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arXiv 1906.02540eess.IVcs.CVphysics.med-ph
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分层贝叶斯心肌灌注定量

Hierarchical Bayesian myocardial perfusion quantification

School of Biomedical Engineering and Imaging Sciences, King’s College London(伦敦国王学院生物医学工程与影像科学学院);The Alan Turing Institute(阿兰·图灵研究所);Philips Healthcare(飞利浦医疗保健);Eindhoven University of Technology(埃因霍温理工大学)

Cian M. Scannell, Amedeo Chiribiri, Adriana D. M. Villa, Marcel Breeuwer, Jack Lee

摘要:

目的:示踪剂动力学模型可用于对比增强MRI数据的定量评估。然而,由于所获取的数据有限和高噪声水平,模型拟合可能产生不可靠的结果。这样的问题在心肌灌注MRI中尤其普遍,导致约束数值解卷积和节段信号平均的折衷,通常用作更复杂的示踪剂动力学模型的替代方案。方法:在这项工作中,使用多层贝叶斯推理的参数估计进行了探索。结果表明,贝叶斯推断,它是可能的,以可靠地适合的两室交换模型灌注数据。与传统的最小二乘方法相比,使用关于动力学参数范围的先验知识以及相邻体素可能具有类似的动力学特性的事实与基于马尔可夫链蒙特卡罗的拟合过程相结合显著提高了灌注估计的可靠性。该方法使用模拟和患者数据进行评估。结果如下:模拟体模的不同噪声实现的平均(标准差)归一化均方误差从最小二乘拟合的0.32(0.55)降至贝叶斯推断的0.13(0.2)。纯粹基于使用贝叶斯推断获得的定量MBF图的冠状动脉疾病存在的评估与所有24个切片中的视觉评估相匹配。当使用通过最小二乘拟合获得的地图时,仅在16/24切片中实现相应的评估。结论:贝叶斯推断允许使用二室交换模型在体素水平上对心肌灌注进行可靠、全自动和用户独立的评估。

英文摘要:

Purpose: Tracer-kinetic models can be used for the quantitative assessment of contrast-enhanced MRI data. However, the model-fitting can produce unreliable results due to the limited data acquired and the high noise levels. Such problems are especially prevalent in myocardial perfusion MRI leading to the compromise of constrained numerical deconvolutions and segmental signal averaging being commonly used as alternatives to the more complex tracer-kinetic models. Methods: In this work, the use of hierarchical Bayesian inference for the parameter estimation is explored. It is shown that with Bayesian inference it is possible to reliably fit the two-compartment exchange model to perfusion data. The use of prior knowledge on the ranges of kinetic parameters and the fact that neighbouring voxels are likely to have similar kinetic properties combined with a Markov chain Monte Carlo based fitting procedure significantly improves the reliability of the perfusion estimates with compared to the traditional least-squares approach. The method is assessed using both simulated and patient data. Results: The average (standard deviation) normalised mean square error for the distinct noise realisations of a simulation phantom falls from 0.32 (0.55) with the least-squares fitting to 0.13 (0.2) using Bayesian inference. The assessment of the presence of coronary artery disease based purely on the quantitative MBF maps obtained using Bayesian inference matches the visual assessment in all 24 slices. When using the maps obtained by the least-squares fitting, a corresponding assessment is only achieved in 16/24 slices. Conclusion: Bayesian inference allows a reliable, fully automated and user-independent assessment of myocardial perfusion on a voxel-wise level using the two-compartment exchange model.

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