在分叉流动实验中大的超顺磁性纳米颗粒的同时磁性颗粒成像和导航
Simultaneous Magnetic Particle Imaging and Navigation of large superparamagnetic nanoparticles in bifurcation flow experiments
摘要：
磁粒子成像（MPI）已成功地用于以高灵敏度实时可视化超顺磁性纳米颗粒在3D体积内的分布。由于MPI扫描仪的磁场拓扑非常适合于在颗粒和微米尺寸的铁磁设备上施加磁力，因此MPI最近已被用于导航微米尺寸的颗粒和微米尺寸的游泳者。在这项工作中，我们分析了磁泳流动性和成像性能的两种不同的粒子类型的磁性粒子成像/导航（MPIN）。MPIN在成像和磁模式之间不断切换，实现准同步导航和粒子成像。我们确定的极限流速为8.18毫升/秒，使用流动分叉实验，允许所有的颗粒只流过一个分支的分叉。此外，我们已经成功地导航粒子通过分支的分叉幻影缩小60%或100%狭窄，同时成像其上的狭窄积累。与治疗物质组合的颗粒具有靶向药物递送的高潜力，并且可以帮助减少剂量并提高药物的功效，例如用于特定的肿瘤治疗和缺血性中风治疗。
英文摘要：
Magnetic Particle Imaging (MPI) has been successfully used to visualize the distribution of superparamagnetic nanoparticles within 3D volumes with high sensitivity in real time. Since the magnetic field topology of MPI scanners is well suited for applying magnetic forces on particles and micron-sized ferromagnetic devices, MPI has been recently used to navigate micron-sized particles and micron-sized swimmers. In this work, we analyze the magnetophoretic mobility and the imaging performance of two different particle types for Magnetic Particle Imaging/Navigation (MPIN). MPIN constantly switches between imaging and magnetic modes, enabling quasi-simultaneous navigation and imaging of particles. We determine the limiting flow velocity to be 8.18 mL/s using a flow bifurcation experiment, that allows all particles to flow only through one branch of the bifurcation. Furthermore, we have succeeded in navigating the particles through the branch of a bifurcation phantom narrowed by either 60% or 100% stenosis, while imaging their accumulation on the stenosis. The particles in combination with therapeutic substances have a high potential for targeted drug delivery and could help to reduce the dose and improve the efficacy of the drug, e.g. for specific tumor therapy and ischemic stroke therapy.
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