磁偶极-偶极相互作用对磁粒子光谱学（MPS）影响的研究：对基于磁性纳米粒子的生物测定和磁粒子成像（MPI）的影响
Investigating the Effect of Magnetic Dipole-Dipole Interaction on Magnetic Particle Spectroscopy (MPS): Implications for Magnetic Nanoparticle-based Bioassays and Magnetic Particle Imaging (MPI)
摘要：
超顺磁性氧化铁纳米颗粒（SPION），具有与生物分子（如蛋白质，核酸等）相当的尺寸。并且具有独特的磁性、良好的生物相容性、低毒性、强催化性能，是许多生物医学应用的有希望的候选物。在大多数SPION系统中存在一个属性，但它尚未被充分利用，这是SPION之间的偶极-偶极相互作用（也称为偶极相互作用）。众所周知，自旋离子系综的磁动力学特性受偶极相互作用的影响很大。然而，它影响基于磁性粒子的生物测定和磁性粒子成像（MPI）性能的确切方式仍然是一个悬而未决的问题。本文的目的是对这一问题给出一个部分的回答。这是通过对两个附近的自旋离子之间的偶极相互作用的数值模拟和实验测量的自旋离子的合奏使用我们的实验室为基础的磁粒子谱（MPS）系统。我们的研究结果表明，即使温和的变化，SPION浓度可能有实质性的影响上的磁动力学的SPION系统和谐波信号的幅度可以增加或减少60%，这取决于MPS系统参数的值。
英文摘要：
Superparamagnetic iron oxide nanoparticles (SPIONs), with comparable size to biomolecules (such as proteins, nucleic acids, etc.) and unique magnetic properties, good biocompatibility, low toxicity, potent catalytic behavior, are promising candidates for many biomedical applications. There is one property present in most SPION systems, yet it has not been fully exploited, which is the dipole-dipole interaction (also called dipolar interaction) between the SPIONs. It is known that the magnetic dynamics of an ensemble of SPIONs are substantially influenced by the dipolar interactions. However, the exact way it affects the performance of magnetic particle-based bioassays and magnetic particle imaging (MPI) is still an open question. The purpose of this paper is to give a partial answer to this question. This is accomplished by numerical simulations on the dipolar interactions between two nearby SPIONs and experimental measurements on an ensemble of SPIONs using our lab-based magnetic particle spectroscopy (MPS) system. Our results show that even moderate changes in the SPION concentration may have substantial effects on the magnetic dynamics of the SPION system and the harmonic signal magnitudes can be increased or decreased by 60%, depending on the values of MPS system parameters.
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