Heart disease remains the leading cause of death in the United States. Compared with risk assessment guidelines that require manual calculation of scores, machine learning-based prediction for disease outcomes such as mortality can be utilized to save time and improve prediction accuracy. This study built and evaluated various machine learning models to predict one-year mortality in patients diagnosed with acute myocardial infarction or post myocardial infarction syndrome in the MIMIC-III database. The results of the best performing shallow prediction models were compared to a deep feedforward neural network (Deep FNN) with back propagation. We included a cohort of 5436 admissions. Six datasets were developed and compared. The models applying Logistic Model Trees (LMT) and Simple Logistic algorithms to the combined dataset resulted in the highest prediction accuracy at 85.12% and the highest AUC at .901. In addition, other factors were observed to have an impact on outcomes as well.
ICD Codes are Insufficient to Create Datasets for Machine Learning: An Evaluation Using All of Us Data for Coccidioidomycosis and Myocardial Infarction
University of Arizona（亚利桑那大学）
本研究依托All of Us数据库，对比ICD编码与临床确诊方式构建的球孢子菌病、心肌梗死患者队列，发现二者重叠度低、临床特征差异显著，证实ICD编码不足以构建机器学习数据集。
Krasnoyarsk State Medical University（克拉斯诺亚尔斯克国立医科大学）；Institut Curie（居里研究所）；PSL Research University（巴黎文理研究大学）；INSERM（法国国家健康与医学研究院）；CBIO-Centre for Computational Biology（计算生物学中心）；Mines ParisTech（巴黎高等矿业学院）；University of Leicester（莱斯特大学）；Lobachevsky University（罗巴切夫斯基大学）
Large observational clinical datasets become increasingly available for mining associations between various disease traits and administered therapy. These datasets can be considered as representations of the landscape of all possible disease conditions, in which a concrete pathology develops through a number of stereotypical routes, characterized by `points of no return' and `final states' (such as lethal or recovery states). Extracting this information directly from the data remains challenging, especially in the case of synchronic (with a short-term follow up) observations. Here we suggest a…
Florida State University（佛罗里达州立大学）；University of Florida（佛罗里达大学）
Predicting the risk of mortality for patients with acute myocardial infarction (AMI) using electronic health records (EHRs) data can help identify risky patients who might need more tailored care. In our previous work, we built computational models to predict one-year mortality of patients admitted to an intensive care unit (ICU) with AMI or post myocardial infarction syndrome. Our prior work only used the structured clinical data from MIMIC-III, a publicly available ICU clinical database. In this study, we enhanced our work by adding the word embedding features from free-text discharge summar…
University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）；Beckman Institute for Advanced Science and Technology（贝克曼先进科学技术研究所）；Carle Illinois College of Medicine（卡尔伊利诺伊医学院）
Myocardial infarction is the leading cause of death worldwide. In this paper, we design domain-inspired neural network models to detect myocardial infarction. First, we study the contribution of various leads. This systematic analysis, first of its kind in the literature, indicates that out of 15 ECG leads, data from the v6, vz, and ii leads are critical to correctly identify myocardial infarction. Second, we use this finding and adapt the ConvNetQuake neural network model--originally designed to identify earthquakes--to attain state-of-the-art classification results for myocardial infarction,…
NYU Langone Health（纽约大学朗格尼医学中心）；NYU Grossman School of Medicine（纽约大学格罗斯曼医学院）；Courant Institute of Mathematics, New York University（纽约大学库朗数学研究所）；New York University（纽约大学）
Myocardial infarction and heart failure are major cardiovascular diseases that affect millions of people in the US. The morbidity and mortality are highest among patients who develop cardiogenic shock. Early recognition of cardiogenic shock is critical. Prompt implementation of treatment measures can prevent the deleterious spiral of ischemia, low blood pressure, and reduced cardiac output due to cardiogenic shock. However, early identification of cardiogenic shock has been challenging due to human providers' inability to process the enormous amount of data in the cardiac intensive care unit (…
Fraunhofer Heinrich Hertz Institute（弗劳恩霍夫海因里希·赫兹研究所）；University Medical Center Schleswig-Holstein（石勒苏益格-荷尔斯泰因大学医学中心）
Objective: We aim to provide an algorithm for the detection of myocardial infarction that operates directly on ECG data without any preprocessing and to investigate its decision criteria. Approach: We train an ensemble of fully convolutional neural networks on the PTB ECG dataset and apply state-of-the-art attribution methods. Main results: Our classifier reaches 93.3% sensitivity and 89.7% specificity evaluated using 10-fold cross-validation with sampling based on patients. The presented method outperforms state-of-the-art approaches and reaches the performance level of human cardiologists fo…
Azad University, Science and Research Branch（阿扎德大学科学与研究分校）；University of California, San Diego（加利福尼亚大学圣迭戈分校）
In medical science, it is very important to gather multiple data on different diseases and one of the most important objectives of the data is to investigate the diseases. Myocardial infarction is a serious risk factor in mortality and in previous studies, the main emphasis has been on people with heart disease and measuring the likelihood of myocardial infarction in them through demographic features, echocardiography, and electrocardiogram. In contrast, the purpose of the present study is to utilize data analysis algorithms and compare their accuracy in patients with a heart attack in order t…
This work evaluates deep learning-based myocardial infarction (MI) quantification using Segment cardiovascular magnetic resonance (CMR) software. Segment CMR software incorporates the expectation-maximization, weighted intensity, a priori information (EWA) algorithm used to generate the infarct scar volume, infarct scar percentage, and microvascular obstruction percentage. Here, Segment CMR software segmentation algorithm is updated with semantic segmentation with U-net to achieve and evaluate fully automated or deep learning-based MI quantification. The direct observation of graphs and the nu…
It is generally acknowledged that claims from observational studies often fail to replicate. An exploratory study was undertaken to assess the reliability of base studies used in meta-analysis of short-term air quality-myocardial infarction risk and to judge the reliability of statistical evidence from meta-analysis that uses data from observational studies. A highly cited meta-analysis paper examining whether short-term air quality exposure triggers myocardial infarction was evaluated as a case study. The paper considered six air quality components - carbon monoxide, nitrogen dioxide, sulfur …
Universidade Federal do Maranhão（马拉尼昂联邦大学）；Faculdade Uninassau（尤纳萨乌学院）
Aim: to evaluate the ability of the nonlinear 24-HRV as a predictor of MI using Machine Learning Methods: The sample was composed of 218 patients divided into two groups (Healthy, n=128; MI n=90). The sample dataset is part of the Telemetric and Holter Electrocardiogram Warehouse (THEW) database, from the University of Rochester Medical Center. We used the most common ML algorithms for accuracy comparison with a setting of 10-fold cross-validation (briefly, Linear Regression, Linear Discriminant Analysis, k-Nearest Neighbour, Random Forest, Supporting Vector Machine, Naïve Bayes, C 5.0 and Sto…
Self-Alignment Learning to Improve Myocardial Infarction Detection from Single-Lead ECG
National Institute of Health Data Science, Peking University（北京大学国家健康数据科学研究院）；State Key Laboratory of General Artificial Intelligence, Peking University（北京大学通用人工智能国家重点实验室）；School of Intelligence Science and Technology, Peking University（北京大学智能科学与技术学院）；Data Science Institute, Imperial College London（伦敦帝国学院数据科学学院）
James B. Conant High School（詹姆斯·B·柯南特高中）；Cleveland Clinic Foundation（克利夫兰诊所基金会）
Heart disease is the leading cause of death worldwide. Currently, 33% of cases are misdiagnosed, and approximately half of myocardial infarctions occur in people who are not predicted to be at risk. The use of Artificial Intelligence could reduce the chance of error, leading to possible earlier diagnoses, which could be the difference between life and death for some. The objective of this project was to develop an application for assisted heart disease diagnosis using Machine Learning (ML) and Deep Neural Network (DNN) algorithms. The dataset was provided from the Cleveland Clinic Foundation, …
Refining Myocardial Infarction Detection: A Novel Multi-Modal Composite Kernel Strategy in One-Class Classification
Tampere University（坦佩雷大学）；VTT Technical Research Centre of Finland（芬兰VTT技术研究中心）；Haltian（哈尔蒂安公司）；Qatar University（卡塔尔大学）；Hamad Medical Corporation（哈马德医疗公司）
IBM Research - Africa（IBM非洲研究院）；University of Oxford（牛津大学）；Guangdong Cardiovascular Institute（广东省心血管病研究所）
Myocardial Infarction (MI) has the highest mortality of all cardiovascular diseases (CVDs). Detection of MI and information regarding its occurrence-time in particular, would enable timely interventions that may improve patient outcomes, thereby reducing the global rise in CVD deaths. Electrocardiogram (ECG) recordings are currently used to screen MI patients. However, manual inspection of ECGs is time-consuming and prone to subjective bias. Machine learning methods have been adopted for automated ECG diagnosis, but most approaches require extraction of ECG beats or consider leads independentl…
University of Jeddah（吉达大学）；Menoufia University（米努菲亚大学）；University of Bradford（布拉德福德大学）；Sejong University（世宗大学）；Misr Higher Institute of Commerce and Computers（米斯尔高等商业与计算机学院）；Nile University（尼罗河大学）；Harbin Institute of Technology（哈尔滨工业大学）
. In this paper, an effective computer-aided diagnosis (CAD) system is presented to detect MI signals using the convolution neural network (CNN) for urban healthcare in smart cities. Two types of transfer learning techniques are employed to retrain the pre-trained VGG-Net (Fine-tuning and VGG-Net as fixed feature extractor) and obtained two new networks VGG-MI1 and VGG-MI2. In the VGG-MI1 model, the last layer of the VGG-Net model is replaced with a specific layer according to our requirements and various functions are optimized to reduce overfitting. In the VGG-MI2 model, one layer of the VGG…
The University of Winnipeg（温尼伯大学）；Qatar University（卡塔尔大学）；Hamad Medical Corporation（哈马德医疗公司）
Cardiac imaging known as echocardiography is a non-invasive tool utilized to produce data including images and videos, which cardiologists use to diagnose cardiac abnormalities in general and myocardial infarction (MI) in particular. Echocardiography machines can deliver abundant amounts of data that need to be quickly analyzed by cardiologists to help them make a diagnosis and treat cardiac conditions. However, the acquired data quality varies depending on the acquisition conditions and the patient's responsiveness to the setup instructions. These constraints are challenging to doctors especi…
University of Leicester（莱斯特大学）；NIHR Leicester Biomedical Research Centre（NIHR莱斯特生物医学研究中心）；Glenfield Hospital（格伦菲尔德医院）；Norwegian University of Science and Technology (NTNU)（挪威科技大学）；Saint-Petersburg State Electrotechnical University（圣彼得堡国立电工大学）
A "heart attack" or myocardial infarction (MI), occurs when an artery supplying blood to the heart is abruptly occluded. The "gold standard" method for imaging MI is Cardiovascular Magnetic Resonance Imaging (MRI), with intravenously administered gadolinium-based contrast (late gadolinium enhancement). However, no "gold standard" fully automated method for the quantification of MI exists. In this work, we propose an end-to-end fully automatic system (MyI-Net) for the detection and quantification of MI in MRI images. This has the potential to reduce the uncertainty due to the technical variabil…
ECGLight: Compute-Light Framework For Paper ECG Digitization and Myocardial Infarction Screening
ETH Zürich（苏黎世联邦理工学院）；Swiss Paraplegic Research（瑞士截瘫研究中心）；University of Campania “Luigi Vanvitelli”（坎帕尼亚“路易吉·万维泰利”大学）；University of Italian Switzerland, Cardiocentro Ticino Institute（意大利瑞士大学提契诺心脏中心研究所）
Machine learning predicts long-term mortality after acute myocardial infarction using systolic time intervals and routinely collected clinical data
École de technologie supérieure, Université du Québec（魁北克大学高等技术学院）；K. N. Toosi University of Technology（K. N. 图什理工大学）；Centre de recherche de l’Institut universitaire de gériatrie de Montréal（蒙特利尔大学老年学研究所）
Predicting Lethal Outcome (Cause) And Understanding Key Biomarkers Linked With Acute Myocardial Infarction Using Deep Artificial Neural Network And Ensemble Of Machine Learning Methodologies
This paper presents a method for building patient-based networks that we call Precision disease networks, and its uses for predicting medical outcomes. Our methodology consists of building networks, one for each patient or case, that describes the dis-ease evolution of the patient (PDN) and store the networks as a set of features in a data set of PDN's, one per observation. We cluster the PDN data and study the within and between cluster variability. In addition, we develop data visualization technics in order to display, compare and summarize the network data. Finally, we analyze a dataset of…
TabulaTime: A Novel Multimodal Deep Learning Framework for Advancing Acute Coronary Syndrome Prediction through Environmental and Clinical Data Integration
Department of Computing, and Mathematics, Manchester Metropolitan University（计算机与数学系，曼彻斯特 Metropolitan 大学）；Blackpool Teaching Hospitals NHS Foundation Trust（布莱克浦教学医院 NHS 基础信托）；Northern Care Alliance, NHS Foundation Trust（北方护理联盟，NHS 基础信托）；Department of Engineering, Manchester Metropolitan University（工程系，曼彻斯特 Metropolitan 大学）；Faculty of Business and Law, Manchester Metropolitan University（商业与法律学院，曼彻斯特 Metropolitan 大学）；Faculty of Medical Sciences, Newcastle University（医学科学学院，纽卡斯尔大学）
Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas（应用数学与系统研究所）；Instituto Mexicano del Seguro Social（墨西哥社会保险研究所）；Hospital Clínico Quirúrgico Hermanos Ameijeiras（阿梅赫拉斯兄弟临床外科医院）
Background: Several studies have highlighted the importance of considering sex differences in the diagnosis and treatment of Acute Coronary Syndrome (ACS). However, the identification of sex-specific risk markers in ACS sub-populations has been scarcely studied. The present study aims to explore machine learning (ML) models to identify in-hospital mortality markers for women and men in ACS sub-populations collected from a public database of electronic health records (EHR). Methods: We extracted 1,299 patients with ST-elevation myocardial infarction (STEMI) and 2,820 patients with non-ST-elevat…
Patients who suffer an acute coronary syndrome are at elevated risk for adverse cardiovascular events such as myocardial infarction and cardiovascular death. Accurate assessment of this risk is crucial to their course of care. We focus on estimating a patient's risk of cardiovascular death after an acute coronary syndrome based on a patient's raw electrocardiogram (ECG) signal. Learning from this signal is challenging for two reasons: 1) positive examples signifying a downstream cardiovascular event are scarce, causing drastic class imbalance, and 2) each patient's ECG signal consists of thous…
In this work, we propose a multi-task recurrent neural network with attention mechanism for predicting cardiovascular events from electronic health records (EHRs) at different time horizons. The proposed approach is compared to a standard clinical risk predictor (QRISK) and machine learning alternatives using 5-year data from a NHS Foundation Trust. The proposed model outperforms standard clinical risk scores in predicting stroke (AUC=0.85) and myocardial infarction (AUC=0.89), considering the largest time horizon. Benefit of using an \gls{mt} setting becomes visible for very short time horizo…
University of Wisconsin - Madison（威斯康星大学麦迪逊分校）；Marshfield Clinic Research Institute（马什菲尔德诊所研究所）；Stanford University（斯坦福大学）
The widespread digitization of patient data via electronic health records (EHRs) has created an unprecedented opportunity to use machine learning algorithms to better predict disease risk at the patient level. Although predictive models have previously been constructed for a few important diseases, such as breast cancer and myocardial infarction, we currently know very little about how accurately the risk for most diseases or events can be predicted, and how far in advance. Machine learning algorithms use training data rather than preprogrammed rules to make predictions and are well suited for…
Causally-informed Deep Learning towards Explainable and Generalizable Outcomes Prediction in Critical Care
Tsinghua University（清华大学）；Institute of Brain and Cognitive Sciences, Tsinghua University（清华大学脑与认知科学研究院）；Chinese PLA General Hospital（中国人民解放军总医院）；Shanghai Artificial Intelligence Laboratory（上海人工智能实验室）
