investigate its decision criteria. Approach: We train an ensemble of fully convolutional neural networks on the PTB ECG dataset and apply state-of-the-art attribution methods. Main results: Our classifier reaches 93.3% sensitivity and 89.7% specificity evaluated using 10-fold cross-validation with sampling based on patients. The presented method outperforms state-of-the-art approaches and reaches the performance level of human cardiologists fo…
Azad University, Science and Research Branch（阿扎德大学科学与研究分校）；University of California, San Diego（加利福尼亚大学圣迭戈分校）
In medical science, it is very important to gather multiple data on different diseases and one of the most important objectives of the data is to investigate the diseases. Myocardial infarction is a serious risk factor in mortality and in previous studies, the main emphasis has been on people with heart disease and measuring the likelihood of myocardial infarction in them through demographic features, echocardiography, and electrocardiogram. In contrast, the purpose of the present study is to utilize data analysis algorithms and compare their accuracy in patients with a heart attack in order t…
This work evaluates deep learning-based myocardial infarction (MI) quantification using Segment cardiovascular magnetic resonance (CMR) software. Segment CMR software incorporates the expectation-maximization, weighted intensity, a priori information (EWA) algorithm used to generate the infarct scar volume, infarct scar percentage, and microvascular obstruction percentage. Here, Segment CMR software segmentation algorithm is updated with semantic segmentation with U-net to achieve and evaluate fully automated or deep learning-based MI quantification. The direct observation of graphs and the nu…
Self-Alignment Learning to Improve Myocardial Infarction Detection from Single-Lead ECG
National Institute of Health Data Science, Peking University（北京大学国家健康数据科学研究院）；State Key Laboratory of General Artificial Intelligence, Peking University（北京大学通用人工智能国家重点实验室）；School of Intelligence Science and Technology, Peking University（北京大学智能科学与技术学院）；Data Science Institute, Imperial College London（伦敦帝国学院数据科学学院）
Refining Myocardial Infarction Detection: A Novel Multi-Modal Composite Kernel Strategy in One-Class Classification
Tampere University（坦佩雷大学）；VTT Technical Research Centre of Finland（芬兰VTT技术研究中心）；Haltian（哈尔蒂安公司）；Qatar University（卡塔尔大学）；Hamad Medical Corporation（哈马德医疗公司）
ICD Codes are Insufficient to Create Datasets for Machine Learning: An Evaluation Using All of Us Data for Coccidioidomycosis and Myocardial Infarction
University of Arizona（亚利桑那大学）
本研究依托All of Us数据库，对比ICD编码与临床确诊方式构建的球孢子菌病、心肌梗死患者队列，发现二者重叠度低、临床特征差异显著，证实ICD编码不足以构建机器学习数据集。
Universidade Federal do Maranhão（马拉尼昂联邦大学）；Faculdade Uninassau（尤纳萨乌学院）
Aim: to evaluate the ability of the nonlinear 24-HRV as a predictor of MI using Machine Learning Methods: The sample was composed of 218 patients divided into two groups (Healthy, n=128; MI n=90). The sample dataset is part of the Telemetric and Holter Electrocardiogram Warehouse (THEW) database, from the University of Rochester Medical Center. We used the most common ML algorithms for accuracy comparison with a setting of 10-fold cross-validation (briefly, Linear Regression, Linear Discriminant Analysis, k-Nearest Neighbour, Random Forest, Supporting Vector Machine, Naïve Bayes, C 5.0 and Sto…
Machine learning predicts long-term mortality after acute myocardial infarction using systolic time intervals and routinely collected clinical data
École de technologie supérieure, Université du Québec（魁北克大学高等技术学院）；K. N. Toosi University of Technology（K. N. 图什理工大学）；Centre de recherche de l’Institut universitaire de gériatrie de Montréal（蒙特利尔大学老年学研究所）
The University of Winnipeg（温尼伯大学）；Qatar University（卡塔尔大学）；Hamad Medical Corporation（哈马德医疗公司）
Cardiac imaging known as echocardiography is a non-invasive tool utilized to produce data including images and videos, which cardiologists use to diagnose cardiac abnormalities in general and myocardial infarction (MI) in particular. Echocardiography machines can deliver abundant amounts of data that need to be quickly analyzed by cardiologists to help them make a diagnosis and treat cardiac conditions. However, the acquired data quality varies depending on the acquisition conditions and the patient's responsiveness to the setup instructions. These constraints are challenging to doctors especi…
Krasnoyarsk State Medical University（克拉斯诺亚尔斯克国立医科大学）；Institut Curie（居里研究所）；PSL Research University（巴黎文理研究大学）；INSERM（法国国家健康与医学研究院）；CBIO-Centre for Computational Biology（计算生物学中心）；Mines ParisTech（巴黎高等矿业学院）；University of Leicester（莱斯特大学）；Lobachevsky University（罗巴切夫斯基大学）
Large observational clinical datasets become increasingly available for mining associations between various disease traits and administered therapy. These datasets can be considered as representations of the landscape of all possible disease conditions, in which a concrete pathology develops through a number of stereotypical routes, characterized by `points of no return' and `final states' (such as lethal or recovery states). Extracting this information directly from the data remains challenging, especially in the case of synchronic (with a short-term follow up) observations. Here we suggest a…
University of Leicester（莱斯特大学）；NIHR Leicester Biomedical Research Centre（NIHR莱斯特生物医学研究中心）；Glenfield Hospital（格伦菲尔德医院）；Norwegian University of Science and Technology (NTNU)（挪威科技大学）；Saint-Petersburg State Electrotechnical University（圣彼得堡国立电工大学）
A "heart attack" or myocardial infarction (MI), occurs when an artery supplying blood to the heart is abruptly occluded. The "gold standard" method for imaging MI is Cardiovascular Magnetic Resonance Imaging (MRI), with intravenously administered gadolinium-based contrast (late gadolinium enhancement). However, no "gold standard" fully automated method for the quantification of MI exists. In this work, we propose an end-to-end fully automatic system (MyI-Net) for the detection and quantification of MI in MRI images. This has the potential to reduce the uncertainty due to the technical variabil…
ECGLight: Compute-Light Framework For Paper ECG Digitization and Myocardial Infarction Screening
ETH Zürich（苏黎世联邦理工学院）；Swiss Paraplegic Research（瑞士截瘫研究中心）；University of Campania “Luigi Vanvitelli”（坎帕尼亚“路易吉·万维泰利”大学）；University of Italian Switzerland, Cardiocentro Ticino Institute（意大利瑞士大学提契诺心脏中心研究所）
Predicting Lethal Outcome (Cause) And Understanding Key Biomarkers Linked With Acute Myocardial Infarction Using Deep Artificial Neural Network And Ensemble Of Machine Learning Methodologies
Automatic and accurate segmentation of the ventricles and myocardium from multi-sequence cardiac MRI (CMR) is crucial for the diagnosis and treatment management for patients suffering from myocardial infarction (MI). However, due to the existence of domain shift among different modalities of datasets, the performance of deep neural networks drops significantly when the training and testing datasets are distinct. In this paper, we propose an unsupervised domain alignment method to explicitly alleviate the domain shifts among different modalities of CMR sequences, \emph{e.g.,} bSSFP, LGE, and T2…
Purpose: A new method for magnetic resonance (MR) imaging water-fat separation using a convolutional neural network (ConvNet) and deep learning (DL) is presented. Feasibility of the method with complex and magnitude images is demonstrated with a series of patient studies and accuracy of predicted quantitative values is analyzed. Methods: Water-fat separation of 1200 gradient-echo acquisitions from 90 imaging sessions (normal, acute and chronic myocardial infarction) was performed using a conventional model based method with modeling of R2* and off-resonance and a multi-peak fat spectrum. A U-N…
University of Southern California（南加州大学）；Universität für Musik und darstellende Kunst Graz（格拉茨音乐与表演艺术大学）
Deep learning methods have shown suitability for time series classification in the health and medical domain, with promising results for electrocardiogram data classification. Successful identification of myocardial infarction holds life saving potential and any meaningful improvement upon deep learning models in this area is of great interest. Conventionally, data augmentation methods are applied universally to the training set when data are limited in order to ameliorate data resolution or sample size. In the method proposed in this study, data augmentation was not applied in the context of …
University of Bourgogne Franche-Comté（勃艮第-弗朗什孔泰大学）；University Hospital of Dijon（第戎大学医院）；CASIS company（CASIS公司）
Cardiac left ventricular (LV) segmentation from short-axis MRI acquired 10 minutes after the injection of a contrast agent (LGE-MRI) is a necessary step in the processing allowing the identification and diagnosis of cardiac diseases such as myocardial infarction. However, this segmentation is challenging due to high variability across subjects and the potential lack of contrast between structures. Then, the main objective of this work is to develop an accurate automatic segmentation method based on deep learning models for the myocardial borders on LGE-MRI. To this end, 2.5 D residual neural n…
Electrocardiogram (ECG) is an authoritative source to diagnose and counter critical cardiovascular syndromes such as arrhythmia and myocardial infarction (MI). Current machine learning techniques either depend on manually extracted features or large and complex deep learning networks which merely utilize the 1D ECG signal directly. Since intelligent multimodal fusion can perform at the stateof-the-art level with an efficient deep network, therefore, in this paper, we propose two computationally efficient multimodal fusion frameworks for ECG heart beat classification called Multimodal Image Fus…
In this paper, we present a novel Image Fusion Model (IFM) for ECG heart-beat classification to overcome the weaknesses of existing machine learning techniques that rely either on manual feature extraction or direct utilization of 1D raw ECG signal. At the input of IFM, we first convert the heart beats of ECG into three different images using Gramian Angular Field (GAF), Recurrence Plot (RP) and Markov Transition Field (MTF) and then fuse these images to create a single imaging modality. We use AlexNet for feature extraction and classification and thus employ end to end deep learning. We perfo…
Qatar University（卡塔尔大学）；Liverpool John Moores University（利物浦约翰摩尔斯大学）；University of Kurdistan Hewler（库尔德斯坦休勒尔大学）；Firat University（菲拉特大学）；Sulaimani Polytechnic University（苏莱曼尼亚理工大学）
The reliable and rapid identification of the COVID-19 has become crucial to prevent the rapid spread of the disease, ease lockdown restrictions and reduce pressure on public health infrastructures. Recently, several methods and techniques have been proposed to detect the SARS-CoV-2 virus using different images and data. However, this is the first study that will explore the possibility of using deep convolutional neural network (CNN) models to detect COVID-19 from electrocardiogram (ECG) trace images. In this work, COVID-19 and other cardiovascular diseases (CVDs) were detected using deep-lear…
Reconstructing 12-Lead ECG from 3-Lead ECG using Variational Autoencoder to Improve Cardiac Disease Detection of Wearable ECG Devices
National Institute of Health Data Science, Peking University, Beijing, China（国家健康数据科学研究院，北京大学，北京，中国）；Institute for Artificial Intelligence, Peking University, Beijing, China（人工智能研究院，北京大学，北京，中国）；State Key Laboratory of General Artificial Intelligence, Beijing 100871, China（通用人工智能国家重点实验室，北京，中国）；School of Intelligence Science and Technology, Peking University, Beijing 100871, China（智能科学与技术学院，北京大学，北京，中国）；Department of Cardiology, Peking University People’s Hospital, Beijing 100044, China（北京大学人民医院心内科，北京，中国）；HeartVoice Medical Technology, Hefei 230088, China（HeartVoice医疗科技，合肥，中国）
Electrocardiogram (ECG) can be reliably used as a measure to monitor the functionality of the cardiovascular system. Recently, there has been a great attention towards accurate categorization of heartbeats. While there are many commonalities between different ECG conditions, the focus of most studies has been classifying a set of conditions on a dataset annotated for that task rather than learning and employing a transferable knowledge between different tasks. In this paper, we propose a method based on deep convolutional neural networks for the classification of heartbeats which is able to ac…
Explaining Deep Learning for ECG Analysis: Building Blocks for Auditing and Knowledge Discovery
Fraunhofer Heinrich Hertz Institute（弗劳恩霍夫海因里希·赫兹研究所）；Physikalisch-Technische Bundesanstalt（德国联邦物理技术研究院）；Charité Universitätsmedizin Berlin（柏林夏里特医学院）；Carl von Ossietzky Universität Oldenburg（奥尔登堡卡尔·冯·奥西茨基大学）
