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arXiv 1902.02303physics.bio-phcond-mat.softnlin.CGq-bio.CB
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活性细胞在非粘附基质上的聚集动力学

Aggregation dynamics of active cells on non-adhesive substrate

Debangana Mukhopadhyay, Rumi De

摘要:

细胞自组装和组织是生物组织发育的基本步骤。在本文中,在一个元胞自动机模型的框架内,我们解决了如何从一个随机迁移的单细胞群体自发出现一个有序的组织模式,没有任何外部线索的影响。该模型基于细胞的主动运动性和它们由于如在实验中观察到的细胞-细胞内聚性而重组的能力。我们的模型成功地模拟了新生簇的形成,并预测了导致紧凑的组织结构的聚集体的时间演变。此外,模拟还捕捉到几个动态特性的增长聚集体,如细胞聚集的速度和非单调增长的聚集体面积,这与现有的实验观察显示出良好的协议。我们进一步调查的时间演化的内聚强度,和紧密性的聚集体,并研究的坚固性的增长结构,通过评估的分形维数,以深入了解肿瘤组织生长的复杂性,这是迄今为止尚未探索。

英文摘要:

Cellular self-assembly and organization are fundamental steps for the development of biological tissues. In this paper, within the framework of a cellular automata model, we address how an ordered tissue pattern spontaneously emerges from a randomly migrating single cell population without the influence of any external cues. This model is based on the active motility of cells and their ability to reorganize due to cell-cell cohesivity as observed in experiments. Our model successfully emulates the formation of nascent clusters and also predicts the temporal evolution of aggregates that leads to the compact tissue structures. Moreover, the simulations also capture several dynamical properties of growing aggregates, such as, the rate of cell aggregation and non-monotonic growth of the aggregate area which show a good agreement with the existing experimental observations. We further investigate the time evolution of the cohesive strength, and the compactness of aggregates, and also study the ruggedness of the growing structures by evaluating the fractal dimension to get insights into the complexity of tumorous tissue growth which were hitherto unexplored.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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