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arXiv 1810.04589q-bio.SC
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受体串扰改善多配体的浓度感测

Receptor crosstalk improves concentration sensing of multiple ligands

Martin Carballo-Pacheco, Jonathan Desponds, Tatyana Gavrilchenko, Andreas Mayer, Roshan Prizak, Gautam Reddy, Ilya Nemenman, Thierry Mora

发表信息：
Phys. Rev. E 99, 022423 (2019)
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摘要：

细胞需要可靠地感知外部配体浓度以实现各种生物功能，如趋化性或信号传导。表面受体对配体的分子识别在许多系统中是简并的，导致不同受体之间的串扰。串扰通常被认为是偏离最佳特异性识别，因为非同源配体的结合可干扰受体的同源配体的检测，可能导致下游信号通路的错误触发。在这里，我们量化的最佳精度感测多个配体的浓度由一组混杂受体。我们证明，串扰可以提高精度的浓度传感和歧视的任务。为了实现更高的精密度，应利用非同源配体的短结合事件中包含的配体浓度的额外信息。我们提出了一个校对计划，以实现多个配体浓度的近似估计，达到接近所得出的最佳界限的精度。我们的研究结果有助于合理化观察到的无处不在的受体串扰分子传感。

英文摘要：

Cells need to reliably sense external ligand concentrations to achieve various biological functions such as chemotaxis or signaling. The molecular recognition of ligands by surface receptors is degenerate in many systems leading to crosstalk between different receptors. Crosstalk is often thought of as a deviation from optimal specific recognition, as the binding of non-cognate ligands can interfere with the detection of the receptor's cognate ligand, possibly leading to a false triggering of a downstream signaling pathway. Here we quantify the optimal precision of sensing the concentrations of multiple ligands by a collection of promiscuous receptors. We demonstrate that crosstalk can improve precision in concentration sensing and discrimination tasks. To achieve superior precision, the additional information about ligand concentrations contained in short binding events of the non-cognate ligand should be exploited. We present a proofreading scheme to realize an approximate estimation of multiple ligand concentrations that reaches a precision close to the derived optimal bounds. Our results help rationalize the observed ubiquity of receptor crosstalk in molecular sensing.

机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。

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