It has been shown that for automated PAP-smear image classification, nucleus features can be very informative. Therefore, the primary step for automated screening can be cell-nuclei detection followed by segmentation of nuclei in the resulting single cell PAP-smear images. We propose a patch based approach using CNN for segmentation of nuclei in single cell images. We then pose the question of ion of segmentation for classification using representation learning with CNN, and whether low-level CNN features may be useful for classification. We suggest a CNN-based feature level analysis and a transfer learning based approach for classification using both segmented as well full single cell images. We also propose a decision-tree based approach for classification. Experimental results demonstrate the effectiveness of the proposed algorithms individually (with low-level CNN features), and simultaneously proving the sufficiency of cell-nuclei detection (rather than accurate segmentation) for classification. Thus, we propose a system for analysis of multi-cell PAP-smear images consisting of a simple nuclei detection algorithm followed by classification using transfer learning.
Northeastern University（东北大学）；Liaoning Petrochemical University（辽宁石油化工大学）；Chengdu University of Information Technology（成都信息工程大学）；China Medical University（中国医科大学）；Suzhou Ruiqian Technology Company Ltd.（苏州睿仟科技有限公司）
Cervical cancer is the seventh most common cancer among all the cancers worldwide and the fourth most common cancer among women. Cervical cytopathology image classification is an important method to diagnose cervical cancer. Manual screening of cytopathology images is time-consuming and error-prone. The emergence of the automatic computer-aided diagnosis system solves this problem. This paper proposes a framework called CVM-Cervix based on deep learning to perform cervical cell classification tasks. It can analyze pap slides quickly and accurately. CVM-Cervix first proposes a Convolutional Neu…
Malaria is a serious disease caused by the Plasmodium parasite that transmitted through the bite of a female Anopheles mosquito and invades human erythrocytes. Malaria must be recognized precisely in order to treat the patient in time and to prevent further spread of infection. The standard diagnostic technique using microscopic examination is inefficient, the quality of the diagnosis depends on the quality of blood smears and experience of microscopists in classifying and counting infected and non-infected cells. Convolutional Neural Networks (CNN) is one of deep learning class that able to a…
Deep Learning with Self-Attention and Enhanced Preprocessing for Precise Diagnosis of Acute Lymphoblastic Leukemia from Bone Marrow Smears in Hemato-Oncology
organization= Department of Mechatronics Engineering , addressline= Rajshahi University of Engineering \& Technology , city= Rajshahi , country= Bangladesh
A COCO-Formatted Instance-Level Dataset for Plasmodium Falciparum Detection in Giemsa-Stained Blood Smears
MIRA Vision Microscopy GmbH（MIRA视觉显微镜 GmbH）；Pattern Recognition Lab, Department of Computer Science, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg（模式识别实验室，计算机科学系，弗赖堡-艾尔兰根-纽伦堡大学）
Shenzhen University（深圳大学）；Tencent Holdings Limited（腾讯控股有限公司）；Nvidia Corporation（英伟达公司）；National Institutes of Health（美国国立卫生研究院）
Fine-grained classification of cervical cells into different abnormality levels is of great clinical importance but remains very challenging. Contrary to traditional classification methods that rely on hand-crafted or engineered features, convolution neural network (CNN) can classify cervical cells based on automatically learned deep features. However, CNN in previous studies do not involve cell morphological information, and it is unknown whether morphological features can be directly modeled by CNN to classify cervical cells. This paper presents a CNN-based method that combines cell image ap…
Peking University（北京大学）；Beijing Institute of Big Data Research（北京大数据研究院）；Massachusetts General Hospital（麻省总医院）
Pap smear testing has been widely used for detecting cervical cancers based on the morphology properties of cell nuclei in microscopic image. An accurate nuclei segmentation could thus improve the success rate of cervical cancer screening. In this work, a method of automated cervical nuclei segmentation using Deformable Multipath Ensemble Model (D-MEM) is proposed. The approach adopts a U-shaped convolutional network as a backbone network, in which dense blocks are used to transfer feature information more effectively. To increase the flexibility of the model, we then use deformable convolutio…
Information Technology University（信息技术大学）；University of North Carolina at Charlotte（北卡罗来纳大学夏洛特分校）；Chughtai Institute of Pathology（楚格泰病理研究所）；Ittefaq hospital（伊特法克医院）
Malaria microscopy, microscopic examination of stained blood slides to detect parasite Plasmodium, is considered to be a gold-standard for detecting life-threatening disease malaria. Detecting the plasmodium parasite requires a skilled examiner and may take up to 10 to 15 minutes to completely go through the whole slide. Due to a lack of skilled medical professionals in the underdeveloped or resource deficient regions, many cases go misdiagnosed; resulting in unavoidable complications and/or undue medication. We propose to complement the medical professionals by creating a deep learning-based …
Indian Institute of Technology Kanpur（印度理工学院坎普尔分校）；Asea Brown Boveri Company（阿西亚布朗勃法瑞公司（ABB公司））；Indian Institute of Science Education and Research Kolkata（印度科学教育与研究学院加尔各答分院）
Purpose: Cervical cancer is one of the primary causes of death in women. It should be diagnosed early and treated according to the best medical advice, as with other diseases, to ensure that its effects are as minimal as possible. Pap smear images are one of the most constructive ways for identifying this type of cancer. This study proposes a cross-attention-based Transfomer approach for the reliable classification of cervical cancer in Pap smear images. Methods: In this study, we propose the CerviFormer -- a model that depends on the Transformers and thereby requires minimal architectural ass…
University of Ottawa（渥太华大学）；Minai University（米尼亚大学）
In this paper we discuss a new method for detecting leukemia in microscopic blood smear images using deep neural networks to diagnose leukemia early in blood. leukemia is considered one of the most dangerous mortality causes for a human being, the traditional process of diagnosis of leukemia in blood is complex, costly, and time-consuming, so patients could not receive medical treatment on time; Computer vision classification technique using deep learning can overcome the problems of traditional analysis of blood smears, our system for leukemia detection provides 97.3 % accuracy in classifying…
The Chinese University of Hong Kong（香港中文大学）；Imsight Medical Technology, Co., Ltd.（视见医疗科技有限公司）；Imperial College London（帝国理工学院）；Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）
Cell instance segmentation in Pap smear image remains challenging due to the wide existence of occlusion among translucent cytoplasm in cell clumps. Conventional methods heavily rely on accurate nuclei detection results and are easily disturbed by miscellaneous objects. In this paper, we propose a novel Instance Relation Network (IRNet) for robust overlapping cell segmentation by exploring instance relation interaction. Specifically, we propose the Instance Relation Module to construct the cell association matrix for transferring information among individual cell-instance features. With the co…
Interpretable pap smear cell representation for cervical cancer screening
Kyungpook National University（庆北国立大学）；Clinical Omics Institute, Kyungpook National University（庆北国立大学临床组学研究所）；Kyungpook National University Chilgok Hospital（庆北国立大学漆谷医院）
Government College of Engineering & Ceramic Technology（政府工程与陶瓷技术学院）；Indian Institute of Science Education and Research (IISER)（印度科学教育与研究学院）
The advent of Deep Learning models like VGG-16 and Resnet-50 has considerably revolutionized the field of image classification, and by using these Convolutional Neural Networks (CNN) architectures, one can get a high classification accuracy on a wide variety of image datasets. However, these Deep Learning models have a very high computational complexity and so incur a high computational cost of running these algorithms as well as make it hard to interpret the results. In this paper, we present a shallow CNN architecture which gives the same classification accuracy as the VGG-16 and Resnet-50 m…
School of Electrical and Information Engineering, Tianjin University（天津大学电气与信息工程学院）；The Hang Seng University of Hong Kong（香港恒生大学）
This paper proposes a novel automatic classification framework for the recognition of five types of white blood cells. Segmenting complete white blood cells from blood smears images and extracting advantageous features from them remain challenging tasks in the classification of white blood cells. Therefore, we present an adaptive threshold segmentation method to deal with blood smears images with non-uniform color and uneven illumination, which is designed based on color space information and threshold segmentation. Subsequently, after successfully separating the white blood cell from the bloo…
National Institutes of Health Clinical Center（美国国立卫生研究院临床中心）
Automation-assisted cervical screening via Pap smear or liquid-based cytology (LBC) is a highly effective cell imaging based cancer detection tool, where cells are partitioned into "abnormal" and "normal" categories. However, the success of most traditional classification methods relies on the presence of accurate cell segmentations. Despite sixty years of research in this field, accurate segmentation remains a challenge in the presence of cell clusters and pathologies. Moreover, previous classification methods are only built upon the extraction of hand-crafted features, such as morphology and…
Jadavpur University（贾达普大学）；Theism Medical Diagnostics Centre（Theism医学诊断中心）
Cervical cancer is one of the most deadly and common diseases among women worldwide. It is completely curable if diagnosed in an early stage, but the tedious and costly detection procedure makes it unviable to conduct population-wise screening. Thus, to augment the effort of the clinicians, in this paper, we propose a fully automated framework that utilizes Deep Learning and feature selection using evolutionary optimization for cytology image classification. The proposed framework extracts Deep feature from several Convolution Neural Network models and uses a two-step feature reduction approac…
Institute of AI for Health, Helmholtz Munich – German Research Center for Environmental Health（亥姆霍兹慕尼黑中心——德国环境健康研究中心健康人工智能研究所）；Politecnico Di Torino（都灵理工大学）；Technical University of Munich（慕尼黑工业大学）；Johns Hopkins University（约翰斯·霍普金斯大学）；University Hospital Bonn（波恩大学医院）；Helmholtz AI, Helmholtz Munich – German Research Center for Environmental Health（亥姆霍兹慕尼黑中心——德国环境健康研究中心亥姆霍兹人工智能）
Diagnosing hematological malignancies requires identification and classification of white blood cells in peripheral blood smears. Domain shifts caused by different lab procedures, staining, illumination, and microscope settings hamper the re-usability of recently developed machine learning methods on data collected from different sites. Here, we propose a cross-domain adapted autoencoder to extract features in an unsupervised manner on three different datasets of single white blood cells scanned from peripheral blood smears. The autoencoder is based on an R-CNN architecture allowing it to focu…
In this paper, we describe how to apply image-to-image translation techniques to medical blood smear data to generate new data samples and meaningfully increase small datasets. Specifically, given the segmentation mask of the microscopy image, we are able to generate photorealistic images of blood cells which are further used alongside real data during the network training for segmentation and object detection tasks. This image data generation approach is based on conditional generative adversarial networks which have proven capabilities to high-quality image synthesis. In addition to synthesi…
This work evaluates the reproducibility of the paper "CNN-generated images are surprisingly easy to spot... for now" by Wang et al. published at CVPR 2020. The paper addresses the challenge of detecting CNN-generated imagery, which has reached the potential to even fool humans. The authors propose two methods which help an image classifier to generalize from being trained on one specific CNN to detecting imagery produced by unseen architectures, training methods, or data sets. The paper proposes two methods to help a classifier generalize: (i) utilizing different kinds of data augmentations an…
University of Genova（热那亚大学）；Istituto Italiano di Tecnologia（意大利技术研究院）；University of Trento（特伦托大学）；Allen Institute for AI（艾伦人工智能研究所）
In this paper we introduce a novel method for general semantic segmentation that can benefit from general semantics of Convolutional Neural Network (CNN). Our segmentation proposes visually and semantically coherent image segments. We use binary encoding of CNN features to overcome the difficulty of the clustering on the high-dimensional CNN feature space. These binary codes are very robust against noise and non-semantic changes in the image. These binary encoding can be embedded into the CNN as an extra layer at the end of the network. This results in real-time segmentation. To the best of ou…
Malaria, a life-threatening disease, infects millions of people every year throughout the world demanding faster diagnosis for proper treatment before any damages occur. In this paper, an end-to-end deep learning-based approach is proposed for faster diagnosis of malaria from thin blood smear images by making efficient optimizations of features extracted from diversified receptive fields. Firstly, an efficient, highly scalable deep neural network, named as DilationNet, is proposed that incorporates features from a large spectrum by varying dilation rates of convolutions to extract features fro…
Bristol Robotics Laboratory（布里斯托尔机器人实验室）；University of Bristol（布里斯托尔大学）；University of Manchester（曼彻斯特大学）
This work demonstrates direct visual sensory-motor control using high-speed CNN inference via a SCAMP-5 Pixel Processor Array (PPA). We demonstrate how PPAs are able to efficiently bridge the gap between perception and action. A binary Convolutional Neural Network (CNN) is used for a classic rock, paper, scissors classification problem at over 8000 FPS. Control instructions are directly sent to a servo motor from the PPA according to the CNN's classification result without any other intermediate hardware.
University of California, Los Angeles（加州大学洛杉矶分校）；Beijing Institute of Technology（北京理工大学）
Given a pre-trained CNN without any testing samples, this paper proposes a simple yet effective method to diagnose feature representations of the CNN. We aim to discover representation flaws caused by potential dataset bias. More specifically, when the CNN is trained to estimate image attributes, we mine latent relationships between representations of different attributes inside the CNN. Then, we compare the mined attribute relationships with ground-truth attribute relationships to discover the CNN's blind spots and failure modes due to dataset bias. In fact, representation flaws caused by dat…
Deep convolutional neural networks (CNNs) have had a major impact in most areas of image understanding, including object category detection. In object detection, methods such as R-CNN have obtained excellent results by integrating CNNs with region proposal generation algorithms such as selective search. In this paper, we investigate the role of proposal generation in CNN-based detectors in order to determine whether it is a necessary modelling component, carrying essential geometric information not contained in the CNN, or whether it is merely a way of accelerating detection. We do so by desig…
Indian Institute of Technology, Kharagpur（印度理工学院卡拉格普尔分校）
Recently, CNN is a popular choice to handle the hyperspectral image classification challenges. In spite of having such large spectral information in Hyper-Spectral Image(s) (HSI), it creates a curse of dimensionality. Also, large spatial variability of spectral signature adds more difficulty in classification problem. Additionally, training a CNN in the end to end fashion with scarced training examples is another challenging and interesting problem. In this paper, a novel target-patch-orientation method is proposed to train a CNN based network. Also, we have introduced a hybrid of 3D-CNN and 2…
School of Electrical Engineering, KAIST（韩国科学技术院电气工程学院）
In convolutional neural networks (CNNs), the filter grouping in convolution layers is known to be useful to reduce the network parameter size. In this paper, we propose a new logarithmic filter grouping which can capture the nonlinearity of filter distribution in CNNs. The proposed logarithmic filter grouping is installed in shallow CNNs applicable in a mobile application. Experiments were performed with the shallow CNNs for classification tasks. Our classification results on Multi-PIE dataset for facial expression recognition and CIFAR-10 dataset for object classification reveal that the comp…
Korea Advanced Institute of Science and Technology（韩国高等科学技术院）；Korea University College of Medicine（高丽大学医学院）
In this paper, we proposed Transferable Ranking Convolutional Neural Network (TRk-CNN) that can be effectively applied when the classes of images to be classified show a high correlation with each other. The multi-class classification method based on the softmax function, which is generally used, is not effective in this case because the inter-class relationship is ignored. Although there is a Ranking-CNN that takes into account the ordinal classes, it cannot reflect the inter-class relationship to the final prediction. TRk-CNN, on the other hand, combines the weights of the primitive classifi…
Fully-connected Conditional Random Field (CRF) is often used as post-processing to refine voxel classification results by encouraging spatial coherence. In this paper, we propose a new end-to-end training method called Posterior-CRF. In contrast with previous approaches which use the original image intensity in the CRF, our approach applies 3D, fully connected CRF to the posterior probabilities from a CNN and optimizes both CNN and CRF together. The experiments on white matter hyperintensities segmentation demonstrate that our method outperforms CNN, post-processing CRF and different end-to-en…
Institute of Information Science, Academia Sinica（中央研究院资讯科学研究所）
Automatic age and gender classification based on unconstrained images has become essential techniques on mobile devices. With limited computing power, how to develop a robust system becomes a challenging task. In this paper, we present an efficient convolutional neural network (CNN) called lightweight multi-task CNN for simultaneous age and gender classification. Lightweight multi-task CNN uses depthwise separable convolution to reduce the model size and save the inference time. On the public challenging Adience dataset, the accuracy of age and gender classification is better than baseline mul…
Hiroshima University（广岛大学）；Hiroshima General Hospital of West Japan Railway Company（西日本旅客铁道株式会社广岛综合医院）；Hiroshima University Hospital（广岛大学医院）
In this paper we report results for recognizing colorectal NBI endoscopic images by using features extracted from convolutional neural network (CNN). In this comparative study, we extract features from different layers from different CNN models, and then train linear SVM classifiers. Experimental results with 10-fold cross validations show that features from first few convolution layers are enough to achieve similar performance (i.e., recognition rate of 95%) with non-CNN local features such as Bag-of-Visual words, Fisher vector, and VLAD.
Glaucoma is a disease in which the optic nerve is chronically damaged by the elevation of the intra-ocular pressure, resulting in visual field defect. Therefore, it is important to monitor and treat suspected patients before they are confirmed with glaucoma. In this paper, we propose a 2-stage ranking-CNN that classifies fundus images as normal, suspicious, and glaucoma. Furthermore, we propose a method of using the class activation map as a mask filter and combining it with the original fundus image as an intermediate input. Our results have improved the average accuracy by about 10% over the…
Indian Institute of Information Technology, Sri City（斯里城印度信息技术学院）
The unsupervised depth estimation is the recent trend by utilizing the binocular stereo images to get rid of depth map ground truth. In unsupervised depth computation, the disparity images are generated by training the CNN with an image reconstruction loss. In this paper, a dual CNN based model is presented for unsupervised depth estimation with 6 losses (DNM6) with individual CNN for each view to generate the corresponding disparity map. The proposed dual CNN model is also extended with 12 losses (DNM12) by utilizing the cross disparities. The presented DNM6 and DNM12 models are experimented …
This paper addresses the problem of video object segmentation, where the initial object mask is given in the first frame of an input video. We propose a novel spatio-temporal Markov Random Field (MRF) model defined over pixels to handle this problem. Unlike conventional MRF models, the spatial dependencies among pixels in our model are encoded by a Convolutional Neural Network (CNN). Specifically, for a given object, the probability of a labeling to a set of spatially neighboring pixels can be predicted by a CNN trained for this specific object. As a result, higher-order, richer dependencies a…
Recently, the example-based single image spectral reconstruction from RGB images task, aka, spectral super-resolution was approached by means of deep learning by Galliani et al. The proposed very deep convolutional neural network (CNN) achieved superior performance on recent large benchmarks. However, Aeschbacher et al showed that comparable performance can be achieved by shallow learning method based on A+, a method introduced for image super-resolution by Timofte et al. In this paper, we propose a moderately deep CNN model and substantially improve the reported performance on three spectral …
This paper proposes a CNN cascade for semantic part segmentation guided by pose-specific information encoded in terms of a set of landmarks (or keypoints). There is large amount of prior work on each of these tasks separately, yet, to the best of our knowledge, this is the first time in literature that the interplay between pose estimation and semantic part segmentation is investigated. To address this limitation of prior work, in this paper, we propose a CNN cascade of tasks that firstly performs landmark localisation and then uses this information as input for guiding semantic part segmentat…
R-CNN style methods are sorts of the state-of-the-art object detection methods, which consist of region proposal generation and deep CNN classification. However, the proposal generation phase in this paradigm is usually time consuming, which would slow down the whole detection time in testing. This paper suggests that the value discrepancies among features in deep convolutional feature maps contain plenty of useful spatial information, and proposes a simple approach to extract the information for fast region proposal generation in testing. The proposed method, namely Relief R-CNN (R2-CNN), ado…
A Hybrid Feature Fusion Deep Learning Framework for Leukemia Cancer Detection in Microscopic Blood Sample Using Gated Recurrent Unit and Uncertainty Quantification
Jagannath University（贾格纳特大学）；Green University of Bangladesh（孟加拉国绿色大学）
Classification of White Blood Cells Using Machine and Deep Learning Models: A Systematic Review
University of Lahore（拉合尔大学）；University of Limerick（利默里克大学）；Dublin Institute of Technology（都柏林理工学院）；National University of Sciences and Technology（国家科技大学）
Wuhan University（武汉大学）；City University of Hong Kong（香港城市大学）；Johns Hopkins University（约翰斯·霍普金斯大学）；Tencent AI Lab（腾讯人工智能实验室）
In this paper, we propose a novel Convolutional Neural Network (CNN) structure for general-purpose multi-task learning (MTL), which enables automatic feature fusing at every layer from different tasks. This is in contrast with the most widely used MTL CNN structures which empirically or heuristically share features on some specific layers (e.g., share all the features except the last convolutional layer). The proposed layerwise feature fusing scheme is formulated by combining existing CNN components in a novel way, with clear mathematical interpretability as discriminative dimensionality reduc…
We propose a novel universal detector for detecting images generated by using CNNs. In this paper, properties of checkerboard artifacts in CNN-generated images are considered, and the spectrum of images is enhanced in accordance with the properties. Next, a classifier is trained by using the enhanced spectrums to judge a query image to be a CNN-generated ones or not. In addition, an ensemble of the proposed detector with emphasized spectrums and a conventional detector is proposed to improve the performance of these methods. In an experiment, the proposed ensemble is demonstrated to outperform…
